Patents by Inventor Young-Tae Chang

Young-Tae Chang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10416153
    Abstract: The present invention relates to a family of fluorescent compounds based on the BODIPY scaffold, and methods for the preparation of said compounds. The present invention further relates to the use of said compounds for the detection of bacterial biofilms, wherein the bacterial biofilm comprises Pseudomonas aeruginosa and the compound specifically binds to a Fap protein of Pseudomonas aeruginosa, or wherein the compound specifically binds to bacterial cells that contain high levels of cyclic-di-guanosine-monophosphate (c-di-GMP).
    Type: Grant
    Filed: April 20, 2016
    Date of Patent: September 17, 2019
    Assignees: NANYANG TECHNOLOGICAL UNIVERSITY, AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH, NATIONAL UNIVERSITY OF SINGAPORE
    Inventors: Young-Tae Chang, Jun-Young Kim, Sahu Srikanta, Michael Christian Givskov, Liang Yang
  • Patent number: 10345637
    Abstract: A display device includes a flat transparent plate, a display panel, at least one film, and a transparent adhesive layer. The display panel is separated below the transparent plate. The at least one film is disposed between the transparent plate and the display panel, and is attached to a lower peripheral region of the transparent plate. The transparent adhesive layer is disposed between the transparent plate and the display panel, and laminates the transparent plate and the display panel. Other various embodiments are possible.
    Type: Grant
    Filed: August 14, 2014
    Date of Patent: July 9, 2019
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Min-Su Chang, Sung-Woon Yoon, Kyo-Ree Lee, Duck-Yong Lee, Young-Tae Jin
  • Patent number: 10215702
    Abstract: There is provided a method of preparing a surface enhanced Raman spectroscopy (SERS) particle comprising the step of encapsulating a plurality of Raman molecules on the surface of a metallic core with a biocompatible protective shell at an elevated temperature selected to decrease the encapsulation time by more than one-fold relative to an encapsulation performed at 20° C.
    Type: Grant
    Filed: July 30, 2012
    Date of Patent: February 26, 2019
    Assignee: Agency for Science, Technology and Research
    Inventors: Shuhua Liu, Kwok Wei Shah, Michelle Low, Zhi Wei Seh, Ming-Yong Han, Kaustabh Kumar Maiti, Kiat Seng Jason Soh, Dinish Unnimadhava Kurup Soudamini Amma, Malini Olivo, Young-Tae Chang
  • Publication number: 20180143185
    Abstract: The present invention relates to a family of fluorescent compounds based on the BODIPY scaffold, and methods for the preparation of said compounds. The present invention further relates to the use of said compounds for the detection of bacterial biofilms, wherein the bacterial biofilm comprises Pseudomonas aeruginosa and the compound specifically binds to a Fap protein of Pseudomonas aeruginosa, or wherein the compound specifically binds to bacterial cells that contain high levels of cyclic-di-guanosine-monophosphate (c-di-GMP).
    Type: Application
    Filed: April 20, 2016
    Publication date: May 24, 2018
    Inventors: Young-Tae Chang, Jun-Young Kim, Sahu Srikanta, Michael Christian Givskov, Liang Yang
  • Publication number: 20180036433
    Abstract: The present invention relates to compounds of Formula (I) as defined herein as well as conjugates comprising said compounds and pharmaceutical compositions comprising said compounds or conjugates. Also encompassed are methods for selectively detecting oligomeric proteins or peptides associated with a conformational disorder in a sample, and methods for diagnosing or treating a conformational disorder associated with protein or peptide oligomers in a subject.
    Type: Application
    Filed: November 3, 2015
    Publication date: February 8, 2018
    Inventors: Young-Tae Chang, Dongdong Su, Chai Lean Teoh, Srikanta Sahu, Thomas Wisniewski
  • Publication number: 20180024136
    Abstract: The present invention relates to the synthesis and characterization of an Abcg2 targeted fluorescence probe (compound of formula I), as well as live imaging of neural stem/progenitor cells (NSPCs) and isolation of live NSPCs using said probe.
    Type: Application
    Filed: February 11, 2016
    Publication date: January 25, 2018
    Inventors: Young-Tae CHANG, Beomsue KIM
  • Publication number: 20170168073
    Abstract: The invention relates to compounds of formula (I) or derivatives, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites or prodrugs thereof, in which the substituents are as defined in the specification. These compounds may be useful as insulin sensors; in insulin secretion studies and as probes for insulin detection.
