Patents by Inventor Yoshitsugu Sakai

Yoshitsugu Sakai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230349819
    Abstract: A fluorescent spectrum correcting method includes comparing fluorescent spectrum obtained from micro-particles labeled with a plurality of fluorescent pigments with reference spectrum to separating the fluorescent spectrum into fluorescent spectrum for each pigment, and previously measured spectrum data is used as the reference spectrum.
    Type: Application
    Filed: July 10, 2023
    Publication date: November 2, 2023
    Inventors: MASAYA KAKUTA, KOJI FUTAMURA, YOSHITSUGU SAKAI, YASUNOBU KATO
  • Patent number: 11727612
    Abstract: Disclosed herein is a microparticle analyzing apparatus including a detecting portion configured to simultaneously detect a fluorescence generated from a microparticle in plural wavelength regions and a displaying portion configured to display thereon detection results in the plural wavelength regions in a form of a spectrum.
    Type: Grant
    Filed: June 23, 2021
    Date of Patent: August 15, 2023
    Assignee: Sony Corporation
    Inventor: Yoshitsugu Sakai
  • Patent number: 11726031
    Abstract: A fluorescent spectrum correcting method includes comparing fluorescent spectrum obtained from micro-particles labeled with a plurality of fluorescent pigments with reference spectrum to separating the fluorescent spectrum into fluorescent spectrum for each pigment, and previously measured spectrum data is used as the reference spectrum.
    Type: Grant
    Filed: August 29, 2022
    Date of Patent: August 15, 2023
    Assignee: SONY GROUP CORPORATION
    Inventors: Masaya Kakuta, Koji Futamura, Yoshitsugu Sakai, Yasunobu Kato
  • Patent number: 11686662
    Abstract: There is provided technology that enables a microparticle sorting device to be adjusted highly accurately without using adjustment beads. The present technology provides a microparticle sorting device including a light detection unit that optically detects a microparticle flowing through a flow path, a droplet forming unit that forms a droplet containing the microparticle, and a device adjustment unit that adjusts the device, in which, in a process of adjusting the device before actual measurement of the microparticle, the device adjustment unit performs optical axis position calibration for calibrating a relative position of the flow path relative to irradiation light and delay time calibration for calibrating a delay time from light irradiation to the microparticle to formation of the droplet on the basis of information obtained from the microparticle to be measured.
    Type: Grant
    Filed: March 12, 2019
    Date of Patent: June 27, 2023
    Assignee: SONY CORPORATION
    Inventor: Yoshitsugu Sakai
  • Publication number: 20220412881
    Abstract: A fluorescent spectrum correcting method includes comparing fluorescent spectrum obtained from micro-particles labeled with a plurality of fluorescent pigments with reference spectrum to separating the fluorescent spectrum into fluorescent spectrum for each pigment, and previously measured spectrum data is used as the reference spectrum.
    Type: Application
    Filed: August 29, 2022
    Publication date: December 29, 2022
    Inventors: MASAYA KAKUTA, KOJI FUTAMURA, YOSHITSUGU SAKAI, YASUNOBU KATO
  • Patent number: 11454588
    Abstract: A fluorescent spectrum correcting method includes comparing fluorescent spectrum obtained from micro-particles labeled with a plurality of fluorescent pigments with reference spectrum to separating the fluorescent spectrum into fluorescent spectrum for each pigment, and previously measured spectrum data is used as the reference spectrum.
    Type: Grant
    Filed: January 6, 2021
    Date of Patent: September 27, 2022
    Assignee: SONY CORPORATION
    Inventors: Masaya Kakuta, Koji Futamura, Yoshitsugu Sakai, Yasunobu Kato
  • Publication number: 20220260491
    Abstract: A fluorescence intensity calculating apparatus, includes a measuring section configured to receive fluorescences generated from plural fluorescent dyes excited by radiating a light to a microparticle multiply-labeled with the plural fluorescent dyes having fluorescence wavelength bands overlapping one another by photodetectors which correspond to different received light wavelength bands, respectively, and whose number is larger than the number of fluorescent dyes, and obtain measured spectra by collecting detected values from the photodetectors, and a calculating section configured to approximate the measured spectra based on a linear sum of single-dyeing spectra obtained from the microparticle individually labeled with the fluorescent dyes, thereby calculating intensities of the fluorescences generated from the fluorescent dyes, respectively.
