Abstract: A chromatography carrier capable of removing an antibody dimer from a solution containing an antibody monomer. The chromatography carrier includes a base carrier containing porous particles and a hydrophobic ligand bound to the base carrier, and has an electric conductivity of 34 mS/cm or less measured by a gradient elution test. The porous particles preferably have an average particle diameter of 66 to 150 ?m, and the hydrophobic ligand preferably has at least one selected from a group consisting of phenyl, n-butyl, n-hexyl, n-octyl, and n-octadecyl.

Abstract: An optical distance measurement device includes: a photodetector including PDs for receiving interference light output from an optical interference unit and outputting detection signals of the interference light; and a switch for selecting one of the detection signals output from the PDs, in which a distance calculation unit calculates a distance to a measurement object on the basis of the detection signal selected by the switch.

Abstract: A stirring device 11 includes a stirring mechanism 7 and a control unit 15. The stirring mechanism 7 includes a motor 74 and a pedestal portion 77. In the stirring device 11, the motor 74 repeats forward rotation and reverse rotation alternately under the control of the control unit 15. Then, the pedestal portion 77 repeats turning in one direction and turning in the other direction alternately. As a result, the test tube S repeats the movement in one direction and the movement in the other direction alternately, and the vortex rotating in one direction and the vortex rotating in the other direction are alternately generated in the mixed solution in the test tube S. Then, the mixed solution in the test tube S is stirred to be rotated, and is stirred to be moved in the vertical direction. Therefore, the mixed solution in the test tube S can be efficiently stirred. As a result, the time required for stirring the mixed solution in the test tube S can be shortened.

Abstract: When a stirring device 11 performs processing of stirring a mixed solution in a test tube S, a holding mechanism 13 and a movement mechanism 14 are operated so that the test tube S is moved to a position of B2. Then, in the test tube S, the cells attached to the inner surface of the test tube S and the liquid are separated. Further, the cells attached to the inner surface of the test tube S are detected by a color sensor 152. Therefore, it is possible to reduce the work for determining the end of the stirring processing by the user. As a result, the workability of the user when using the stirring device 11 can be improved.

Abstract: An adsorbent, which can be produced by a method in which a particle size, a pore size, a specific surface area or the like can be easily controlled, and is suitable for isolation of biomolecules. The adsorbent contains aggregates of calcium phosphate-based particles, and has an average pore size of 15 to 36 nanometers and a specific surface area of 40 to 90 m2/mL when measurement is carried out by mercury porosimetry.

Abstract: An optical distance measurement device includes: a photodetector including PDs for receiving interference light output from an optical interference unit and outputting detection signals of the interference light; and a switch for selecting one of the detection signals output from the PDs, in which a distance calculation unit calculates a distance to a measurement object on the basis of the detection signal selected by the switch.

Abstract: An insulated DC-DC converter includes a substrate, a transformer, a primary side electronic component and a primary side wire defining a primary side circuit together with a primary winding, a secondary side electronic component and a secondary side wire defining a secondary side circuit insulated from the primary side circuit, together with a secondary winding, the secondary side electronic component including a choke coil, and an inter-circuit electronic component and an inter-primary side circuit wire connected over the primary side circuit and the secondary side circuit while insulating the primary side circuit and the secondary side circuit from each other in a DC manner.

Abstract: An antibody purification method, including bringing a solution containing an antibody and HCP into contact with a chromatography media to separate the antibody and the HCP, wherein the chromatography media contains a base media containing porous particles, and a compound having a plurality of primary amino groups bonded to the base media, and 20 to 55% of the primary amino groups in the compound having the plurality of primary amino groups are modified with a hydrophobic group, and collection efficiency of the antibody is 85% or more, and an amount of the HCP in an antibody solution after purification is less than 45 ppm.

Abstract: In one embodiment, the invention provides a method of treating a subject who suffers from a neoplasm (including a cancer such as a radiotherapeutic-resistant cancer) by administering to the subject a therapeutically effective amount of (a) 5-formyl-2?-deoxyuridine (fdU or foUdR) or a 5-formyl-2?-deoxyuridine derivative, optionally in combination with 5-hydroxy-2?-deoxyuridine (hUdR); and (b) at least one composition selected from the group consisting of either 5-fluorouracil (5-FU), a 5-FU prodrug (e.g. 5-fluoro-2?-deoxyuridine (FdU)) or 5-FU metabolite. In a preferred embodiment, a subject who suffers from colorectal cancer (CRC) or metastatic colorectal cancer (mCRC) is treated with a therapeutically-effective amount of fdU and either 5-FU or the 5-FU prodrug 5-fluoro-2?-deoxyuridine (FdU). Related pharmaceutical compositions are also provided.

Abstract: A method for preparing a chromatography medium having the properties of high virus adsorption and high fluidity, and a method for producing a virus vaccine using the chromatography medium are provided. The chromatography medium is obtained by forming a sulfated polysaccharide bound with porous particles having an exclusion limit molecular weight of 6000 Da or less when pure water is used as mobile phase and standard polyethylene glycol is used and an average particle size in the range of 30-200 ?m.