    Type: Application
    Filed: November 26, 2014
    Publication date: June 15, 2017
    Inventors: Young-Tae CHANG, Duanting ZHAI, Sung-Chan LEE, Nam-Young KANG
  • Patent number: 9570037
    Abstract: Technologies are generally described for controlling remote display. In some examples, a method for controlling a remote display device using a handheld computing device includes receiving, by a handheld computing device, one or more data from one or more remote display devices over a wireless communication network, selecting a remote display device based on the received data and sending a control signal to the selected remote display device.
    Type: Grant
    Filed: September 11, 2014
    Date of Patent: February 14, 2017
    Assignee: Empire Technology Development LLC
    Inventor: Young-Tae Chang
  • Patent number: 9513294
    Abstract: A library of novel amino-triazolyl-BODIPY compounds is described. Particular compounds of the library serve as selective fluorescent probes for human serum albumin (HSA) and for live primary neurons. The fluorescent probe for HSA binds uniquely and specifically to the fatty acid site 1 of HSA, and thus proves a valuable and unique probe for drugs that bind to such a site on HSA. Methods of synthesis for the library compounds are also described.
    Type: Grant
    Filed: December 26, 2013
    Date of Patent: December 6, 2016
    Assignees: National University of Singapore, Agency for Science, Technology and Research
    Inventors: Young-Tae Chang, Jun Cheng Er, Cheryl Kit Mun Leong, Seong Wook Yun, Marc Vendrell Escobar, Mui Kee Tang
  • Patent number: 9423396
    Abstract: The present invention is directed to a fluorescence compound represented by structural Formula (I), with specificity to neural stem cells: (I), or a pharmaceutically acceptable salt thereof. The variables for structural Formula (I) are defined herein. Also described are methods for detection of beta cells, pancreatic islets and microglia cells, comprising using a compound of structural Formula (I) or pharmaceutically acceptable salts thereof. Compounds of structural Formula (I) can also differentiate healthy pancreatic islet cells from diabetic pancreatic islet cells.
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: August 23, 2016
    Assignees: National University of Singapore, Agency for Science, Technology and Research
    Inventors: Young-Tae Chang, Sung Chan Lee, Nam-Young Kang, Seong Wook Yun, Cheryl Kit Mun Leong, Hyung Ho Ha
  • Patent number: 9423395
    Abstract: The present invention is directed to a novel family of fluorophores based on the BODIPY scaffold, and methods for their synthesis. The BODIPY-based fluorophores disclosed herein are used for the selective visualization of cells that exist in the M-phase of the cell cycle. The present invention further relates to methods for the image-based monitoring of mitotic progression in live cells.
    Type: Grant
    Filed: January 14, 2014
    Date of Patent: August 23, 2016
    Assignees: National University of Singapore, Agency for Science, Technology and Research
    Inventors: Young-Tae Chang, Duanting Zhai, Sung-Chan Lee, Seong-Wook Yun, Yun-Mi Jeong, Nam-Young Kang, Sung-Jin Park
  • Patent number: 9335323
    Abstract: A method for sorting pluripotent cells using a compound which is eliminated from the pluripotent cells through the MDR1 transporter.
    Type: Grant
    Filed: January 7, 2013
    Date of Patent: May 10, 2016
    Assignee: KYOTO UNIVERSITY
    Inventors: Motonari Uesugi, Nao Hirata, Asako Murata, Young-Tae Chang, Norio Nakatsuji, Hirofumi Suemori, Eihachiro Kawase, Kaori Yamauchi, Kazumitsu Ueda, Yuto Fujibayashi, Shinya Yamanaka, Masato Nakagawa
  • Publication number: 20160084769
    Abstract: The present invention relates to Caffeine Orange, a novel aqueous-phase fluorescence turn-on sensor for caffeine that is structurally based on a BODIPY-scaffold. The present invention further provides for methods of detecting and measuring caffeine in aqueous media. A change in the intensity or visible color of the fluorescence is detectable by either a fluorimeter or by the naked eye. The methods disclosed herein provide for the utilization of a reverse-phase SPE column, optionally as a component in a syringe or a microfluidics-based automation detection system. The invention further provides for the solid phase extraction of an analyte such as caffeine from a liquid medium, the extraction occurring on a microfluidic disc.
    Type: Application
    Filed: April 17, 2014
    Publication date: March 24, 2016
    Inventors: Young-Tae Chang, Wang Xu, Duanting Zhai, Yoon-Kyoung Cho, Tae-Hyeong Kim
  • Patent number: 9267949
    Abstract: The present invention discloses a series of alkylamino BODIPY dyes, methods for preparing a library of alkyl-amino BODIPY dyes via solid-phase synthesis, and the use of the alkyl-amino BODIPY dyes as fluorescent sensors for protein detection, cell imaging and cytometry applications, and staining of certain cell line.
