Abstract: An optical comb filter, comprising an input/output collimator (50), an output collimator (60), a spectroscope (10), and first, second and third GT resonant cavities (20, 30, 40), wherein each GT resonant cavity comprises a transparent solid block coated with a membrane layer and a spacing part, a through hole is provided on the transparent solid block, and the transparent solid block and the spacing part form a hollow cavity; and rectangular orientation of an insertion loss curve is realized, and the bandwidth utilization rate is high.

Abstract: Disclosed herein are compounds, compositions and methods for modulating splicing of SMN2 mRNA in a subject. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders, including spinal muscular atrophy.

Abstract: Provided herein are antisense compounds and methods for recruiting one or more non-cleaving protein to a target nucleic acid in a cell. In certain instances such recruitment of a non-cleaving protein alters the function or activity of the target nucleic acid. In certain such instances, the target nucleic acid a pre-mRNA and the recruitment of the non-cleaving protein results in a change in splicing of the pre-mRNA.

Abstract: A tunable PLC optical filter having sequentially connected thermally tunable Mach-Zehnder (MZ) interferometers is described. The cascade of MZ interferometers, each having a free spectral ranges matching ITU frequency grid spacing, are tuned so as to have a common passband centered on the frequency of the signal being selected, while having at least one of the stopbands centered on any other ITU frequency. Any other optical channel that may be present at any other ITU frequency is suppressed as a result. Another MZ interferometer in series with the cascade of interferometers including an asymmetric or variable coupler, is tuned to have low transmission at the center frequency of the selected optical channel.

Abstract: Disclosed herein are compounds, compositions and methods for modulating splicing of SMN2 mRNA in a cell, tissue or animal. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders, including spinal muscular atrophy.

Abstract: The present patent application discloses a single-fiber coupled multi-wavelength optical transceiver, comprising a fiber ferrule, a circulator subassembly, a multiplexer/demultiplexer subassembly, an optical transmitting subassembly and an optical receiving subassembly. The circulator subassembly comprises three ports. The optical transceiver comprises an optical receiving unit and an optical transmitting unit. The light beams of the optical receiving unit incidents from the fiber ferrule to the first port of the circulator, then output to multiplexer/demultiplexer through the second port of the circulator subassembly. The light beams is then split by the multiplexer/de-multiplexer and received by the receiver optical subassembly.

Abstract: A self-assembled engineered lattice of nanometer-scale silica particles, or other suitable particles generally resembling regularly-sized spheres, is configured in a separation bed for electrophoresis, isoelectric focusing, chromatography, or other voltage-induced separation of analytes. After separation, the analytes are immobilized on the separation bed and then ionized using matrix-assisted laser desorption/ionization (MALDI) for use with a mass spectrometer. The nanoparticles can be coated with polymers that activate to immobilize the analytes or assist with MALDI. The separation can occur in two dimensions.

Abstract: The present invention provides systems, methods and kits which enable or utilize an immunologically-based assay, such as a Western immunoassay, to separate, detect or to monitor an analyte or a mixture of analytes such as biomolecules.

Abstract: Disclosed herein are compounds, compositions and methods for modulating splicing of SMN2 mRNA in a subject. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders, including spinal muscular atrophy.

Abstract: Disclosed herein are compounds, compositions and methods for modulating splicing of SMN2 mRNA in a cell, tissue or animal. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders, including spinal muscular atrophy.

Abstract: Disclosed herein are compounds, compositions and methods for treatment of diseases and disorders, including spinal muscular atrophy.

Abstract: A tunable PLC optical filter having sequentially connected thermally tunable Mach-Zehnder (MZ) interferometers is described. The cascade of MZ interferometers, each having a free spectral ranges matching ITU frequency grid spacing, are tuned so as to have a common passband centered on the frequency of the signal being selected, while having at least one of the stopbands centered on any other ITU frequency. Any other optical channel that may be present at any other ITU frequency is suppressed as a result. Another MZ interferometer in series with the cascade of interferometers including an asymmetric or variable coupler, is tuned to have low transmission at the center frequency of the selected optical channel.

Abstract: A tunable optical filter is configured to take point measurements at a few optical frequencies per frequency channel of a DWDM optical network. The measurement frequencies are shifted by pre-determined amounts relative to the optical frequency channel being characterized. Since the spectral shape of the tunable optical filter is known, the center optical frequency, the modulation bandwidth, and the total optical power of the channel can be obtained from as few as three optical measurements. The center optical frequency and the total optical power can be continuously monitored by providing a tunable filter stage coupled to an interleaver stage, and computing a ratio and a weighted sum the optical signals at the two outputs of the interleaver stage.

Abstract: Provided herein are antisense compounds and methods for recruiting one or more non-cleaving protein to a target nucleic acid in a cell. In certain instances such recruitment of a non-cleaving protein alters the function or activity of the target nucleic acid. In certain such instances, the target nucleic acid a pre-mRNA and the recruitment of the non-cleaving protein results in a change in splicing of the pre-mRNA.

Abstract: A tunable optical filter is configured to take point measurements at a few optical frequencies per frequency channel of a DWDM optical network. The measurement frequencies are shifted by pre-determined amounts relative to the optical frequency channel being characterized. Since the spectral shape of the tunable optical filter is known, the center optical frequency, the modulation bandwidth, and the total optical power of the channel can be obtained from as few as three optical measurements. The center optical frequency and the total optical power can be continuously monitored by providing a tunable filter stage coupled to an interleaver stage, and computing a ratio and a weighted sum the optical signals at the two outputs of the interleaver stage.

Abstract: Disclosed herein are compounds, compositions and methods for modulating splicing of SMN2 mRNA in a cell, tissue or animal. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders, including spinal muscular atrophy.

Abstract: An optical device for rearranging wavelength channels in an optical network is disclosed. The optical device has a wavelength selective coupler having one input port and a plurality of output ports coupled to a plurality of input ports of an optical grating demultiplexor such as an arrayed waveguide grating. The wavelength channels in each of the input ports are dispersed by the demultiplexor and are directed to a plurality of output ports of the optical grating demultiplexor. As a result, at least one wavelength channel at each of the input ports of the optical grating demultiplexor is coupled into a common output port. The optical device is useful in passive optical networks wherein a same demultiplexor is used for simultaneous multiplexing and demultiplexing of wavelength channels.

Abstract: Disclosed herein are compounds, compositions and methods for modulating splicing of SMN2 mRNA in a subject. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders, including spinal muscular atrophy.

Abstract: Disclosed herein are compounds, compositions and methods for modulating splicing of SMN2 mRNA in a cell, tissue or animal. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders, including spinal muscular atrophy.

Abstract: An optical device for rearranging wavelength channels in an optical network is disclosed. The optical device has a wavelength selective coupler having one input port and a plurality of output ports coupled to a plurality of input ports of an optical grating demultiplexor such as an arrayed waveguide grating. The wavelength channels in each of the input ports are dispersed by the demultiplexor and are directed to a plurality of output ports of the optical grating demultiplexor. As a result, at least one wavelength channel at each of the input ports of the optical grating demultiplexor is coupled into a common output port. The optical device is useful in passive optical networks wherein a same demultiplexor is used for simultaneous multiplexing and demultiplexing of wavelength channels.