Patents by Inventor Youssef Biadillah
Youssef Biadillah has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20190290427Abstract: Apparatus (40) for compressing a transcatheter cardiac stent-valve (10) comprises: a first compressor stage (100) including a hollow channel (42) with a tapered interior surface configured for compressing a stent-valve in response to longitudinal advancement of the stent-valve within the channel; and a second compressor stage (102) comprising a crimper for compressing a portion of the stent-valve without longitudinal advancement.Type: ApplicationFiled: April 1, 2019Publication date: September 26, 2019Applicant: Symetis SAInventors: Luc Mantanus, Fabien Lombardi, Pierre Simonin, Youssef Biadillah, Jean-Luc Hefti, Stephane Delaloye
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Patent number: 10420658Abstract: Embodiments of the present disclosure are related to devices and techniques for para-valve sealing of an expandable stent-valve implanted using a catheter. In some embodiments, a stent-valve is provided which comprises a seal sleeve/cuff containing material that swells when contacted by blood. A piercing tool may be included and used to permit a user to puncture the sleeve/cuff prior to introduction into a patient's body. In some embodiments, the sleeve/cuff has an integral tubular structure configured to withstand balloon expansion of the stent-valve during or after implantation. In some embodiments, the seal is provided as a separate component from the stent-valve.Type: GrantFiled: March 13, 2014Date of Patent: September 24, 2019Assignee: SYMETIS SAInventors: Stéphane Delaloye, Jacques Essinger, Jean-Luc Hefti, Youssef Biadillah, Luc Mantanus, Fabien Lombardi, Lionel Flaction, Yutit Wanakoht
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Patent number: 10376359Abstract: Embodiments of the present disclosure are directed to stents, valved-stents, and associated methods and systems for their delivery via minimally-invasive surgery.Type: GrantFiled: September 10, 2010Date of Patent: August 13, 2019Assignee: SYMETIS SAInventors: Jacques Essinger, Youssef Biadillah, Stephane Delaloye, Jean-Luc Hefti, Luc Mantanus, Reynald Passerini
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Publication number: 20190231523Abstract: A delivery catheter for a prosthetic heart valve, the valve expandable from a collapsed condition for delivery to an expanded condition for implantation, the delivery catheter comprising: a holder for engaging the valve in the collapsed state of the valve, the holder configured such that (i) in response to a radial compression force exerted thereon, the holder has a first shape defining an exposed engagement region for engaging at least a portion of the collapsed prosthetic heart valve for restraining axial displacement of the prosthetic valve in at least one axial direction of the catheter, and (ii) in response to removal of the radial compression force upon expansion of the valve, at least a portion of the holder transitions to a second shapeType: ApplicationFiled: April 13, 2019Publication date: August 1, 2019Applicant: Symetis SAInventors: Fabien Lombardi, Youssef Biadillah, Jean-Luc Hefti, Luc Mantanus, Stephane Delaoye
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Publication number: 20190201193Abstract: A stent-valve for transcatheter implantation to replace a cardiac valve, the stent valve being compressible to a compressed state for delivery, and expandable to an operative state for implantation, the stent-valve comprising a stent, a plurality of leaflets for defining a prosthetic valve, an inner skirt, an outer skirt, and a paravalve seal for sealing against surrounding tissue. In some embodiments, the paravalve seal comprises material that swells in response to contact with blood. In some embodiments, the seal comprises a flap or pocket that is distensible in response to backpressure and/or paravalve back-flow of blood.Type: ApplicationFiled: March 7, 2019Publication date: July 4, 2019Applicant: Symetis SAInventors: Stephane Delaloye, Jacques Essinger, Jean-Luc Hefti, Youssef Biadillah, Luc Mantanus, Fabien Lombardi
