Patents by Inventor Yoo-Soo Yang

Yoo-Soo Yang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Exosome-based anticancer agent
    Patent number: 11952412
    Abstract: The present invention provides a recombinant exosome and uses thereof. More particularly, the present invention provides a recombinant exosome wherein a phagocytosis promoting protein is presented on the surface of the exosome.
    Type: Grant
    Filed: April 3, 2022
    Date of Patent: April 9, 2024
    Assignee: SHIFTBIO
    Inventors: Eun-ee Koh, Eun Jung Lee, Yoo Soo Yang, In-San Kim
  • Therapeutic Compounds for Red Blood Cell-Mediated Delivery of an Active Pharmaceutical Ingredient to a Target Cell
    Publication number: 20240043846
    Abstract: Therapeutic compounds for red blood cell-mediated delivery of an active pharmaceutical ingredient to a target cell are described. The therapeutic compounds are configured to bind CD47 on the surface of a red blood cell and to be subsequently transferred to CD47 on the surface of the target cell, the therapeutic compound ultimately being internalized by the target cell via endocytosis. The target cell may be a cancer cell, a virus-infected cell, or a fibrotic cell.
    Type: Application
    Filed: November 18, 2022
    Publication date: February 8, 2024
    Inventors: HoWon J. Kim, In-San Kim, Jay S. Kim, Sun Hwa Kim, Ick Chan Kwon, Jong Won Lee, Yoo Soo Yang, Hong Yeol Yoon
  • NOVEL EXOSOME-BASED ANTICANCER AGENT
    Publication number: 20220251170
    Abstract: The present invention provides a recombinant exosome and uses thereof. More particularly, the present invention provides a recombinant exosome wherein a phagocytosis promoting protein is presented on the surface of the exosome.
    Type: Application
    Filed: April 3, 2022
    Publication date: August 11, 2022
    Inventors: Eun-ee KOH, Eun Jung LEE, Yoo Soo YANG, In-San KIM
  • Exosome-based anticancer agent
    Patent number: 11319360
    Abstract: The present invention provides a recombinant exosome and uses thereof. More particularly, the present invention provides a recombinant exosome wherein a phagocytosis promoting protein is presented on the surface thereof.
    Type: Grant
    Filed: December 29, 2017
    Date of Patent: May 3, 2022
    Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Eun-ee Koh, Eun Jung Lee, Yoo Soo Yang, In-San Kim
  • NOVEL RECOMBINANT EXOSOME AND USE THEREOF
    Publication number: 20210393736
    Abstract: Provided is a recombinant exosome, and more specifically, to a recombinant exosome obtained from a eukaryotic cell transfected for the expression of a glucose transporter protein (GLUT) and a membrane fusogenic protein, and use thereof.
    Type: Application
    Filed: September 3, 2021
    Publication date: December 23, 2021
    Applicant: TANDEM CO., LTD.
    Inventors: Yeon-Sun HONG, Yoo Soo YANG, Cherl Hyun JEONG, In-San KIM
  • NOVEL RECOMBINANT PLASMA MEMBRANE-BASED VESICLE, FOR TREATING CANCER
    Publication number: 20210106632
    Abstract: The present invention relates to a recombinant plasma membrane-based vesicle, and more specifically to a recombinant plasma membrane-based vesicle comprising a VSV-G mutated protein in which histidine, the 162nd amino acid, has been substituted with arginine, and a pharmaceutical composition for treating cancer comprising the recombinant plasma membrane-based vesicle.
    Type: Application
    Filed: September 28, 2018
    Publication date: April 15, 2021
    Applicant: TANDEM CO., LTD.
    Inventors: Gi-Beom KIM, Yoo Soo YANG, In-San KIM, Gihoon NAM
  • NOVEL ANTICANCER FUSION PROTEIN AND USE THEREOF
    Publication number: 20210054047
    Abstract: The present invention relates to a novel anticancer fusion protein and use thereof, and more particularly, provides a fusion protein in which a tumor necrosis factor (TNF) superfamily protein is linked to a self-assembled protein, which is capable of forming a protein nanocage by self-assembly of the self-assembled protein.
    Type: Application
    Filed: September 4, 2020
    Publication date: February 25, 2021
    Applicants: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY, KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Min-Woo KIH, Eun Jung LEE, Yoo Soo YANG, Cherl Hyun JEONG, In-San KIM, Soyoun KIM
  • Nanocage and use thereof
    Patent number: 10905774
    Abstract: The present invention relates to a novel recombinant nanocage and use thereof wherein the nanocage is formed by self-assembly of a fusion protein including a phagocytosis enhancing protein and a self-assembling protein, and to a protein nanocage complex in which an immunogenic cell death inducer is loaded in the nanocage as an active ingredient.
    Type: Grant
    Filed: January 15, 2019
    Date of Patent: February 2, 2021
    Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Gi Hoon Nam, Eun Jung Lee, Yoo Soo Yang, Cherl Hyun Jeong, In-San Kim, Kwangmeyung Kim
  • NOVEL EXOSOME-BASED ANTICANCER AGENT
    Publication number: 20200148746
    Abstract: The present invention provides a recombinant exosome and uses thereof. More particularly, the present invention privides a recombinant exosome wherein a phagocytosis promoting protein is presented on the surface thereof.
