Patents by Inventor Yoshitaka Ushio

Yoshitaka Ushio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for removing multimers of human serum albumin
    Patent number: 7001885
    Abstract: Multimers of human serum albumin are removed from a solution of human serum albumin containing the multimers by bringing the human serum albumin solution into contact with an anion-exchanger equilibrated with a buffer containing a salt in a concentration ranging from 10 to 150 mM and having a pH value ranging from 5 to 9.5.
    Type: Grant
    Filed: June 20, 2002
    Date of Patent: February 21, 2006
    Assignee: Juridical Foundation the Chemo-Sero-Therapeutic Research Institute
    Inventors: Satoshi Adachi, Hiroshi Mizokami, Yoshitaka Tajima, Yoshinobu Miyatsu, Toshinobu Nouchi, Yoshitaka Ushio
  • Humanized immunoglobulin reacting specifically with Fas ligand or active fragments thereof and region inducing apoptosis originating in Fas ligand
    Patent number: 6777540
    Abstract: Novel humanized immunoglobulins and active fragments thereof which are specifically reactive to Fas ligand are provided, and a site on Fas ligand which is important to inhibit apoptosis induced by the Fas-Fas ligand interaction against Fas-expressing cells is demonstrated. The novel humanized immunoglobulins and active fragments thereof which are specifically reactive to Fas ligand are prepared from hybridomas which produce monoclonal antibodies specifically reactive to Fas ligand, via recombinant DNA techniques. The humanized immunoglobulins can inhibit the physiological reactions between Fas ligand and Fas such as apoptosis. Further, identification of the site which is on Fas ligand and responsible for apoptosis induction allows creation of recombinant proteins or peptides which are specifically reactive to the amino acids within the site so as to inhibit apoptosis, and to find new therapeutic or diagnostic agents.
    Type: Grant
    Filed: April 15, 1999
    Date of Patent: August 17, 2004
    Inventors: Ko Okumura, Motomi Nakata, Hirofumi Higuchi, Yoshitaka Ushio, Hiroaki Maeda, Yasuyuki Eda
  • Method for converting multimers of human serum albumin into monomers thereof
    Publication number: 20030027991
    Abstract: A method for converting a multimer of human serum albumin into monomers thereof comprises the step of treating the multimer with an alkaline solution. This method permits the efficient and quite simple conversion of human serum albumin multimers into monomers thereof at a low cost.
    Type: Application
    Filed: June 21, 2002
    Publication date: February 6, 2003
    Applicant: Juridical Fdn. The Chemo-Sero-Therap. Res. Ctr.
    Inventors: Toshinobu Nouchi, Hiroshi Mizokami, Yoshitaka Tajima, Hiroyuki Yokote, Satoshi Adachi, Yoshinobu Miyatsu, Tetsuro Tanabe, Yoshitaka Ushio, Shinichi Shibata
  • Method for removing multimers of human serum albumin
    Publication number: 20020183492
    Abstract: Multimers of human serum albumin are removed from a solution of human serum albumin containing the multimers by bringing the human serum albumin solution into contact with an anion-exchanger equilibrated with a buffer containing a salt in a concentration ranging from 10 to 150 mM and having a pH value ranging from 5 to 9.5.
    Type: Application
    Filed: June 20, 2002
    Publication date: December 5, 2002
    Applicant: Juridical Foundation The Chemo-Sero-Therapeutic Research Institute
    Inventors: Satoshi Adachi, Hiroshi Mizokami, Yoshitaka Tajima, Yoshinobu Miyatsu, Toshinobu Nouchi, Yoshitaka Ushio