Patents by Inventor Yoshiaki Isobe

Yoshiaki Isobe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190308958
    Abstract: The present invention provides a compound of formula (1) and a pharmaceutical composition comprising the compound useful as a nerve regeneration promoter wherein R1-L- is R1—OC(O)—, or the like, R1 is hydrogen atom, optionally-substituted C1-6 alkyl group, optionally-substituted 3- to 8-membered cycloalkyl group, or the like, R2 is hydrogen atom or the like, Ring A is formula (2) or formula (3) wherein R3 is hydrogen atom, optionally-substituted C1-6 alkyl group, or the like, the part of X, Y, and Z is X?Y—Z, X—Y?Z, or X—Y—Z, X is nitrogen atom, NR4 (R4 is hydrogen atom, optionally-substituted C1-6 alkyl group, or the like), or the like, Y is carbon atom or the like, and Z is carbon atom, nitrogen atom or the like.
    Type: Application
    Filed: April 24, 2019
    Publication date: October 10, 2019
    Applicant: Sumitomo Dainippon Pharma Co., Ltd.
    Inventors: Hitoshi Watanabe, Yoshiaki Isobe, Hidenori Kimura, Yuji Fujiwara
  • Patent number: 10323024
    Abstract: The present invention provides a compound of formula (1) and a pharmaceutical composition comprising the compound useful as a nerve regeneration promoter wherein R1-L- is R1—OC(O)—, or the like, R1 is hydrogen atom, optionally-substituted C1-6 alkyl group, optionally-substituted 3- to 8-membered cycloalkyl group, or the like, R2 is hydrogen atom or the like, Ring A is formula (2) or formula (3) wherein R3 is hydrogen atom, optionally-substituted C1-6 alkyl group, or the like, the part of X, Y, and Z is X?Y—Z, X—Y?Z, or X—Y—Z, X is nitrogen atom, NR4 (R4 is hydrogen atom, optionally-substituted C1-6 alkyl group, or the like), or the like, Y is carbon atom or the like, and Z is carbon atom, nitrogen atom or the like.
    Type: Grant
    Filed: January 12, 2017
    Date of Patent: June 18, 2019
    Assignee: SUMITOMO DAINIPPON PHARMA CO., LTD.
    Inventors: Hitoshi Watanabe, Yoshiaki Isobe, Hidenori Kimura, Yuji Fujiwara
  • Publication number: 20190169191
    Abstract: The present invention relates to a substituted purine derivative of formula (1) wherein R1 is alkoxy or the like, R2 is alkyl or the like, Ring Q1 is aryl or the like, W1 is alkylene or the like, Ring Q2 is aromatic carbocyclyl or the like, n is 1-4, R3 is hydrogen atom or the like, X1 is single bond or the like, W2 is alkylene or the like, and R4 is hydrogen atom or the like, or a pharmaceutically acceptable salt thereof, which has a potent inhibitory effect against TLR7, and thereby is useful for treating autoimmune disease.
    Type: Application
    Filed: April 25, 2017
    Publication date: June 6, 2019
    Applicant: SUMITOMO DAINIPPON PHARMA CO., LTD.
    Inventors: Shingo TOJO, Yoshiaki ISOBE, Eiji IDEUE, Hiroaki FUJIWARA, Daisuke URABE
  • Publication number: 20190016711
    Abstract: The present invention provides a compound of formula (1) and a pharmaceutical composition comprising the compound useful as a nerve regeneration promoter wherein R1-L- is R1—OC(O)—, or the like, R1 is hydrogen atom, optionally-substituted C1-6 alkyl group, optionally-substituted 3- to 8-membered cycloalkyl group, or the like, R2 is hydrogen atom or the like, Ring A is formula (2) or formula (3) wherein R3 is hydrogen atom, optionally-substituted C1-6 alkyl group, or the like, the part of X, Y, and Z is X?Y—Z, X—Y?Z, or X—Y—Z, X is nitrogen atom, NR4 (R4 is hydrogen atom, optionally-substituted C1-6 alkyl group, or the like), or the like, Y is carbon atom or the like, and Z is carbon atom, nitrogen atom or the like.
    Type: Application
    Filed: January 12, 2017
    Publication date: January 17, 2019
    Applicant: SUMITOMO DAINIPPON PHARMA CO., LTD.
    Inventors: Hitoshi WATANABE, Yoshiaki ISOBE, Hidenori KIMURA, Yuji FUJIWARA
  • Publication number: 20180280499
    Abstract: The present invention provides a compound of the formula (1): wherein X, R1, R2, R3, R4, R5, R6, Y1, Y2, L, and m are as defined in the description, and a pharmaceutically acceptable salt thereof, which are useful as a vaccine adjuvant.
