Abstract: The application provides tri-specific antibody monomers having a N-terminal and a C-terminal, comprising in tandem from the N-terminal to the C-terminal, a first scFv domain at the N-terminal, a Fab domain, a Fc domain, and a second scFv domain at the C-terminal. In one embodiment, the first scFv domain, the Fab domain, and the second scFv domain each has a binding specificity against a different antigen.

Abstract: A multi-specific antibody-like protein having a first monomer comprising a first binding monomer, a CH1 domain, a first hinge, a first CH2 domain, and a first CH3 domain, a second monomer comprising a second binding monomer, a CL domain, a second hinge, a second CH2 domain, and a second CH3 domain, wherein the first binding monomer and a second binding monomer are configured to form a dimer, wherein the first monomer and the second monomer are covalently paired through at least one disulfide bond between the CH1 domain and the CL domain and at least one disulfide bond between the first hinge and the second hinge, wherein the first monomer and second monomer may comprise optionally a first binding domain (D1) and a second binding domain (D2), and a fourth binding domain (D4) and a fifth binding domain (D5), and wherein the multi-specific antibody-like protein is at least bi-specific.

Abstract: The application provides multi-specific antibody-like proteins may comprising one or more binding domains including a first binding domain (D1), a second binding domain (D2), a third binding domain (D3), a fourth binding domain (D4), a fifth binding domain (D5), or a sixth binding domain (D6). The multi-specific antibody-like protein disclosed herein may be mono-specific, bi-specific, tri-specific, tetra-specific, penta-specific or hexa-specific. The binding domains such as D1, D2, D3, D4, D5, and D6 may each independently have a binding affinity to specificity against a T cell activating receptor, an immune cell receptor, an immune checkpoint molecule, a co-stimulation factor, a receptor of a leukocyte, a tumor antigen, a tumor associated antigen (TAA), a receptor of a tissue cell, a receptor of a cancer cell, or a combination thereof.

Abstract: Example embodiments relate to power amplifiers and Doherty amplifiers that include the same. One example embodiment includes a power amplifier. The power amplifier includes one or more radiofrequency (RF) output terminals. The power amplifier also includes a Gallium Nitride (GaN) semiconductor die on which a power field-effect transistor (FET) is integrated. The FET includes a plurality of FET cells that are adjacently arranged in a row. The FET cells are connected either directly or indirectly to the one or more RF output terminals via a respective first inductor. For FET cells arranged at opposing ends of the row of FET cells, a total FET cell gate width and an inductance of the first inductor is larger and smaller than the total FET cell gate width and inductance of the first inductor for one or more FET cells arranged in the middle of the row of FET cells, respectively.

Abstract: An isolated monoclonal antibody (mAb) or antigen-binding fragment thereof having a binding specificity to human CD19, wherein the isolated mAb or antigen-binding fragment comprises an amino acid sequence having an identity with a sequence selected from SEQ ID NO. 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 91, or 93, wherein the identity is not less than at least 95%.

Abstract: Systems and methods for constructing a panoramic view based on a changing viewpoint are disclosed. An exemplary system includes a storage device configured to receive first image data of a scene for a first viewpoint at a first predetermined elevation. The system further includes at least one processor configured to convert the first image data to candidate image data for at one or more second predetermined elevations using a deep learning neural network. The at least one processor is further configured to receive a user view request for virtually viewing the scene and determine second image data for a second viewpoint associated with the user view request, by mapping the second viewpoint to the one or more second predetermined elevations. The at least one processor is also configured to render the three-dimensional model of the scene based on the second image data and display the panoramic view in response to the user view request.

Abstract: A method for video processing is provided. The method comprises obtaining an image of a scene, obtaining a video that records an area included in the scene, determining one or more frames from the plurality of frames of the video, determining pairs of matched features, generating a plurality of composite frames by combining each of the selected one or more frames with the image of the scene based on the pairs of matched features, and generating a composite video based on the plurality of composite frames. Each of the pairs of matched features is related to an object that is in both the image and the one or more frames. Each of the pairs of matched features is associated with one or more pixels of the image of the scene and one or more pixels of a selected frame of the one or more frames.

Abstract: The application provides the anti-PD-L1 monoclonal antibodies, antigen binding portions thereof, therapeutic compositions thereof and/or nucleic acid encoding the same, and their use to upregulate the function of T-cells to enhance cell-mediated immune responses in the treatment of cancer and other T-cell dysfunctional disorders.

