Patents by Inventor Yitzhak Pilpel

Yitzhak Pilpel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENDOPLASMIC RETICULUM TARGETING SIGNAL
    Publication number: 20200354731
    Abstract: Isolated polynucleotides comprising a transcriptional unit are disclosed, the transcriptional unit comprising: (i) a nucleic acid sequence that encodes a secreted protein of interest; (ii) an endoplasmic reticulum (ER) targeting sequence as set forth in SEQ ID NO: 2, said ER targeting sequence being heterologous to said secreted protein of interest; (iii) a promoter; and (iv) a transcription termination site.
    Type: Application
    Filed: July 28, 2020
    Publication date: November 12, 2020
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Jeffrey E. GERST, Lisha Qiu Jin LIM, Yitzhak PILPEL, Tsviya OLENDER, Dvir DAHARY, Osnat COHEN-ZONTAG
  • RECOMBINANT PROTEIN PRODUCTION IN HETEROLOGOUS SYSTEMS
    Publication number: 20160152991
    Abstract: Isolated polynucleotides are disclosed which increase the efficiency of gene expression in a heterologous cell. The polynucleotide sequences which encode polypeptides are adapted such that the average rate of translation of the first at least about 30 amino acids is slower by at least two fold than the average rate of translation of the remaining amino acids of the polypeptide.
    Type: Application
    Filed: February 10, 2016
    Publication date: June 2, 2016
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Yitzhak PILPEL, Tamir TULLER, Sivan NAVON, Menachem RUBINSTEIN
  • Recombinant protein production in heterologous systems
    Patent number: 9267142
    Abstract: Isolated polynucleotides are disclosed which increase the efficiency of gene expression in a heterologous cell. The polynucleotide sequences which encode polypeptides are adapted such that the average rate of translation of the first at least about 30 amino acids is slower by at least two fold than the average rate of translation of the remaining amino acids of the polypeptide.
    Type: Grant
    Filed: January 25, 2011
    Date of Patent: February 23, 2016
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Yitzhak Pilpel, Tamir Tuller, Sivan Navon, Menachem Rubinstein
  • RECOMBINANT PROTEIN PRODUCTION IN HETEROLOGOUS SYSTEMS
    Publication number: 20120329091
    Abstract: Isolated polynucleotides are disclosed which increase the efficiency of gene expression in a heterologous cell. The polynucleotide sequences which encode polypeptides are adapted such that the average rate of translation of the first at least about 30 amino acids is slower by at least two fold than the average rate of translation of the remaining amino acids of the polypeptide.
    Type: Application
    Filed: January 25, 2011
    Publication date: December 27, 2012
    Applicant: Yeda Research and Development Co., Ltd.
    Inventors: Yitzhak Pilpel, Tamir Tuller, Sivan Navon, Menachem Rubinstein