Abstract: The present invention provides a suppression type antisense oligonucleotide targeting TDP-43 mRNA, containing a nucleotide sequence complementary to a sequence consisting of at least 10 continuous nucleotides in a nucleotide sequence shown in any of SEQ ID NOs: 2-4, and a promotion type antisense oligonucleotide targeting TDP-43 mRNA, containing a nucleotide sequence complementary to a sequence consisting of at least 10 continuous nucleotides in a nucleotide sequence shown in SEQ ID NO: 5.

Abstract: The present invention provides a suppression type antisense oligonucleotide targeting TDP-43 mRNA, containing a nucleotide sequence complementary to a sequence consisting of at least 10 continuous nucleotides in a nucleotide sequence shown in any of SEQ ID NOs: 2-4, and a promotion type antisense oligonucleotide targeting TDP-43 mRNA, containing a nucleotide sequence complementary to a sequence consisting of at least 10 continuous nucleotides in a nucleotide sequence shown in SEQ ID NO: 5.

Abstract: The present invention provides a pharmaceutical composition effective for treatment of the PolyQ diseases, which can be safely administered to humans. The present invention provides a pharmaceutical composition comprising: one selected from the group consisting of arginine, a physiologically acceptable salt thereof, and a solvate thereof, as an active ingredient, in which the pharmaceutical composition is used in treatment or prevention of the PolyQ diseases, and the the PolyQ disease is one selected from the group consisting of Huntington disease, inherited spinocerebellar ataxias, dentatorubral palliodoluysian atrophy, and spinal bulbar muscular atrophy.

Abstract: A cam sensor is provided in a position opposing one surface side of a cam driven sprocket in a valve timing control device. When the valve timing control device is in a high revolution state, a weight is pivoted by centrifugal force caused by the rotation. This allows a projection at the weight to be detected by the cam sensor. In this case, for each rotation of the valve timing control device, the projection of the weight passes the detectable position of the cam sensor and a pulse is generated in a cam signal to be transmitted from the cam sensor to an ECU.

Abstract: When an engine operates at low engine speed, the tip end of a cam nose of an intake cam is at a second position. As the engine speed increases and exceeds a first engine speed, the tip end of the cam nose of the intake cam moves to a first position. When the engine operates at high engine speed, the tip end of the cam nose of the intake cam is at the first position. As the engine speed decreases and becomes lower than a second engine speed smaller than the first engine speed, the tip end of the cam nose of the intake cam moves to the second position different from the first position.

Abstract: When an engine operates at low engine speed, the tip end of a cam nose of an intake cam is at a second position. As the engine speed increases and exceeds a first engine speed, the tip end of the cam nose of the intake cam moves to a first position. When the engine operates at high engine speed, the tip end of the cam nose of the intake cam is at the first position. As the engine speed decreases and becomes lower than a second engine speed smaller than the first engine speed, the tip end of the cam nose of the intake cam moves to the second position different from the first position.

Abstract: A cam sensor is provided in a position opposing one surface side of a cam driven sprocket in a valve timing control device. When the valve timing control device is in a high revolution state, a weight is pivoted by centrifugal force caused by the rotation. This allows a projection at the weight to be detected by the cam sensor. In this case, for each rotation of the valve timing control device, the projection of the weight passes the detectable position of the cam sensor and a pulse is generated in a cam signal to be transmitted from the cam sensor to an ECU.

Abstract: During a low revolution period, centrifugal force applied to a weight is small and therefore the rotating operation of the weight is restricted. This prevents a lock pin from being fitted to the lock pin fitting hole of a floating cam portion, and the floating cam portion idles around a cam fixing shaft. During a high revolution period, centrifugal force applied to the weight increases, and therefore the weight rotates around the rotation shaft. In this way, the tip end of the lock pin is fitted to the lock pin fitting portion of the floating cam portion. Therefore, during the high revolution period, the floating cam portion is fixed with respect to the rotating direction of the variable valve system by the lock pin.

Abstract: Compounds that selectively bind to expanded polyglutamine repeats are disclosed. Such compounds are characterized in that they bind to a first polyglutamine peptide consisting of 60 glutamine residues under conditions in which they do not bind to a second polyglutamine peptide consisting of 20 glutamine residues. Conjugates of such compounds, nucleic acids encoding the same, and methods of use thereof are also disclosed.

Abstract: Compounds that selectively bind to expanded polyglutamine repeats are disclosed. Such compounds are characterized in that they bind to a first polyglutamine peptide consisting of 60 glutamine residues under conditions in which they do not bind to a second polyglutamine peptide consisting of 20 glutamine residues. Conjugates of such compounds, nucleic acids encoding the same, and methods of use thereof are also disclosed.

Abstract: Compounds that selectively bind to expanded polyglutamine repeats are disclosed. Such compounds are characterized in that they bind to a first polyglutamine peptide consisting of 60 glutamine residues under conditions in which they do not bind to a second polyglutamine peptide consisting of 20 glutamine residues. Conjugates of such compounds, nucleic acids encoding the same, and methods of use thereof are also disclosed.

