Patents by Inventor Yuan-Jyue Chen

Yuan-Jyue Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10689684
    Abstract: This disclosure describes techniques to improve the sequencing of polynucleotides by decreasing the likelihood of errors occurring during a sequencing calibration process. In implementations, regions of polynucleotides that are used for the calibration process can be modified to reduce a number of polynucleotides that have a same nucleotide at one or more positions of the calibration regions. In some cases, the calibration regions can be modified by adding a sequence to the polynucleotides that replaces the original calibration regions. Also, the calibration regions can be modified by rearranging the nucleotides at the different positions of the calibration regions. Additionally, the calibration regions can be modified by adding sequences of varying length to the polynucleotides being sequenced to produce polynucleotides having varying length with different calibration regions.
    Type: Grant
    Filed: February 14, 2017
    Date of Patent: June 23, 2020
    Assignee: Microsoft Technology Licensing, LLC
    Inventors: Yuan-Jyue Chen, Karin Strauss, Luis H. Ceze, Lee Organick, Randolph Lopez, Georg Seelig
  • Publication number: 20200004926
    Abstract: This disclosure describes an efficient method to copy all polynucleotides encoding digital data of digital files in a polynucleotide storage container while maintaining random access capabilities over a collection of files or data items in the container. The disclosure further describes a process whereby random-access and sequencing of the polynucleotides are combined in a single step.
    Type: Application
    Filed: June 29, 2018
    Publication date: January 2, 2020
    Inventors: Karin Strauss, Yuan Jyue Chen
  • Publication number: 20190376120
    Abstract: Techniques for random access of particular DNA strands from a mixture of DNA strands are described. DNA strands that encode pieces of the same digital file are labeled with the same identification sequence. The identification sequence is used to selectively separate DNA strands that contain portions of the same digital file from other DNA strands. A DNA staple positions DNA strands with the identification sequence adjacent to sequencing adaptors. DNA ligase joins the molecules to create a longer molecule with the region encoding the digital file flanked by sequencing adaptors. DNA strands that include sequencing adaptors are sequenced and the sequence data is available for further analysis. DNA strands without the identification sequence are not joined to sequencing adaptors, and thus, are not sequenced. As a result, the sequencing data produced by the DNA sequencer comes from those DNA strands that included the identification sequence.
    Type: Application
    Filed: October 30, 2017
    Publication date: December 12, 2019
    Inventors: Karin STRAUSS, Yuan-Jyue CHEN
  • Publication number: 20190358604
    Abstract: A system includes a synthesizer unit having a fluid input to receive fluids and a communication input to receive commands to synthesize data-encoded DNA sequences and cleave the DNA. A first flexible chemistry reaction chamber module may be fluidically coupled to the synthesizer unit to receive the data-encoded DNA sequences and amplify the sequences. A deposition unit may be fluidically coupled to the first flexible chemistry reaction chamber module to receive the amplified DNA sequences and encapsulate the amplified DNA sequences into one or more wells in a storage plate for storage and retrieval to and from a plate storage unit. Retrieved DNA may be processed and read by further units.
    Type: Application
    Filed: May 22, 2018
    Publication date: November 28, 2019
    Inventors: Bichlien H. Nguyen, Douglas P. Kelley, Karin Strauss, Robert Carlson, Hsing-Yeh Parker, John Mulligan, Luis H. Ceze, Yuan-Jyue Chen, Douglas Carmean
  • Publication number: 20180265921
    Abstract: This disclosure describes frameworks and techniques related to the random access of digital data encoded by polynucleotides. Digital data of a data file can be encoded as a series of nucleotides and one or more polynucleotide sequences can be generated that encode the digital data for the data file. The bits of the digital data can be segmented to produce multiple polynucleotide sequences that encode the bits of the digital data with each polynucleotide sequence encoding an individual segment of the digital data. The individual segments can be grouped together and associated with a group identifier. Each data file can be associated with a number of group identifiers and the number of segments in each group can be within a specified range. Primers corresponding to the group identifiers can be used to selectively access the polynucleotides that encode the digital data of a data file.
    Type: Application
    Filed: March 15, 2017
    Publication date: September 20, 2018
    Inventors: Yuan-Jyue Chen, Karin Strauss, Luis H. Ceze, Lee Organick
  • Publication number: 20180253528
    Abstract: Artificial polynucleotides may have different characteristics than natural polynucleotides so conventional base-calling algorithms may make incorrect base calls. However, because artificial polynucleotides are typically designed to have certain characteristics, the known characteristics of the artificial polynucleotide can be used to modify the base-calling algorithm. This disclosure describes polynucleotide sequencers adapted to sequence artificial polynucleotides by modifying a base-calling algorithm of the polynucleotide sequencer according to known characteristics of the artificial polynucleotides. The base-calling algorithm analyzes raw data generated by a polynucleotide sequencer and identifies which nucleotide base occupies a given position on a polynucleotide strand.
    Type: Application
    Filed: May 26, 2017
    Publication date: September 6, 2018
    Inventors: Karin Strauss, Siena Dumas Ang, Luis Ceze, Yuan-Jyue Chen, Hsing-Yeh Parker, Bichlien Nguyen, Robert Carlson
  • Publication number: 20180230509
    Abstract: This disclosure describes techniques to improve the sequencing of polynucleotides by decreasing the likelihood of errors occurring during a sequencing calibration process. In implementations, regions of polynucleotides that are used for the calibration process can be modified to reduce a number of polynucleotides that have a same nucleotide at one or more positions of the calibration regions. In some cases, the calibration regions can be modified by adding a sequence to the polynucleotides that replaces the original calibration regions. Also, the calibration regions can be modified by rearranging the nucleotides at the different positions of the calibration regions. Additionally, the calibration regions can be modified by adding sequences of varying length to the polynucleotides being sequenced to produce polynucleotides having varying length with different calibration regions.