    Type: Application
    Filed: October 6, 2016
    Publication date: October 4, 2018
    Inventors: Hidenori Kimura, Hitoshi Ban, Yoshiaki Isobe, Hitoshi Watanabe
  • Patent number: 9479330
    Abstract: With a portal server, a request for information from a terminal of a second user that is an agent for a first user is received, and an encrypted data directed to a terminal of the first user, stored in an encrypted-data memory unit, is re-encrypted using a re-encryption key for the second user, stored in a first encryption-key memory unit, and is transmitted to the terminal of the second user, with the terminal of the second user, the re-encrypted data received is decrypted using an encryption key for the second user, stored in a second encryption-key memory unit, and time keys specified by the terminal of the first user, related to a time-period during which browsing of the information is permitted.
    Type: Grant
    Filed: June 13, 2014
    Date of Patent: October 25, 2016
    Assignee: Hitachi, Ltd.
    Inventors: Kosuke Anzai, Hisayoshi Sato, Yoshiaki Isobe, Suguru Iwasaki
  • Patent number: 9419804
    Abstract: A data authenticity assurance method carried out by a management computer including: a first step of receiving the first data piece from the computer; a second step of selecting a plurality of second data pieces at predetermined intervals in chronological order from among the plurality of second data pieces held in the data holding part; a third step of performing an arithmetic operation for each of the hash values of the selected plurality of second data pieces; a fourth step of generating signature target data by combining the first data piece received from the computer with the hash values of the selected plurality of second data pieces; and a fifth step of generating a second data piece by assigning the digital signature to the signature target data by using the preset key, and holding the generated second data piece in chronological order sequentially in the data holding part.
    Type: Grant
    Filed: October 2, 2012
    Date of Patent: August 16, 2016
    Assignee: HITACHI, LTD.
    Inventors: Natsuki Watanabe, Yoko Hashimoto, Kosuke Anzai, Kunihiko Miyazaki, Naoki Hayashi, Yoshiaki Isobe, Tomohisa Kumagai, Daisuke Miyamoto
  • Publication number: 20150082040
    Abstract: With a portal server, a request for information from a terminal of a second user that is an agent for a first user is received, and an encrypted data directed to a terminal of the first user, stored in an encrypted-data memory unit, is re-encrypted using a re-encryption key for the second user, stored in a first encryption-key memory unit, arid is transmitted to the terminal of the second user, with the terminal of the second user, the re-encrypted data received is decrypted using an encryption key for the second user, stored in a second encryption-key memory unit, and time keys specified by the terminal of the first user, related to a time-period during which browsing of the information is permitted.
    Type: Application
    Filed: June 13, 2014
    Publication date: March 19, 2015
    Applicant: Hitachi, Ltd.
    Inventors: KOSUKE ANZAI, Hisayoshi Sato, Yoshiaki Isobe, Suguru Iwasaki
  • Patent number: 8969362
    Abstract: The present invention provides an 8-oxoadenine compound having immunomodulating activities such as an interferon inducing activity and useful as an antiviral agent and antiallergic agent, which is represented by the following formula (1): [wherein the ring A represents a 6-10 membered aromatic carbocyclic ring and the like, R represents a halogen atom, an alkyl group and the like, n represents an integer of 0-2, Z1 represents alkylene, X2 represents oxygen atom, sulfur atom, SO2, NR5, CO, CONR5, NR5CO and the like, Y1, Y2 and Y3 represent independently a single bond or an alkylene group, X1 represents oxygen atom, sulfur atom, NR4 (R4 is hydrogen atom or an alkyl group) or a single bond, R2 represents a substituted or unsubstituted alkyl group, R1 represents hydrogen atom, hydroxy group, an alkoxy group, an alkoxycarbonyl group or a haloalkyl group] or its pharmaceutically acceptable salt.
    Type: Grant
    Filed: October 21, 2013
    Date of Patent: March 3, 2015
    Assignees: AstraZeneca Aktiebolag, Sumitomo Dainippon Pharma Co., Ltd.
    Inventors: Ayumu Kurimoto, Kazuki Hashimoto, Yoshiaki Isobe, Stephen Brough, Ian Millichip, Hiroki Wada, Roger Bonnert, Thomas Mcinally
  • Publication number: 20140298034
    Abstract: A data authenticity assurance method carried out by a management computer including: a first step of receiving the first data piece from the computer; a second step of selecting a plurality of second data pieces at predetermined intervals in chronological order from among the plurality of second data pieces held in the data holding part; a third step of performing an arithmetic operation for each of the hash values of the selected plurality of second data pieces; a fourth step of generating signature target data by combining the first data piece received from the computer with the hash values of the selected plurality of second data pieces; and a fifth step of generating a second data piece by assigning the digital signature to the signature target data by using the preset key, and holding the generated second data piece in chronological order sequentially in the data holding part.
