Patents by Inventor Yuichi Hirata

Yuichi Hirata has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20050039222
    Abstract: A targeting vector was constructed by replacing exon regions in the SGRF gene with appropriate drug marker genes. This vector was transfected into mouse ES cell lines to obtain chimeric mice, which were then crossed with C57BL/6J mice to obtain mice comprising cells in which one SGRF gene alleles was inactivated. By crossing these mice with each other, the present inventors succeeded in producing mice in which both SGRF gene alleles were inactivated. These genetically modified animals can be used to predict the side effects of drugs such as SGRF antagonists.
    Type: Application
    Filed: October 24, 2002
    Publication date: February 17, 2005
    Inventors: Kiyoshi Habu, Yuichi Hirata
  • Patent number: 6828426
    Abstract: A novel human gene having a significant homology with a VEGF-C gene, a member of the VEGF family, has been isolated by the PCR method using primers designed based on the sequence of EST that is assumed to be homologous with the C-terminal region of the VEGF-C gene. Mouse and rat genes have been isolated based on the human gene isolated as above. A protein encoded by the above human gene has been isolated by introducing the gene into Escherichia coli and expressing it. The isolated protein and genes can be applied to, for example, gene therapy for the VEGF-D deficiency, wound healing, and promotion of collateral vessel formation. Furthermore, VEGF-D protein inhibitors can be used as a novel anticancer drug, etc.
    Type: Grant
    Filed: January 14, 1999
    Date of Patent: December 7, 2004
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Yuichi Hirata, Junichi Nezu
  • Publication number: 20030180256
    Abstract: A full-length cDNA corresponding to an EST (AA418955), which does not show any homology to other proteins in the database but has a weak homology to G-CSF, has been successfully isolated by synthesizing printers based on the EST sequence, and effecting PCR-cloning from a human fetal spleen library. Sequencing of the thus-isolated cDNA and analysis of its structure revealed that the cDNA has typical characteristics of a factor belonging to the IL-6/G-CSF/MGF family. It is also found out that the culture supernatant of said sequence-transfected CHO cells shows a proliferation supporting activity towards bone marrow cells in the coexistence of kit ligand.
    Type: Application
    Filed: May 15, 2003
    Publication date: September 25, 2003
    Applicant: Chugai Seiyaku Kabushiki Kaisha, a Japanese corporation
    Inventor: Yuichi Hirata
  • Patent number: 6610285
    Abstract: A full-length cDNA corresponding to an EST (AA418955), which does not show any homology to other proteins in the database but has a weak homology to G-CSF, has been successfully isolated by synthesizing primers based on the EST sequence, and effecting PCR-cloning from a human fetal spleen library. Sequencing of the thus-isolated cDNA and analysis of its structure revealed that the cDNA has typical characteristics of a factor belonging to the IL-6/G-CSF/MGF family. It is also found out that the culture supernatant of said sequence-transfected CHO cells shows a proliferation supporting activity towards bone marrow cells in the coexistence of kit ligand.
    Type: Grant
    Filed: October 13, 2000
    Date of Patent: August 26, 2003
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventor: Yuichi Hirata
  • Publication number: 20030115746
    Abstract: A car side panel assembly line capable of increasing a productivity by shortening an operation time and having a set station ST2, a welding station ST3, and a next operation station ST4 disposed in series in this order, comprising a set carriage 91 having, thereon, a set jig 91 capable of holding the side panel W in upright attitude from the side and installed reciprocatingly between the set station ST2 and the welding station ST3 and a frame carriage 81 having a lower frame 80 and an upper frame 81, capable of holding, between both frames 80, 81, the side panel W in upright attitude through clamp members (821, 822, 823, 831, 832, 833) mounted on the frames 80, 81, installed reciprocatingly between the welding station ST3 and the next operation station ST4, and allowing to exchange the side panel W with the set carriage 91.
    Type: Application
    Filed: January 6, 2003
    Publication date: June 26, 2003
    Inventors: Hideo Saito, Yuichi Hirata, Satoru Matsuo, Masayuki Fukumori, Shinji Ikeda, Makoto Urano, Kazunao Uchiyama, Takeshi Endo, Chitoshi Kato, Hidetaka Murai, Yuki Mori, Yukihiro Yaguchi
  • Publication number: 20020177194
    Abstract: Several ESTs deduced as a part of a cDNA encoding a protein that is homologous with a membrane-bound steroid binding protein PMBP were found. Based on the sequence data of these ESTs, a consensus sequence was extracted, and primers were designed based on this consensus sequence. Using the thus designed primers, a polymerase chain reaction of human genes was effected. As a result, a gene encoding a novel steroid hormone binding protein that is homologous with PMBP was successfully isolated from a human for the first time.
    Type: Application
    Filed: June 7, 2002
    Publication date: November 28, 2002
    Applicant: Chugai Seiyaku Kabushiki Kaisha, a Japanese corporation
    Inventor: Yuichi Hirata
  • Patent number: 6432674
    Abstract: Several ESTs deduced as a part of a cDNA encoding a protein that is homologous with a membrane-bound steroid binding protein PMBP were found. Based on the sequence data of these ESTs, a consensus sequence was extracted, and primers were designed based on this consensus sequence. Using the thus designed primers, a polymerase chain reaction of human genes was effected. As a result, a gene encoding a novel steroid hormone binding protein that is homologous with PMBP was successfully isolated from a human for the first time.
    Type: Grant
    Filed: May 5, 2000
    Date of Patent: August 13, 2002
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventor: Yuichi Hirata
  • Patent number: 6121423
    Abstract: A reshaped antibody comprising:(A) L chains comprising:(1) a human C region, and(2) an L chain V region comprising human L chain FRs and L chain CDRs of a mouse monoclonal antibody; and(B) H chains comprising:(1) a human H chain C region, and(2) an H chain V region comprising human H chain FRs, and H chain CDRs of a mouse monoclonal antibody to human IL-6. Since the major portions of the reshaped human antibody are derived from human, and the mouse CDRs are less immunogenic, then the present reshaped human antibody is less immunogenic, and therefore inhibits information transfer by IL-6, and is promising as a therapeutic agent for diseases caused by IL-6.
    Type: Grant
    Filed: December 4, 1998
    Date of Patent: September 19, 2000
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Masayuki Tsuchiya, Koh Sato, Yuichi Hirata
  • Patent number: 5856135
    Abstract: A reshaped antibody comprising:(A) L chains comprising:(1) a human C region, and(2) an L chain V region comprising human L chain FRs and L chain CDRs of a mouse monoclonal antibody; and(B) H chains comprising:(1) a human H chain C region, and(2) an H chain V region comprising human H chain FRs, and H chain cDRs of a mouse monoclonal antibody to human IL-6. Since the major portions of the reshaped human antibody are derived from human, and the mouse CDRs are less immunogenic, then the present reshaped human antibody is less immunogenic, and therefore inhibits information transfer by IL-6, and is promising as a therapeutic agent for diseases caused by IL-6.
    Type: Grant
    Filed: February 20, 1996
    Date of Patent: January 5, 1999
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Masayuki Tsuchiya, Koh Sato, Yuichi Hirata