Patents by Inventor Yu-Chin Lai

Yu-Chin Lai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8865925
    Abstract: A method for manufacturing a hydrophilic silicone macromer is provided. A hydrosilylation between a Si—H bond of a polysiloxane and a C?C bond of a hydrophilic monomer is performed by using a rhodium-containing catalyst to form the polysiloxane having a hydrophilic side chain having an amide group or a phosphoryl choline group. After performing an end-capping reaction, the hydrophilic silicone macromer is formed.
    Type: Grant
    Filed: December 14, 2012
    Date of Patent: October 21, 2014
    Assignee: Pegavision Corporation
    Inventors: Wei-Jia Ting, Heng-Yi Li, Yu-Chin Lai, Han-Yi Chang
  • Publication number: 20140155515
    Abstract: A silicone hydrogel composition is disclosed. The composition includes at least one silicone macromer, a hydroxy-functionalized silicone-containing monomer, a first hydrophibic monomer and at least one crosslinker, in which the first hydrophibic monomer is N-vinyl pyrrolidone. The silicone macromer and the hydroxy-functionalized silicone-containing monomer are mutually soluble with N-vinylpyrrolidone. Silicone hydrogel contact lenses prepared from the silicone hydrogel composition are also disclosed.
    Type: Application
    Filed: April 25, 2013
    Publication date: June 5, 2014
    Applicant: Pegavision Corporation
    Inventors: Yu-Chin LAI, Min-Tzung YEH, Heng-Yi LI, Wei-Jia TING
  • Patent number: 8119753
    Abstract: A silicone hydrogel comprising monomeric units of one or more amino monomers, wherein the amino monomers are of formula IA, IB, IIA or IIB and monomeric units of one or more silicone monomers wherein R1, R2 and R3 are independently selected from hydrogen, C1-C6 alkyl or CH2OH; R4 is a C1-C10 alkyl optionally substituted with hydroxyl or carboxylic acid; E is a polymerizable group; X is an anion suitable for quaternary nitrogen; and n is 0, 1, 2, or 3 and m is an integer from 1 to 8.
    Type: Grant
    Filed: October 1, 2008
    Date of Patent: February 21, 2012
    Assignee: Bausch & Lomb Incorporated
    Inventors: Yu-Chin Lai, Weihong Lang
  • Patent number: 8101698
    Abstract: Provided are surface modified contact lenses formed from one or more fumaric-or itaconic-containing prepolymers having polymerizable functionality that is complimentary to polymerizable hydrophilic polymers.
    Type: Grant
    Filed: March 25, 2011
    Date of Patent: January 24, 2012
    Assignee: Bausch & Lomb Incorporated
    Inventor: Yu-Chin Lai
  • Patent number: 8071704
    Abstract: Provided are surface modified contact lenses formed from one or more fumaric- or itaconic-containing prepolymers having reactive functionality that is complimentary to surface modifying polymers.
    Type: Grant
    Filed: September 30, 2008
    Date of Patent: December 6, 2011
    Assignee: Bausch & Lomb Incorporated
    Inventors: Weihong Lang, Yu-Chin Lai
  • Patent number: 8071661
    Abstract: Biomedical devices are provided herein which are formed from a polymerization product of a mixture comprising (a) a copolymer which is the reaction product of one or more polymerizable polyhydric alcohols and one or more polymerizable fluorine-containing monomers; and (b) a biomedical device-forming comonomer.
    Type: Grant
    Filed: December 8, 2008
    Date of Patent: December 6, 2011
    Assignee: Bausch & Lomb Incorporated
    Inventors: Yu-Chin Lai, Weihong Lang
  • Patent number: 8071660
    Abstract: A method for making a surface modified biomedical device is disclosed, the method comprising contacting a surface of a biomedical device with a copolymer which is the reaction product of one or more polymerizable polyhydric alcohols and one or more polymerizable fluorine-containing monomers.
