Patents by Inventor Yoshiki Sakaino

Yoshiki Sakaino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7846716
    Abstract: An object of the present invention is to provide a microchip whereby, when chemical analysis is conducted, a specimen liquid can be directly collected and weighed without using any collecting and weighing devices. The present invention provides a microchip for analyzing liquid samples, which has a measuring structure for weighing and collecting a given amount of a specimen liquid within a range of 0.05 to 10 ?l from an excessive amount of the specimen liquid which was introduced in the chip, wherein the measuring structure is located at the upstream side of an analysis element for analyzing a target substance in the specimen liquid inside the microchip.
    Type: Grant
    Filed: April 28, 2006
    Date of Patent: December 7, 2010
    Assignee: Fujifilm Corporation
    Inventors: Bo Yang, Yukio Sudo, Yoshiki Sakaino, Hideyuki Karaki, Akira Wakabayashi
  • Patent number: 7820402
    Abstract: The immunoassay element for quantitatively analyzing an antigen by determining the change in enzymatic activity of an enzyme-labelled antigen or antibody caused by an immunological reaction. The immunoassay element comprises a substrate layer containing a non-diffusible substrate which forms a diffusible material in the presence of the labelling enzyme, and a reagent layer containing a fragmenting enzyme for further fragmenting the diffusible material into a lower molecular weight product. As the non-diffusible substrate, a substrate capable of reacting solely with the labelling enzyme and incapable of reacting the fragmenting enzyme is utilized. When an endo-active glucosidase is used as the labelling enzyme, and an exo-active glucosidase is used the fragmenting enzyme in the reagent layer, the non-diffusible substrate of the substrate layer is preferred to be an endo type selectively reactive substrate, which means a substrate having a reactivity specific to endo-active glucosidase.
    Type: Grant
    Filed: September 19, 2005
    Date of Patent: October 26, 2010
    Assignee: Fuji Photo Film Co., Ltd.
    Inventors: Yoshiki Sakaino, Hitomi Ito, Toshihiro Mori, Osamu Seshimoto, Toshihisa Ito, Yoshikazu Amano
  • Publication number: 20080317628
    Abstract: A check sheet includes: a reagent container that contains a reagent that changes color by being brought into contact with a target element generated from skin; and a plurality of filters provided in different positions from each other at the opposite side to the side of the reagent container to be attached to the skin along the reagent container, and emitting light in wavelength regions different from each other. A check sheet includes: a reagent container that contains a reagent that changes color by being brought into contact with a target element generated from skin; and a filter provided at the opposite side to the side of the reagent container to be attached to the skin, and transmitting light in a part of a wavelength region detectable by a light detector detecting a color of the reagent.
    Type: Application
    Filed: June 19, 2008
    Publication date: December 25, 2008
    Applicant: FUJIFILM CORPORATION
    Inventors: Hideyasu ISHIBASHI, Yoshiki Sakaino, Hiroshi Yamaguchi, Hiroyuki Niwano
  • Patent number: 7410613
    Abstract: A humoral testing apparatus in which a measuring light is irradiated to a reagent area forming a color as a result of a reaction and an optical density of the reagent area is detected by a detecting operation of light intensity of the reflected light. The humoral testing apparatus enables a humoral test to be performed accurately in cases where nonuniformity occurs with the reaction of a reagent with a humoral sample within the reagent area, or in cases where fine dust is present within each detecting spot in the reagent areas. The light reflected from the reagent areas is detected with a two-dimensional photodetector. The independent light intensity detecting operations are performed with respect to the subareas of the reagent area of a reagent layer. A photo detection signal S, which represents the intensity of the reflected light is statistically processed with a signal processing section 51.
    Type: Grant
    Filed: March 27, 2003
    Date of Patent: August 12, 2008
    Assignee: Fujifilm Corporation
    Inventors: Yoshihide Iwaki, Kentarou Nakamura, Hideaki Tanaka, Yoshiki Sakaino, Kaoru Terashima, Hitoshi Shimizu
  • Patent number: 7407578
    Abstract: A liquid filtering instrument 10 according to the present invention achieves filtered liquid by pressure-reduced filtration, and it comprises a filter member 12 in which a liquid filter 15 is accommodated, and a holder member 14 for stocking filtered liquid passed through the liquid filter 15, wherein the filter member 12 and the holder member 14 are formed in capable of being fitted so as to be kept substantially air-tight and water-tight under pressure reduced state.
