Patents by Inventor Yue-Wei Lee

Yue-Wei Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of positive strand RNA viruses
    Patent number: 11957667
    Abstract: Methods of treating a disease caused by a positive strand RNA virus. The methods include administering to a subject in need thereof an effective amount of a compound of Formula I or Formula II.
    Type: Grant
    Filed: July 7, 2021
    Date of Patent: April 16, 2024
    Assignee: National Health Research Institutes
    Inventors: Shiow-Ju Lee, Cheng-Wei Yang, Yue-Zhi Lee, Hsing-Yu Hsu
  • METHODS OF TREATING AND PREVENTING DISEASE BY CLAMPING OF SKIN
    Publication number: 20190038498
    Abstract: The invention provides methods of treating diseases, such as various cancers, neoplasms, autoimmune diseases, and infectious diseases, among others, by clamping the skin of a subject in need of treatment so as to apply a compressive force that is sufficient to cause damage, often manifested in pain or bruising, to the underlying tissue. The invention additionally provides kits containing clamps capable of regulating the distance between the arms of the clamp such that a user of the clamp will apply a safe amount of pressure to the skin of a subject that is sufficient to cause tissue bruising and/or pain.
    Type: Application
    Filed: February 28, 2017
    Publication date: February 7, 2019
    Inventors: David Yue-Wei LEE, Long Zhang CHEN
  • Salvinorin Derivatives and Uses Thereof
    Publication number: 20100324131
    Abstract: The invention features salvinorin compositions that are selective for kappa opioid receptors; methods of treating mania by using a selective kappa receptor agonist; and methods of treating mood disorders, such as depressive disorders and manic disorders, using salvinorin compositions.
    Type: Application
    Filed: August 6, 2010
    Publication date: December 23, 2010
    Inventors: Cécile Béguin, William A. Carlezon, Bruce M. Cohen, Minsheng He, David Yue-Wei Lee, Michele R. Richards, Lee-Yuan Liu Chen
  • METHODS AND COMPOSITIONS FOR THE USE OF SARGASSUM FUSIFORME FOR THE INHIBITION OF HIV-1 INFECTION
    Publication number: 20100247564
    Abstract: The methods, kits, articles, and compositions of the invention feature a natural product (e.g., Sargassum fusiforme), an extract thereof, and fatty acid components of the extract (e.g., palmitic acid) for the treatment of a viral infection, e.g., HIV or herpes. The natural products used in the methods and compositions of the invention include brown algae, specifically algae of the Sargassum fusiforme species. The Sargassum fusiforme algae, extracts thereof, specific components of the extract, and related compounds of the invention may be used to treat or prevent HIV and herpes infections.
    Type: Application
    Filed: May 23, 2008
    Publication date: September 30, 2010
    Inventors: David Yue-wei Lee, Mario Canki
  • Salvinorin derivatives and uses thereof
    Patent number: 7629475
    Abstract: The invention features salvinorin compositions that are selective for kappa opioid receptors; methods of treating mania by using a selective kappa receptor agonist; and methods of treating mood disorders, such as depressive disorders and manic disorders, using salvinorin compositions.
    Type: Grant
    Filed: March 14, 2005
    Date of Patent: December 8, 2009
    Assignee: The McLean Hospital Corporation
    Inventors: Cécile Béquin, William A. Carlezon, Bruce M. Cohen, Minsheng He, David Yue-Wei Lee, Michele R. Richards, Lee-Yuan Liu-Chen
  • Androgenic steroid compounds and a method of making and using the same
    Patent number: 6864248
    Abstract: An androgenic steroid compound of the formula: wherein: X, Y, Z, R1, R2, R3, R5 and R6 are as defined herein.
