Patents by Inventor Yoshitsugu Kosugi

Yoshitsugu Kosugi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7401604
    Abstract: An engine control device and method that prevents fuel injection quantity from becoming unstable due to a rapid change of a correction quantity even in a predetermined operation state such as acceleration time and thus stabilizes an air-fuel ratio. Under a predetermined operating state, even when feedback control of oxygen in exhaust gas is stopped, a correction quantity immediately before the predetermined operating state is held by a correction quantity storage part and the correction of the fuel injection time is performed based on the correction quantity.
    Type: Grant
    Filed: February 20, 2007
    Date of Patent: July 22, 2008
    Assignee: Yamaha Hatsudoki Kabushiki Kaisha
    Inventors: Harumi Furukawa, Yoshitsugu Kosugi
  • Publication number: 20070199552
    Abstract: An engine control device and method that prevents fuel injection quantity from becoming unstable due to a rapid change of a correction quantity even in a predetermined operation state such as acceleration time and thus stabilizes an air-fuel ratio. Under a predetermined operating state, even when feedback control of oxygen in exhaust gas is stopped, a correction quantity immediately before the predetermined operating state is held by a correction quantity storage part and the correction of the fuel injection time is performed based on the correction quantity.
    Type: Application
    Filed: February 20, 2007
    Publication date: August 30, 2007
    Applicant: YAMAHA HATSUDOKI KABUSHIKI KAISHA
    Inventors: Harumi FURUKAWA, Yoshitsugu KOSUGI
  • Publication number: 20070129589
    Abstract: A novel olefin production process for forming at least one olefin from two or more olefins in the presence of a catalyst containing at least one selected from the group consisting of nickel, aluminum, manganese, iron and copper which is supported by a regular mesoporous material. In the above olefin production process, propylene can be formed from ethylene and butene. In the above olefin production process, water vapor can be contained in a reaction gas in a molar ratio based on the total of the raw material olefins of 0.001 to 1.
    Type: Application
    Filed: September 3, 2003
    Publication date: June 7, 2007
    Inventors: Masakazu Iwamoto, Yoshitsugu Kosugi
  • Patent number: 6960454
    Abstract: The invention relates to a thermophilic enzyme having ?-glycosidase activity which comprises the amino acid sequence of SEQ ID NO: 2 in which one or a plurality of amino acid residues may be deleted, replaced or added.
    Type: Grant
    Filed: August 6, 1999
    Date of Patent: November 1, 2005
    Assignee: Director-General of Agency of Industrial Science and Technology
    Inventors: Ikuo Matsui, Kazuhiko Ishikawa, Hiroyasu Ishida, Yoshitsugu Kosugi
  • Publication number: 20040161826
    Abstract: The invention is directed to novel thermostable aminotransferases useful in synthesizing an amino acid derivative with high optical purity, and nucleic acids encoding the enzyme. The invention also includes antibodies that specifically bind to the aminotransferases of the invention.
    Type: Application
    Filed: March 26, 2004
    Publication date: August 19, 2004
    Applicant: National Institute of Advanced Industrial Science and Technology, a Tokyo, Japan corporation
    Inventors: Ikuo Matsui, Kazuhiko Ishikawa, Hiroyasu Ishida, Yoshitsugu Kosugi, Eriko Matsui
  • Publication number: 20030129723
    Abstract: The present invention provides a polypeptide that has a thermophilic endoglucanase activity, a DNA that comprises a nucleotide sequence encoding the polypeptide, a recombinant DNA and an expression vector that comprise the DNA, a transformant that is transformed by the expression vector, and a method of producing the polypeptide using the transformant. The endoglucanase of the present invention shows a maximum activity at a high temperature range around 97° C., so that it is industrially useful.
    Type: Application
    Filed: November 14, 2002
    Publication date: July 10, 2003
    Applicant: RAKUTO KASEI INDUSTRIAL CO., LTD.
    Inventors: Kazuhiko Ishikawa, Hiroyasu Ishida, Yoshitsugu Kosugi, Susumu Ando, Akio Shimomura
  • Publication number: 20020102635
    Abstract: The invention relates to a thermophilic enzyme having &bgr;-glycosidase activity which comprises the amino acid sequence of SEQ ID NO: 2 in which one or a plurality of amino acid residues may be deleted, replaced or added.
    Type: Application
    Filed: August 6, 1999
    Publication date: August 1, 2002
    Inventors: IKUO MATSUI, KAZUHIKO ISHIKAWA, HIROYASU ISHIDA, YOSHITSUGU KOSUGI
  • Publication number: 20020081697
    Abstract: The invention is directed to novel thermostable aminotransferases useful in synthesizing an amino acid derivative with high optical purity, and nucleic acids encoding the enzyme. The invention also includes antibodies that specifically bind to the aminotransferases of the invention.
    Type: Application
    Filed: September 28, 2001
    Publication date: June 27, 2002
    Inventors: Ikuo Matsui, Kazuhiko Ishikawa, Hiroyasu Ishida, Yoshitsugu Kosugi, Eriko Matsui
  • Patent number: 6391604
    Abstract: A thermostable phosphatidylethanolamine N-methyltransferase and a process for producing the enzyme are provided. A host cell is transformed with an expression vector containing DNA encoding a thermostable enzyme derived from hyper-thermophilic archaea such as Pyrococcus, the enzyme having phosphatidylethanolamine N-methyltransferase activity and an optimum temperature of 90° C. or higher, and the transformed host cell is cultured.