    Type: Grant
    Filed: July 21, 2005
    Date of Patent: August 5, 2008
    Assignee: Fujifilm Corporation
    Inventors: Yoshiki Sakaino, Yukio Sudo
  • Publication number: 20080166268
    Abstract: A test sheet to be adhered to an object at the point of use is disclosed. The test sheet includes: a substrate film including an adhesive layer on one side thereof; a reagent layer disposed on the substrate film on the same side as the adhesive layer, the reagent layer including a reagent, the reagent changing the color thereof depending on an amount of substance evaporating from a surface of the object; a first correction chart disposed on the substrate film on the side opposite from the adhesive layer, the first correction chart being used for correcting color of an image obtained by photographing the object with the test sheet adhered thereto; and a second correction chart used for correcting lightness of the image.
    Type: Application
    Filed: January 9, 2008
    Publication date: July 10, 2008
    Inventors: Hiroshi Yamaguchi, Hideyasu Ishibashi, Yoshiki Sakaino
  • Patent number: 7369243
    Abstract: An optical measuring apparatus comprises: an illuminating section that illuminates a first object with a first light; a light changing section that changes an intensity of the first light illuminating the first object; a light receiving device that receives a second light transmitted through or reflected from the first object; and an output section that outputs a measurement result according to i) a state of the light changing section and ii) an amount of the second light received by the light receiving device. In addition, an optical measuring apparatus comprises: the illuminating section; the light receiving device; a light receiving time changing section that changes a light receiving time of the light receiving device; and an output section that outputs a measurement result according to i) the light receiving time and ii) an amount of the second light received by the light receiving device.
    Type: Grant
    Filed: May 21, 2004
    Date of Patent: May 6, 2008
    Assignee: Fujifilm Corporation
    Inventors: Yoshiki Sakaino, Yoshihiko Abe, Kaoru Terashima
  • Publication number: 20080019869
    Abstract: It is an object of the invention to provide a multilayer analysis element with small intra-lot and lot-to-lot differences that has high measurement accuracy and which is small in size. The present invention provides a multilayer analysis element for liquid sample analysis wherein at least one functional layer and at least one porous liquid sample spreading layer of non-fibrous porous film are integrally laminated in this order on one side of a water-impermeable planar support, and the non-fibrous porous film has a bending rupture strength of 20 gram-weight or more and a tensile percentage of 2% or less when the film is stretched with a tensile force of 50 gram-weight.
    Type: Application
    Filed: February 18, 2005
    Publication date: January 24, 2008
    Applicant: Fuji Photo Film Co., Ltd.
    Inventors: Kentaro Nakamura, Kazuya Kawasaki, Yoshiki Sakaino, Toshihisa Ito, Osamu Seshimoto
  • Patent number: 7300629
    Abstract: A blood testing unit is provided with a closed vessel having an outer vessel body and an inner vessel body, and a reagent layer is accommodated in the closed vessel. Reagents which react with a blood sample are supported on the reagent layer. The closed vessel is comprised such that at least either one of the outer vessel body and the inner vessel body is provided with an aperture, through which air is capable of being introduced from the exterior to the interior of the one vessel body, and the one vessel body is provided with a sealing member for closing the aperture.
    Type: Grant
    Filed: March 28, 2003
    Date of Patent: November 27, 2007
    Assignee: Fujifilm Corporation
    Inventors: Yoshihide Iwaki, Kentarou Nakamura, Hideaki Tanaka, Yoshiki Sakaino, Kaoru Terashima
  • Patent number: 7282179
    Abstract: A blood testing unit comprises a closed vessel having a blood introducing section formed at a certain area of the closed vessel. A blood constituent separating section is located within the closed vessel to separate plasma and/or serum from the blood sample introduced through the blood introducing section into the closed vessel. A reagent layer is located within the closed vessel, such that the reagent layer can be seen from the exterior. The reagent layer comprises a region for spreading the plasma and/or the serum, which has been separated by the blood constituent separating section from the blood sample, and a reagent supporte donor in the spreading region, the reagent undergoing a reaction with the plasma and/or the serum and forming a color as a result of the reaction.