    Type: Grant
    Filed: November 4, 2003
    Date of Patent: March 8, 2005
    Assignee: Research Triangle Institute
    Inventors: C. Edgar Cook, John A. Kepler, Yue-Wei Lee, Mansukh C. Wani
  • Androgenic steroid compounds and a method of making and using the same
    Publication number: 20040097477
    Abstract: An androgenic steroid compound of the formula: 1
    Type: Application
    Filed: November 4, 2003
    Publication date: May 20, 2004
    Applicant: Research Triangle Institute
    Inventors: C. Edgar Cook, John A. Kepler, Yue-Wei Lee, Mansukh C. Wani
  • Androgenic steroid compounds and a method of making and using the same
    Patent number: 6670352
    Abstract: An androgenic steroid compound of the formula: wherein: X, Y, Z, R1, R2, R3, R5 and R6 are as defined herein.
    Type: Grant
    Filed: January 22, 2002
    Date of Patent: December 30, 2003
    Assignee: Research Triangle Institute
    Inventors: C. Edgar Cook, John A. Kepler, Yue-Wei Lee, Mansukh C. Wani
  • Androgenic steroid compounds and a method of making and using the same
    Publication number: 20020103177
    Abstract: An androgenic steroid compound of the formula: 1
    Type: Application
    Filed: January 22, 2002
    Publication date: August 1, 2002
    Inventors: C. Edgar Cook, John A. Kepler, Yue-Wei Lee, Mansukh C. Wani
  • Androgenic steroid compounds and a method of making and using the same
    Patent number: 6369047
    Abstract: An androgenic steroid compound of the formula: wherein: X Y, Z, R1, R2, R3, R5 and R6 are as defined herein.
    Type: Grant
    Filed: June 9, 1999
    Date of Patent: April 9, 2002
    Assignee: Research Triangle Institute
    Inventors: C. Edgar Cook, John A. Kepler, Yue-Wei Lee, Mansukh C. Wani
  • ANDROGENIC STEROID COMPOUNDS AND A METHOD OF MAKING AND USING THE SAME
    Publication number: 20020002156
    Abstract: An androgenic steroid compound of the formula: 1
    Type: Application
    Filed: June 9, 1999
    Publication date: January 3, 2002
    Inventors: C. EDGAR COOK, JOHN A. KEPLER, YUE-WEI LEE, MANSUKH C. WANI
  • 17.beta.-nitro-11.beta.-arylsteroids and their derivatives having agonist or antagonist hormonal properties
    Patent number: 6093707
    Abstract: The invention is directed to a novel class of steroids which exhibit potent antiprogestational activity.
    Type: Grant
    Filed: November 5, 1999
    Date of Patent: July 25, 2000
    Assignee: Research Triangle Institute
    Inventors: C. Edgar Cook, John A. Kepler, Rupa S. Shetty, Gary S. Bartley, David Yue-wei Lee
  • 20-keto-11.beta.-arylsteroids and their derivatives having agonist or antagonist hormonal properties
    Patent number: 6020328
    Abstract: The invention is directed to 20-keto-11.beta.-arylsteroids of formula I: ##STR1## wherein R.sup.1, R.sup.6, R.sup.7, R.sup.9, R.sup.12 and X are as defined by the specification. The compounds exhibit progestational and antiprogestational activities.
    Type: Grant
    Filed: March 6, 1998
    Date of Patent: February 1, 2000
    Assignee: Research Triangle Institute
    Inventors: C. Edgar Cook, John A. Kepler, Ping-sheng Zhang, Yue-wei Lee, C. Ray Tallent
  • 17.beta.-nitro-11.beta.-arylisteroids and their derivatives having agonist or antagonist hormonal properties
    Patent number: 6015805
    Abstract: The invention is directed to 11.beta.-arylsteroids of formula II: ##STR1## wherein R.sup.1, R.sup.6, R.sup.8, R.sup.12 and X are as defined by the specification. The compounds exhibit potent antiprogestational activity and are useful in the treatment of fibroids, endometriosis, cervical ripening prior to delivery, hormone replacement therapy and in the control of fertility.
    Type: Grant
    Filed: May 25, 1999
    Date of Patent: January 18, 2000
    Assignee: Research Triangle Research North Carolina
    Inventors: C. Edgar Cook, John A. Kepler, Rupa S. Shetty, Gary S. Bartley, David Yue-wei Lee
  • 17.beta.-nitro-11.beta.-arylsteroids and their derivatives having agonist or antagonist hormonal properties
    Patent number: 5962444
    Abstract: The invention is directed to 17.beta.-nitro-11.beta.-arylsteroids of formula I: ##STR1## wherein R.sup.1, R.sup.6, R.sup.7, R.sup.12 and X are as defined by the specification. The compounds exhibit potent antiprogestational activity and are useful in the treatment of fibroids, endometriosis, cervical ripening prior to delivery, hormone replacement therapy and in the control of fertility.