    Type: Grant
    Filed: December 8, 2008
    Date of Patent: December 6, 2011
    Assignee: Bausch & Lomb Incorporated
    Inventors: Weihong Lang, Yu-Chin Lai
  • Publication number: 20110172374
    Abstract: Provided are surface modified contact lenses formed from one or more fumaric- or itaconic-containing prepolymers having polymerizable functionality that is complimentary to polymerizable hydrophilic polymers.
    Type: Application
    Filed: March 25, 2011
    Publication date: July 14, 2011
    Inventor: Yu-Chin Lai
  • Patent number: 7935770
    Abstract: Provided are surface modified contact lenses formed from one or more fumaric- or itaconic-containing prepolymers having polymerizable functionality that is complimentary to polymerizable hydrophilic polymers.
    Type: Grant
    Filed: July 3, 2007
    Date of Patent: May 3, 2011
    Assignee: Bausch & Lomb Incorporated
    Inventor: Yu-Chin Lai
  • Patent number: 7781554
    Abstract: Polysiloxanes having vinyl or epoxy functionality. The polysiloxanes are used to form polymer-based materials having properties particularly suited for biomedical device applications. The polysiloxanes are of general formula I: wherein R is a C2-10 alkenyl, a C2-10 alkyl with an epoxy group or a C5-C7cycloalkyl with an epoxy group; R2, R3 and R4 are each independently selected from the group consisting of hydrogen, C1-4 alkyl, C1-4 fluoroalkyl, optionally substituted phenyl and optionally substituted benzyl; A is —OH or —NHR5, wherein R5 is hydrogen or a C1-3 alkyl; and B is —R1-A or —R6, wherein R1 is a linking group having an alkylene group with 2 to 8 carbon atoms wherein the alkylene group optionally includes ether, urethane or ureido linkages; and R6 is selected from the group consisting of C1-4 alkyl, optionally substituted phenyl or optionally substituted benzyl; and m and n are integers with an m:n ratio from 30:1 to 3:1.
    Type: Grant
    Filed: March 5, 2008
    Date of Patent: August 24, 2010
    Assignee: Bausch & Lomb Incorporated
    Inventors: Yu-Chin Lai, Edmond T. Quinn, Weihong Lang, Ivan M. Nunez
  • Publication number: 20100168356
    Abstract: Biomedical devices are provided herein which are formed from a polymerization product of a monomeric mixture comprising (a) a polymerizable monomer containing a boronic acid moiety and an electron withdrawing moiety; and (b) a biomedical device-forming comonomer.
    Type: Application
    Filed: December 18, 2009
    Publication date: July 1, 2010
    Inventors: Yu-Chin Lai, Weihong Lang, David Paul Vanderbilt, Paul L. Valint, JR., Joseph A. McGee
  • Patent number: 7691917
    Abstract: Prepolymers comprising at least one block of Formula II and terminated with a polymerizable ethylenically unsaturated radical are useful in hydrogel materials are disclosed: wherein n, R, R1, R2 and X+ are as defined herein.
    Type: Grant
    Filed: June 14, 2007
    Date of Patent: April 6, 2010
    Assignee: Bausch & Lomb Incorporated
    Inventors: Yu-Chin Lai, Weihong Lang, Edmond T. Quinn
  • Publication number: 20100039613
    Abstract: At least one of the surfaces of a silicone contact lens is a wrinkled surface, providing the contact lens surface with a desired topography. The wrinkled surface may include random ridges, either over the entire surface of the lens, or in a desired pattern on the surface of the lens.
    Type: Application
    Filed: October 19, 2009
    Publication date: February 18, 2010
    Applicant: BAUSCH & LOMB INCORPORATED
    Inventors: Ravi Sharma, Robert M. Braun, Daniel M. Ammon, JR., Jay F. Kunzler, Yu-Chin Lai
  • Patent number: 7632876
    Abstract: A polysiloxane prepolymer that is useful for forming biomedical devices has the formula: M(*Dii*PS)x*Dii*M??(I) wherein: each M is independently a polymerizable ethylenically unsaturated radical; each Dii is independently a diradical residue of a diisocyanate; each PS is independently a diradical residue of a polysiloxane-diol or a polysiloxane-diamine; each * is independently —NH—CO—NH—, —NH—COO— or —OCO—NH—; and x is at least 2.
