Patents by Inventor Yoko IRUKAYAMA

Yoko IRUKAYAMA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sulfonamide derivative or pharmaceutically acceptable acid-addition salt
    Patent number: 11673867
    Abstract: The present invention aims to provide a novel low-molecular-weight compound showing an orexin receptor agonist activity and expected to be useful as a prophylactic or therapeutic agent for narcolepsy and the like. The present invention provides a compound represented by the formula (I): wherein each symbol is as described in the description, or a pharmaceutically acceptable acid addition salt thereof, which has an orexin receptor agonist activity, and an orexin receptor agonist containing the compound or a pharmaceutically acceptable acid addition salt thereof.
    Type: Grant
    Filed: December 11, 2018
    Date of Patent: June 13, 2023
    Assignees: University of Tsukuba, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Hiroshi Nagase, Tsuyoshi Saitoh, Masashi Yanagisawa, Yoko Irukayama
  • SULFONAMIDE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE ACID-ADDITION SALT
    Publication number: 20210078955
    Abstract: The present invention aims to provide a novel low-molecular-weight compound showing an orexin receptor agonist activity and expected to be useful as a prophylactic or therapeutic agent for narcolepsy and the like. The present invention provides a compound represented by the formula (I): wherein each symbol is as described in the description, or a pharmaceutically acceptable acid addition salt thereof, which has an orexin receptor agonist activity, and an orexin receptor agonist containing the compound or a pharmaceutically acceptable acid addition salt thereof.
    Type: Application
    Filed: December 11, 2018
    Publication date: March 18, 2021
    Applicants: University of Tsukuba, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Hiroshi NAGASE, Tsuyoshi SAITOH, Masashi YANAGISAWA, Yoko IRUKAYAMA
  • Morphinan derivative and medical usage thereof
    Patent number: 10377763
    Abstract: The purpose of the present invention is to provide a compound useful as a prophylactic or therapeutic agent for various diseases and symptoms related to orexin receptors, and a medical usage of the same. The present invention provides a morphinan derivative represented by the general formula (I) below or a pharmaceutically acceptable acid addition salt thereof, the morphinan derivative having excellent selectivity for and antagonism against orexin receptors and excellent therapeutic and prophylactic effects on drug dependence, and an orexin receptor antagonist and a therapeutic or prophylactic agent for drug dependence each containing it as an active ingredient.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: August 13, 2019
    Assignee: UNIVERSITY OF TSUKUBA
    Inventors: Hiroshi Nagase, Naoshi Yamamoto, Yoko Irukayama, Tsuyoshi Saitoh, Masashi Yanagisawa, Yasuyuki Nagumo
  • Sulfonamide derivative and pharmaceutically acceptable acid addition salt thereof
    Patent number: 10351522
    Abstract: The present invention aims to provide a novel low-molecular-weight compound exhibiting an orexin receptor agonist activity and expected to be useful as a prophylactic or therapeutic agent for narcolepsy and the like. The present invention provides a compound represented by the formula (I): wherein each symbol is as defined in the description, or a pharmaceutically acceptable acid addition salt thereof, which has an orexin receptor agonist activity, and an orexin receptor agonist containing the compound or a pharmaceutically acceptable acid addition salt thereof.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: July 16, 2019
    Assignees: UNIVERSITY OF TSUKUBA, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Hiroshi Nagase, Masashi Yanagisawa, Tsuyoshi Saitoh, Noriki Kutsumura, Yoko Irukayama
  • MORPHINAN DERIVATIVE AND MEDICAL USAGE THEREOF
    Publication number: 20180305369
    Abstract: The purpose of the present invention is to provide a compound useful as a prophylactic or therapeutic agent for various diseases and symptoms related to orexin receptors, and a medical usage of the same. The present invention provides a morphinan derivative represented by the general formula (I) below or a pharmaceutically acceptable acid addition salt thereof, the morphinan derivative having excellent selectivity for and antagonism against orexin receptors and excellent therapeutic and prophylactic effects on drug dependence, and an orexin receptor antagonist and a therapeutic or prophylactic agent for drug dependence each containing it as an active ingredient.
    Type: Application
    Filed: October 28, 2016
    Publication date: October 25, 2018
    Applicant: UNIVERSITY OF TSUKUBA
    Inventors: Hiroshi NAGASE, Naoshi YAMAMOTO, Yoko IRUKAYAMA, Tsuyoshi SAITOH, Masashi YANAGISAWA, Yasuyuki NAGUMO
  • SULFONAMIDE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALT THEREOF
    Publication number: 20180179151
    Abstract: The present invention aims to provide a novel low-molecular-weight compound exhibiting an orexin receptor agonist activity and expected to be useful as a prophylactic or therapeutic agent for narcolepsy and the like. The present invention provides a compound represented by the formula (I): wherein each symbol is as defined in the description, or a pharmaceutically acceptable acid addition salt thereof, which has an orexin receptor agonist activity, and an orexin receptor agonist containing the compound or a pharmaceutically acceptable acid addition salt thereof.
    Type: Application
    Filed: June 10, 2016
    Publication date: June 28, 2018
    Applicants: UNIVERSITY OF TSUKUBA, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Hiroshi NAGASE, Masashi YANAGISAWA, Tsuyoshi SAITOH, Noriki KUTSUMURA, Yoko IRUKAYAMA