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Patent number: 10285811Abstract: A delivery catheter for a prosthetic heart valve, the valve expandable from a collapsed condition for delivery to an ex paneled condition for implantation, the delivery catheter comprising: a holder for engaging the valve in the collapsed state of the valve, the holder configured such that (i) in response to a radial compression force exerted thereon, the holder has a first shape defining an exposed engagement region for engaging at least a portion of the collapsed prosthetic heart valve for restraining axial displacement of the prosthetic valve in at least one axial direction of the catheter, and (ii) in response to removal of the radial compression force upon expansion of the valve, at least a portion of the holder transitions to a second shape.Type: GrantFiled: February 6, 2014Date of Patent: May 14, 2019Assignee: SYMETIS, SAInventors: Fabien Lombardi, Youssef Biadillah, Jean-Luc Hefti, Luc Mantanus, Stéphane Delaloye
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Patent number: 10258464Abstract: A stent-valve for transcatheter implantation to replace a cardiac valve, the stent valve being compressible to a compressed state for delivery, and expandable to an operative state for implantation, the stent-valve comprising a stent, a plurality of leaflets for defining a prosthetic valve, an inner skirt, an outer skirt, and a paravalve seal for sealing against surrounding tissue. In some embodiments, the paravalve seal comprises material that swells in response to contact with blood. In some embodiments, the seal comprises a flap or pocket that is distensible in response to backpressure and/or paravalve back-flow of blood.Type: GrantFiled: March 25, 2013Date of Patent: April 16, 2019Assignee: SYMETIS SAInventors: Stéphane Delaloye, Jacques Essinger, Jean-Luc Hefti, Youssef Biadillah, Luc Mantanus, Fabien Lombardi
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Patent number: 10245145Abstract: Apparatus (40) for compressing a transcatheter cardiac stent-valve (10) comprises: a first compressor stage (100) including a hollow channel (42) with a tapered interior surface configured for compressing a stent-valve in response to longitudinal advancement of the stent-valve within the channel; and a second compressor stage (102) comprising a crimper for compressing a portion of the stent-valve without longitudinal advancement.Type: GrantFiled: September 16, 2014Date of Patent: April 2, 2019Assignee: SYMETIS SAInventors: Luc Mantanus, Fabien Lombardi, Pierre Simonin, Youssef Biadillah, Jean-Luc Hefti, Stéphane Delaloye
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Patent number: 10201418Abstract: A device for heart valve replacement comprises a valve component having at least two valve leaflets preferably made of pericardium tissue. Each valve leaflet includes at least two tabs. The device further includes a stent component configured to be radially compressible into a compressed state and expandable into a functional state. The stent component comprises a first end, a second end and at least one intermediate section arranged between said first and said second end. The intermediate section has at least two commissural posts generally aligned parallel to an axis spanning from the first end to the second end. The commissural posts are formed in the shape of a wishbone.Type: GrantFiled: April 29, 2016Date of Patent: February 12, 2019Assignee: SYMETIS, SAInventors: Youssef Biadillah, Stephane Delaloye, Fabien Lombardi, Jean-Luc Hefti
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Publication number: 20180313726Abstract: The disclosure relates to devices, solutions and methods for collecting and processing samples of bodily fluids containing cells (as well as embodiments for the collection, and processing and/or analysis of other fluids including toxic and/or hazardous substances/fluids). In addition, the disclosure relates generally to function genomic studies and to the isolation and preservation of cells from saliva and other bodily fluids (e.g., urine), for cellular analysis. With respect to devices for collection of bodily fluids, some embodiments include two mating bodies, a cap and a tube (for example), where, in some embodiments, the cap includes a closed interior space for holding a sample preservative solution and mates with the tube to constitute the (closed) sample collection device. Upon mating, the preservation solution flows into the closed interior space to preserve cells in the bodily fluid. The tube is configured to receive a donor sample of bodily fluid (e.g.Type: ApplicationFiled: June 29, 2018Publication date: November 1, 2018Inventors: Youssef BIADILLAH, Stephen D. ANDREWS
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Publication number: 20180235758Abstract: Bioabsorbable medical devices such as vascular closures, mitral chorea replacements, and mitral leaflet extensions are provided.Type: ApplicationFiled: October 27, 2016Publication date: August 23, 2018Inventors: Youssef Biadillah, Martijn Antonius Johannes Cox
