Patents by Inventor Yufang Xu

Yufang Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11306095
    Abstract: The present invention relates to a pteridinone derivative serving as an EGFR inhibitor and use thereof. Specifically, the present invention relates to a compound represented by the following formula I, pharmaceutical composition comprising the compound of the following formula I, and use of the compound in preparation of drugs for treating EGFR-mediated diseases or inhibiting EGFR.
    Type: Grant
    Filed: May 30, 2016
    Date of Patent: April 19, 2022
    Assignee: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Honglin Li, Yufang Xu, Zhenjiang Zhao, Wei Zhou, Yuqiong Xu, Deheng Sun, Xia Wang, Zhuo Chen
  • Publication number: 20220098134
    Abstract: The present invention provides a compound as represented by formula I, or a pharmaceutically acceptable salt or ester, a prodrug, an optical isomer, a stereoisomer, or a solvate thereof. The compound provided by the present invention can be used for preparing drugs for preventing or treating hypertension, or hypertension-related diseases, or pulmonary hypertension, or pulmonary hypertension-related diseases. The compound provided by the present invention has a different mechanism from existing drugs for treating hypertension and pulmonary hypertension, thereby laying a new material foundation for the development of drugs for treating hypertension and pulmonary hypertension.
    Type: Application
    Filed: June 12, 2020
    Publication date: March 31, 2022
    Inventors: Honglin LI, Zhenjiang ZHAO, Rui WANG, Yinchu SHEN, Jianjun FU, Yufang XU, Xuhong QIAN, Qian JIAO, Shiliang LI
  • Publication number: 20210179598
    Abstract: Provided is a selective JAK2 inhibitor and application thereof. In particular, it relates to the compound of the following Formula (I), and the use of the compound in the treatment of JAK2-mediated related diseases and in the preparation of the medicament for treating JAK2-mediated related diseases.
    Type: Application
    Filed: April 12, 2019
    Publication date: June 17, 2021
    Applicant: East China University of Science and Technology
    Inventors: Honglin LI, Yufang XU, Zhenjiang ZHAO, Lili ZHU
  • Publication number: 20210155604
    Abstract: Related to a quinazoline compound serving as an EFGR triple mutation inhibitor and applications thereof. Specifically, disclosed are a compound as represented by the following formula (I), a pharmaceutical composition comprising the compound of formula (I), and applications of the compound in treating a related disease mediated by EGFR and in a medicament for treating the related disease mediated by EGFR.
    Type: Application
    Filed: April 12, 2019
    Publication date: May 27, 2021
    Inventors: Honglin LI, Jian DING, Yufang XU, Hua XIE, Qiannan LI, Tao ZHANG, Zhenjiang ZHAO
  • Patent number: 10919869
    Abstract: A thiazole derivative serving as a DHODH inhibitor, and applications thereof. The present invention specifically relates to a compound represented by formula I, a pharmaceutical composition containing the compound represented by formula (I), and applications of the compound in the preparation of drugs for treating diseases mediated by the DHODH or drugs for inhibiting the DHODH.
    Type: Grant
    Filed: May 17, 2017
    Date of Patent: February 16, 2021
    Assignee: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Honglin Li, Yufang Xu, Rui Wang, Zhenjiang Zhao, Wenlin Song, Liuxin Xu
  • Patent number: 10479798
    Abstract: The present invention relates to six-membered ring benzo derivatives as a DPP-4 inhibitor and a use thereof. In particular, the present invention relates to a compound as shown in formula I, a pharmaceutical composition containing the compound as shown in formula I and a use of the compound in the preparation of drugs for treating DPP-4 related diseases or inhibiting DPP-4.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: November 19, 2019
    Assignees: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY, SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
    Inventors: Honglin Li, Hualiang Jiang, Yufang Xu, Jia Li, Zhenjiang Zhao, Jingya Li, Hongling Xu, Shiliang Li
  • Publication number: 20190292162
    Abstract: A thiazole derivative serving as a DHODH inhibitor, and applications thereof. The present invention specifically relates to a compound represented by formula I, a pharmaceutical composition containing the compound represented by formula (I), and applications of the compound in the preparation of drugs for treating diseases mediated by the DHODH or drugs for inhibiting the DHODH.
    Type: Application
    Filed: May 17, 2017
    Publication date: September 26, 2019
    Inventors: Honglin LI, Yufang XU, Rui WANG, Zhenjiang ZHAO, Wenlin SONG, Liuxin XU
  • Publication number: 20190290620
    Abstract: The present invention relates to applications of a novel thiazole derivative in treating ulcerative colitis and in the preparation of drugs for treating ulcerative colitis.
    Type: Application
    Filed: May 17, 2017
    Publication date: September 26, 2019
    Inventors: Honglin LI, Zhenjiang ZHAO, Rui WANG, Yufang XU, Wanqi WANG, Yingfang YANG
  • Publication number: 20190134008
    Abstract: Provided are applications of a thiazole derivative in treating virus infection and in the preparation of drugs for treating virus infection.
