Patents by Inventor Yueh-Liang Tsou

Yueh-Liang Tsou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220348652
    Abstract: Disclosed herein are recombinant antibodies exhibiting binding affinity to CD47 polypeptide. According to some embodiments of the present disclosure, the recombinant antibodies are capable of blocking the interaction of CD47 and signal receptor protein-alpha (SIRP?). Accordingly, also disclosed herein are pharmaceutical compositions comprising the recombinant antibodies, and uses thereof in the treatment CD47-related diseases.
    Type: Application
    Filed: April 22, 2022
    Publication date: November 3, 2022
    Applicant: AnTaimmu BioMed Co., Ltd.
    Inventors: San-Tai SHEN, Yueh-Liang TSOU, Jen-Chieh LIN, Chia-Chi LIU
  • Patent number: 11434277
    Abstract: Disclosed herein are methods for high-throughput screening of a virus-specific neutralizing antibody. According to certain embodiments of the present disclosure, the virus is an influenza virus. Also disclosed herein are the antibodies selected by the high-throughput screening method, and the uses thereof in the prophylaxis and/or treatment of viral infection.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: September 6, 2022
    Assignee: ACADEMIA SINICA
    Inventors: An-Suei Yang, Ing-Chien Chen, Yi-Kai Chiu, Chung-Ming Yu, Cheng-Chung Lee, Chao-Ping Tung, Yueh-Liang Tsou, Yi-Jen Huang, Chia-Lung Lin, Hong-Sen Chen, Hwei-Jiung Wang
  • Publication number: 20210070843
    Abstract: Disclosed herein are methods for high-throughput screening of a virus-specific neutralizing antibody. According to certain embodiments of the present disclosure, the virus is an influenza virus. Also disclosed herein are the antibodies selected by the high-throughput screening method, and the uses thereof in the prophylaxis and/or treatment of viral infection.
    Type: Application
    Filed: October 19, 2018
    Publication date: March 11, 2021
    Inventors: An-Suei YANG, Ing-Chien CHEN, Yi-Kai CHIU, Chung-Ming YU, Cheng-Chung LEE, Chao-Ping TUNG, Yueh-Liang TSOU, Yi-Jen HUANG, Chia-Lung LIN, Hong-Sen CHEN, Hwei-Jiung WANG
  • Patent number: 10752673
    Abstract: Disclosed herein are methods for high-throughput screening of a functional antibody fragment for an immunoconjugate that targets a protein antigen. The method combines a phage-displayed synthetic antibody library and high-throughput cytotoxicity screening of non-covalently assembled immunotoxins or cytotoxic drug to identify highly functional synthetic antibody fragments for delivering toxin payloads.
    Type: Grant
    Filed: June 12, 2017
    Date of Patent: August 25, 2020
    Assignee: ACADEMIA SINICA
    Inventors: An-Suei Yang, Hong-Sen Chen, Chung-Ming Yu, Shin-Chen Hou, Wei-Ying Kuo, Yi-Kai Chiu, Yueh-Liang Tsou, Hung-Ju Hsu, Hwei-Jiung Wang, Shih-Hsien Chuang, Chao-Pin Lee
  • Patent number: 10562976
    Abstract: Disclosed herein is an immunoconjugate comprising an antibody, a functional motif, and a linker connecting the functional motif to the antibody. According to embodiments of the present disclosure, the antibody may recognize tumor-associated antigens (TAAs), and serves as a targeting module for delivering the functional motif connected therewith to the tumor cells thereby inhibiting tumor growth or detecting the distribution of tumor cells. Also disclosed herein are methods of treating cancers and methods of diagnosing cancers by use of the present immunoconjugate.