    Type: Grant
    Filed: March 28, 2003
    Date of Patent: October 16, 2007
    Assignee: Fujifilm Corporation
    Inventors: Yoshihide Iwaki, Kentarou Nakamura, Hideaki Tanaka, Yoshiki Sakaino, Kaoru Terashima, Ichizou Toya
  • Publication number: 20070227967
    Abstract: A filter for separating blood cells, which comprises: a substrate; and at least one water-insoluble substance fixed to the substrate, wherein the at least one water-insoluble substance has an equivalent circle diameter of 4 ?m or less and a height equal to or larger than the equivalent circle diameter, wherein blood cells are separated by substantially being captured with the at least one water-insoluble substance; and a blood filtration instrument and a blood analytical device, using the filter for filtration of blood and body fluid.
    Type: Application
    Filed: April 4, 2007
    Publication date: October 4, 2007
    Inventors: Yoshiki Sakaino, Bo Yang, Shotaro Ogawa
  • Publication number: 20070221563
    Abstract: To provide a nucleic acid-adsorbing porous membrane which has an excellent separating ability, which provides a good washing efficiency, which permits convenient and expeditious procedures, which is adapted for automation and reduction in size, which can be mass produced with substantially identical separating capability, and which is adapted for a method of separating and purifying nucleic acids and to provide an apparatus using the same, a nucleic acid-adsorbing porous membrane for separating and purifying a nucleic acid, comprises a nucleic acid-adsorbing solid phase for use in a method for separating and purifying the nucleic acid, the solid phase adsorbing the nucleic acid, the method comprising the steps of: (1) adsorbing the nucleic acid to the solid phase by allowing a sample solution containing the nucleic acid to come into contact with the nucleic acid-adsorbing solid phase; (2) washing the solid phase by allowing a washing solution to come into contact with the solid phase, while the nucleic acid i
    Type: Application
    Filed: October 20, 2004
    Publication date: September 27, 2007
    Applicant: FUJI PHOTO FILM CO., LTD.
    Inventors: Yoshiki Sakaino, Yoshihiko Makino, Toshihiro Mori
  • Publication number: 20070219509
    Abstract: A blood collecting needle, which comprises: a needle tube having a human-body puncturing needle tube and a stopper-body puncturing needle tube, wherein the needle tube has an outer diameter having substantially the same dimension from a tip of the human-body puncturing needle tube to a tip of the stopper-body puncturing needle tube, the needle tube has an inner diameter having substantially the same dimension from the tip of the human-body puncturing needle tube to the tip of the stopper-body puncturing needle tube, and the blood collecting needle satisfies equation (1): 0.35?D1<0.70??(equation 1) wherein D1 represents the outer diameter (mm) of the needle tube.
    Type: Application
    Filed: March 14, 2007
    Publication date: September 20, 2007
    Inventors: Tomoko Tashiro, Yoshiki Sakaino, Yoshihiko Abe
  • Publication number: 20070178521
    Abstract: An integrated assay chip for assaying one or more components of a specimen, which comprises: (1) one or more pretreatment elements for pretreating a specimen; (2) one or more multilayer dry assay elements capable of assaying one or more components of the pretreated specimen; and (3) one or more flow channels connecting the pretreatment element and the multilayer dry assay element is provided.
    Type: Application
    Filed: March 15, 2005
    Publication date: August 2, 2007
    Inventors: Yoshiki Sakaino, Yukio Sudo, Yoshihiko Abe, Bo Yang
  • Publication number: 20070178009
    Abstract: An analysis element for use in a blood test method enabling easy and simple operations that are performed quickly up to measurement, an analysis element for use in a blood test method that operations up to the measurement for many components can be quickly performed, and that is safe and has a sufficient measurement accuracy thereof, and an analysis element for use in a test method using body fluids and urines of humans and animals, plain water, seawater, soil extract, agricultural products, marine products, processed-food extracts, and liquid for use in scientific research as specimens, are provided, the present invention relates to a multi-component measurement dry analysis element for use in a method for testing a specimen, the method using an area sensor as a detector to obtain a result of measurement according to information represented by 1000 pixels or more per one component, and to perform simultaneous measurements of plural components.