    Type: Grant
    Filed: March 3, 2000
    Date of Patent: May 21, 2002
    Assignee: Agency of Industrial Science and Technology
    Inventors: Ikuo Matsui, Kazuhiko Ishikawa, Hiroyasu Ishida, Yoshitsugu Kosugi, Yasutaka Tahara
  • Patent number: 6255081
    Abstract: The present invention relates to a thermostable Flap endonuclease whose optimum temperature is 75° C. or more and DNA coding for (a) a protein consisting of the amino acid sequence shown in SEQ ID NO:2 or (b) a protein with Flap endonuclease activity, consisting of an amino acid sequence where in the amino acid sequence (a), one or more amino acids are deleted, substituted or added. According to the present invention, there is provided a thermostable Flap endonuclease whose optimum temperature for reaction is 75° C. or more. Further, this enzyme is thermally stable, so it becomes possible to develop new techniques of conducting artificial homologous recombination or genetic shuffling highly efficiently by coupling the enzyme reaction with PCR.
    Type: Grant
    Filed: October 21, 1998
    Date of Patent: July 3, 2001
    Assignee: Director - General of Agency of Industrial Science and Technology
    Inventors: Ikuo Matsui, Kazuhiko Ishikawa, Yoshitsugu Kosugi, Eriko Matsui, Satoko Kawasaki
  • Patent number: 6251649
    Abstract: The present invention relates to a thermostable Flap endonuclease whose optimum temperature is 75° C. or more and DNA coding for (a) a protein consisting of the amino acid sequence shown in SEQ ID NO:2 or (b) a protein with Flap endonuclease activity, consisting of an amino acid sequence where in the amino acid sequence (a), one or more amino acids are deleted, substituted or added. According to the present invention, there is provided a thermostable Flap endonuclease whose optimum temperature for reaction is 75° C. or more. Further, this enzyme is thermally stable, so it becomes possible to develop new techniques of conducting artificial homologous recombination or genetic shuffling highly efficiently by coupling the enzyme reaction with PCR.
    Type: Grant
    Filed: September 3, 1998
    Date of Patent: June 26, 2001
    Assignee: Director - General of Agency of Industrial Science and Technology
    Inventors: Ikuo Matsui, Kazuhiko Ishikawa, Yoshitsugu Kosugi, Eriko Matsui, Satoko Kawasaki
  • Patent number: 6133012
    Abstract: An acyl peptide hydrolase having an optimum temperature range of 90-95.degree. C. and a gene encoding the same are disclosed. With the above enzyme, it becomes possible to conduct amino terminal analysis of acylated proteins and peptides at high temperatures.
    Type: Grant
    Filed: January 30, 1998
    Date of Patent: October 17, 2000
    Assignee: Director General of Agency of Industrial Science & Technology
    Inventors: Kazuhiko Ishikawa, Ikuo Matsui, Hiroyasu Ishida, Yoshitsugu Kosugi, Katsuhiko Higuchi
  • Patent number: 6001626
    Abstract: Disclosed are a thermophilic phospholipase having an optimum temperature range of 95 to 105.degree. C. which is useful in high-temperature degumming processes in oil refining process and high-temperature processing of phospholipids; and a method for producing a thermophilic phospholipase comprising culturing a microorganism capable of producing the phospholipase in a culture medium and collecting the phospholipase from the resultant culture.
    Type: Grant
    Filed: December 1, 1997
    Date of Patent: December 14, 1999
    Assignee: Director-General of Agency of Industrial Science and Technology
    Inventors: Yoshitsugu Kosugi, Katsuhiko Higuchi, Kazuhiko Ishikawa, Ikuo Matsui, Joh Yong-Goe
  • Patent number: 5292649
    Abstract: The reaction of a lipase upon a fatty acid is effected by an improved method which comprises bringing the lipase bonded at multiple points to an anion-exchange residue or a carrier and a carrier having a free anion-exchange group admixed therewith into contact with a reaction mixture containing an oily substance including the fatty acid and a water-soluble substance thereby forming an oily product and a water-soluble product in the reaction mixture and subsequently separating the two reaction products.
    Type: Grant
    Filed: July 9, 1992
    Date of Patent: March 8, 1994
    Assignee: Agency of Industrial Science & Technology, Ministy of International Trade & Industry
    Inventors: Yoshitsugu Kosugi, Hideo Suzuki, Akio Sato
  • Patent number: 5010004
    Abstract: A water-soluble substrate and an oily substrate are continuously reacted with immobilized lipase in a reaction vessel having vertically maintained apart upper and lower conically-shaped regions, respectively, for separation of a water-soluble product and an oily product, a plurality of lipase reaction zones each containing immobilized lipase capable of being fluidized and an agitating means, and a plurality of intermediate separation zones for separation of an oily substance and a water-soluble substance. The lipase reaction zones and the intermediate separation zones are disposed alternately between the upper and lower conically-shaped separation regions. Boundaries between the lipase reaction zones and intermediate separation zones are pervious to liquid but impervious to the immobilized lipase.
    Type: Grant
    Filed: October 11, 1988
    Date of Patent: April 23, 1991
    Assignees: Agency of Industrial Science & Technology, Ministry of International Trade & Industry
    Inventors: Yoshitsugu Kosugi, Hideoki Tanaka, Hideo Suzuki, Masaru Shiraki
  • Patent number: 4013512
    Abstract: A lipid hydrolyzing enzyme-containing substance is brought into contact with an insoluble carrier having a hydrophobic organic compound attached thereto in the form of a hydrophobic residue so that the lipid hydrolyzing enzyme is adsorbed by the hydrophobic residue attached to the insoluble carrier. Then, the lipid hydrolyzing enzyme adsorbed on the carrier is isolated by elution.
    Type: Grant
    Filed: September 18, 1974
    Date of Patent: March 22, 1977
    Assignee: Agency of Industrial Science & Technology
    Inventors: Yoshitsugu Kosugi, Hideo Suzuki, Akira Kamibayashi