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Patent number: 10034762Abstract: The present disclosure describes embodiments for treating a defect in a tissue, the tissue having internal and external surfaces. A device includes a first portion for positioning at one of the internal and external surfaces for applying a treatment force to the defect. In addition, the device has a second portion for applying a counter-force, where the second portion is operable to be positioned so that the counter-force is applied on the other of the internal and external surfaces, away from the defect so as to substantially avoid application of force at the defect. Furthermore, the device includes a coupling member for connecting the inner and outer portions. Methods of using the device are described, for example in an intervertebral disc having a herniation.Type: GrantFiled: June 1, 2015Date of Patent: July 31, 2018Inventors: Neil Godara, Youssef Biadillah
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Publication number: 20180031543Abstract: A solution is described for preserving cells and/or extra-cellular components in naturally expressed bodily fluids (e.g. saliva, sputum, urine) for further downstream analysis and/or for diagnosis of a medical condition. The solution may be hypertonic with respect to blood. Techniques are described for enriching cells from a sample of a naturally expressed bodily fluid, and/or for analysis, e.g. to diagnose medical conditions such as cancer, obesity, infections, autism, Alzheimer disease, hetotological disorders, cardiovascular disease or disorders, diabetes, vulnerable plack, LTBI, HIV infection, COPD, ACQS.Type: ApplicationFiled: February 9, 2016Publication date: February 1, 2018Inventors: Stephen ANDREWS, Youssef BIADILLAH, Manasi JAIN, David S. FRANK, John R. ZEMAN, Charles T. TACKNEY
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Publication number: 20170071734Abstract: Some embodiments of the present disclosure provide a stent-valve for transcatheter implantation to replace a cardiac valve. In some embodiments, the stent valve being compressible to a compressed state for delivery, and expandable to an operative state for implantation. In some embodiments, the stent-valve comprises a stent, a plurality of leaflets for defining a prosthetic valve, an inner skirt, an outer skirt, and a paravalve seal for sealing against surrounding tissue. In some embodiments, the paravalve seal comprising material that swells in response to contact with blood or components thereof.Type: ApplicationFiled: November 4, 2016Publication date: March 16, 2017Inventors: Stephane Delaloye, Jacques Essinger, Jean-Luc Hefti, Youssef Biadillah, Luc Mantanus, Fabien Lombardi
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Publication number: 20170035568Abstract: A delivery catheter (12) for a stent valve (10), the delivery catheter having a distal portion (14) insertable into an anatomy, the distal portion comprising an accommodation region (18) for accommodating a stent-valve for delivery into the anatomy, the delivery catheter further comprising at least one sheath (20; 22) that is translatable between a closed position for at least partly closing the accommodation region and an open position for at least partly opening the accommodation region.Type: ApplicationFiled: August 12, 2016Publication date: February 9, 2017Inventors: Fabien Lombardi, Jacques Essinger, Stephane Delaloye, Jean-Luc Hefti, Luc Mantanus, Youssef Biadillah
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Publication number: 20170016807Abstract: The disclosure relates to devices, solutions and methods for collecting and processing samples of bodily fluids containing cells (as well as embodiments for the collection, and processing and/or analysis of other fluids including toxic and/or hazardous substances/fluids). In addition, the disclosure relates generally to function genomic studies and to the isolation and preservation of cells from saliva and other bodily fluids (e.g., urine), for cellular analysis. With respect to devices for collection of bodily fluids, some embodiments include two mating bodies, a cap and a tube (for example), where, in some embodiments, the cap includes a closed interior space for holding a sample preservative solution and mates with the tube to constitute the (closed) sample collection device. Upon mating, the preservation solution flows into the closed interior space to preserve cells in the bodily fluid. The tube is configured to receive a donor sample of bodily fluid (e.g.Type: ApplicationFiled: August 3, 2016Publication date: January 19, 2017Applicant: ABOGEN, INC.Inventors: Youssef BIADILLAH, Stephen ANDREWS
