Patents by Inventor Yingzhong Li

Yingzhong Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220016191
    Abstract: Disclosed herein are genetically modified herpesviruses for the treatment of cancer. Also provided are methods of treating cancer using genetically modified herpesviruses.
    Type: Application
    Filed: May 14, 2021
    Publication date: January 20, 2022
    Applicant: Massachusetts Institute of Technology
    Inventors: Ron Weiss, Jin Huh, Yingzhong Li
  • Publication number: 20210324413
    Abstract: Genetic circuits have been developed to regulate behaviors of replicon RNA in responses to small molecules, which has broader applications, such as for quantitative expression of cargo genes, temporary expression of immunomodulatory cytokines or antigens for better cancer immunotherapy or vaccination, and for increased safety in use of self-replicating vectors or in combination with other viral-delivery vectors. Described herein are genetic circuits suitable for systems that either require a tight off state or a slow off state, which can serve for instance where either a kill switch or prolonged protein expression (e.g., of vaccine antigens) are needed.
    Type: Application
    Filed: April 15, 2021
    Publication date: October 21, 2021
    Applicant: Massachusetts Institute of Technology
    Inventors: Darrell J. Irvine, Ron Weiss, Yingzhong Li, Jan Lonzaric, Parisa Yousefpour
  • Publication number: 20210324414
    Abstract: This disclosure provides engineered genetic systems for sequestering and/or destroying viruses, compositions and cells comprising the genetic systems, and methods of treating viral infections, reducing viral load, and/or reducing viral spread. The disclosure also provides libraries comprising elements to be incorporated into the engineered genetic systems.
    Type: Application
    Filed: April 16, 2021
    Publication date: October 21, 2021
    Applicants: Massachusetts Institute of Technology, University of Massachusetts
    Inventors: Ron Weiss, Jin Huh, Yingzhong Li, Eric Goldstein, Hava Siegelmann
  • Publication number: 20200281994
    Abstract: The present disclosure relates to synthetic oncolytic viruses comprising a lipid nanoparticle comprising one or more types of lipid and a self-amplifying replicon RNA comprising a sequence that encodes an immunomodulatory molecule.
    Type: Application
    Filed: January 10, 2020
    Publication date: September 10, 2020
    Applicants: Massachusetts Institute of Technology, The Ohio State University
    Inventors: Darrell J. Irvine, Karl Dane Wittrup, Ron Weiss, Yingzhong Li, Noor Momin, Yizhou Dong
  • Publication number: 20200224174
    Abstract: The disclosure provides methods for an in vitro evolution technique to identify and characterize mutations in the non-structural genes of an alphavirus replicon that increase the strength and persistence of expression of the replicon genome. Also provided herein are in vivo methods for administering to an animal model a mutated alphavirus replicon that codes for a gene of experimental or therapeutic interest in the subgenome of the alphavirus replicon. The mutations identified herein improve the therapeutic potential of self-replicating RNA, which may have implications for cancer immunotherapy and beyond, e.g., for vaccination or gene therapy.
    Type: Application
    Filed: January 10, 2020
    Publication date: July 16, 2020
    Applicant: Massachusetts Institute of Technology
    Inventors: Darrell J. Irvine, Ron Weiss, Yingzhong Li
  • Patent number: D879991
    Type: Grant
    Filed: November 21, 2019
    Date of Patent: March 31, 2020
    Inventor: Yingzhong Li
  • Patent number: D879992
    Type: Grant
    Filed: November 22, 2019
    Date of Patent: March 31, 2020
    Inventor: Yingzhong Li
  • Patent number: D882108
    Type: Grant
    Filed: November 21, 2019
    Date of Patent: April 21, 2020
    Inventor: Yingzhong Li
  • Patent number: D893739
    Type: Grant
    Filed: November 21, 2019
    Date of Patent: August 18, 2020
    Inventor: Yingzhong Li