    Type: Grant
    Filed: December 2, 2005
    Date of Patent: December 15, 2009
    Assignee: Bausch & Lomb Incorporated
    Inventors: Yu-Chin Lai, Weihong Lang, Edmond T. Quinn
  • Patent number: 7625598
    Abstract: At least one of the surfaces of a silicone contact lens is a wrinkled surface, providing the contact lens surface with a desired topography. The wrinkled surface may include random ridges, either over the entire surface of the lens, or in a desired pattern on the surface of the lens.
    Type: Grant
    Filed: December 15, 2006
    Date of Patent: December 1, 2009
    Assignee: Bausch & Lomb Incorporated
    Inventors: Ravi Sharma, Robert M. Braun, Daniel M. Ammon, Jr., Jay F. Kunzler, Yu-Chin Lai
  • Publication number: 20090227804
    Abstract: Polysiloxanes having vinyl or epoxy functionality. The polysiloxanes are used to form polymer-based materials having properties particularly suited for biomedical device applications. The polysiloxanes are of general formula I: wherein R is a C2-10 alkenyl, a C2-10 alkyl with an epoxy group or a C5-C7cycloalkyl with an epoxy group; R2, R3 and R4 are each independently selected from the group consisting of hydrogen, C1-4 alkyl, C1-4 fluoroalkyl, optionally substituted phenyl and optionally substituted benzyl; A is —OH or —NHR5, wherein R5 is hydrogen or a C1-3 alkyl; and B is —R1-A or —R6, wherein R1 is a linking group having an alkylene group with 2 to 8 carbon atoms wherein the alkylene group optionally includes ether, urethane or ureido linkages; and R6 is selected from the group consisting of C1-4 alkyl, optionally substituted phenyl or optionally substituted benzyl; and m and n are integers with an m:n ratio from 30:1 to 3:1.
    Type: Application
    Filed: March 5, 2008
    Publication date: September 10, 2009
    Inventors: Yu-Chin Lai, Edmond T. Quinn, Weihong Lang, Ivan M. Nunez
  • Publication number: 20090173045
    Abstract: Packaging systems for storing ophthalmic devices such as contact lenses and to methods for packaging such ophthalmic devices with solutions to improve the comfort of the lenses during wear are disclosed. A packaging system includes an ophthalmic device stored in an aqueous packaging solution comprising a hydrophilic polymer having one or more non-ethylenically-unsaturated carboxylic acid terminal groups.
    Type: Application
    Filed: October 9, 2008
    Publication date: July 9, 2009
    Inventors: Yu-Chin Lai, Weihong Lang
  • Publication number: 20090173643
    Abstract: Packaging systems for storing ophthalmic devices such as contact lenses and to methods for packaging such ophthalmic devices with solutions to improve the comfort of the lenses during wear are disclosed. A packaging system includes an ophthalmic device stored in an aqueous packaging solution comprising a copolymer which is the reaction product of one or more polymerizable polyhydric alcohols and one or more polymerizable fluorine-containing monomers.
    Type: Application
    Filed: October 9, 2008
    Publication date: July 9, 2009
    Inventors: Yu-Chin Lai, Weihong Lang
  • Publication number: 20090156708
    Abstract: Biomedical devices are provided herein which are formed from a polymerization product of a mixture comprising (a) a copolymer which is the reaction product of one or more polymerizable polyhydric alcohols and one or more polymerizable fluorine-containing monomers; and (b) a biomedical device-forming comonomer.
    Type: Application
    Filed: December 8, 2008
    Publication date: June 18, 2009
    Inventors: Yu-Chin Lai, Weihong Lang
  • Publication number: 20090153793
    Abstract: A method for making a surface modified biomedical device is disclosed, the method comprising contacting a surface of a biomedical device with a copolymer which is the reaction product of one or more polymerizable polyhydric alcohols and one or more polymerizable fluorine-containing monomers.
    Type: Application
    Filed: December 8, 2008
    Publication date: June 18, 2009
    Inventors: Weihong Lang, Yu-Chin Lai