Patents by Inventor Yongshuai Chai

Yongshuai Chai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210047290
    Abstract: Disclosed in the present invention are an indoleamine-2,3-dioxygenase inhibitor and a preparation method therefor. The inhibitor of the present invention has a structure as represented by general formula (I), wherein the definitions of Ar, E, Y, X, V, D, W, B, ring A and ring B are as shown in the description and claims. Also disclosed in the present invention is a preparation method for the inhibitor. The compound of general formula (I) of the present invention can be used as an indoleamine-2,3-dioxygenase inhibitor for preparing a medicament for preventing and/or treating indoleamine-2,3-dioxygenase-mediated diseases.
    Type: Application
    Filed: February 12, 2019
    Publication date: February 18, 2021
    Inventors: Zhaoyin WANG, Wei GUO, Yongshuai CHAI
  • Publication number: 20200246295
    Abstract: The present disclosure provides a compound of Formula (I); or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are defined herein. The disclosure also relates to a method for manufacturing the compounds of the disclosure, and its therapeutic uses. The present disclosure further provides pharmaceutical composition of the compounds of the disclosure and a combination of pharmacologically active agents and a compound of the disclosure.
    Type: Application
    Filed: April 21, 2020
    Publication date: August 6, 2020
    Inventors: Yongshuai CHAI, Sven Erik GODTFREDSEN, Mark KAGAN, Yugang LIU, Mahavir PRASHAD, Zhaoyin WANG, Saijie ZHU
  • Patent number: 10668035
    Abstract: The present disclosure provides a compound of Formula (I); or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are defined herein. The disclosure also relates to a method for manufacturing the compounds of the disclosure, and its therapeutic uses. The present disclosure further provides pharmaceutical composition of the compounds of the disclosure and a combination of pharmacologically active agents and a compound of the disclosure.
    Type: Grant
    Filed: April 18, 2019
    Date of Patent: June 2, 2020
    Assignee: Novartis AG
    Inventors: Yongshuai Chai, Sven Erik Godtfredsen, Mark Kagan, Yugang Liu, Mahavir Prashad, Zhaoyin Wang, Saijie Zhu
  • Publication number: 20190240177
    Abstract: The present disclosure provides a compound of Formula (I); or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are defined herein. The disclosure also relates to a method for manufacturing the compounds of the disclosure, and its therapeutic uses. The present disclosure further provides pharmaceutical composition of the compounds of the disclosure and a combination of pharmacologically active agents and a compound of the disclosure.
    Type: Application
    Filed: April 18, 2019
    Publication date: August 8, 2019
    Inventors: Yongshuai CHAI, Sven Erik GODTFREDSEN, Mark KAGAN, Yugang LIU, Mahavir PRASHAD, Zhaoyin WANG, Saijie ZHU