Abstract: The application provides a multi-specific antibody-like protein having a N-terminal and a C-terminal, comprising in tandem from the N-terminal to the C-terminal, a first binding domain (D1) at the N-terminal, a second binding domain (D2) comprising a light chain moiety, a Fc region, a third binding domain (D3), and a fourth binding domain (D4) at the C-terminal, wherein the light chain moiety comprises a fifth binding domain (D5) covalently attached to the C-terminal, a sixth binding domain (D6) covalently attached to the N-terminal, or both, and wherein the D1, D2, D3, D4, D5 and D6 each has a binding specificity against a tumor antigen, an immune signaling antigen, or a combination thereof.

Abstract: An antitumor pharmaceutical camptothecin derivative and an antibody-drug conjugate thereof. By means of a series of molecular structure modifications, an optimal camptothecin antitumor drug is obtained, so as to be more suitable as a drug for antibody conjugation.

Abstract: An information playback method and device, a computer readable storage medium, and an electronic device, relating to the technical field of computers. Said method comprises: performing identification on a spatial image in a 3D model and obtaining an information display device and a display area in the spatial image (201); determining the display position information corresponding to the display area (202); overlaying an information playback layer in the display area according to the display position information so as to play back display information in the information playback layer (203). By overlaying an information playback layer on the information display device in a 3D model, further information exchange can be implemented in the 3D model, so that user can experience a more reality-like scenario in the 3D model, thereby enhancing user experience.

Abstract: Example embodiments relate to lead frame based molded radio frequency packages. One example package includes a substrate. The package also includes a first electrical component arranged on the substrate. Additionally, the package includes a second electrical component. Further, the package includes a plurality of leads that are arranged spaced apart from the substrate and fixed in position relative thereto by a solidified molding compound. The leads were part of a lead frame prior to separating the package from the lead frame. The substrate was physically and electrically connected to the lead frame using a plurality of spaced apart connecting members prior to separating the package from the lead frame. During the separating of the package from the lead frame, each connecting member was divided into a first connecting member part and a second connecting member part. In addition, the package includes a frame part.

Abstract: The applications provides the anti-CD3 monoclonal antibodies, antigen-binding portions thereof, therapeutic compositions thereof and/or nucleic acid encoding the same, and their use to active CD3+ T-cells to enhance cell-mediated immune responses in the treatment of cancer and other T-cell dysfunctional disorders.

Abstract: The application provides anti-ROR1 monoclonal antibodies, antigen binding portions thereof, therapeutic compositions thereof and/or nucleic acid encoding the same, and their use to upregulate the function of T-cells to enhance cell-mediated immune responses in the treatment of cancer and other T-cell dysfunctional disorders.

Abstract: Provided herein are methods and uses for treatment or prophylaxis of a senescent cell associated disease or disorder by administering a senolytic combination comprising dasatinib and quercetin or an analog thereof to a subject in need thereof. In certain embodiments, the senescent cell associated disease or disorder is a cardiovascular disease or disorder, inflanunatory disease or disorder, a pulmonary disease or disorder, a neurological disease or disorder, or a metabolic disease or disorder.

Abstract: The present application discloses a camptothecin drug and its antibody conjugate. Based on a comprehensive understanding of ADC drugs, the inventor designed a series of active anti-tumor exatecan-derivatives. The designed anti-tumor molecular compound showed good anti-tumor activity in the experiment.

Abstract: A louver awning with a hidden louver opening and closing driving structure includes an awning frame assembly, a plurality of louvers rotatably mounted on a top portion of the awning frame assembly, linkage bars for linking the louvers, and a louver opening and closing driving structure. The awning frame assembly includes a plurality of columns and ring beams fitted together. The louver opening and closing driving structure comprises a hand-operated mechanism, a transmission assembly and a louver transmission mechanism. The transmission assembly is used to transmit power input by the hand-operated mechanism to the louver transmission mechanism, and the louver transmission mechanism is used to drive the louvers to rotate so as to realize opening and closing of the louvers.

Abstract: By inserting cysteine (C) into a heavy chain and/or a light chain of a target antibody at specific insertion site, and performing a site-specific conjugation through a free thiol group (—SH) from the site-specific inserted cysteine and a linker conjugated with a highly potent small molecule cytotoxin, a cysteine modified antibody-drug conjugate with good homogeneity is provided. The specific insertion sites of cysteine are position 205 and/or position 206 (Kabat numbering scheme) of the light chain of the antibody, and/or position 439 (Kabat numbering scheme) of the heavy chain.

Abstract: Example embodiments relate to amplifiers having improved stability.

Abstract: The application provides anti-PD-1 monoclonal antibodies, antigen binding portions thereof, therapeutic compositions thereof and/or nucleic acid encoding the same, and their use to upregulate the function of T-cells to enhance cell-mediated immune responses in the treatment of cancer and other T-cell dysfunctional disorders.