Abstract: An object of the present invention is to provide a drug which prevents progress of Alzheimer's disease and a method of preventing progress of Alzheimer's disease. 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof has an effect of suppressing brain atrophy and is useful as an agent for preventing or treating brain atrophy. Brain atrophy observed in aging or neurodegenerative diseases can be prevented or treated by administering 1-(3-(2-(1-Benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof.

Abstract: Provided is a radio communication device which can prevent interference between SRS and PUCCH when the PUCCH transmission bandwidth fluctuates and suppress degradation of CQI estimation accuracy by the band where no SRS is transmitted. The device includes: an SRS code generation unit (201) which generates an SRS (Sounding Reference Signal) for measuring uplink line data channel quality; an SRS arrangement unit (202) which frequency-multiplexes the SRS on the SR transmission band and arranges it; and an SRS arrangement control unit (208) which controls SRS frequency multiplex so as to be uniform in frequency without modifying the bandwidth of one SRS multiplex unit in accordance with the fluctuation of the reference signal transmission bandwidth according to the SRS arrangement information transmitted from the base station and furthermore controls the transmission interval of the frequency-multiplexed SRS.

Abstract: Provided are a drug and a method which suppress progress of tauopathy such as Alzheimer's disease. 1-(3-(2-(1-B enzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof has an effect of reducing the amount of phosphorylated tau protein and an effect of reducing the amount of amyloid ? protein in the brain parenchyma, and thus is effective as an agent for preventing or treating tauopathy. Tauopathy can be prevented or treated by administering 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof.

Abstract: An object of the present invention is to provide a drug and a method which suppress progress of disease in which the amount of amyloid ? protein in the brain is increased, such as Alzheimer’s disease. 1-(3-(2-(1-Benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof has an effect of reducing the amount of amyloid ? protein in the brain parenchyma, and thus is effective as an agent for reducing the amount of amyloid ? protein in the brain. Disease in which the amount of amyloid ? protein in the brain is increased, such as Alzheimer’s disease, can be prevented or treated by administering 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof.

Abstract: An object of the present invention is to provide a drug and a method which suppress progress of disease in which the amount of amyloid ? protein in the brain is increased, such as Alzheimer's disease. 1-(3-(2-(1-Benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof has an effect of reducing the amount of amyloid ? protein in the brain parenchyma, and thus is effective as an agent for reducing the amount of amyloid ? protein in the brain. Disease in which the amount of amyloid ? protein in the brain is increased, such as Alzheimer's disease, can be prevented or treated by administering 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof.

Abstract: An object of the present invention is to provide an excellent drug for preventing or treating spinocerebellar ataxia. 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof has an effect of suppressing brain atrophy, especially cerebellar atrophy, and is useful as an agent for preventing or treating spinocerebellar ataxia. Cerebellar atrophy observed in spinocerebellar ataxia can be prevented or treated by administering 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof.

Abstract: An object of the present invention is to provide a drug which prevents progress of Alzheimer's disease and a method of preventing progress of Alzheimer's disease. Alzheimer's disease can be effectively prevented or treated by initiating administration of a pharmaceutical composition comprising 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof as an active ingredient to a patient within a certain period from clinical diagnosis of Alzheimer's disease.

Abstract: An object of the present invention is to provide an excellent drug for preventing or treating spinocerebellar ataxia. 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof has an effect of suppressing brain atrophy, especially cerebellar atrophy, and is useful as an agent for preventing or treating spinocerebellar ataxia. Cerebellar atrophy observed in spinocerebellar ataxia can be prevented or treated by administering 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof.

Abstract: An object of the present invention is to provide a drug and a method which suppress progress of disease in which the amount of amyloid ? protein in the brain is increased, such as Alzheimer's disease. 1-(3-(2-(1-Benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof has an effect of reducing the amount of amyloid ? protein in the brain parenchyma, and thus is effective as an agent for reducing the amount of amyloid ? protein in the brain. Disease in which the amount of amyloid ? protein in the brain is increased, such as Alzheimer's disease, can be prevented or treated by administering 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof.

Abstract: A factory for manufacturing an absorbent article includes a building that includes an upper story and a lower story located below the upper story. The upper story and lower story include a floor, a wall provided along an entire periphery of the floor, an illumination device provided on a ceiling, and an air conditioner having an air outlet for discharging air, respectively. An opening is formed in the floor of the upper story. The upper story includes a paying-out device to which a material coil on which a nonwoven fabric is wound is attached and that pays out the nonwoven fabric. The nonwoven fabric serves as at least one type among a plurality of types of materials. The lower story includes a processing section that processes the plurality of types including the nonwoven fabric that is transported from the upper story through the opening.

Abstract: An object of the present invention is to provide a drug which prevents progress of Alzheimer's disease and a method of preventing progress of Alzheimer's disease. 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof has an effect of suppressing brain atrophy and is useful as an agent for preventing or treating brain atrophy. Brain atrophy observed in aging or neurodegenerative diseases can be prevented or treated by administering 1-(3-(2-(1-Benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof.

