Abstract: Provided are a bovine rotavirus fusion protein and calf diarrhea multivalent vaccine. The bovine rotavirus fusion protein contains a VP6 fragment, wherein the VP6 fragment contains an amino acid sequence as represented by SEQ ID NO. 4, and at least one loop region of the following (a)˜(c) is substituted with an antigenic epitope derived from bovine coronavirus and/or an antigenic epitope derived from E. coli: (a) amino acid residues of sites 168-177; with an amino acid sequence as represented by SEQ ID NO. 1; (b) amino acid residues of sites 194-205; with an amino acid sequence as represented by SEQ ID NO. 2; and (a) amino acid residues of sites 296-316, with an amino acid sequence as represented by SEQ ID NO. 3, The bovine rotavirus fusion protein contains a plurality of antigenic epitopes, and can enable a host to generate a plurality of antibodies after immunizing the host.

Abstract: Anti-annexin A1 antibodies are provided and methods of treating FAP and cancer using Anti-annexin A1 antibodies, antibody fragments or fusion proteins, including bispecific antibodies targeting two different annexin A1 epitopes, are also provided.

Abstract: Anti-Fn amyloid-like FadA antibodies and compositions are provided and methods of treating cancers, including pancreatic and colorectal, and periodontal diseases. Methods include preventing, reducing development, or treating disease in a subject in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an agent which inhibits or blocks an amyloid-like FadA secreted from Fusobacterium nucleatum (Fn).

Abstract: Anti-annexin A1 antibodies are provided and methods of treating FAP and cancer using Anti-annexin A1 antibodies, antibody fragments or fusion proteins, including bispecific antibodies targeting two different annexin A1 epitopes, are also provided.

Abstract: A method, an apparatus, and a computer program product are provided. The apparatus may be a regulator circuit. The regulator circuit includes a first voltage regulator to regulate a first input voltage to the first voltage regulator, the first voltage regulator including a P-type metal-oxide-semiconductor (PMOS), a second voltage regulator to regulate a second input voltage to the second voltage regulator, and a switch circuit to selectively activate at least one of the first voltage regulator or the second voltage regulator. In one aspect, the second voltage regulator includes an N-type metal-oxide-semiconductor (NMOS). In one aspect, the second voltage regulator comprises a two-stage operational transconductance amplifier (OTA) circuit. In an aspect, the first voltage regulator is coupled to the second voltage regulator.

Abstract: The present invention relates to detecting serum anti-FadA antibodies in test samples from a patient. Additionally, aspects of the present invention provide the basis for detection of serum anti-FadA antibody levels from test samples and correlation with various conditions of clinical relevance.

Abstract: A method, an apparatus, and a computer program product are provided. The apparatus may be a regulator circuit. The regulator circuit includes a first voltage regulator to regulate a first input voltage to the first voltage regulator, the first voltage regulator including a P-type metal-oxide-semiconductor (PMOS), a second voltage regulator to regulate a second input voltage to the second voltage regulator, and a switch circuit to selectively activate at least one of the first voltage regulator or the second voltage regulator. In one aspect, the second voltage regulator includes an N-type metal-oxide-semiconductor (NMOS). In one aspect, the second voltage regulator comprises a two-stage operational transconductance amplifier (OTA) circuit. In an aspect, the first voltage regulator is coupled to the second voltage regulator.

Abstract: A method, an apparatus, and a computer program product are provided. The apparatus may be a regulator circuit. The regulator circuit includes a first voltage regulator to regulate a first input voltage to the first voltage regulator, the first voltage regulator including a P-type metal-oxide-semiconductor (PMOS), and a second voltage regulator to regulate a second input voltage to the second voltage regulator, the second voltage regulator including an N-type metal-oxide-semiconductor (NMOS). In an aspect, the first voltage regulator is coupled to the second voltage regulator.

Abstract: Certain aspects of the present disclosure provide an inductor-enclosed switchable voltage-controlled oscillator (VCO), for use in a frequency synthesizer of a radio frequency integrated circuit (RFIC), for example. One example apparatus is a frequency synthesizer that generally includes a first VCO circuit comprising a first inductor and a second VCO circuit comprising a second inductor, wherein at least a portion of the first VCO circuit is disposed inside a loop of the second inductor. According to certain aspects, at least a portion of the second VCO circuit is disposed inside a loop of the first inductor.

Abstract: Embodiments of the present teachings disclose method, system, and programs for a multi-phase ranking system for implementation with a personalized content system. The disclosed method, system, and programs utilize a weighted AND system to compute a dot product of the user profile and a content profile in a first phase, a content quality indicator in the second phase and a rules filter in a third phase.

