Abstract: The invention provides compositions and methods for treating cancers. The methods comprising administering a PD-1 axis binding antagonist and an anti-GPC3 antibody. The compositions comprising a pharmaceutical composition for treating cancer which comprises a PD-1 axis binding antagonist and an anti-GPC3 antibody. Also disclosed are a pharmaceutical composition to be used in combination with a PD-1 axis binding antagonist for treating cancer which comprises an anti-GPC3 antibody as the active ingredient; and a pharmaceutical composition to be used in combination with an anti-GPC3 antibody for treating cancer which comprises as the active ingredient a PD-1 axis binding antagonist.

Abstract: The invention provides compositions and methods for treating cancers. The methods comprising administering a PD-1 axis binding antagonist and an anti-GPC3 antibody. The compositions comprising a pharmaceutical composition for treating cancer which comprises a PD-1 axis binding antagonist and an anti-GPC3 antibody. Also disclosed are a pharmaceutical composition to be used in combination with a PD-1 axis binding antagonist for treating cancer which comprises an anti-GPC3 antibody as the active ingredient; and a pharmaceutical composition to be used in combination with an anti-GPC3 antibody for treating cancer which comprises as the active ingredient a PD-1 axis binding antagonist.

Abstract: An objective of the present disclosure is to provide: anticancer agents having an immune cell-activating effect, a cytotoxic activity, or an antitumor activity, but having a low effect on non-tumor tissues such as normal tissues and having few side effects; combination therapies using those anticancer agents and other anticancer agents; and pharmaceutical combinations for use in those combination therapies. Anticancer agents expected to be applied to various types of cancers, which have an immune cell-activating effect, a cytotoxic activity, or an antitumor activity while having a low effect on non-tumor tissues such as normal tissues and having few side effects by using as an active ingredient an anti-CD137 antigen-binding molecule of the present disclosure, the binding activity of which to CD137 changes depending on various substances (for example, low molecular weight compounds) in target tissues, are provided.

Abstract: An objective of the present disclosure is to provide anti-CD137 antigen-binding molecules which have immunocyte-activating effect, cytotoxic activity, or anti-tumor activity, and meanwhile have reduced effect on non-tumor tissues such as normal tissues and produce less side effects, and methods of using the same. Anti-CD137 antigen-binding molecules which have immunocyte-activating effect, cytotoxic activity, or anti-tumor activity, and meanwhile have reduced effect on non-tumor tissues such as normal tissues and produce less side effects, are provided by discovering and producing CD137 antigen-binding molecules whose binding activity to CD137 depends on various substances (for example, small molecule compounds) in target tissues. Methods of using the same, pharmaceutical formulations, and such are also provided. The present disclosure also provides an antigen-binding molecule whose binding activity to an antigen varies depending on a small molecule compound, a preparation method thereof, and uses thereof.

Abstract: The coating film formed on an automobile body has softness during a film formation even on a thermally expandable/shrinkable base, and the cured film has an excellent appearance. Provided is a method for forming a multilayer coating film, the method comprises: applying an aqueous intermediate coating composition and preheating the applied composition at 60 to 90° C. to form an uncured film; preheating to form an uncured base coating film and a clear coating film; and baking and curing these uncured films to form a multilayer coating film, wherein the aqueous intermediate coating composition comprises (a) an acrylic resin emulsion having a specific properties, and (b) a film formation auxiliary agent that is a fatty acid diester compound having a boiling point of 280° C. to 350° C., and a cured film comprising (a) and (b) at a mass ratio of 3:1 has a rupture elongation of 1% or more.

Abstract: A method for forming a multilayer coated film on an electrodeposition-coated alloyed hot-dip galvanized steel plate include step (1) of applying an aqueous intermediate coating composition (X), step (2) of applying an aqueous base coating composition (Y), step (3) of applying a clear coating composition (Z) containing an epoxide, and step (4) of heat-curing each coated film. The coating composition (X) contains a hydroxyl group-containing acrylic resin (A), a polyurethane resin (B), a hydroxyl group-containing polyester resin (C), a melamine resin (D), and an active methylene-blocked polyisocyanate compound (E). The ratio of (A) to (B) is controlled to a specific range, and an elongation at break, Young's modulus and Tukon hardness of the coated film of the coating composition (X) are controlled to specific ranges.

