Abstract: A seat pad manufacturing method is provided. The method includes disposing a sheet member inside a foaming mold for shaping a seat pad, then injecting a foaming resin material into the foaming mold and foaming a resin foamed body through mold clamping, and demolding the resin foamed body in a state in which the sheet member is buried in the resin foamed body. Both end parts of the sheet member in the right-left direction and both end parts of the sheet member in the extending direction are each temporarily fastened to the surface of the mold through a fastener. The foaming resin material is injected into a space between the mold surface and the sheet member. A central part of the sheet member deforms into a shape curved in a convex shape as the sheet member is pressed upward through expansion of the foaming resin material.

Abstract: A cushion material manufacturing method for obtaining a cushion material is provided. The cushion material have a foam body having a surface portion formed of an air permeability control surface portion and an air permeability uncontrol surface portion and a covering material configured to cover the air permeability uncontrol surface portion. The cushion material manufacturing method includes covering the air permeability uncontrol surface portion of the foam body with the covering material.

Abstract: A passenger-seat-cushion-member manufacturing method including a step of shaping the porous structural body by using a 3D printer; and a step of coupling the filling body side coupling part including the shaped porous structural body to the seat body side coupling part, to fill the seat body with the filling body.

Abstract: A porous structural body 1 made of flexible resin or rubber, the porous structural body includes a skeleton part 2 throughout its entirety. The skeleton part includes a plurality of bone parts 2B and a plurality of coupling parts 2J coupling end parts of the plurality of respective bone parts with each other. The skeleton part has a plurality of annular parts 211 each constituted of the plurality of bone parts and the plurality of coupling parts into an annular shape. Each annular part zones a virtual surface V1 by its inner peripheral side edge part 2111. At least a part of each of one or a plurality of the virtual surfaces is covered with one or a plurality of partially connected films 31. Each of the one or plurality of partially connected films is connected to only a part of the annular part in a peripheral direction.

Abstract: A seat pad 1 is a seat pad including a resin foamed body 50, and a sheet member 70 buried in the resin foamed body, and when a direction orthogonal to a right-left direction and a thickness direction of the seat pad is referred to as an extending direction of the seat pad, at least a central part of the sheet member is curved in a convex shape on a back surface side of the seat pad in the extending direction.

Abstract: A porous structural body 1 is a porous structural body made of flexible resin or rubber, the porous structural body including a skeleton part 2 throughout an entirety thereof, wherein the skeleton part includes: a plurality of bone parts 2B; and a plurality of connection parts 2J that connect end portions of the plurality of bone parts, and wherein the porous structural body is configured such that a plurality of portions of the skeleton part interfere with each other when the porous structural body is compressed to deform in a predetermined weight input direction.

Abstract: Provided is a cushion pad, in which a seating body portion of a seating portion has a bottomless or bottomed first hole arranged at a position at which the first hole overlaps a pair of ischial bones of a seated person in a horizontal projection plane and three or more bottomless or bottomed second holes with areas that are smaller than an area of the first hole in a horizontal projection plane, a center point O51 of the first hole is on or inside a triangle TR obtained by connecting center points of any three second holes from among the three or more second holes in the horizontal projection plane and in the seating portion, the inside of the first hole is a void space, or a soft material portion is arranged inside the first hole.

Abstract: In a vehicle seat pad 1, a seating portion has a plurality of bottomless or bottomed holes 10h, and in a horizontal projection plane, a ratio R11U of a total area of under-femoral-region holes in an upper surface of a femoral region-placed portion with respect to an entire area of the femoral region-placed portion, a ratio R12CU of a total area of under-hip holes in an upper surface of an under-hip center portion with respect to an entire area of the under-hip center portion, and a ratio R12SU of a total area of under-hip holes in upper surfaces of a pair of under-hip side portions with respect to entire areas of the pair of under-hip side portions satisfy R11U>R12 CU>R12SU.

Abstract: A seat pad manufacturing method is provided. The method includes disposing a sheet member inside a foaming mold for shaping a seat pad, then injecting a foaming resin material into the foaming mold and foaming a resin foamed body through mold clamping, and demolding the resin foamed body in a state in which the sheet member is buried in the resin foamed body. Both end parts of the sheet member in the right-left direction and both end parts of the sheet member in the extending direction are each temporarily fastened to the surface of the mold through a fastener. The foaming resin material is injected into a space between the mold surface and the sheet member. A central part of the sheet member deforms into a shape curved in a convex shape as the sheet member is pressed upward through expansion of the foaming resin material.

Abstract: Described herein is an approach for targeting multiple critical checkpoint genes involved in T cell exhaustion, for example, PD-1, TIM3, and LAG-3 in a manner that allows knock-down of their expression in T cells that also express a T cell receptor targeted to cancer cells, e.g., a CAR targeted to a cancer antigen or a T cell receptor (TCR).

Abstract: A cushion material with improved vibration absorptivity, and a cushion material manufacturing method for easily obtaining the cushion material are provided. The cushion material (1) includes a foam body (2) having a surface portion (20) formed of an air permeability control surface portion (21) and an air permeability uncontrol surface portion (22), and a covering material (3) configured to cover the air permeability uncontrol surface portion (22). The cushion material manufacturing method is a cushion material manufacturing method for obtaining the cushion material (1), and includes covering the air permeability uncontrol surface portion (22) of the foam body (2) with the covering material (3).

