Abstract: Disclosed is sublingual administration of riluzole. In particular, a method for treating a neuropsychiatric disorder or symptom by administering a sublingual formulation of riluzole is provided. In addition, a method of relieving or reducing oral pain using the sublingual formulation of riluzole is disclosed.

Abstract: Disclosure is a compound with one or more arm(s) for drug conjugation and a conjugate including the compound so as to provide high drug-to-moiety ratio and conjugate more drugs to the conjugate.

Abstract: An environmentally friendly water-based printing ink manufacturing method includes the steps of: placing a color paste into a barrel for stirring at a high speed, placing an anti-scratch hardener and a slow-drying agent in batches and continuing stirring, placing a mixture of anti-scratch hardener and slow-drying agent in a specific ratio, placing a scratch-resistant and chemical-resistant resin and a wear-resistant wetting resin, placing a defoaming agent and continuing stirring for a first predetermined time, placing a thickener and continuing stirring for a second predetermined time, placing a wetting agent and continuing stirring for a third predetermined time, placing a film-forming agent and continuing stirring for a fourth predetermined time, measuring the pH value of the printing ink and adjusting the printing ink to make the printing ink weakly alkaline, filtering the printing ink and packing the printing ink into barrels to complete the manufacturing process.

Abstract: Provided are a composition and a method for preventing thrombogenesis. The composition includes a conjugate of heparin and a viral capsid protein, wherein the heparin is covalently bonded with the viral capsid protein.

Abstract: Provided are a quantum dot composition, a method of manufacturing the same, a cured product thereof, and a display device including the same, specifically a quantum dot composition for electrohydrodynamic inkjet printing, a method of manufacturing the same, a cured product thereof, and a display device including the same.

Abstract: The present invention relates to a marked fatty acid derivative, a precursor compound thereof, and use thereof in a contrast agent. The derivative is represented by formula I: wherein M is 99mTc or Re; R, R1, R2, R3, R4 and R5, and A1-A12 are independently H, an aliphatic chain or an alicyclic; J, X, and Y are independently absent, or —O—, —S— or (II), and J, X, and Y are not simultaneously absent; R6-R14 are independently H or an aliphatic chain, and R13 and R14 are not H simultaneously; z is 1-6, a is 0-5, b is 0-5, and c is 0-3; d is 0-27, e is 0-27, f is 0-28, g is 0-7, and at least two of d, e, f and g are not 0. The present invention provides a completely novel structure type that can be used for preparing a novel myocardial metabolism contrast agent, possessing important clinical application prospects.

Abstract: The invention provides an automatic stirring device in the field of fluid machinery and bioreactors, focusing on enhancing fluid control efficiency and consistency in biological cultivation processes. It utilizes a flexible channel body or reactor body to facilitate the flow of nutrient solution along specific channels (such as S-shaped flexible channels or S-shaped loop channels), designed to reduce shear forces and achieve iso-level uniform flow. A power system and monitoring and control system are employed to regulate the flow of nutrient solution and monitor cultivation conditions in real-time, thus supporting various bioprocess cultivation requirements.

Abstract: Targeted recommendations may be provided to specific user segments. The users may be segmented on or more user parameters that facilitate targeted provision of recommendations to the individual segments of users. A recommendation may prompt a user to take a recommended action in the game.

Abstract: The present disclosure relates to methods for the treatment of diseases or disorders (e.g., cancer) with mTOR inhibitors. Specifically, the disclosure relates to methods of treating a subject having a cancer by administering a particular dosage of an mTOR inhibitor. In some embodiments this disclosure includes methods for delaying, preventing, or treating acquired resistance to RAS inhibitors using a dosage of an mTOR inhibitor. In some embodiments, this disclosure relates to methods of treating or preventing adverse events associated with administration of an mTOR inhibitor using tacrolimus.

Abstract: The invention discloses a method for preparing esomeprazole magnesium trihydrate by crystal transformation, and relates to the technical field of pharmaceutical preparations and crystallization. It includes the following steps of preparing an esomeprazole potassium aqueous solution, preparing a magnesium sulfate heptahydrate aqueous solution, a reactive crystallization process to obtain the esomeprazole magnesium tetrahydrate, and filtering the obtained esomeprazole magnesium tetrahydrate to obtain a sphaerocrystal of esomeprazole magnesium trihydrate. The method for preparing esomeprazole magnesium trihydrate by crystal transformation in the present invention is characterized by using the esomeprazole potassium aqueous solution and the magnesium sulfate aqueous solution for ion exchange to obtain the esomeprazole magnesium tetrahydrate.