    Type: Application
    Filed: April 29, 2022
    Publication date: August 18, 2022
    Inventors: Yasunobu KATO, Yoshitsugu SAKAI
  • Patent number: 11340167
    Abstract: A fluorescence intensity calculating apparatus, includes a measuring section configured to receive fluorescences generated from plural fluorescent dyes excited by radiating a light to a microparticle multiply-labeled with the plural fluorescent dyes having fluorescence wavelength bands overlapping one another by photodetectors which correspond to different received light wavelength bands, respectively, and whose number is larger than the number of fluorescent dyes, and obtain measured spectra by collecting detected values from the photodetectors, and a calculating section configured to approximate the measured spectra based on a linear sum of single-dyeing spectra obtained from the microparticle individually labeled with the fluorescent dyes, thereby calculating intensities of the fluorescences generated from the fluorescent dyes, respectively.
    Type: Grant
    Filed: April 14, 2020
    Date of Patent: May 24, 2022
    Assignee: Sony Corporation
    Inventors: Yasunobu Kato, Yoshitsugu Sakai
  • Patent number: 11262305
    Abstract: A fluorescence intensity calculating apparatus, includes a measuring section configured to receive fluorescences generated from plural fluorescent dyes excited by radiating a light to a microparticle multiply-labeled with the plural fluorescent dyes having fluorescence wavelength bands overlapping one another by photodetectors which correspond to different received light wavelength bands, respectively, and whose number is larger than the number of fluorescent dyes, and obtain measured spectra by collecting detected values from the photodetectors, and a calculating section configured to approximate the measured spectra based on a linear sum of single-dyeing spectra obtained from the microparticle individually labeled with the fluorescent dyes, thereby calculating intensities of the fluorescences generated from the fluorescent dyes, respectively.
    Type: Grant
    Filed: May 28, 2021
    Date of Patent: March 1, 2022
    Assignee: Sony Corporation
    Inventors: Yasunobu Kato, Yoshitsugu Sakai
  • Patent number: 11156544
    Abstract: The present technology provides a technology for stabilizing break-off timings. Therefore, according to the present technology, there is provided a microparticle analysis device or the like including at least: a flow path in which a fluid including a sample flow containing microparticles and a sheath flow flowing to contain the sample flow; a droplet formation unit configured to form a droplet in the fluid by imparting vibration to the fluid using a vibration element; an electric charge application unit configured to apply electric charge to a droplet containing the microparticles; an imaging unit configured to obtain a photo of a phase of a certain time; and a control unit configured to control a timing at which the droplet breaks off on a basis of the photo.
    Type: Grant
    Filed: February 5, 2020
    Date of Patent: October 26, 2021
    Assignee: Sony Corporation
    Inventors: Yuya Suzuki, Fumitaka Otsuka, Masashi Kimoto, Shingo Imanishi, Yoshitsugu Sakai
  • Publication number: 20210319604
    Abstract: Disclosed herein is a microparticle analyzing apparatus including a detecting portion configured to simultaneously detect a fluorescence generated from a microparticle in plural wavelength regions and a displaying portion configured to display thereon detection results in the plural wavelength regions in a form of a spectrum.
    Type: Application
    Filed: June 23, 2021
    Publication date: October 14, 2021
    Inventor: Yoshitsugu SAKAI
  • Patent number: 11135585
    Abstract: The present technology is mainly directed to providing a technology that enables smooth setting of sheath liquid. Provided is a fluid control device including at least a support portion that supports a sheath liquid storage unit and a sealed portion that houses the support portion. The support portion is detachable from the sealed portion, and the sealed portion is controlled by pressurization in order to feed sheath liquid stored in the sheath liquid storage unit to a microparticle measurement device.
    Type: Grant
    Filed: March 7, 2017
    Date of Patent: October 5, 2021
    Assignee: SONY CORPORATION
    Inventors: Yoshitsugu Sakai, Ichiro Fujii, Ryoichi Kubota, Shinichi Hasegawa, Takashi Miyata, Emi Ikeda
  • Publication number: 20210285879
    Abstract: A fluorescence intensity calculating apparatus, includes a measuring section configured to receive fluorescences generated from plural fluorescent dyes excited by radiating a light to a microparticle multiply-labeled with the plural fluorescent dyes having fluorescence wavelength bands overlapping one another by photodetectors which correspond to different received light wavelength bands, respectively, and whose number is larger than the number of fluorescent dyes, and obtain measured spectra by collecting detected values from the photodetectors, and a calculating section configured to approximate the measured spectra based on a linear sum of single-dyeing spectra obtained from the microparticle individually labeled with the fluorescent dyes, thereby calculating intensities of the fluorescences generated from the fluorescent dyes, respectively.