Abstract: A golf club head comprising a face portion and a main body portion, wherein at least the face portion or a face of the face portion comprises an amorphous alloy having a glass transition range. The amorphous alloy preferably has a composition represented by the general formula X.sub.a M.sub.b Al.sub.c (where X is at least one element selected from the group consisting of Zr and Hf, M is at least one element selected from the group consisting of Mn, Fe, Co, Ni, Ti and Cu, and a, b and c are, in atomic percentages, 25.ltoreq.a.ltoreq.85, 5.ltoreq.b.ltoreq.70 and 0<c.ltoreq.35), and comprises at least 50% by volume thereof being an amorphous phase. The golf club head has a high strength and yet has a low elastic modulus.

Abstract: A golf club head made of a hollow metal comprising a face and a body, wherein at least the face is made of a rapidly solidified Al-based alloy having a high strength, high elasticity and light weight. This golf club head makes it possible to stroke a ball without elastic deformation of its face and also to fly the ball farther with the initial speed thereof maintained, by using the Al-based alloy at least in the face. In addition, the use of the Al-based alloy makes it possible to form a large head and a long shaft so that balls can be stroked to fly over a long carry in an accurate direction.

Abstract: A method of manufacturing a press-formed product having a base portion and a projecting portion which is integral with the base portion and projects in a direction different from the base portion, wherein a first forming part for forming the base portion and a second forming part which is integral with the first forming part and projects in a direction different from the first forming part are provided in a divided forming mold, and the first forming part communicates with an accommodating hole having an alloy material input port which is smaller in area than the first forming part, the method comprising the steps of moving a material placed in the accommodating hole, in the state of plastic flow by means of pressure means, and moving the material in the state of plastic flow while sequentially changing the direction of movement of the material, from the accommodating hole to the first forming part and then from the first forming part to the second forming part, thereby press-feeding and forming the alloy mat

Abstract: A pharmaceutical composition containing serum thymic factor (FTS) and a method for using FTS containing compositions for treating a variety of immunodeficiencies and autoimmune diseases including multiple sclerosis, Guillain-Barre syndrome, inflammatory neuropathy, polyneuritis and other immunodemyelinating diseases.

Abstract: A cooling mold having first and second water cooling jackets which are provided inside the mold, a primary cooling water jetting mouth which is located at a distance of 15 to 40 mm from a meniscus of the molten metal, and a secondary cooling water jetting mouth which is located at a position with an interval of 20 to 45 mm between a contact point of a primary jet of cooling water and another contact point of a secondary jet of cooling water on an ingot.

Abstract: A cooling mold has first and second water cooling jackets provided inside the mold. A primary cooling water jetting mouth is located at a distance between 15 and 40 mm from the meniscus of the molten metal. A secondary cooling water jetting mouth is located at an interval of 20 to 45 mm between a contact point of a primary jet of cooling water and another contact point of a secondary jet of cooling water on an ingot. The primary and secondary cooling water jetting mouths are respectively set at an angle of 15 to 30 degrees and of 30 to 60 degrees relative to the ingot surface. The primary jet of cooling water from the primary mouth impinges on the molten metal cooled in the cooling mold at a distance from the meniscus to establish a transition boiling zone and a film boiling zone. The secondary jet of cooling water impinges on initial zones of the transition boiling zone and the film boiling zone to break-out a vapor film.

Abstract: Billets are produced from powdery alloys by a process which comprises densely packing in a can a powdery metal or alloy easy of plastic working and a powdery alloy difficult of plastic working in that order, sealing hermetically the can and thereafter degassing the same; or a process which comprises densely packing a powdery alloy difficult of plastic working in a can and, then, densely packing a powdery metal or powdery alloy easy of plastic working in the can to make the powdery metal or alloy into a lid of the can, wherein the powdery alloy easy of plastic working is coarse powder, while the powdery alloy difficult of plastic working is fine powder, and the powdery alloy is a rapidly solidified powdery alloy comprising an Al-base, Mg-base, Ni-base, Ti-base or Fe-base alloy.

Abstract: A botulinum toxin neutralizer comprising at least one fatty acid having the number of carbon atoms of at least 12. Such a fatty acid may be any of saturated fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, nonadecanoic acid, arachidic acid, and behenic acid or any of unsaturated fatty acids such as oleic acid. The toxin neutralizer acts as if it were an antagonistic receptor for botulinum toxin and, when encountering botulinum toxin in human body, directly combines with the toxin and disables the toxin from combining with the neuromuscular tissues of human body to prevent the outbreak of botulism. The toxin thus neutralized and affixed to the botulinum toxin neutralizer is excreted from the human body. The botulinum toxin neutralizer can be manufactured easily and economically from a naturally occurring glyceride and is thus far less costly then the known antitoxin of ganglioside GT1b produced from bovine brain.

Abstract: A cast starting method in horizontal continuous casting, including the steps of locating an orifice plate having an orifice between a molten metal outlet of a tundish and a mold, the orifice plate being formed on its front side with a recess expanded in a range surrounding an outlet of the orifice, locating a starting block in the mold to let a rear end surface of the starting block contact a front surface of the orifice plate to define a closed space by the recess, locating a starting pin in the closed space at a position not aligned to the outlet of the orifice, letting a molten metal flow from the tundish through the orifice into the closed space, and drawing the starting block with the molten metal after solidified out of the mold.