Patents by Inventor Yoshikatsu Akiyama

Yoshikatsu Akiyama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9643174
    Abstract: Provided is a temperature responsive adsorbent prepared by immobilizing a copolymer containing at least N-isopropylacrylamide to a base material surface. The copolymer has at least a strong cation exchange group. In addition, the copolymer contains the strong cation exchange group in an amount of 0.01 to 5 mol % relative to N-isopropylacrylamide in terms of monomer.
    Type: Grant
    Filed: November 17, 2014
    Date of Patent: May 9, 2017
    Assignee: ASAHI KASEI MEDICAL CO., LTD.
    Inventors: Ichiro Koguma, Hiroki Shigematsu, Kazuo Okuyama, Teruo Okano, Yoshikatsu Akiyama, Kenichi Nagase
  • Patent number: 9643173
    Abstract: Provided is a temperature responsive adsorbent prepared by immobilizing a copolymer containing at least N-isopropylacrylamide to a base material surface. The copolymer has at least a strong cation exchange group. In addition, the copolymer contains the strong cation exchange group in an amount of 0.01 to 5 mol % relative to N-isopropylacrylamide in terms of monomer.
    Type: Grant
    Filed: December 19, 2011
    Date of Patent: May 9, 2017
    Assignee: ASAHI KASEI MEDICAL CO., LTD.
    Inventors: Ichiro Koguma, Hiroki Shigematsu, Kazuo Okuyama, Teruo Okano, Yoshikatsu Akiyama, Kenichi Nagase
  • Publication number: 20170067861
    Abstract: A temperature responsive monolithic porous material is obtained that comprises a polymer having a hydration ability that changes in a temperature range of 0 to 80° C. and being immobilized to a surface of the porous material at a high density by binding an atom transfer radical polymerization initiator to a surface of the porous material, and inducing a growth reaction of a polymer, having a hydration ability that changes in a temperature range of 0 to 80° C., from the initiator using an atom transfer radical process under a presence of a catalyst.
    Type: Application
    Filed: November 17, 2016
    Publication date: March 9, 2017
    Inventors: Kenichi NAGASE, Jun KOBAYASHI, Akihiko KIKUCHI, Yoshikatsu AKIYAMA, Hideko KANAZAWA, Teruo OKANO
  • Publication number: 20150080484
    Abstract: Provided is a temperature responsive adsorbent prepared by immobilizing a copolymer containing at least N-isopropylacrylamide to a base material surface. The copolymer has at least a strong cation exchange group. In addition, the copolymer contains the strong cation exchange group in an amount of 0.01 to 5 mol % relative to N-isopropylacrylamide in terms of monomer.
    Type: Application
    Filed: November 17, 2014
    Publication date: March 19, 2015
    Applicant: ASAHI KASEI MEDICAL CO., LTD.
    Inventors: Ichiro KOGUMA, Hiroki SHIGEMATSU, Kazuo OKUYAMA, Teruo OKANO, Yoshikatsu AKIYAMA, Kenichi NAGASE
  • Patent number: 8916189
    Abstract: This invention is intended to provide cell aggregates that can reproduce functions of the myocardium, such as the function of beating, and thus are available for myocardial regenerative therapy, and to provide a cell culture support for producing the same. According to this invention, a cell culture support for forming string-shaped cardiomyocyte aggregates, which has a substrate portion having one surface on which at least one linear cell-adherent region is formed is provided.
    Type: Grant
    Filed: May 16, 2008
    Date of Patent: December 23, 2014
    Assignees: Dai Nippon Printing Co., Ltd., Tokyo Women's Medical University
    Inventors: Masanao Watanabe, Teruo Okano, Masayuki Yamato, Tatsuya Shimizu, Yoshikatsu Akiyama
  • Publication number: 20140335610
    Abstract: A cell culture substrate is used comprising a photopolymerization initiator immobilized on a surface of the cell culture substrate, and a linear polymer immobilized on a part or the entirety of the surface via the photopolymerization initiator, and wherein the photopolymerization initiator is thioxanthone. Thereby, advantageously, a single type or multiple types of cells are efficiently cultured on specific regions of the culture substrate, and efficiently detached only by changing temperature on the surface of the substrate.
