Abstract: An objective is to provide an Fc-modified antibody or the like having a long serum half-life according to a CCAP method, more specifically, an antibody or the like where IgBP is bound to only one site, based on findings of the inventors. Provided is an objective antibody or the like by purification and production of an Fc-modified antibody or the like with a column bound to an Fc region of an antibody. Specifically, an antibody where only one of two binding sites of Fc is selectively modified is provided by allowing an IgBP-bound antibody produced by a CCAP method to adsorb to a carrier of an IgBP-immobilized column, or forming a state where only one Fc of an antibody is bound to an IgBP binding column and then adding a peptide reagent for CCAP to the column to perform a reaction of a CCAP method in the column.

Abstract: It is an object of the present invention to provide a method for modifying an antibody in a specific and simple manner, and others. The present invention relates to: an IgG-binding peptide, an IgG-binding peptide modified with a crosslinking agent, a complex of an IgG-binding peptide modified with the crosslinking agent and IgG, a method for producing the complex, and others.

Abstract: The present invention provides a compound represented by formula [I] shown below or a pharmaceutically acceptable salt thereof that has an inhibitory effect on 20-HETE producing enzyme.

Abstract: A stirring and defoaming device is a stirring and defoaming device of a revolution and rotation type, wherein a vacuum unit for sucking air in each container to bring the inside of each container into a vacuum state includes sealing bodies that seal respective containers, a vacuum generation source, a suction path running toward a revolution center with each container as a starting end, passing through the revolution center to go outside the system, and reaching the vacuum generation source placed outside the system, at least part of the suction path being an independent path from the starting end in association with each container, and at least two or more vacuum measurement units, each provided in an independent path.

Abstract: A component production method includes: a step of binding a long frame by a plurality of support devices arranged along the frame; a step of measuring, with a distance sensor, a distance to the frame supported by the plurality of support devices; a step in which, based on frame shape data prerecorded in a memory, the support devices move support positions where the frame is supported so that a calculated radial position of the frame being supported by the support devices matches the data about the frame shape; a step of fixing the frame in a state in which the data about the frame shape matches the radial position of the frame; and a step of performing a hole-making operation on the fixed frame.

Abstract: The invention relates to an antibody which binds to myelin oligodendrocyte glycoprotein (MOG), an antibody fragment thereof, a hybridoma which produces the antibody or the antibody fragment, a nucleic acid containing a nucleotide sequence which encodes the antibody or the antibody fragment, a transformant cell containing a vector containing the nucleic acid, a method for producing the antibody or the antibody fragment, a composition containing the antibody or the antibody fragment and a method for detecting or measuring an antigen that is present in the brain, a method for diagnosing or treating a brain disease, a method for improving the property of an antibody of accumulating in the brain and a method for increasing the amount of an antibody in the brain which use the antibody or the antibody fragment.

Abstract: A drive apparatus is provided for driving a multi-phase rotating electric machine. The rotating electric machine includes a plurality of winding groups for respective phases. The drive apparatus includes a first inverter connected with start terminals of the winding groups of the rotating electric machine, a second inverter connected with intermediate terminals of the winding groups, and an energization controller configured to selectively perform energization of the winding groups by the first inverter and energization of the winding groups by the second inverter. Each of the first and second inverters includes a plurality of switch pairs respectively corresponding to the winding groups and each consisting of an upper-arm switch and a lower-arm switch that are connected in series with each other. Moreover, each of the upper-arm and lower-arm switches of the first inverter is configured to have bidirectionally-conducting and bidirectionally-blocking functions.

Abstract: The purpose of the present invention is to provide a solid-phase carrier on which an IgG-binding peptide is immobilized, the peptide being usable for IgG purification, having resistance to repeated washing with an alkaline solution after IgG purification, and having a high binding affinity for IgG. Specifically, the present invention relates to a solid-phase carrier on which an IgG-binding peptide is immobilized, wherein the two cysteine residues on the outside of the peptide are linked as shown in the following formula: (in the formula, the upper cysteine residue is on the N-terminal side of the peptide, and the lower cysteine residue is on the C-terminal side of the peptide).

Abstract: The present invention provides an IgG-binding peptide which can be used for the purification of IgG and has excellent stability, e.g., alkali stability. The present invention also provides a method for purifying IgG using the IgG-binding peptide. Specifically, the present invention relates to a solid-phase support including an IgG-binding peptide, an IgG separation column including the solid-phase support, a kit including the solid-phase support or the column, and a method for purifying IgG using the solid-phase support or the column.

Abstract: An object of the present invention is to provide a method by which a peptide having a specific binding capability that can be used for purification of a target molecule can be produced at a low cost, and specifically relates to a peptide fusion protein including one or more peptides having specific binding capability and a scaffold protein, the peptide being inserted into the amino acid sequence of the scaffold protein directly or via a peptide linker, and/or being linked to the N-terminal and/or C-terminal of the scaffold protein.