    Type: Application
    Filed: February 14, 2017
    Publication date: August 16, 2018
    Inventors: Yuan-Jyue Chen, Karin Strauss, Luis H. Ceze, Lee Organick, Randolph Lopez, Georg Seelig
  • Publication number: 20180223340
    Abstract: This disclosure describes techniques to improve the accuracy of random access of data stored in polynucleotide sequence data storage systems. Primers used in polynucleotide sequence replication and amplification can be scored against a number of criteria that indicate the fitness of sequences of nucleotides to function as primers. Primers having scores that indicate a particular fitness to function as primers can be added to a specific group of primers. The primers from the group of primers can be used in amplification and replication of polynucleotide sequences that encode digital data. Additionally, an amount of overlap between primer targets and payloads encoding digital data can be determined. Minimizing the amount of overlap between primer targets and payloads can improve the efficiency of polynucleotide replication and amplification. The bits of the digital data can be randomized to minimize the amount of overlap between payloads encoding the digital data and primer targets.
    Type: Application
    Filed: February 8, 2017
    Publication date: August 9, 2018
    Inventors: Yuan-Jyue Chen, Luis H. Ceze, Sergey Yekhanin, Siena Dumas Ang, Karin Strauss
  • Publication number: 20180223341
    Abstract: This disclosure describes techniques to improve the accuracy of random access of data stored in polynucleotide sequence data storage systems. Primers used in polynucleotide sequence replication and amplification can be scored against a number of criteria that indicate the fitness of sequences of nucleotides to function as primers. Primers having scores that indicate a particular fitness to function as primers can be added to a specific group of primers. The primers from the group of primers can be used in amplification and replication of polynucleotide sequences that encode digital data. Additionally, an amount of overlap between primer targets and payloads encoding digital data can be determined. Minimizing the amount of overlap between primer targets and payloads can improve the efficiency of polynucleotide replication and amplification. The bits of the digital data can be randomized to minimize the amount of overlap between payloads encoding the digital data and primer targets.
    Type: Application
    Filed: February 8, 2017
    Publication date: August 9, 2018
    Inventors: Yuan-Jyue Chen, Karin Strauss, Luis H. Ceze, Siena Dumas Ang, Sergey Yekhanin
  • Patent number: 7826553
    Abstract: A multilevel LINC transmitter. The multilevel LINC transmitter comprises a multilevel signal component separator, a phase modulator block, a mixer block, an up-converter block, a predistorter and an RF block. The multilevel signal component separator comprises a multilevel scaler and converts an input signal to phase signals. The phase modulator block and the predistorter are coupled to the multilevel signal component separator. The mixer block is coupled to the phase modulator block and the predistorter. The up-converter block is coupled to the mixer block. The RF block comprises a plurality of power amplifiers coupled to the up-converter block and a power combiner coupled to the power amplifiers.
    Type: Grant
    Filed: May 30, 2007
    Date of Patent: November 2, 2010
    Assignees: Mediatek Inc., National Taiwan University
    Inventors: Yuan-Jyue Chen, Kai-Yuan Jheng, An-Yeu Wu
  • Patent number: 7724839
    Abstract: A multilevel LINC transmitter. The multilevel LINC transmitter comprises a multilevel signal component separator, a phase modulator block, and an RF block. The multilevel signal component separator comprises a multilevel scaler and converts a base band signal to constant envelope signals. The phase modulator block is coupled to the multilevel signal component separator. The RF block comprises a plurality of power amplifiers coupled to the phase modulator block and the multilevel scaler and a power combiner coupled to the power amplifiers.
    Type: Grant
    Filed: June 4, 2007
    Date of Patent: May 25, 2010
    Assignee: Mediatek Inc.
    Inventors: Yuan-Jyue Chen, Kai-Yuan Jheng, An-Yeu Wu, Hen-Wai Tsao, Posen Tseng
  • Publication number: 20080019459
    Abstract: A multilevel LINC transmitter. The multilevel LINC transmitter comprises a multilevel signal component separator, a phase modulator block, and an RF block. The multilevel signal component separator comprises a multilevel scaler and converts a base band signal to constant envelope signals. The phase modulator block is coupled to the multilevel signal component separator. The RF block comprises a plurality of power amplifiers coupled to the phase modulator block and the multilevel scaler and a power combiner coupled to the power amplifiers.
    Type: Application
    Filed: June 4, 2007
    Publication date: January 24, 2008
    Applicants: MEDIATEK INC., NATIONAL TAIWAN UNIVERISTY
    Inventors: Yuan-Jyue Chen, Kai-Yuan Jheng, An-Yeu Wu, Hen-Wai Tsao, Posen Tseng
  • Publication number: 20080019456
    Abstract: A multilevel LINC transmitter. The multilevel LINC transmitter comprises a multilevel signal component separator, a phase modulator block, a mixer block, an up-converter block, a predistorter and an RF block. The multilevel signal component separator comprises a multilevel scaler and converts an input signal to phase signals. The phase modulator block and the predistorter are coupled to the multilevel signal component separator. The mixer block is coupled to the phase modulator block and the predistorter. The up-converter block is coupled to the mixer block. The RF block comprises a plurality of power amplifiers coupled to the up-converter block and a power combiner coupled to the power amplifiers.
    Type: Application
    Filed: May 30, 2007
    Publication date: January 24, 2008
    Applicants: MEDIATEK INC., NATIONAL TAIWAN UNIVERSITY
    Inventors: Yuan-Jyue Chen, Kai-Yuan Jheng, An-Yeu Wu