Abstract: A side vehicle body structure ensures rigidity and shock absorption performance of the body, avoids widening of the body, and smooths the flow of exhaust gas. Embodiments include an engine, an exhaust apparatus, and a rear pillar extending upward from a rear-side portion of a side sill extending in the vehicle front-rear direction. The exhaust apparatus is disposed along the vehicle front-rear direction on the vehicle-width-direction outer side relative to the side sill. An exhaust system member is located at a going-around portion, with respect to the rear pillar, from the front side to the rear side and from the outer side to the inner side in the vehicle width direction. The rear pillar has a cross section orthogonal to the vehicle up-down direction having a shape in which a portion between front and rear ends is located on the vehicle-width-direction outer side relative to these front and rear ends.

Abstract: A seat pad with improved thermal comfort and improved vibration absorptivity and a seat pad manufacturing method for easily obtaining the seat pad are provided. In the seat pad (1), when a surface portion (2) up to 10 mm from a surface (1f) is cut out and the air permeability AR1 of the surface portion (2) is measured in compliance with JIS K 6400, the air permeability AR1 is more than 5 cc/cm2/sec and 25 cc/cm2/sec or less. The seat pad manufacturing method is a seat pad manufacturing method for obtaining the seat pad (1) by supplying a molding material into a molding die and performing foam molding. As the molding die, a molding die an inner surface of which is covered with polystyrene or polyethylene is used.

Abstract: A passenger-seat-cushion-member manufacturing method including a step of shaping the porous structural body by using a 3D printer; and a step of coupling the filling body side coupling part including the shaped porous structural body to the seat body side coupling part, to fill the seat body with the filling body.

Abstract: In a vehicle seat pad 1, a seating portion has a plurality of bottomless or bottomed holes 10h, and in a horizontal projection plane, a ratio R11U of a total area of under-femoral-region holes in an upper surface of a femoral region-placed portion with respect to an entire area of the femoral region-placed portion, a ratio R12CU of a total area of under-hip holes in an upper surface of an under-hip center portion with respect to an entire area of the under-hip center portion, and a ratio R12SU of a total area of under-hip holes in upper surfaces of a pair of under-hip side portions with respect to entire areas of the pair of under-hip side portions satisfy R11U>R12 CU>R12SU.

Abstract: A seat pad 1 is a seat pad including a resin foamed body 50, and a sheet member 70 buried in the resin foamed body, and when a direction orthogonal to a right-left direction and a thickness direction of the seat pad is referred to as an extending direction of the seat pad, at least a central part of the sheet member is curved in a convex shape on a back surface side of the seat pad in the extending direction.

Abstract: Provided is a cushion pad, in which a seating body portion of a seating portion has a bottomless or bottomed first hole arranged at a position at which the first hole overlaps a pair of ischial bones of a seated person in a horizontal projection plane and three or more bottomless or bottomed second holes with areas that are smaller than an area of the first hole in a horizontal projection plane, a center point O51 of the first hole is on or inside a triangle TR obtained by connecting center points of any three second holes from among the three or more second holes in the horizontal projection plane and in the seating portion, the inside of the first hole is a void space, or a soft material portion is arranged inside the first hole.

Abstract: A side vehicle body structure ensures rigidity and shock absorption performance of the body, avoids widening of the body, and smooths the flow of exhaust gas. Embodiments include an engine, an exhaust apparatus, and a rear pillar extending upward from a rear-side portion of a side sill extending in the vehicle front-rear direction. The exhaust apparatus is disposed along the vehicle front-rear direction on the vehicle-width-direction outer side relative to the side sill. An exhaust system member is located at a going-around portion, with respect to the rear pillar, from the front side to the rear side and from the outer side to the inner side in the vehicle width direction. The rear pillar has a cross section orthogonal to the vehicle up-down direction having a shape in which a portion between front and rear ends is located on the vehicle-width-direction outer side relative to these front and rear ends.

Abstract: Disclosed are epicardium-derived mesenchymal cells (EPDCs) that differentiate to fates that are commonly adopted by mesenchymal cells elsewhere in the body, but not currently associated with the epicardium. Also disclosed are methods, systems and assays relating to adipocyte and/or osteogenic differentiation in EPDCs that are often related to disease or disregulated states, i.e. the “atypical” fates of epicardium-derived cells. Disclosed are specific EPDC cells that model both the typical fates and atypical fates of EPDCs, and resultant uses of such EPDC cells in systems, methods, compositions and drug discovery.

Abstract: This hot rolled steel contains, in terms of mass %, C: 0.01 to 0.1%, Si: 0.01 to 0.1%, Mn: 0.1 to 3%, P: not more than 0.1%, S: not more than 0.03%, Al: 0.001 to 1%, N: not more than 0.01%, Nb: 0.005 to 0.08%, and Ti: 0.001 to 0.2%, with a remainder being iron and unavoidable impurities, wherein a formula: [Nb]×[C]?4.34×10?3 is satisfied, a grain boundary density of solid solution C is not less than 1 atom/nm2 and not more than 4.5 atoms/nm2, and a grain size of cementite grains precipitated at grain boundaries within the steel sheet is not more than 1 ?m.