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Publication number: 20170001191Abstract: Some embodiments are directed to a bodily fluid sample collection device for the collection of naturally expressed bodily fluids and include a cap engageable with a tube to close a mouth of the tube. The cap includes a chamber for containing a reagent. The tube defines at least partly a sample collection space for receiving the naturally expressed bodily fluid. The cap comprises first and second cap portions relatively movable with respect to each other. The first and second cap portions are configured such that, responsive to engagement of the cap on the tube, one of the cap portions is caused to move integrally relative to the other cap portion to open the chamber and permit fluid communication between the chamber and the sample collection space. The reagent in the chamber is thereby permitted to mix with the bodily fluid in the sample collection space. A method of organizing and processing samples is also described.Type: ApplicationFiled: January 20, 2015Publication date: January 5, 2017Inventors: Youssef BIADILLAH, Stephen ANDREWS, Bryce G. RUTTER, Melvin J. LEEDLE, Jonathan SUNDY, Benjamin Cooper PRIESS, Chris BRIDEN
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Publication number: 20160317298Abstract: A device for heart valve replacement comprises a valve component having at least two valve leaflets preferably made of pericardium tissue. Each valve leaflet includes at least two tabs. The device further includes a stent component configured to be radially compressible into a compressed state and expandable into a functional state. The stent component comprises a first end, a second end and at least one intermediate section arranged between said first and said second end. The intermediate section has at least two commissural posts generally aligned parallel to an axis spanning from the first end to the second end. The commissural posts are formed in the shape of a wishbone.Type: ApplicationFiled: April 29, 2016Publication date: November 3, 2016Inventors: Youssef Biadillah, Stephane Delaloye, Fabien Lombardi, Jean-Luc Hefti
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Publication number: 20160262884Abstract: A delivery apparatus for delivering a stent-valve for implantation within the body, the delivery apparatus configured for introduction into the body through an arterial introducer of a type having a stem insertable into the body and a mouth section that remains outside the body, the mouth section including a haemostasis valve, and wherein the delivery apparatus comprises: a first constraining sheath at a stent-valve accommodation region of the apparatus at a distal end of the apparatus, and configured for constraining at least a portion of a stent-valve at the accommodation region in a radially collapsed configuration; a delivery introducer captive on the delivery apparatus, and slidable between a first position surrounding at least a portion of the stent-valve accommodation region, and a second position in which the delivery introducer slides proximally of the stent-valve accommodation region; wherein the delivery introducer is insertable at least partly into the mouth of a said arterial introducer, the deliType: ApplicationFiled: October 28, 2014Publication date: September 15, 2016Applicant: SYMETIS SAInventors: Fabien LOMBARDI, Jacques ESSINGER, Stéphane DELALOYE, Jean-Luc HEFTI, Luc MANTANUS, Youssef BIADILLAH, Pierre SIMONIN
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Patent number: 9442046Abstract: The disclosure relates to devices, solutions and methods for collecting and processing samples of bodily fluids containing cells (as well as embodiments for the collection, and processing and/or analysis of other fluids including toxic and/or hazardous substances/fluids). In addition, the disclosure relates generally to function genomic studies and to the isolation and preservation of cells from saliva and other bodily fluids (e.g., urine), for cellular analysis. With respect to devices for collection of bodily fluids, some embodiments include two mating bodies, a cap and a tube (for example), where, in some embodiments, the cap includes a closed interior space for holding a sample preservative solution and mates with the tube to constitute the (closed) sample collection device. Upon mating, the preservation solution flows into the closed interior space to preserve cells in the bodily fluid. The tube is configured to receive a donor sample of bodily fluid (e.g.Type: GrantFiled: June 19, 2012Date of Patent: September 13, 2016Assignee: AboGen, Inc.Inventors: Youssef Biadillah, Stephen Douglas Andrews