Abstract: The coating film formed on an automobile body has softness during a film formation even on a thermally expandable/shrinkable base, and the cured film has an excellent appearance. Provided is a method for forming a multilayer coating film, the method comprises: applying an aqueous intermediate coating composition and preheating the applied composition at 60 to 90° C. to form an uncured film; preheating to form an uncured base coating film and a clear coating film; and baking and curing these uncured films to form a multilayer coating film, wherein the aqueous intermediate coating composition comprises (a) an acrylic resin emulsion having a specific properties, and (b) a film formation auxiliary agent that is a fatty acid diester compound having a boiling point of 280° C. to 350° C., and a cured film comprising (a) and (b) at a mass ratio of 3:1 has a rupture elongation of 1% or more.

Abstract: A method for forming a multilayer coated film on an electrodeposition-coated alloyed hot-dip galvanized steel plate include step (1) of applying an aqueous intermediate coating composition (X), step (2) of applying an aqueous base coating composition (Y), step (3) of applying a clear coating composition (Z) containing an epoxide, and step (4) of heat-curing each coated film. The coating composition (X) contains a hydroxyl group-containing acrylic resin (A), a polyurethane resin (B), a hydroxyl group-containing polyester resin (C), a melamine resin (D), and an active methylene-blocked polyisocyanate compound (E). The ratio of (A) to (B) is controlled to a specific range, and an elongation at break, Young's modulus and Tukon hardness of the coated film of the coating composition (X) are controlled to specific ranges.

Abstract: This invention relates to a medicament for treating and/or preventing a cancer, comprising a combination of an antibody against a cancer antigen CAPRIN-1 protein that is specifically expressed on the surface of the cancer cell, and an antitumor agent, wherein the antibody and the antitumor agent are combined together or separately, and to a use of the medicament.

Abstract: According to the present invention, a cancer antigen protein to be specifically expressed on the surfaces of cancer cells is identified and thus the use of an antibody targeting the cancer antigen protein as an agent for treating and/or preventing a cancer is provided. Specifically, the present invention provides a pharmaceutical composition for treating and/or preventing a cancer, which comprises an antibody or a fragment thereof as an active ingredient having immunological reactivity to a partial polypeptide of CAPRIN-1, which is represented by any of even-numbered sequences of SEQ ID NOS: 2 to 30, wherein the polypeptide has the amino acid sequence represented by SEQ ID NO: 37 or an amino acid sequence having 80% or more sequence identity with the amino acid sequence.

Abstract: According to the present invention, a cancer antigen protein to be specifically expressed on the surfaces of cancer cells is identified and thus the use of an antibody targeting the cancer antigen protein as an agent for treating and/or preventing a cancer is provided. Specifically, the present invention provides a pharmaceutical composition for treating and/or preventing a cancer, which comprises an antibody or a fragment thereof as an active ingredient having immunological reactivity to a partial polypeptide of CAPRIN-1, which is represented by any of even-numbered sequences of SEQ ID NOS: 2 to 30, wherein the polypeptide has the amino acid sequence represented by SEQ ID NO: 37 or an amino acid sequence having 80% or more sequence identity with the amino acid sequence.

Abstract: This invention relates to a medicament for treating and/or preventing a cancer, comprising a combination of an antibody against a cancer antigen CAPRIN-1 protein that is specifically expressed on the surface of the cancer cell, and an antitumor agent, wherein the antibody and the antitumor agent are combined together or separately, and to a use of the medicament.

Abstract: An automotive clear coating composition includes a hydroxyl group-containing acrylic resin obtained using hydroxyalkyl(meth)acrylate having a hydroxyalkyl group having 4-9 carbon atoms as at least a part of its monomer; and a polyfunctional isocyanate compound in which at least a part thereof is an isocyanurate type isocyanate compound. The prepared composition has 25 to 50 mass % of a soft segment part with respect to a total solid content of such acrylic resin and the polyfunctional isocyanate compound, and a ratio of a soft segment part derived from a lactone-containing monomer with respect to the total solid content of such acrylic resin and the polyfunctional isocyanate compound of not more than 4.5 mass %. A cured coating film has a dynamic glass transition temperature within a range of 30 to 60° C. The soft segment part is represented by —CH2)n— wherein n represents an integer of 4 or more.