Abstract: The invention relates to an antibody which binds to myelin oligodendrocyte glycoprotein (MOG), an antibody fragment thereof, a hybridoma which produces the antibody or the antibody fragment, a nucleic acid containing a nucleotide sequence which encodes the antibody or the antibody fragment, a transformant cell containing a vector containing the nucleic acid, a method for producing the antibody or the antibody fragment, a composition containing the antibody or the antibody fragment and a method for detecting or measuring an antigen that is present in the brain, a method for diagnosing or treating a brain disease, a method for improving the property of an antibody of accumulating in the brain and a method for increasing the amount of an antibody in the brain which use the antibody or the antibody fragment.

Abstract: The present invention relates to a carrier core material for electrophotographic developer, having a ferrite composition and having a supernatant transmittance of 85.0% or more, a method for producing the carrier core material, a carrier for electrophotographic developer, containing the carrier core material, and a developer containing the carrier.

Abstract: The invention relates to an antibody which binds to chondroitin sulfate proteoglycan 5 (CSPG5) or an antibody fragment thereof, a hybridoma which produces the antibody or the antibody fragment thereof, a nucleic acid comprising a nucleotide sequence encoding the antibody or the antibody fragment thereof, a transformant cell comprising a vector comprising the nucleic acid, a method for producing the antibody or the antibody fragment thereof, a composition comprising the antibody or the antibody fragment thereof, and a method for detecting or measuring an antigen present in the brain, a method for diagnosing or treating a brain disease, a method for enhancing the property of accumulating in a brain of an antibody, and a method for increasing the amount of an antibody in the brain, each of which using the antibody or the antibody fragment thereof, and the like.

Abstract: Provision of an affinity carrier using a mutant VHH antibody. An affinity carrier comprising: a solid phase carrier; and an immunoglobulin-binding protein bound to the solid phase carrier; wherein the immunoglobulin-binding protein comprises a mutant VHH antibody or a fragment of the mutant VHH antibody that recognizes an epitope in at least one region selected from the group consisting of amino acids 127 to 184 of SEQ ID NO: 22 and amino acids 13 to 210 of SEQ ID NO: 23.

Abstract: The invention provides a hair cosmetic comprising a novel block copolymer capable of sustainably imparting properties such as slipperiness to hair. The hair cosmetic of the present invention comprises a block copolymer having a hydrophobic segment and a hydrophilic segment, wherein the hydrophobic segment has a monomer unit composed of at least one monomer selected from the following Formula 1 and Formula 2, wherein the hydrophilic segment has a monomer unit composed of a monomer of the following formula 3: where R1 is hydrogen or a methyl group, R2 is hydrogen or fluorine, m is an integer of 1 to 6, and n is an integer of 5 to 15, where R1 is hydrogen or a methyl group, R3 and R4 are each independently an alkyl group having 1 to 6 carbon atoms, m is an integer of 1 to 6, and p is an integer of 5 to 70, where R1 is hydrogen or a methyl group, m is an integer of 1 to 6, and R5 are each independently a functional group that hydrolyzes and cross-links.

Abstract: The invention provides an inorganic particle dispersion comprising a novel block copolymer capable of improving dispersibility of inorganic particles, particularly an inorganic particle dispersion for a cosmetic.

Abstract: A transport jig includes: a frame member; and a support section that is installed on the frame member and that supports a plurality of elongated members. The elongated members are each entirely housed inside the frame member in a lengthwise direction and the support section supports the plurality of elongated members in parallel with one another in one direction.

Abstract: A component manufacturing method includes a step of calculating, for a plurality of keyholes formed on a skin and disposed in a row along a first axial direction on the skin, a first imaginary line that passes an average position in a second axial direction perpendicular to the first axial direction and is parallel to the first axial direction, a step of calculating, for a plurality of keyholes formed on a frame and disposed in a row along a third axial direction on the frame, a second imaginary line that passes an average position in a fourth axial direction perpendicular to the third axial direction and is parallel to the third axial direction, and a step of superimposing the skin and the frame such that the first imaginary line and the second imaginary line coincide.

Abstract: A component manufacturing method includes a step in which a robot for attachment gripping a long frame presses the frame against a tabular skin and a step in which, in a state in which the frame is pressed against the skin, a robot for riveting gripping a first rivet inserts the first rivet into a first through-hole formed in the skin and a second through-hole formed in the frame. In the step, the robot for riveting changes a position in the gripped first rivet in a direction perpendicular to an axial direction of the first rivet according to a force received by the first rivet from the skin or the frame.

Abstract: A display device according to the present invention comprises: a light source configured to emit light in a manner capable of changing an emission direction as needed within a predetermined irradiation region; a first screen located in said irradiation region; a first reflective unit disposed closer to said light source than said first screen; a second reflective unit disposed at a position where the light reflected by said first reflective unit reaches; and a second screen disposed at a position where the light reflected by said second reflective unit reaches.