    Type: Application
    Filed: October 2, 2012
    Publication date: October 2, 2014
    Applicant: Hitachi, Ltd.
    Inventors: Natsuki Watanabe, Yoko Hashimoto, Kosuke Anzai, Kunihiko Miyazaki, Naoki Hayashi, Yoshiaki Isobe, Tomohisa Kumagai, Daisuke Miyamoto
  • Publication number: 20140045837
    Abstract: The present invention provides an 8-oxoadenine compound having immunomodulating activities such as an interferon inducing activity and useful as an antiviral agent and antiallergic agent, which is represented by the following formula (1): [wherein the ring A represents a 6-10 membered aromatic carbocyclic ring and the like, R represents a halogen atom, an alkyl group and the like, n represents an integer of 0-2, Z1 represents alkylene, X2 represents oxygen atom, sulfur atom, SO2, NR5, CO, CONR5, NR5CO and the like, Y1, Y2 and Y3 represent independently a single bond or an alkylene group, X1 represents oxygen atom, sulfur atom, NR4 (R4 is hydrogen atom or an alkyl group) or a single bond, R2 represents a substituted or unsubstituted alkyl group, R1 represents hydrogen atom, hydroxy group, an alkoxy group, an alkoxycarbonyl group or a haloalkyl group] or its pharmaceutically acceptable salt.
    Type: Application
    Filed: October 21, 2013
    Publication date: February 13, 2014
    Applicants: AstraZeneca Aktiebolag, Dainippon Sumitomo Pharma Co., Ltd.
    Inventors: Ayumu Kurimoto, Kazuki Hashimoto, Yoshiaki Isobe, Stephen Brough, Ian Millichip, Hiroki Wada, Roger Bonnert, Thomas Mcinally
  • Patent number: 8575180
    Abstract: The present invention provides an 8-oxoadenine compound having immunemodulating activities such as an interferon inducing activity and useful as an antiviral agent and antiallergic agent, which is represented by the following formula (1): [wherein the ring A represents a 6-10 membered aromatic carbocyclic ring and the like, R represents a halogen atom, an alkyl group and the like, n represents an integer of 0-2, Z1 represents alkylene, X2 represents oxygen atom, sulfur atom, SO2, NR5, CO, CONR5, NR5CO and the like, Y1, Y2 and Y3 represent independently a single bond or an alkylene group, X1 represents oxygen atom, sulfur atom, NR4 (R4 is hydrogen atom or an alkyl group) or a single bond, R2 represents a substituted or unsubstituted alkyl group, R1 represents hydrogen atom, hydroxy group, an alkoxy group, an alkoxycarbonyl group or a haloalkyl group] or its pharmaceutically acceptable salt.
    Type: Grant
    Filed: July 20, 2011
    Date of Patent: November 5, 2013
    Assignees: AstraZeneca Aktiebolag, Dainippon Sumitomo Pharma Co., Ltd.
    Inventors: Ayumu Kurimoto, Kazuki Hashimoto, Yoshiaki Isobe, Stephen Brough, Ian Millichip, Hiroki Wada, Roger Bonnert, Thomas Mcinally
  • Publication number: 20130179957
    Abstract: The present invention shortens the time required for watch list verification, and shortens the time required generally for the personal identification processing which includes watch list verification. In a personal identification system, a biometric information watch list comparison function (31) performs a first comparison of first biometric information in a traveler information DB (53), and biometric information on a biometric information watch list (52). Thereafter, a simplified alien immigration examination comparison function (41) performs a second comparison of the first biometric information in the traveler information DB (53), and second biometric information acquired by a biometric information acquisition function (62). As a result of the comparison, in the case where the difference between the time of the first comparison and the current time is within a previously defined time period, a terminal displays a first comparison result, and a second comparison result.
    Type: Application
    Filed: May 16, 2011
    Publication date: July 11, 2013
    Applicant: HITACHI, LTD.
    Inventors: Osamu Takata, Yosuke Kaga, Yoshiaki Isobe, Masahiro Mimura, Nobuo Takahashi
  • Patent number: 8476288
    Abstract: The invention provides salts of 4-(dimethylamino)butyl 2-(4-((2-amino-4-methyl-6-(pentylamino)pyrimidin-5-yl)methyl)phenyl)acetate, pharmaceutical compositions containing them and their use in therapy.
    Type: Grant
    Filed: May 20, 2010
    Date of Patent: July 2, 2013
    Assignees: AstraZeneca AB, Dainippon Sumitomo Pharma Co., Ltd.