    Type: Application
    Filed: December 29, 2017
    Publication date: May 14, 2020
    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Eun-ee KOH, Eun Jung LEE, Yoo Soo YANG, In-San KIM
  • NOVEL RECOMBINANT EXOSOME CONTAINING HYALURONIDASE AND USE THEREOF
    Publication number: 20190365653
    Abstract: The present invention relates to a recombinant exosome containing hyaluronidase and a use thereof, and more particularly to a recombinant exosome that presents hyaluronidase on its surface and use thereof as an anticancer agent.
    Type: Application
    Filed: June 4, 2018
    Publication date: December 5, 2019
    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Yeon-Sun Hong, Yoo Soo Yang, In-San Kim
  • METHOD OF ACTIVATING DENDRITIC CELLS
    Publication number: 20190328721
    Abstract: Described are methods for activating dendritic cells using a Rho-related protein kinase (ROCK) inhibitor, optionally in combination with one or more of an immunogenic cell death-inducing chemotherapeutic, photodynamic therapy, or radiation therapy. The methods and treated cells are useful, for example, in treating cancer, optionally in combination with one or more of an immunogenic cell death-inducing chemotherapeutic, immune checkpoint inhibitor, photodynamic therapy, or radiation therapy.
    Type: Application
    Filed: April 25, 2019
    Publication date: October 31, 2019
    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: GiHoon NAM, Yoo Soo Yang, In-San Kim, Seung-Yoon Park
  • METHOD FOR INDUCING TRANSDIFFERENTIATION OF IMMUNE CELLS BASED ON EXOSOMES
    Publication number: 20190307794
    Abstract: The present invention relates to a method of inducing trans-differentiating a first type of immune cell into a second type of immune cell comprising: isolating exosomes from the second type of immune cell that has undergone differentiation, and treating the first type of immune cell or a cell population including the first type of immune cell with the isolated exosomes in vitro.
    Type: Application
    Filed: April 9, 2019
    Publication date: October 10, 2019
    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Yeon-Sun HONG, Hyo Suk Kim, Yoo Soo Yang, Sun Hwa Kim, In-San Kim, Ick Chan Kwon
  • NOVEL NANOCAGE AND USE THEREOF
    Publication number: 20190216947
    Abstract: The present invention relates to a novel recombinant nanocage and use thereof wherein the nanocage is formed by self-assembly of a fusion protein including a phagocytosis enhancing protein and a self-assembling protein, and to a protein nanocage complex in which an immunogenic cell death inducer is loaded in the nanocage as an active ingredient.
    Type: Application
    Filed: January 15, 2019
    Publication date: July 18, 2019
    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Gi Hoon NAM, Eun Jung Lee, Yoo Soo Yang, Cherl Hyun Jeong, In-San Kim, Kwangmeyung Kim
  • NOVEL RECOMBINANT EXOSOME AND USE THEREOF
    Publication number: 20180028600
    Abstract: Provided is a recombinant exosome, and more specifically, to a recombinant exosome obtained from a eukaryotic cell transfected for the expression of a glucose transporter protein (GLUT) and a membrane fusogenic protein, and use thereof.
    Type: Application
    Filed: July 14, 2017
    Publication date: February 1, 2018
    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Yeon-Sun HONG, Yoo Soo YANG, Cherl Hyun JEONG, In-San KIM
  • Polyphenol compounds with modulating neurotransmitter release
    Patent number: 8263643
    Abstract: Disclosed is a composition for modulating the release of a neurotransmitter, which includes naturally extracted polyphenols as an active ingredient. The disclosed composition suppresses the formation of a SNARE complex, thereby modulating the release of a neurotransmitter, and thus can be used as a modulator for a reaction within a cell related to the SNARE complex. Such an inhibitor of the SNARE complex formation can be used as a composition for reducing wrinkles and relieving pain.
    Type: Grant
    Filed: March 12, 2008
    Date of Patent: September 11, 2012
    Assignee: Sungkyunkwan University Foundation for Corporate Collaboration
    Inventors: Dae-Hyuk Kweon, Yeon-Kyun Shin, Chang-Hwa Jung, Yoo-Soo Yang
  • POLYPHENOL COMPOUNDS WITH MODULATING NEUROTRANSMITTER RELEASE
    Publication number: 20110112181
    Abstract: Disclosed is a composition for modulating the release of a neurotransmitter, which includes naturally extracted polyphenols as an active ingredient. The disclosed composition suppresses the formation of a SNARE complex, thereby modulating the release of a neurotransmitter, and thus can be used as a modulator for a reaction within a cell related to the SNARE complex. Such an inhibitor of the SNARE complex formation can be used as a composition for reducing wrinkles and relieving pain.
    Type: Application
    Filed: March 12, 2008
    Publication date: May 12, 2011
    Applicant: SUNGKYUNKWAN UNIVERSITY FOUNDATION FOR CORPORATE COLLABORATION
    Inventors: Dae-Hyuk Kweon, Yeon-Kyun Shin, Chang-Hwa Jung, Yoo-Soo Yang