    Type: Application
    Filed: November 20, 2012
    Publication date: November 13, 2014
    Applicant: TOKYO WOMEN'S MEDICAL UNIVERSITY
    Inventors: Kazuhiro Fukumori, Yoshikatsu Akiyama, Masayuki Yamato, Teruo Okano
  • Patent number: 8809053
    Abstract: Methods and reagents are described for myocardial regenerative therapy using cardiomyocytes that are cultured ex vivo to have a controlled orientation of beating. This is achieved by growing the cardiomyocytes on a culture support that is coated with a polymerizable liquid crystal which is oriented so as to be in a liquid crystal phase state prior to curing with ionizing radiation or ultraviolet rays.
    Type: Grant
    Filed: August 6, 2008
    Date of Patent: August 19, 2014
    Assignees: Dai Nippon Printing Co., Ltd., Tokyo Women's Medical University
    Inventors: Masanao Watanabe, Teruo Okano, Masayuki Yamato, Tatsuya Shimizu, Yoshikatsu Akiyama
  • Publication number: 20140124445
    Abstract: A temperature responsive monolithic porous material is obtained that comprises a polymer having a hydration ability that changes in a temperature range of 0 to 80° C. and being immobilized to a surface of the porous material at a high density by binding an atom transfer radical polymerization initiator to a surface of the porous material, and inducing a growth reaction of a polymer, having a hydration ability that changes in a temperature range of 0 to 80° C., from the initiator using an atom transfer radical process under a presence of a catalyst.
    Type: Application
    Filed: March 12, 2012
    Publication date: May 8, 2014
    Applicants: CellSeed Inc., Hideko KANAZAWA, TOKYO WOMEN'S MEDICAL UNIVERSITY
    Inventors: Kenichi Nagase, Jun Kobayashi, Akihiko Kikuchi, Yoshikatsu Akiyama, Hideko Kanazawa, Teruo Okano
  • Publication number: 20130317129
    Abstract: Provided is a temperature responsive adsorbent prepared by immobilizing a copolymer containing at least N-isopropylacrylamide to a base material surface. The copolymer has at least a strong cation exchange group. In addition, the copolymer contains the strong cation exchange group in an amount of 0.01 to 5 mol % relative to N-isopropylacrylamide in terms of monomer.
    Type: Application
    Filed: December 19, 2011
    Publication date: November 28, 2013
    Applicant: ASAHI KASEI MEDICAL CO., LTD.
    Inventors: Ichiro Koguma, Hiroki Shigematsu, Kazuo Okuyama, Teruo Okano, Yoshikatsu Akiyama, Kenichi Nagase
  • Patent number: 8557583
    Abstract: An object of the present invention is to provide a cell culture support making the detachment of a cell sheet easy as well as enabling the formation of a uniform cell sheet.
    Type: Grant
    Filed: March 11, 2008
    Date of Patent: October 15, 2013
    Assignees: Dai Nippon Printing Co., Ltd., Tokyo Woman's Medical University, Cellseed Inc.
    Inventors: Masanao Watanabe, Kenichi Hagiwara, Teruo Okano, Masayuki Yamato, Tatsuya Shimizu, Yoshikatsu Akiyama, Hiroya Watanabe, Keisuke Ashiba
  • Publication number: 20080009063
    Abstract: An object of the present invention is to provide a cell culture substrate capable of quickly forming a cell sheet and easily removing the cell sheet after formed. The present invention relates to a cell culture substrate for forming a cell sheet by culturing cells, comprising a plurality of projections each having a top face and depressions formed between the projections, in which the depressions each have an opening whose dimensions are too small for a cell to be cultured to enter and the cell sheet is removable. The present invention further relates to a method of preparing a cell sheet using the substrate and a cell sheet prepared by the method.