Abstract: Disclosed are a cleaning system and method for a solar cell. The cleaning system includes a cleaning device including a soaking tank configured to accommodate cleaner; and a filtering device configured to filter a first substance being a mixture of the cleaner and mask residue in the soaking tank. The filtering device including: a sucking apparatus including an sucking port for sucking the first substance; a spraying apparatus, including a spraying port oriented a region that the sucking port is capable of sucking in a bottom of the soaking tank, and the spraying port being configured to spry liquid or gas to flush the bottom of the soaking tank; and a filtering apparatus, connected to the sucking apparatus to receive and filter the first substance sucked by the sucking port.

Abstract: An electrical apparatus and a method for controlling heating thereof are disclosed. Before detecting a mobile electrical apparatus is in operation, the electrical apparatus may first receive input for a driving heating mode selected by a user. The driving heating mode corresponds to an enablement of a heating function is allowed or an enablement of a heating function is to be allowed. Thus, the battery heating function may be enabled or disabled according to the operating parameters of the battery and the motor based on the current driving heating mode. Further, a heating mode that matches the electrical apparatus may be selected based on usage habits and the current driving environment of the electrical apparatus for heating the battery. Further, the example methods avoid ineffective heating increased by manually controlling a battery self-healing function and the resulting high energy consumption in related technologies.

Abstract: A sensor system for detecting at least one analyte in an environment includes a dehumidifier system including at least one of a condenser unit and a desiccant unit and a sensor responsive to the analyte in fluid connection with the dehumidifier system.

Abstract: One embodiment of the present disclosure provides a scintillation crystal and a method and a device for preparing the scintillation crystal. A molecular formula of the scintillation crystal is: Cey:Cas:Lu2(1-xysz)Y2zSc2xSiO5, wherein x=0-1, y=0.0000001-0.06, z=0.00001-0.5, s=0.0000001-0.05.

Abstract: The present disclosure is directed to novel bispecific Fc fusion proteins with an IF-15 domain, an Interleukin-15 receptor alpha (IF-15R?) sushi domain, an Fc domain and a soluble PD-1 (sPD-1) variant domain, polynucleotides encoding said bispecific Fc fusion proteins, methods of making and using thereof.

Abstract: A large-area switchable electro-optic light modulator or display and method of manufacture are disclosed. The large-area light modulator comprises an array of individual light modulator units sandwiched between two larger light-transmissive substrates coated on their inner surfaces with light-transmissive electrode layers with electrical connections to each unit that do not compromise the transparency of the light modulator in an open state. The large-area display comprises an array of individual display units. A large-area light-transmissive substrate coated on its inner surface with a light-transmissive electrode layer is superposed on the individual display units with electrical connections to each unit that do not compromise the transparency of the display. The light modulator and the display can be readily manufactured using conventional equipment.

Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof.

Abstract: Semiconductor device and the manufacturing method thereof are disclosed. An exemplary method comprises forming a first stack structure and a second stack structure in a first area over a substrate, wherein each of the stack structures includes semiconductor layers separated and stacked up; depositing a first interfacial layer around each of the semiconductor layers of the stack structures; depositing a gate dielectric layer around the first interfacial layer; forming a dipole oxide layer around the gate dielectric layer; removing the dipole oxide layer around the gate dielectric layer of the second stack structure; performing an annealing process to form a dipole gate dielectric layer for the first stack structure and a non-dipole gate dielectric layer for the second stack structure; and depositing a first gate electrode around the dipole gate dielectric layer of the first stack structure and the non-dipole gate dielectric layer of the second stack structure.

Abstract: A bispecific antibody simultaneously targeting two different epitopes or targets is coupled with a camptothecin drug to form a bispecific antibody-toxin conjugate that is stable in treatment and excellent in uniformity, and a drug-to-antibody ratio (DAR) thereof is 6.0-8.0. The antibody-toxin conjugate has a structure as represented by general formula (I), wherein Ab represents the bispecific antibody simultaneously targeting two different epitopes or targets, which is coupled with a linker-camptothecin drug. In addition, the present invention further relates to a preparation and purification method for the antibody-toxin conjugate, and an application thereof in tumor treatment. Furthermore, the present invention further relates to a linker-drug compound capable of being coupled with Ab to form the antibody-toxin conjugate.

Abstract: An exhaust system of a straddled off-road traveling vehicle includes: an exhaust passage extending from an exhaust port of an internal combustion engine of the straddled off-road traveling vehicle and including a lateral portion passing through a lateral space of the internal combustion engine; a silencer connected to the exhaust passage at a position downstream of the lateral portion in a flow direction of an exhaust gas; a main catalyst located inside the silencer; and a precatalyst located at the lateral portion and having a heat capacity smaller than a heat capacity of the main catalyst.