    Inventors: Nicholas James Bennett, Thomas McInally, Austen Pimm, Yoshiaki Isobe
  • Patent number: 8433922
    Abstract: In additional enrollment of a template in a biometric authentication system, the template is automatically enrolled on the basis of a plurality of authentication results to assure a user's convenience and security. A post-migration authentication server receives a first template and a second template from a post-migration authentication terminal, performs authentication on the basis of the comparison result between the received first template and the user's preliminarily first enrolled template, and provisionally enrolls the first template and the second template. It repeats the reception, authentication, and provisional enrollment and calculates a match probability from a plurality of comparison results of the provisionally first enrolled templates, determines whether or not to store a second enrolled template on the basis of the match probability, and automatically enrolls the second template in the post-migration authentication server.
    Type: Grant
    Filed: September 1, 2010
    Date of Patent: April 30, 2013
    Assignee: Hitachi, Ltd.
    Inventors: Yosuke Kaga, Osamu Takata, Yoshiaki Isobe, Kenta Takahashi, Takao Murakami
  • Publication number: 20130088327
    Abstract: In a biometric authentication system, a delivery server includes a parameter conversion unit which generates, by converting the parameter, a parameter for delivery, a template conversion unit which generates, by converting the template, a template for delivery, and a delivery unit which delivers the template for delivery and the parameter for delivery to one of the client terminal and an authentication device; the authentication device includes a sensor which obtains biometric information on a registered user, a feature quantity obtaining unit which obtains a feature quantity from the biometric information, and a feature quantity conversion unit which generates, by converting the feature quantity using the parameter for delivery, a converted feature quantity; and the client terminal includes a match determination unit which determines, by comparing the converted feature quantity with the template for delivery, whether or not the converted feature quantity and the template for delivery match.
    Type: Application
    Filed: August 16, 2012
    Publication date: April 11, 2013
    Applicant: HITACHI, LTD.
    Inventors: Kenta Takahashi, Yoshiaki Isobe
  • Patent number: 8412940
    Abstract: At registration time, feature data array for registration is generated from biometric information, and position correction template and comparison template. At authentication time, feature data array for authentication is generated from biometric information acquired by the client, and converted feature data for position correction obtained by converting the feature data array for authentication is transmitted to the server. The server detects position correction amount of the feature data array for authentication relative to the feature data array for registration using the position correction template and the converted feature data, and transmits the position correction amount to client. Client corrects the feature data array for authentication and transmits the converted feature data array for comparison to the server.
    Type: Grant
    Filed: August 21, 2009
    Date of Patent: April 2, 2013
    Assignee: Hitachi, Ltd.
    Inventors: Kenta Takahashi, Shinji Hirata, Yoshiaki Isobe
  • Publication number: 20130013527
    Abstract: The present invention provides a system and a method for speeding up immigration. In first immigration, first biometric information is stored in a immigration biometric information DB. A normal immigration client terminal displays a first result of comparing an ID information watch list with a biometric information watch list. In subsequent second immigration, the first biometric information in the immigration biometric information DB is compared with second biometric information obtained by a simplified immigration client terminal. Then, the simplified immigration client terminal displays a second result of comparing the first biometric information with the watch list information that is added after the first comparison is done. Thus even if the number of registrations in a watch list database is large, a small amount of similar watch list information is displayed, reducing the time for checking the results by the operator.
    Type: Application
    Filed: March 23, 2012
    Publication date: January 10, 2013
    Applicant: HITACHI, LTD.
    Inventors: Osamu Takata, Yosuke Kaga, Yoshiaki Isobe, Takuya Kusunoki, Nobuo Takahashi
  • Patent number: 8332916
    Abstract: A service providing system using the biometrics identification without inputting the user ID poses the problem that the consideration of a service is erroneously claimed to the registered user not using the service due to the erroneous identification. According to this invention, the threshold of the value of the degree of similarity for user identification is set strictly for each registered biometrics information of the user in accordance with the declaration of the loss caused by the erroneous identification.
    Type: Grant
    Filed: February 26, 2009
    Date of Patent: December 11, 2012
    Assignee: Hitachi, Ltd.
    Inventors: Yoshiaki Isobe, Takao Murakami, Kenta Takahashi
  • Patent number: 8312521
    Abstract: A biometric authentication device has a threat of an attack of pretending to be someone else by such as forgery. The present invention supports a service provider to appropriately decide the level of such threat. A vulnerability verification server 150 is provided in the system, and the vulnerability of each biometric product is centrally managed. A service provider 130 sends the information that specifies the device in which a client terminal 110 executes the biometric authentication to the vulnerability verification server 150, and receives the vulnerability information. The service provider 130 decides whether the service can be provided or not to the client terminal 110 using the vulnerability information that was received.
    Type: Grant
    Filed: March 23, 2007
    Date of Patent: November 13, 2012
    Assignee: Hitachi, Ltd.
    Inventors: Yoshiaki Isobe, Masahiro Mimura