Abstract: A clear coating composition for an automobile, including a hydroxyl group-containing acrylic resin and a polyfunctional isocyanate compound, in which: the hydroxyl group-containing acrylic resin is a hydroxyl group-containing acrylic resin obtained by using hydroxyalkyl(meth)acrylate having a hydroxyalkyl group with 4 to 9 carbon atoms as at least a part of its monomer; at least a part of the polyfunctional isocyanate compound is an isocyanurate type isocyanate compound; and the clear coating composition is prepared such that the clear coating composition includes 25 to 50 mass % of a soft segment part with respect to a total solid content of the hydroxyl group-containing acrylic resin and the polyfunctional isocyanate compound, a ratio of a soft segment part derived from a lactone-containing monomer with respect to the total solid content of the hydroxyl group-containing acrylic resin and the polyfunctional isocyanate compound is not more than 4.

Abstract: The present invention is directed to a variable distortion aberration image pickup device that is capable of varying distortion aberration with its center at any desired point either inside or outside an image where, specifically, distortion aberration is effectively developed and/or eliminated with the distortion center at any desired point both inside and outside the image as desired, and such an image pickup device is also capable of varying distortion aberration with its center at a desired point either inside or outside the image, separately in individual directions, where specifically an image is processed so as to have distortion aberration with its center at any desired point both inside and outside the image, with varied distortion ratios from one direction to another.

Abstract: A surface mounting quartz crystal oscillator has an IC chip containing an oscillator circuit, and a quartz crystal unit which are sealed in a container body by a metal cover, wherein stray capacitances C1, C2 are equivalently in parallel with oscillation capacitors Ca, Cb connected to one and the other ends of the crystal unit, respectively. A gap between the IC chip and a crystal blank of the crystal unit, and a gap between the crystal blank and metal cover are set in accordance with a changing amount of the oscillation frequency due to a change in the stray capacitances C1, C2 in a direction in which a change in equivalent series capacitance is reduced, as viewed from the crystal unit, while maintaining a spacing between the IC chip and metal cover.

Abstract: A surface mounting quartz crystal oscillator has an IC chip containing an oscillator circuit, and a quartz crystal unit which are sealed in a container body by a metal cover, wherein stray capacitances C1, C2 are equivalently in parallel with oscillation capacitors Ca, Cb connected to one and the other ends of the crystal unit, respectively. A gap between the IC chip and a crystal blank of the crystal unit, and a gap between the crystal blank and metal cover are set in accordance with a changing amount of the oscillation frequency due to a change in the stray capacitances C1, C2 in a direction in which a change in equivalent series capacitance is reduced, as viewed from the crystal unit, while maintaining a spacing between the IC chip and metal cover.

Abstract: A data compression apparatus includes a dictionary buffer for holding data of the immediately preceding line of successively inputted two-dimensional image data, a buffer for extracting a plurality of continuous data strings from the inputted data of the current line to store them as a partial data string to be compressed, a scanning comparison section for detecting whether or not the same data string as the partial data string to be compressed exists in the data stored in the dictionary buffer, and a code generator by which in the case where the presence of the same data string is detected by the scanning comparison section, data of the position and the length of a partial data string on the data of the immediately preceding line stored in the dictionary buffer is outputted as data of that partial data string of the current line.

Abstract: A sorting apparatus in which, while its scale is limited so as not to become large, all of base axis data supplied as its input are sorted in order, and, at the same time, the sorted base axis data are outputted in the sorted order. The sorting apparatus includes a plurality of sorter sections, a base axis data train divider section for supplying partial base axis data trains to these sorter sections, and a comparative result output section for merge/sorting (comparatively selecting) the results of sorting of the individual partial base axis data trains in the plural sorter sections and sequentially outputting the sorted ones of the base axis data in the sorted order. Thus, in the sorting apparatus, base axis data are divided into a plurality of partial base axis data trains, and, after the partial base axis data trains are partially concurrently sorted in the plural sorter sections, the base axis data are sequentially outputted from the comparative result output section in the sorted order.

Abstract: A sorting apparatus in which, while its scale is limited so as not to become large, all of base axis data supplied as its input are sorted in order, and, at the same time, the sorted base axis data are outputted in the sorted order. The sorting apparatus includes a plurality of sorter sections, a base axis data train divider section for supplying partial base axis data trains to these sorter sections, and a comparative result output section for merge/sorting (comparatively selecting) the results of sorting of the individual partial base axis data trains in the plural sorter sections and sequentially outputting the sorted ones of the base axis data in the sorted order. Thus, in the sorting apparatus, base axis data are divided into a plurality of partial base axis data trains, and, after the partial base axis data trains are partially concurrently sorted in the plural sorter sections, the base axis data are sequentially outputted from the comparative result output section in the sorted order.