    Type: Application
    Filed: July 3, 2007
    Publication date: January 10, 2008
    Applicants: DAI NIPPON PRINTING CO., LTD.
    Inventors: Teruo Okano, Masayuki Yamato, Yoshikatsu Akiyama, Masanao Watanabe, Hiroyuki Naganuma, Masami Nara
  • Patent number: 6956077
    Abstract: A temperature-responsive polymer and polymer material which has ester bond(s) and/or acid amide bond(s) respectively at one or more sites in the side chain and can be arbitrarily controlled by varying the side chain is provided.
    Type: Grant
    Filed: January 31, 2000
    Date of Patent: October 18, 2005
    Assignee: Amersham Biosciences KK
    Inventors: Yoshikatsu Akiyama, Kimihiro Yoshizako, Yukio Hasegawa, Teruo Okano
  • Publication number: 20050224415
    Abstract: A temperature-responsive polymer and polymer material which has ester bond(s) and/or acid amide bond(s) respectively at one or more sites in the side chain and can be arbitrarily controlled by varying the side chain is provided. The process for production thereof and the use thereof are also provided.
    Type: Application
    Filed: May 19, 2005
    Publication date: October 13, 2005
    Inventors: Yoshikatsu Akiyama, Kimihiro Yoshizako, Yukio Hasegawa, Teruo Okano
  • Patent number: 6805793
    Abstract: A novel method for separating a target substance, for example, metal ion, drug or biological component is provided. According to the method, the surface of a packing undergoes a chemical or physical environmental change under a physical stimulus so that the interaction of a substance interacting with the target substance is reversibly changed in an aqueous solution, thus effecting separation.
    Type: Grant
    Filed: May 9, 2003
    Date of Patent: October 19, 2004
    Assignees: Japan Chemical Innovation Institute, The Agency of Industrial Science and Technology of the Ministry of International Trade and Industry
    Inventors: Kimihiro Yoshizako, Yoshikatsu Akiyama, Katsuhiko Ueno, Teruo Okano
  • Publication number: 20040134846
    Abstract: A separatory material comprising a composite material containing a stimulus-responsive polymer and a substance interacting specifically with a target substance, wherein said stimulus-responsive polymer undergoes a structural change upon a physical stimulus so that the interaction of said substance interacting specifically with the target substance is affected by the chemical or physical environmental change, thereby causing a reversible change in the interaction force with the target substance due to the physical stimulus, which separatory material is characterized in that said stimulus-responsive polymer has no affinity with said substance interacting specifically with the target substance.
    Type: Application
    Filed: February 26, 2004
    Publication date: July 15, 2004
    Inventors: Yoshikatsu Akiyama, Kimihiro Yoshizako, Teruo Okano, Katsuhiko Ueno
  • Publication number: 20030205527
    Abstract: A novel method for separating a target substance, for example, metal ion, drug or biological component is provided. According to the method, the surface of a packing undergoes a chemical or physical environmental change under a physical stimulus so that the interaction of a substance interacting with the target substance is reversibly changed in an aqueous solution, thus effecting separation.
    Type: Application
    Filed: May 9, 2003
    Publication date: November 6, 2003
    Inventors: Kimihiro Yoshizako, Yoshikatsu Akiyama, Katsuhiko Ueno, Teruo Okano
  • Patent number: 6641735
    Abstract: A novel method for separating a target substance, for example, metal ion, drug or biological component is provided. According to the method, the surface of a packing undergoes a chemical or physical environmental change under a physical stimulus so that the interaction of a substance interacting with the target substance is reversibly changed in an aqueous solution, thus effecting separation.
    Type: Grant
    Filed: March 23, 2000
    Date of Patent: November 4, 2003
    Assignees: Japan Chemical Innovation Institute, The Agency of Industrial Science and Technology the Ministry of International Trade and Industry
    Inventors: Kimihiro Yoshizako, Yoshikatsu Akiyama, Katsuhiko Ueno, Teruo Okano