    Type: Application
    Filed: March 15, 2005
    Publication date: August 2, 2007
    Inventors: Yoshiki Sakaino, Yoshihiko Abe, Yukio Sudo
  • Publication number: 20070149944
    Abstract: A blood collecting needle, which comprises: a needle hub; a human-body puncturing needle tube provided at one side of the needle hub; and a plug-body puncturing needle tube provided at the other side of the needle hub, wherein an outer diameter of a tip of the human-body puncturing needle tube and an outer diameter of a tip of the plug-body puncturing needle tube are different from each other.
    Type: Application
    Filed: December 7, 2006
    Publication date: June 28, 2007
    Inventors: Tomoko Tashiro, Yoshiki Sakaino, Yoshihiko Abe
  • Publication number: 20070077169
    Abstract: A microchip comprises: a flow path substrate; an inlet port; a flow path adapted to cause a plurality of kinds of liquid to flow while mixing the plurality of kinds of liquid; and a decompression port configured to communicate with the flow path and to be connectable to a decompression unit, wherein the flow path includes a first flow path portion and a second flow path portion provided so that they are alternately formed, and wherein the first flow path portion has a larger cross-sectional area than the flow path portion other than the first flow path portion, and wherein the second flow path portion has a smaller cross-sectional area than the first flow path portion; and a blood test method comprises: mixing a blood with a dilute solution by utilizing the microchip described above.
    Type: Application
    Filed: September 27, 2006
    Publication date: April 5, 2007
    Inventors: Bo Yang, Yoshiki Sakaino, Hideyuki Karaki, Akira Wakabayashi
  • Publication number: 20060263242
    Abstract: An object of the present invention is to provide a microchip whereby, when chemical analysis is conducted, a specimen liquid can be directly collected and weighed without using any collecting and weighing devices. The present invention provides a microchip for analyzing liquid samples, which has a measuring structure for weighing and collecting a given amount of a specimen liquid within a range of 0.05 to 10 ?l from an an excessive amount of the specimen liquid which was introduced in the chip, wherein the measuring structure is located at the upstream side of an analysis element for analyzing a target substance in the specimen liquid inside the microchip.
    Type: Application
    Filed: April 28, 2006
    Publication date: November 23, 2006
    Applicant: FUJI PHOTO FILM CO., LTD.
    Inventors: Bo Yang, Yukio Sudo, Yoshiki Sakaino, Hideyuki Karaki, Akira Wakabayashi
  • Patent number: 7113875
    Abstract: A plurality of different kinds of reagents are supported at different positions on a reagent layer. A humoral testing apparatus irradiates measuring light which has a wavelength adapted to one of the plurality of the reagent areas which forms a color, and detects the intensity of the light reflected from the reagent areas with the photodetector with respect to each of the reagents, and thus detects the optical densities of the reagent areas.
    Type: Grant
    Filed: March 27, 2003
    Date of Patent: September 26, 2006
    Assignee: Fuji Photo Film Co., Ltd.
    Inventors: Kaoru Terashima, Yoshiki Sakaino, Hideaki Tanaka, Kentarou Nakamura, Yoshihide Iwaki, Hitoshi Shimizu
  • Publication number: 20060211127
    Abstract: A blood testing unit comprises a closed vessel having a blood introducing section formed at a certain area of the closed vessel. A blood constituent separating section is located within the closed vessel to separate plasma and/or serum from the blood sample introduced through the blood introducing section into the closed vessel. A reagent layer is located within the closed vessel, such that the reagent layer can be seen from the exterior. The reagent layer comprises a region for spreading the plasma and/or the serum, which has been separated by the blood constituent separating section from the blood sample, and a reagent supported on or in the spreading region, the reagent undergoing a reaction with the plasma and/or the serum and forming a color as a result of the reaction.
    Type: Application
    Filed: May 18, 2006
    Publication date: September 21, 2006
    Inventors: Yoshihide Iwaki, Kentarou Nakamura, Hideaki Tanaka, Yoshiki Sakaino, Kaoru Terashima, Ichizou Toya