Abstract: An object of the present invention is to provide a drug and a method which suppress progress of tauopathy such as Alzheimer's disease. 1-(3-(2-(1-Benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof has an effect of reducing the amount of phosphorylated tau protein and an effect of reducing the amount of amyloid ? protein in the brain parenchyma, and thus is effective as an agent for preventing or treating tauopathy. Tauopathy can be prevented or treated by administering 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof.

Abstract: An object of the present invention is to provide a drug which prevents progress of Alzheimer's disease and a method of preventing progress of Alzheimer's disease. Alzheimer's disease can be effectively prevented or treated by initiating administration of a pharmaceutical composition comprising 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof as an active ingredient to a patient within a certain period from clinical diagnosis of Alzheimer's disease.

Abstract: An object of the present invention is to provide an excellent drug for preventing or treating spinocerebellar ataxia. 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof has an effect of suppressing brain atrophy, especially cerebellar atrophy, and is useful as an agent for preventing or treating spinocerebellar ataxia. Cerebellar atrophy observed in spinocerebellar ataxia can be prevented or treated by administering 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof.

Abstract: A factory for manufacturing an absorbent article includes a building that includes an upper story and a lower story located below the upper story. The upper story and lower story include a floor, a wall provided along an entire periphery of the floor, an illumination device provided on a ceiling, and an air conditioner having an air outlet for discharging air, respectively. An opening is formed in the floor of the upper story. The upper story includes a paying-out device to which a material coil on which a nonwoven fabric is wound is attached and that pays out the nonwoven fabric. The nonwoven fabric serves as at least one type among a plurality of types of materials. The lower story includes a processing section that processes the plurality of types including the nonwoven fabric that is transported from the upper story through the opening.

Abstract: Method for manufacturing an absorbent article, the method including: while a lower bandlike member is transported in a transport direction, a process in which a cutting position is determined and an adhesion area is formed by putting adhesive on each side of the cutting position of the lower bandlike member in the transport direction; a process in which elastic members are placed so that a part of each of the elastic members overlaps the adhesion area, the elastic members being stretched in the transport direction; a process in which an upper bandlike member is stacked on and adheres to the lower bandlike member and the elastic member on the adhesion area; a process in which the lower bandlike member and the upper bandlike member are folded on the center in the intersecting direction; a process in which a welded section on which the lower bandlike member and the upper bandlike member are to be welded to each other is formed on each side of the cutting position in the transport direction; a process in which an

Abstract: A manufacturing apparatus for manufacturing a composite sheet associated with an absorbent article, including: a producing device that produces a substrate sheet by fixing a stretchable sheet to at least low-extensible sheet, the stretchable sheet continuing along a transporting direction, the stretchable sheet being in an extended state in which the stretchable sheet is extended in the transporting direction, the producing is performed while the producing device is transporting the stretchable sheet; a reference-section forming apparatus that forms a physical reference section on the substrate sheet, the substrate sheet being in a first extended state and being transported; a contraction apparatus in which the substrate sheet that has the reference section formed on it contracts until the substrate sheet becomes in a second extended state whose extension ratio is smaller than an extension ratio of the first extended state; and a processing apparatus that performs the certain process to the substrate sheet, t

Abstract: A fixing device for fixing an elastic sheet and a low-stretchable sheet via fixing parts while superposing the sheets in a thickness direction includes: a rotating member including protrusions on an outer peripheral surface to form the fixing parts and rotatable along a transport direction; and a sandwiching member arranged at a predetermined position of the rotating member in a rotational direction, and sandwiching the sheets by a surface portion in cooperation with each of the protrusions to form the fixing parts when each of the protrusions passes through the predetermined position, the surface portion being larger than a top surface of each of the protrusions. At a sandwiching position in which the sheets are sandwiched cooperatively by the sandwiching member and the rotating member, the low-stretchable sheet is located between the elastic sheet and the top surface of each of the protrusions of the rotating member.

Abstract: A method for manufacturing an absorbent article, the method including: while a lower bandlike member is transported in a transport direction, a process in which a cutting position is determined and an adhesion area is formed on each side of the cutting position of the lower bandlike member in the transport direction; a process in which leg elastic members are placed so that a part of each of the leg elastic members overlaps the adhesion area, the leg elastic members being stretched in a direction having a component parallel to the transport direction; a process in which an upper bandlike member is stacked on and adheres to the lower bandlike member and the leg elastic member on the adhesion area; a process in which the lower bandlike member and the upper bandlike member are folded on the center in the intersecting direction; a process in which a welded section on which the lower bandlike member and the upper bandlike member are to be welded to each other is formed on each side of the cutting position in the t

Abstract: A manufacturing apparatus for manufacturing an absorbent article, the manufacturing apparatus including: an upstream transport mechanism and a downstream transport mechanism that transports a stretchable sheet-like member along a transporting direction, the stretchable sheet-like member continuing along the transporting direction; an extension-ratio adjustment mechanism that is located between the upstream transport mechanism and the downstream transport mechanism, and that adjusts an extension ratio at which the stretchable sheet-like member extends in the transporting direction; and a processing apparatus that performs the certain process to the stretchable sheet-like member that is being transported by the downstream transport mechanism.