    Type: Grant
    Filed: June 15, 2012
    Date of Patent: February 23, 2016
    Assignees: National University of Singapore, Agency for Science, Technology and Research
    Inventors: Young-Tae Chang, Marc Vendrell Escobar, Duanting Zhai, Nam-Young Kang, Yogeswari Chandran
  • Patent number: 9254290
    Abstract: The present invention provides a method for screening a diabetes treating agent comprising the following steps: (a) preparing cells inside a culture medium; (b) treating the culture medium with a test substance; (c) treating the result of step (b) with a glucose derivative which is not metabolized; and (d) measuring the glucose derivative which has flowed into the cells, wherein the test substance is determined to be a diabetes treating agent if the test substance accelerates uptake of the glucose derivative in the cells. Therefore, the described pharmaceutical composition, including a triazin-based compound as an active ingredient, can be useful for application in preventing or treating diabetes.
    Type: Grant
    Filed: July 28, 2011
    Date of Patent: February 9, 2016
    Assignee: GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Darren R. Williams, Da-Woon Jung, Young-Tae Chang
  • Publication number: 20150355168
    Abstract: The present invention is directed to a novel family of fluorophores based on the BODIPY scaffold, and methods for their synthesis. The BODIPY-based fluorophores disclosed herein are used for the selective visualization of cells that exist in the M-phase of the cell cycle. The present invention further relates to methods for the image-based monitoring of mitotic progression in live cells.
    Type: Application
    Filed: January 14, 2014
    Publication date: December 10, 2015
    Inventors: Young-Tae Chang, Duanting Zhai, Sung-Chan Lee, Seong-Wook Yun, Yun-Mi Jeong, Nam-Young Kang, Sung-Jin Park
  • Patent number: 9201014
    Abstract: A compound of structural formula (I): The values and alternative values are as defined herein. The invention also includes biosensors comprising nanoparticles functionalized with a compound of structural formula (I). Also described is a method for labeling a biomolecule using a compound of structural formula (I) and a method of detecting a target biomolecule using a compound of structural formula (I) or a biosensor of the invention.
    Type: Grant
    Filed: September 24, 2012
    Date of Patent: December 1, 2015
    Assignees: National University of Singapore, Agency for Science, Technology and Research
    Inventors: Young-Tae Chang, Animesh Samanta, Marc Vendrell Escobar, Nam-Young Kang, Kaustabh Kumar Maiti, Kiat Seng Soh, Dinish Unnimadhava Kurup Soudamini Amma, Malini Olivo, Sung-Jin Park, Raj Kumar Das
  • Publication number: 20150309040
    Abstract: A library of novel amino-triazolyl-BODIPY compounds is described. Particular compounds of the library serve as selective fluorescent probes Human Serum Albumin (HSA) and for live primary neurons. The fluorescent probe for HSA binds uniquely and specifically to the fatty acid site 1 of HSA, and thus proves a valuable and unique probe for drugs that bind to such a site on HSA. Methods of synthesis for the library compounds are also described.
    Type: Application
    Filed: December 26, 2013
    Publication date: October 29, 2015
    Inventors: Young-Tae Chang, Jun Cheng Er, Cheryl Kit Mun Leong, Seong Wook Yun, Marc Vendrell Escobar, Mui Kee Tang
  • Publication number: 20150293109
    Abstract: A fluorescent rosamine dye having specificity for neural stem cells, specifically, proliferative neural stem cells, and represented by Structural Formula (I): wherein X is an anion, is described herein. Synthesis of the fluorescent rosamine dye and use of the fluorescent rosamine dye to detect symmetric and asymmetric division of neural stem cells are also described.
    Type: Application
    Filed: October 28, 2013
    Publication date: October 15, 2015
    Inventors: Young-Tae Chang, Seong-Wook Yun, Hyung Ho Ha
  • Patent number: 9144573
    Abstract: The present invention generally relates to prostaglandin transport. More specifically, the invention is directed to compounds that inhibit prostaglandin transport and subsequent COX-2 induction, and methods relating thereto.
    Type: Grant
    Filed: July 23, 2012
    Date of Patent: September 29, 2015
    Assignees: Albert Einstein College of Medicine of Yeshiva University, New York University
    Inventors: Victor L. Schuster, Yuling Chi, Young-Tae Chang, Jaeki Min