Abstract: An insulated DC-DC converter includes a substrate, a transformer, a primary side electronic component and a primary side wire defining a primary side circuit together with a primary winding, a secondary side electronic component and a secondary side wire defining a secondary side circuit insulated from the primary side circuit, together with a secondary winding, the secondary side electronic component including a choke coil, and an inter-circuit electronic component and an inter-primary side circuit wire connected over the primary side circuit and the secondary side circuit while insulating the primary side circuit and the secondary side circuit from each other in a DC manner.

Abstract: In one embodiment, the invention provides a method of treating a subject who suffers from a neoplasm (including a cancer such as a radiotherapeutic-resistant cancer) by administering to the subject a therapeutically effective amount of (a) 5-formyl-2?-deoxyuridine (fdU or foUdR) or a 5-formyl-2?-deoxyuridine derivative, optionally in combination with 5-hydroxy-2?-deoxyuridine (hUdR); and (b) at least one composition selected from the group consisting of either 5-fluorouracil (5-FU), a 5-FU prodrug (e.g. 5-fluoro-2?-deoxyuridine (FdU)) or 5-FU metabolite. In a preferred embodiment, a subject who suffers from colorectal cancer (CRC) or metastatic colorectal cancer (mCRC) is treated with a therapeutically-effective amount of fdU and either 5-FU or the 5-FU prodrug 5-fluoro-2?-deoxyuridine (FdU). Related pharmaceutical compositions are also provided.

Abstract: A polyisocyanate composition is produced by reaction of bis(isocyanatomethyl) cyclohexane with trimethylolpropane, and contains a trimethylolpropane-monomolecular-body obtained by reaction of three molecules of bis(isocyanatomethyl) cyclohexane with one molecule of trimethylolpropane, and a trimethylolpropane-bimolecular-body obtained by reaction of five molecules of bis(isocyanatomethyl) cyclohexane with two molecules of trimethylolpropane; and the molar ratio of trimethylolpropane-monomolecular-body relative to trimethylolpropane-bimolecular-body (trimethylolpropane-monomolecular-body/trimethylolpropane-bimolecular-body) contained in the polyisocyanate composition is 1.5 or more and 4.5 or less.

Abstract: In a lathe equipped with a spindle for rotatably driving a work and a tool rest having a turret (rotary member) rotatably supporting a plurality of tools in an indexable manner about a horizontal axis, the tool rest is detachably installed on a tool rest installation portion formed so as to be positioned on an operator side so that the tools of the turret face the work side gripped by the spindle in an attachable and detachable manner.

Abstract: An adsorbent, which can be produced by a method in which a particle size, a pore size, a specific surface area or the like can be easily controlled, and is suitable for isolation of biomolecules. The adsorbent contains aggregates of calcium phosphate-based particles, and has an average pore size of 15 to 36 nanometers and a specific surface area of 40 to 90 m2/mL when measurement is carried out by mercury porosimetry.

Abstract: A machine tool includes a spindle equipped with a workpiece gripping portion arranged so as to face an operator side, the spindle being configured to rotatably drive a workpiece gripped by the workpiece gripping portion, and a tool mount equipped with a rotary member supporting a plurality of tools in a rotatably indexable manner about an axis parallel to an axis of the spindle. The tool mount is arranged at a tool mount installation portion formed to be positioned on the operator side in a manner such that the rotary member faces a workpiece gripping portion side.

Abstract: The present invention provides a porous cellulose gel having a high mechanical strength capable of being operated at a higher flow rate, and a method for producing the same. To a suspension liquid of cellulose particles, a crosslinking agent in an amount of from 4 to 12 times the amount of the cellulose monomer in terms of moles and an alkali in an amount of from 0.1 to 1.5 times the amount of the crosslinking agent in terms of moles are added continuously dropwise or added dividedly over a prescribed period of time, whereby flow rate characteristics of a resulting porous cellulose gel can be enhanced. According to the invention, the production efficiency of a polymer substance, such as a nucleic acid and a protein can be enhanced.

Abstract: A chip discharging device of a machine tool is equipped with a chip discharging member for discharging chips generated by machine processing to a workpiece to an outside of the machine tool, and a chip shooter for introducing the chips to the chip discharging member. The chip shooter connects an introducing opening for introducing the generated chips and a discharging opening for discharging the chips toward the chip discharging member by a guide wall surface. The guide wall surface includes a vertical wall surface and a plurality of inclined wall surfaces inclined with respect to the vertical wall surface. At least a boundary parts between the inclined wall surfaces and a boundary part between the inclined wall surface and the vertical wall surface are formed by a flat surface or a curved surface.

Abstract: A method for preparing a chromatography medium having the properties of high virus adsorption and high fluidity, and a method for producing a virus vaccine using the chromatography medium are provided. The chromatography medium is obtained by forming a sulfated polysaccharide bound with porous particles having an exclusion limit molecular weight of 6000 Da or less when pure water is used as mobile phase and standard polyethylene glycol is used and an average particle size in the range of 30-200 ?m.

Abstract: A Chromatography medium having the properties of high virus adsorption and high fluidity, and a method for producing a virus vaccine using these are provided. The Chromatography medium is formed by binding a sulfated polysaccharide to porous particles having an exclusion limit molecular weight of 6000 Da or less when pure water is used as mobile phase and standard polyethylene glycol is used and an average particle size in the range of 30-200 ?m.