    Type: Grant
    Filed: October 22, 2018
    Date of Patent: February 18, 2020
    Assignee: Academia Sinica
    Inventors: An-Suei Yang, Wei-Ying Kuo, Hung-Ju Hsu, Hong-Sen Chen, Yu-Chi Chou, Yueh-Liang Tsou, Hung-Pin Peng, Jhih-Wei Jian, Chung-Ming Yu, Yi-Kai Chiu, Ing-Chein Chen, Chao-Ping Tung, Michael Hsiao, Hwei-Jiung Wang
  • Publication number: 20190040151
    Abstract: Disclosed herein is an immunoconjugate comprising an antibody, a functional motif, and a linker connecting the functional motif to the antibody. According to embodiments of the present disclosure, the antibody may recognize tumor-associated antigens (TAAs), and serves as a targeting module for delivering the functional motif connected therewith to the tumor cells thereby inhibiting tumor growth or detecting the distribution of tumor cells. Also disclosed herein are methods of treating cancers and methods of diagnosing cancers by use of the present immunoconjugate.
    Type: Application
    Filed: October 22, 2018
    Publication date: February 7, 2019
    Applicant: Academia Sinica
    Inventors: An-Suei YANG, Wei-Ying KUO, Hung-Ju HSU, Hong-Sen CHEN, Yu-Chi CHOU, Yueh-Liang TSOU, Hung-Pin PENG, Jhih-Wei JIAN, Chung-Ming YU, Yi-Kai CHIU, Ing-Chein CHEN, Chao-Ping TUNG, Michael HSIAO, Hwei-Jiung WANG
  • Patent number: 10004796
    Abstract: The present invention relates to a recombinant adenoviral vector for generating immunity against enterovirus infection. In one embodiment, the recombinant adenoviral vector of the invention comprises an expression cassette encoding a PI protein and a 3 CD protease of an enterovirus. In another embodiment, the recombinant adenoviral vector of the invention comprises an expression cassette encoding a 3C protease or a 3CD protease of an enterovirus. The present invention also relates to a vaccine composition comprising the recombinant adenoviral vector as described. A method of inducing an immune response in a subject against enterovirus infection using the recombinant adenoviral vector and the vaccine composition is provided. Further provided is a method for producing virus like particles of an enterovirus by expressing the adenoviral vector as described herein in mammalian cells.
    Type: Grant
    Filed: March 26, 2015
    Date of Patent: June 26, 2018
    Assignee: National Health Research Institutes
    Inventors: Yen-Hung Chow, Yueh-Liang Tsou, Pele Choi-Sing Chong
  • Publication number: 20170355750
    Abstract: Disclosed herein are methods for high-throughput screening of a functional antibody fragment for an immunoconjugate that targets a protein antigen. The method combines a phage-displayed synthetic antibody library and high-throughput cytotoxicity screening of non-covalently assembled immunotoxins or cytotoxic drug to identify highly functional synthetic antibody fragments for delivering toxin payloads.
    Type: Application
    Filed: June 12, 2017
    Publication date: December 14, 2017
    Applicant: Academia Sinica
    Inventors: An-Suei YANG, Hong-Sen CHEN, Chung-Ming YU, Shin-Chen HOU, Wei-Ying KUO, Yi-Kai CHIU, Yueh-Liang TSOU, Hung-Ju HSU, Hwei-Jiung WANG, Shih-Hsien CHUANG, Chao-Pin LEE
  • Publication number: 20170056491
    Abstract: The present invention relates to a recombinant adenoviral vector for generating immunity against enterovirus infection. In one embodiment, the recombinant adenoviral vector of the invention comprises an expression cassette encoding a PI protein and a 3 CD protease of an enterovirus. In another embodiment, the recombinant adenoviral vector of the invention comprises an expression cassette encoding a 3C protease or a 3CD protease of an enterovirus. The present invention also relates to a vaccine composition comprising the recombinant adenoviral vector as described. A method of inducing an immune response in a subject against enterovirus infection using the recombinant adenoviral vector and the vaccine composition is provided. Further provided is a method for producing virus like particles of an enterovirus by expressing the adenoviral vector as described herein in mammalian cells.
    Type: Application
    Filed: March 26, 2015
    Publication date: March 2, 2017
    Inventors: Yen-Hung Chow, Yueh-Liang Tsou, Pele Choi-Sing Chong