    Type: Application
    Filed: June 2, 2017
    Publication date: May 9, 2019
    Inventors: Ke XU, Honglin LI, Yufang XU, Zhenjiang ZHAO, Lili ZHU, Wenlin SONG, Yi TONG
  • Publication number: 20180148454
    Abstract: The present invention relates to a pteridinone derivative serving as an EGFR inhibitor and use thereof. Specifically, the present invention relates to a compound represented by the following formula I, pharmaceutical composition comprising the compound of the following formula I, and use of the compound in preparation of drugs for treating EGFR-mediated diseases or inhibiting EGFR.
    Type: Application
    Filed: May 30, 2016
    Publication date: May 31, 2018
    Inventors: Honglin LI, Yufang XU, Zhenjiang ZHAO, Wei ZHOU, Yuqiong XU, Deheng SUN, Xia WANG, Zhuo CHEN
  • Patent number: 9896033
    Abstract: A semi-automatic foot-pedal device is provided, which includes a panel and a pedal-connecting component connected with the panel. The pedal-connecting component includes an upper bracket, a left bracket, a lower bracket, a right bracket and an elastic unit; when the pedal-connecting component is in a closed state, the panel moves away from the upper bracket to transform the pedal-connecting component into an elastically spread state under a force on the panel in a downward direction and the elastic unit generates pushing force toward its two opposite directions; when the pedal-connecting component is in a spread state, the panel moves towards the upper bracket to transform the pedal-connecting component into an elastically closed state under a force on the panel in an obliquely-upward direction and the elastic unit generates pushing force toward its two opposite directions.
    Type: Grant
    Filed: February 20, 2017
    Date of Patent: February 20, 2018
    Assignee: WINBO-DONGJIAN AUTOMOTIVE TECHNOLOGY CO., LTD.
    Inventors: Yongbo Chen, Jie Yang, Wei Huang, Ming Zhong, Wei Hu, Yufang Xu
  • Publication number: 20170313715
    Abstract: The present invention relates to six-membered ring benzo derivatives as a DPP-4 inhibitor and a use thereof. In particular, the present invention relates to a compound as shown in formula I, a pharmaceutical composition containing the compound as shown in formula I and a use of the compound in the preparation of drugs for treating DPP-4 related diseases or inhibiting DPP-4.
    Type: Application
    Filed: October 30, 2015
    Publication date: November 2, 2017
    Inventors: Honglin LI, Hualiang JIANG, Yufang XU, Jia LI, Zhenjiang ZHAO, Jingya LI, Hongling XU, Shiliang LI
  • Publication number: 20170158140
    Abstract: A semi-automatic foot-pedal device is provided, which includes a panel and a pedal-connecting component connected with the panel. The pedal-connecting component includes an upper bracket, a left bracket, a lower bracket, a right bracket and an elastic unit; when the pedal-connecting component is in a closed state, the panel moves away from the upper bracket to transform the pedal-connecting component into an elastically spread state under a force on the panel in a downward direction and the elastic unit generates pushing force toward its two opposite directions; when the pedal-connecting component is in a spread state, the panel moves towards the upper bracket to transform the pedal-connecting component into an elastically closed state under a force on the panel in an obliquely-upward direction and the elastic unit generates pushing force toward its two opposite directions.
    Type: Application
    Filed: February 20, 2017
    Publication date: June 8, 2017
    Inventors: YONGBO CHEN, JIE YANG, WEI HUANG, MING ZHONG, WEI HU, YUFANG XU
  • Patent number: 9670213
    Abstract: Provided are a pteridine ketone derivative used as an EGFR, BLK, and FLT3 inhibitor and applications thereof. Specifically, provided are a compound of the following formula I, a pharmaceutical composition containing the compound of the formula I, and use of compound in preparing medicine for treating diseases mediated by EGFR, BLK, or FLT3 or inhibiting EGFR, BLK, and FLT3.
    Type: Grant
    Filed: April 2, 2013
    Date of Patent: June 6, 2017
    Assignee: East China University of Science and Technology
    Inventors: Honglin Li, Yufang Xu, Zhenjiang Zhao, Xiaofeng Liu, Wei Zhou, Fang Bai, Mengzhu Xue, Lei Zhang, Youli Zhang
  • Patent number: 9573467
    Abstract: A semi-automatic foot-pedal device is provided, which comprises a panel and a pedal-connecting component connected with the panel. The pedal-connecting component comprises an upper bracket, a left bracket, a lower bracket, a right bracket and an elastic unit; when the pedal-connecting component is in a closed state, the panel moves away from the upper bracket to transform the pedal-connecting component into an elastically spread state under a force on the panel in a downward direction; when the pedal-connecting component is in a spread state, the panel moves towards the upper bracket to transform the pedal-connecting component into an elastically closed state under a force on the panel in an obliquely-upward direction. The semi-automatic foot-pedal device of the present disclosure has a novel structure, and does not need a conventional motor system, so it saves the electric power and is safer to use.
