Patents by Inventor Yinqing Li

Yinqing Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210366572
    Abstract: Disclosed are thermodynamic and multiplication methods concerning CRISPR-Cas systems, and apparatus therefor.
    Type: Application
    Filed: February 23, 2021
    Publication date: November 25, 2021
    Applicants: The Broad Institute, Inc., Massachusetts Institute of Technology, President and Fellows of Harvard College
    Inventors: Feng Zhang, Yinqing Li, David Arthur Scott, Joshua Asher Weinstein, Patrick Hsu
  • Patent number: 10930367
    Abstract: Disclosed are thermodynamic and multiplication methods concerning CRISPR-Cas systems, and apparatus therefor.
    Type: Grant
    Filed: June 12, 2015
    Date of Patent: February 23, 2021
    Assignees: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Feng Zhang, Yinqing Li, David Arthur Scott, Joshua Asher Weinstein, Patrick Hsu
  • Patent number: 10731153
    Abstract: The disclosure provides novel large serine recombinases and their respective recognition sites, as well as libraries of orthogonal recombinase recognition sites. Uses of the large serine recombinases, recognition sites, and libraries of orthogonal recombinase recognition sites also are provided.
    Type: Grant
    Filed: January 20, 2017
    Date of Patent: August 4, 2020
    Assignees: Massachusetts Institute of Technology, INRIA (French Institute for Research in Computer Science and Automation)
    Inventors: Ron Weiss, Xavier Cesar Duportet, Gregory Batt, Yinqing Li
  • Patent number: 10563207
    Abstract: Provided is a modular construction of synthetic gene circuits in mammalian cells using TALE transcriptional repressors.
    Type: Grant
    Filed: March 6, 2015
    Date of Patent: February 18, 2020
    Inventors: Zhen Xie, Ron Weiss, Yinqing Li, Yun Jiang, Weixi Liao, He Chen
  • Publication number: 20190264186
    Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA or RNA-targeting systems comprising a novel DNA or RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.
    Type: Application
    Filed: January 23, 2017
    Publication date: August 29, 2019
    Applicants: The Broad Institute Inc., Massachusetts Institute of Technology, University of Tokyo, The USA, As Represented by The Secretary Department of Health and Human Services
    Inventors: Takashi Yamano, Hiroshi Nishimasu, Bernd Zetsche, Ian Slaymaker, Yinqing Li, Iana Fedorova, Kira Makarova, Linyi Gao, Eugene Koonin, Feng Zhang, Osamu Nureki
  • Publication number: 20190218276
    Abstract: Transcriptomes of individual neurons provide rich information about cell types and dynamic states. However, it is difficult to capture rare dynamic processes, such as adult neurogenesis, because isolation from dense adult tissue is challenging, and markers for each phase are limited. Here, Applicants developed Nuc-seq, Div-Seq, and Dronc-Seq. Div-seq combines Nuc-Seq, a scalable single nucleus RNA-Seq method, with EdU-mediated labeling of proliferating cells. Nuc-Seq can sensitively identify closely related cell types within the adult hippocampus. Div-Seq can track transcriptional dynamics of newborn neurons in an adult neurogenic region in the hippocampus. Dronc-Seq uses a microfluidic device to co-encapsulate individual nuclei in reverse emulsion aqueous droplets in an oil medium together with one uniquely barcoded mRNA-capture bead. Finally, Applicants found rare adult newborn GABAergic neurons in the spinal cord, a non-canonical neurogenic region.
    Type: Application
    Filed: October 27, 2016
    Publication date: July 18, 2019
    Applicants: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Aviv Regev, Feng Zhang, Naomi Habib, Yinqing Li, Matthias Heidenreich, Lukasz Swiech, Anindita Basu, David Weitz, Inbal Avraham Davidi
  • Publication number: 20180312824
    Abstract: The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRISPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. In particular the present invention comprehends optimized functional CRISPR-Cas enzyme systems. In particular the present invention comprehends engineered new guide architectures and enzymes to be used in optimized Staphylococcus aureus CRISPR-Cas enzyme systems.
    Type: Application
    Filed: December 12, 2017
    Publication date: November 1, 2018
    Inventors: Feng Zhang, Winston Yan, Osamu Nureki, Kaijie Zheng, Le Cong, Hiroshi Nishimasu, Fei Ran, Yinqing Li
  • Publication number: 20170211061
    Abstract: The disclosure provides novel large serine recombinases and their respective recognition sites, as well as libraries of orthogonal recombinase recognition sites. Uses of the large serine recombinases, recognition sites, and libraries of orthogonal recombinase recognition sites also are provided.
    Type: Application
    Filed: January 20, 2017
    Publication date: July 27, 2017
    Applicants: Massachusetts Institute of Technology, INRIA (French Institute for Research in Computer Science and Automation)
    Inventors: RON WEISS, Xavier Cesar Duportet, Gregory Batt, Yinqing Li
  • Publication number: 20170145426
    Abstract: Provided is a modular construction of synthetic gene circuits in mammalian cells using TALE transcriptional repressors.
    Type: Application
    Filed: March 6, 2015
    Publication date: May 25, 2017
    Inventors: Zhen XIE, Ron WEISS, Yinqing LI, Yun JIANG, Weixi LIAO, He CHEN
  • Publication number: 20160326546
    Abstract: Provided herein, in some embodiments, are modular transcriptional architectures and methods for regulated expression of guide RNAs in cells, such as human cells, which are based on Clustered Regularly Interspaced Palindromic Repeats (CRISPR) systems.
    Type: Application
    Filed: May 4, 2016
    Publication date: November 10, 2016
    Applicants: Massachusetts Institute of Technology, Raytheon BBN Technologies, Corp.
    Inventors: Samira Kiani, Ron Weiss, Jacob S. Beal, Mohammad Reza Ebrahimkhani, Zhen Xie, Yinqing Li
  • Publication number: 20150356239
    Abstract: Disclosed are thermodynamic and multiplication methods concerning CRISPR-Cas systems, and apparatus therefor.
    Type: Application
    Filed: June 12, 2015
    Publication date: December 10, 2015
    Inventors: Feng Zhang, Yinqing Li, David Arthur Scott, Joshua Asher Weinstein, Patrick Hsu