    Type: Grant
    Filed: May 29, 1998
    Date of Patent: October 5, 1999
    Assignee: Research Triangle Institute
    Inventors: C. Edgar Cook, John A. Kepler, Rupa S. Shetty, Gary S. Bartley, David Yue-wei Lee
  • Androgenic steroid compounds and a method of making and using the same
    Patent number: 5952319
    Abstract: An androgenic steroid compound of the formula: ##STR1## wherein: X, Y, Z, R.sup.1, R.sup.2, R.sup.3, R.sup.5 and R.sup.6 are as defined herein.
    Type: Grant
    Filed: November 26, 1997
    Date of Patent: September 14, 1999
    Assignee: Research Triangle Institute
    Inventors: C. Edgar Cook, John A. Kepler, Yue-Wei Lee, Mansukh C. Wani
  • Hexahydroindenopyridine compounds having antispermatogenic activity
    Patent number: 5952336
    Abstract: Hexahydroindenopyridine compounds having the following formula and relative stereochemistry ##STR1## where R.sup.1 is C.sub.1-6 alkyl; R.sup.2 is hydrogen or C.sub.1-6 alkyl; R.sup.3 is carboxyl or a group which is metabolized to a carboxyl group under mammalian physiological conditions; R.sup.4 is halogen; mixtures of said compound and acid addition salts thereof exhibit potent antispermatogenic activity and are useful in a method of inhibiting spermatogenesis in mammals.
    Type: Grant
    Filed: January 31, 1997
    Date of Patent: September 14, 1999
    Assignee: Research Triangle Institute
    Inventors: C. Edgar Cook, Joseph M. Jump, Pingsheng Zhang, John R. Stephens, Patricia A. Fail, Yue-Wei Lee, Mansukh C. Wani
  • Method for treating alcohol dependence
    Patent number: 5783189
    Abstract: Isoflavonoids containing a carbon-carbon linked .beta.-D-glucose moiety at the C-8 position and isolated from the Chinese herbal plant Pueraria lobata are useful for treating alcohol dependence.
    Type: Grant
    Filed: April 23, 1996
    Date of Patent: July 21, 1998
    Assignee: Natural Pharmacia International, Inc.
    Inventors: Yue-Hu Pei, David Overstreet, Amir Hosein Rezvani, David Yue-Wei Lee
  • Derivatives of 2-nitro-imidazoles as hypoxic cell markers
    Patent number: 5674693
    Abstract: Derivatives of 2-nitro-imidazole, such as 1-(2-hydroxy-3-piperidinopropyl)-2-nitro-imidazole, are useful as hypoxic cell markers for immunochemical detection of hypoxia in tumor tissue.
    Type: Grant
    Filed: March 18, 1994
    Date of Patent: October 7, 1997
    Assignee: Natural Pharmacia International Inc.
    Inventors: James Arthur Raleigh, David Yue-Wei Lee
  • Hexahydroindenopyridine compounds having antispermatogenic activity
    Patent number: 5319084
    Abstract: Hexahydroindenopyridine compounds having the following formula and relative stereochemistry ##STR1## where R.sup.1 is C.sub.1-6 alkyl, R.sup.2 is hydrogen or C.sub.1-6 alkyl and R.sup.3 is carboxyl or a group which is metabolized to a carboxyl group under mammalian physiological conditions exhibit potent antispermatogenic activity and are useful in a method of inhibiting spermatogenesis in mammals.
    Type: Grant
    Filed: August 16, 1993
    Date of Patent: June 7, 1994
    Assignee: Research Triangle Institute
    Inventors: C. Edgar Cook, Yue-Wei Lee, Mansukh C. Wani, Patricia A. Fail, Joseph M. Jump