Patents by Inventor Yizhe WU

Yizhe WU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250034135
    Abstract: Disclosed is a BCL-2 protein apoptosis inducer, and further disclosed are the uses of the compound and a pharmaceutical composition comprising the compound in the preparation of a drug for treating diseases related to anti-apoptotic protein BCL-2. The compound has potent BCL-2/BAK blocking activity, and can be used for treating diseases such as infectious diseases, immune diseases, inflammatory diseases or cell proliferation abnormalities that benefit from the inhibition of anti-apoptotic protein BCL-2.
    Type: Application
    Filed: December 6, 2022
    Publication date: January 30, 2025
    Inventors: Xingguo LIU, Mingbo SU, Yizhe WU, Anhui GAO, Xinglu ZHOU, Li ZHONG, Miao HU, Jinglai HUANG, Hanghui JING, Jianrong ZHU
  • Publication number: 20240360146
    Abstract: Disclosed are a Bruton's tyrosine kinase and a mutant degrader thereof; or a stereoisomer thereof, or a stereoisomer mixture thereof or a pharmaceutically acceptable salt thereof, and an application thereof in the preparation of a drug for treating diseases, disorders or conditions that would benefit from the degradation of the Bruton's tyrosine kinase and the mutant thereof. The compound of the present invention can degrade BTK protein, can degrade BTKC481S protein, has an anti-proliferation inhibiting effect on tumor cell strains Mino and OCI-LY10, shows good anti-tumor activity in an OCI-LY10 subcutaneous transplantation tumor model, has an inhibiting effect on B cell activation, and can be applied to B cell or plasma cell proliferative diseases and autoimmune diseases. The compound of the present invention has good oral absorption properties, and can be applied to oral treatment of human or animal B cell or plasma cell proliferative diseases and autoimmune diseases.
    Type: Application
    Filed: June 30, 2022
    Publication date: October 31, 2024
    Inventors: Xinglu ZHOU, Jia LI, Xingguo LIU, Yubo ZHOU, Miao HU, Xiaomin LUO, Jiangfeng XIE, Weijuan KAN, Mingbo SU, Yizhe WU
  • Publication number: 20240317689
    Abstract: Disclosed in the present invention is a compound having a structure shown in general formula I, or a stereoisomer thereof, a pharmaceutically acceptable salt thereof, or a solvate thereof. Further disclosed in the present invention are a composition comprising the compound, a preparation and an application. The compound of the present invention has a significant activation effect on KCNQ2/3 potassium ions, and can be used for treating diseases related to potassium channel ion flow, especially for treating central nervous system diseases.
    Type: Application
    Filed: August 26, 2022
    Publication date: September 26, 2024
    Inventors: Miao HU, Yizhe WU, Xingguo LIU, Xinglu ZHOU
  • Publication number: 20240043430
    Abstract: The present disclosure discloses a crystal form of a casein kinase 1? inhibitor and a preparation method and use of the crystal form. Specifically, the present disclosure relates to a crystal form of the compound (S)-2-(1-(4-amino-3-(2,3-difluoro-4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-5-chloro-3-phenylquinazoline-4(3H)one methanesulfonate and a preparation method and use of the crystal form. The crystal form of the casein kinase 1? inhibitor compound of the present disclosure has good water solubility and oral absorption, and can be better used for the treatment of malignant tumors and autoimmune diseases that benefit from the inhibition of casein kinase 1? activity.
    Type: Application
    Filed: December 21, 2021
    Publication date: February 8, 2024
    Inventors: Xinglu ZHOU, Xingguo LIU, Miao HU, Jianrong ZHU, Yizhe WU
  • Patent number: 11114083
    Abstract: An anti-snoring apparatus including a low frequency sound generating device that applies a low frequency sound to a subject producing a snoring sound, and a controller including circuitry that converts the snoring sound to a received signal, obtain snoring sound information from the received signal, process the snoring sound information such that an impact of the snoring sound is determined based on the snoring sound information, and cause the low frequency sound generating device to apply the low frequency sound to the subject when the impact is higher than a threshold.
    Type: Grant
    Filed: May 24, 2018
    Date of Patent: September 7, 2021
    Assignee: MaRI Co., Ltd.
    Inventors: Hirofumi Taki, Rodrigo Bornhausen-Demarch, Yizhe Wu, Rie Tomizawa
  • Publication number: 20200160828
    Abstract: An anti-snoring apparatus including a low frequency sound generating device that applies a low frequency sound to a subject producing a snoring sound, and a controller including circuitry that converts the snoring sound to a received signal, obtain snoring sound information from the received signal, process the snoring sound information such that an impact of the snoring sound is determined based on the snoring sound information, and cause the low frequency sound generating device to apply the low frequency sound to the subject when the impact is higher than a threshold.
    Type: Application
    Filed: May 24, 2018
    Publication date: May 21, 2020
    Applicant: MaRI Co., Ltd,
    Inventors: Hirofumi TAKI, Rodrigo BORNHAUSEN-DEMARCH, Yizhe WU, Rie TOMIZAWA