    Type: Grant
    Filed: December 17, 2014
    Date of Patent: February 21, 2017
    Assignee: WINBO DONGJIAN AUTO ACCESSORIES MANUFACTURING CO., LTD.
    Inventors: Yongbo Chen, Jie Yang, Wei Huang, Ming Zhong, Wei Hu, Yufang Xu
  • Publication number: 20160089975
    Abstract: A semi-automatic foot-pedal device is provided, which comprises a panel and a pedal-connecting component connected with the panel. The pedal-connecting component comprises an upper bracket, a left bracket, a lower bracket, a right bracket and an elastic unit; when the pedal-connecting component is in a closed state, the panel moves away from the upper bracket to transform the pedal-connecting component into an elastically spread state under a force on the panel in a downward direction; when the pedal-connecting component is in a spread state, the panel moves towards the upper bracket to transform the pedal-connecting component into an elastically closed state under a force on the panel in an obliquely-upward direction. The semi-automatic foot-pedal device of the present disclosure has a novel structure, and does not need a conventional motor system, so it saves the electric power and is safer to use.
    Type: Application
    Filed: December 17, 2014
    Publication date: March 31, 2016
    Inventors: YONGBO CHEN, JIE YANG, WEI HUANG, MING ZHONG, WEI HU, YUFANG XU
  • Publication number: 20150126508
    Abstract: Provided are a pteridine ketone derivative used as an EGFR, BLK, and FLT3 inhibitor and applications thereof. Specifically, provided are a compound of the following formula I, a pharmaceutical composition containing the compound of the formula I, and use of compound in preparing medicine for treating diseases mediated by EGFR, BLK, or FLT3 or inhibiting EGFR, BLK, and FLT3.
    Type: Application
    Filed: April 2, 2013
    Publication date: May 7, 2015
    Inventors: Honglin Li, Yufang Xu, Zhenjiang Zhao, Xiaofeng Liu, Wei Zhou, Fang Bai, Mengzhu Xue, Lei Zhang, Youli Zhang
  • Patent number: 7541463
    Abstract: The invention discloses novel sulfur-containing naphthalimide derivatives, and the preparation and uses thereof. The conjugated plane of naphthalimide derivatives of the invention is enlarged by incorporating 5-or 6-membered heteroaromatic ring and/or introducing S heteroatom, thus increasing the anti-tumor activity of naphthalimide. The compounds of the invention displays significant inhibiting activities to the proliferation of various tumor cells such as human lung cancer, gastric cancer, liver cancer, leucocythemia and the like. The inhibition of cell proliferation is dose-dependent.
    Type: Grant
    Filed: October 31, 2005
    Date of Patent: June 2, 2009
    Assignees: East China University of Science and Technology, Shanghai Institute of Materia Medica, Chinese Academy of Science, Dalian University of Technology
    Inventors: Xuhong Qian, Yonggang Li, Yufang Xu, Jian Ding, Liping Lin, Zehong Miao, Hong Zhu, Baoyuan Qu
  • Publication number: 20080234287
    Abstract: The invention discloses novel sulfur-containing naphthalimide derivatives, and the preparation and uses thereof. The conjugated plane of naphthalimide derivatives of the invention is enlarged by incorporating 5- or 6-membered heteroaromatic ring and/or introducing S heteroatom, thus increasing the anti-tumor activity of naphthalimide. The compounds of the invention displays significant inhibiting activities to the proliferation of various tumor cells such as human lung cancer, gastric cancer, liver cancer, leucocythemia and the like. The inhibition of cell proliferation is dose-dependent.
    Type: Application
    Filed: May 7, 2008
    Publication date: September 25, 2008
    Inventors: Xuhong Qian, Yonggang Li, Yufang Xu, Jian Ding, Liping Lin, Zehong Miao, Hong Zhu, Baoyuan Qu
  • Publication number: 20060111367
    Abstract: The invention discloses novel sulfur-containing naphthalimide derivatives, and the preparation and uses thereof. The conjugated plane of naphthalimide derivatives of the invention is enlarged by incorporating 5-or 6-membered heteroaromatic ring and/or introducing S heteroatom, thus increasing the anti-tumor activity of naphthalimide. The compounds of the invention displays significant inhibiting activities to the proliferation of various tumor cells such as human lung cancer, gastric cancer, liver cancer, leucocythemia and the like. The inhibition of cell proliferation is dose-dependent.
    Type: Application
    Filed: October 31, 2005
    Publication date: May 25, 2006
    Inventors: Xuhong Qian, Yonggang Li, Yufang Xu, Jian Ding, Liping Lin, Zehong Miao, Hong Zhu, Baoyuan Qu