    Type: Application
    Filed: May 28, 2021
    Publication date: September 16, 2021
    Inventors: Yasunobu Kato, Yoshitsugu Sakai
  • Patent number: 11112345
    Abstract: Provided is a microparticle measurement device including a light emission unit that emits light to a microparticle to be analyzed and a light detection unit that detects light generated from the microparticle at a predetermined detection position. The microparticle measurement device further includes an analysis unit that is connected to the light detection unit and analyzes a detection value of the light detected by the light detection unit. The light detection unit is movable from the detection position.
    Type: Grant
    Filed: March 7, 2017
    Date of Patent: September 7, 2021
    Assignee: SONY CORPORATION
    Inventors: Yoshitsugu Sakai, Masaaki Abe, Koichi Tsukihara, Shoji Akiyama, Shinichi Hasegawa
  • Patent number: 11074727
    Abstract: Disclosed herein is a microparticle analyzing apparatus including a detecting portion configured to simultaneously detect a fluorescence generated from a microparticle in plural wavelength regions and a displaying portion configured to display thereon detection results in the plural wavelength regions in a form of a spectrum.
    Type: Grant
    Filed: November 8, 2018
    Date of Patent: July 27, 2021
    Assignee: Sony Corporation
    Inventor: Yoshitsugu Sakai
  • Publication number: 20210123859
    Abstract: A fluorescent spectrum correcting method includes comparing fluorescent spectrum obtained from micro-particles labeled with a plurality of fluorescent pigments with reference spectrum to separating the fluorescent spectrum into fluorescent spectrum for each pigment, and previously measured spectrum data is used as the reference spectrum.
    Type: Application
    Filed: January 6, 2021
    Publication date: April 29, 2021
    Inventors: MASAYA KAKUTA, KOJI FUTAMURA, YOSHITSUGU SAKAI, YASUNOBU KATO
  • Publication number: 20210080372
    Abstract: There is provided technology that enables a microparticle sorting device to be adjusted highly accurately without using adjustment beads. The present technology provides a microparticle sorting device including a light detection unit that optically detects a microparticle flowing through a flow path, a droplet forming unit that forms a droplet containing the microparticle, and a device adjustment unit that adjusts the device, in which, in a process of adjusting the device before actual measurement of the microparticle, the device adjustment unit performs optical axis position calibration for calibrating a relative position of the flow path relative to irradiation light and delay time calibration for calibrating a delay time from light irradiation to the microparticle to formation of the droplet on the basis of information obtained from the microparticle to be measured.
    Type: Application
    Filed: March 12, 2019
    Publication date: March 18, 2021
    Inventor: YOSHITSUGU SAKAI
  • Patent number: 10908075
    Abstract: A fluorescent spectrum correcting method includes comparing fluorescent spectrum obtained from micro-particles labeled with a plurality of fluorescent pigments with reference spectrum to separating the fluorescent spectrum into fluorescent spectrum for each pigment, and previously measured spectrum data is used as the reference spectrum.
    Type: Grant
    Filed: August 10, 2018
    Date of Patent: February 2, 2021
    Assignee: SONY CORPORATION
    Inventors: Masaya Kakuta, Koji Futamura, Yoshitsugu Sakai, Yasunobu Kato
  • Publication number: 20200324286
    Abstract: The present technology is mainly directed to providing a technology that enables smooth setting of sheath liquid. To achieve the object, in the present technology, provided is a fluid control device including at least: a support portion that supports a sheath liquid storage unit; and a sealed portion that houses the support portion, in which the support portion is detachable from the sealed portion, and the sealed portion is controlled by pressurization in order to feed sheath liquid stored in the sheath liquid storage unit to a microparticle measurement device.
    Type: Application
    Filed: March 7, 2017
    Publication date: October 15, 2020
    Inventors: YOSHITSUGU SAKAI, ICHIRO FUJII, RYOICHI KUBOTA, SHINICHI HASEGAWA, TAKASHI MIYATA, EMI IKEDA
  • Publication number: 20200319081
    Abstract: The present technology is mainly directed to providing a technology capable of reducing contamination risk. To achieve the object, in the present technology, provided is a microparticle measurement device including at least: a light emission unit that emits light to a microparticle to be analyzed; a light detection unit that detects light generated from the microparticle at a predetermined detection position; and an analysis unit that is connected to the light detection unit and analyzes a detection value of the light detected by the light detection unit, in which the light detection unit is movable from the detection position.
    Type: Application
    Filed: March 7, 2017
    Publication date: October 8, 2020
    Inventors: YOSHITSUGU SAKAI, MASAAKI ABE, KOICHI TSUKIHARA, SHOJI AKIYAMA, SHINICHI HASEGAWA