Abstract: A method and device for measuring a substance's concentration in a fluid. The method includes first passing a sample to be measured through a chemical sensor at least twice and recording the response value each time; forming a simultaneous equation set using the equation relation between the response value obtained during each measurement and the concentration of the substance, and the mass equation relation satisfied by the concentration change caused by a physical, chemical reaction during each measurement and by the change of the mass, electric quantity, and heat; solving for the concentration of the substance measured and the sensor calibration parameter. The method, used as an absolute measurement method, can be applied to calibrate the sample concentration of a fluid, overcomes the effects on the measurements caused by temperature, humidity, pressure, and some interfering gas, requires no sensor calibration, and substantially enhances the measurements' stability and reliability.

Abstract: The present invention relates to detecting serum anti-FadA antibodies in test samples from a patient. Additionally, aspects of the present invention provide the basis for detection of serum anti-FadA antibody levels from test samples and correlation with various conditions of clinical relevance.

Abstract: A method and device for measuring a substance's concentration in a fluid. The method includes first passing a sample to be measured through a chemical sensor at least twice and recording the response value each time; forming a simultaneous equation set using the equation relation between the response value obtained during each measurement and the concentration of the substance, and the mass equation relation satisfied by the concentration change caused by a physical, chemical reaction during each measurement and by the change of the mass, electric quantity, and heat; solving for the concentration of the substance measured and the sensor calibration parameter. The method, used as an absolute measurement method, can be applied to calibrate the sample concentration of a fluid, overcomes the effects on the measurements caused by temperature, humidity, pressure, and some interfering gas, requires no sensor calibration, and substantially enhances the measurements' stability and reliability.

Abstract: A method of identifying a subject with increased risk of colorectal cancer includes obtaining a biological sample from the subject, measuring the level of Fusobacterium nucleatum in the biological sample, and comparing the measured level to a control level, wherein an increased measured level compared to the control level is indicative of increased risk of colorectal cancer in the subject.

Abstract: Embodiments of the present teachings disclose method, system, and programs for data driven dynamic logging. Data is received by a logging system where the data is flagged for dynamic logging when one or more dynamic flagging level criteria are satisfied. Data is evaluated by a logging module wrapper, which determines whether to log the data using the default logging level or dynamic logging level, according to whether the data is flagged. A logging module logs information in a logging database according to the default logging level or dynamic logging level. Based on the logged information and detected abnormalities the dynamic flagging level and dynamic logging level are automatically or manually adjusted.

Abstract: A method, an apparatus, and a computer program product are provided. The apparatus may be a regulator circuit. The regulator circuit includes a first voltage regulator to regulate a first input voltage to the first voltage regulator, the first voltage regulator including a P-type metal-oxide-semiconductor (PMOS), and a second voltage regulator to regulate a second input voltage to the second voltage regulator, the second voltage regulator including an N-type metal-oxide-semiconductor (NMOS). In an aspect, the first voltage regulator is coupled to the second voltage regulator.

Abstract: Certain aspects of the present disclosure provide an inductor-enclosed switchable voltage-controlled oscillator (VCO), for use in a frequency synthesizer of a radio frequency integrated circuit (RFIC), for example. One example apparatus is a frequency synthesizer that generally includes a first VCO circuit comprising a first inductor and a second VCO circuit comprising a second inductor, wherein at least a portion of the first VCO circuit is disposed inside a loop of the second inductor. According to certain aspects, at least a portion of the second VCO circuit is disposed inside a loop of the first inductor.

Abstract: A method and device for measuring a substance's concentration in a fluid. The method includes first passing a sample to be measured through a chemical sensor at least twice and recording the response value each time; forming a simultaneous equation set using the equation relation between the response value obtained during each measurement and the concentration of the substance, and the mass equation relation satisfied by the concentration change caused by a physical, chemical reaction during each measurement and by the change of the mass, electric quantity, and heat; solving for the concentration of the substance measured and the sensor calibration parameter. The method, used as an absolute measurement method, can be applied to calibrate the sample concentration of a fluid, overcomes the effects on the measurements caused by temperature, humidity, pressure, and some interfering gas, requires no sensor calibration, and substantially enhances the measurements' stability and reliability.

Abstract: A method of treating intrauterine inflammation in a subject associated with intrauterine bacterial infection includes administering to the subject a therapeutically effective amount of a toll-like receptor 4 antagonist. The therapeutically effective amount administered to the subject is an amount effective in reducing intrauterine inflammation in the subject.

Abstract: Embodiments of the present teachings disclose method, system, and programs for a multi-phase ranking system for implementation with a personalized content system. The disclosed method, system, and programs utilize a weighted AND system to compute a dot product of the user profile and a content profile in a first phase, a content quality indicator in the second phase and a rules filter in a third phase.