Patents by Inventor Yukinori Sakashita
Yukinori Sakashita has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11933804Abstract: In a case where a dispensing tip is imaged from below, liquid attached to the tip falls downward and contaminates an imaging mechanism. An automatic analyzer includes: a buffer that has a hole for holding a tip for dispensing, the hole passing through the tip; a probe for dispensing having a tip to which the tip is attached; an imaging unit that images the tip; and a controller that controls the tip such that the tip is mounted on the probe by pressing the probe against the tip that passes through the hole to be held by the buffer, in which the imaging unit is disposed to image the tip from an upper side to a lower side in a gravity direction.Type: GrantFiled: May 29, 2019Date of Patent: March 19, 2024Assignee: HITACHI HIGH-TECH CORPORATIONInventors: Takahiro Kumagai, Kazuhiro Noda, Yukinori Sakashita
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Publication number: 20230366902Abstract: To provide an automatic analyzer that can be designed with a high degree of freedom in accordance with cooling performance by cooling air in a space separated from a reagent refrigerator and suppresses the occurrence of dew condensation in the reagent refrigerator. An automatic analyzer has a reagent refrigerator 20 that cools a reagent container 21 by using a refrigerant, a refrigerant cooling unit 201 that cools the refrigerant to circulate in the device, an air blowing unit 204 that takes in air fed to the reagent refrigerator 20 from the outside of the device, and a blowing air cooling unit 202 that cools air flowing from the air blowing unit 204 by using the refrigerant. The inside of the reagent refrigerator is positively pressurized by the blowing air that is taken in from the outside by the air blowing unit and is cooled by the blowing air cooling unit 202 to suppress the occurrence of dew condensation.Type: ApplicationFiled: August 18, 2021Publication date: November 16, 2023Inventors: Shun KURIKI, Yukinori SAKASHITA, Kazuhiro NODA, Nobuya FUKUDA
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Publication number: 20230251253Abstract: An electrochemiluminescence method of detecting an analyte in a liquid sample and a corresponding analysis system. An analyte in a liquid sample is detected by first providing a receptacle containing a fluid comprising protein coated magnetic microparticles to a stirring unit. Stirring of the fluid is necessary since the density of the microparticles is usually higher than the density of the buffer fluid. Thus the microparticles tend to deposit on the bottom of the receptacle leading to an aggregation of the microparticles because of weak interactions. To obtain representative measurements a homogeneous distribution of the microparticles in the buffer fluid is necessary to ensure a constant concentration of microparticles for each analysis cycle. It is further necessary to provide disaggregation of the microparticles, which is also realized by stirring the fluid. Stirring is conducted with a rotational frequency that is adapted to the amount of fluid to be stirred.Type: ApplicationFiled: April 14, 2023Publication date: August 10, 2023Applicants: Roche Diagnostics Operations, Inc., Hitachi High-Tech CorporationInventors: Ralf Kraus, Oliver Larbolette, Friedrich Staebler, Yoshihiro Yamashita, Yukinori Sakashita, Shinya Matsuoka, Michihiro Saito, Taku Sakazume, Katsuaki Takahashi
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Patent number: 11703504Abstract: An electrochemiluminescence method of detecting an analyte in a liquid sample and a corresponding analysis system. An analyte in a liquid sample is detected by first providing a receptacle containing a fluid comprising protein coated magnetic microparticles to a stirring unit. Stirring of the fluid is necessary since the density of the microparticles is usually higher than the density of the buffer fluid. Thus the microparticles tend to deposit on the bottom of the receptacle leading to an aggregation of the microparticles because of weak interactions. To obtain representative measurements a homogeneous distribution of the microparticles in the buffer fluid is necessary to ensure a constant concentration of microparticles for each analysis cycle. It is further necessary to provide disaggregation of the microparticles, which is also realized by stirring the fluid. Stirring is conducted with a rotational frequency that is adapted to the amount of fluid to be stirred.Type: GrantFiled: September 5, 2019Date of Patent: July 18, 2023Assignees: ROCHE DIAGNOSTICS OPERATIONS, INC., HITACHI HIGH-TECH CORPORATIONInventors: Ralf Kraus, Oliver Larbolette, Friedrich Staebler, Yoshihiro Yamashita, Yukinori Sakashita, Shinya Matsuoka, Michihiro Saito, Taku Sakazume, Katsuaki Takahashi
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Publication number: 20230061292Abstract: Provided is an automatic analyzer capable of reducing risks such as infection, injury, and damage to the device caused by manual operation of a user. In the automatic analyzer according to the present disclosure, an unused vessel holding unit is configured to be able to hold a cleaning member that cleans a hole for mounting a reaction vessel, and a reaction vessel transport unit or a specimen probe picks up the cleaning member from the unused vessel holding unit, transports the cleaning member to the reaction vessel mounting unit, and inserts and removes the cleaning member into and from the hole, thereby cleaning the inner surface of the hole.Type: ApplicationFiled: January 21, 2021Publication date: March 2, 2023Inventors: Shun KURIKI, Kazuhiro NODA, Yukinori SAKASHITA
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Patent number: 11467174Abstract: The purpose of the present invention is to constantly keep a state in a flow cell steady by filling a detection flow channel with a liquid. The configuration of the present invention for solving the aforementioned problem is as follows. Specifically, the present invention is an automatic analysis apparatus provided with a detection unit including a flow cell that accommodates a liquid serving as an analysis subject; a suction nozzle that is positioned upstream of the flow cell and that sucks the liquid to be introduced into the flow cell; a pump that is positioned downstream of the flow cell and that supplies the liquid to the flow cell; flow channels that connect the flow cell, the suction nozzle, and the pump; a power source; and a power-cutting instructing unit that gives an instruction to cut the power supply at least to the pump.Type: GrantFiled: January 19, 2017Date of Patent: October 11, 2022Assignee: Hitachi High-Tech CorporationInventors: Yoshihiro Kabe, Yukinori Sakashita, Katsuhiro Kambara, Taku Sakazume, Tatsuya Fukugaki
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Publication number: 20220317140Abstract: Provided is a reagent cooler that prevents occurrence of condensation and further uniforms a temperature in the cooler with low power consumption and a simple structure. The reagent cooler includes a refrigerant pipe that is disposed inside an outer wall of the reagent cooler 103 and circulates a refrigerant inside the outer wall; a blowing pipe 109 that is disposed inside the outer wall and guides outside air existing outside the reagent cooler to inside of the reagent cooler; and a blowing unit 114 that is disposed at the blowing pipe and diffuses the outside air into the inside of the reagent cooler through the blowing pipe. With the outside air cooled by the outer wall and taken into the inside of the reagent cooler, the reagent cooler is positively pressurized and the internal temperature is made uniform.Type: ApplicationFiled: February 25, 2020Publication date: October 6, 2022Inventors: Nobuya FUKUDA, Kazuhiro NODA, Yukinori SAKASHITA
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Publication number: 20210318350Abstract: In a case where a dispensing tip is imaged from below, liquid attached to the tip falls downward and contaminates an imaging mechanism. An automatic analyzer includes: a buffer that has a hole for holding a tip for dispensing, the hole passing through the tip; a probe for dispensing having a tip to which the tip is attached; an imaging unit that images the tip; and a controller that controls the tip such that the tip is mounted on the probe by pressing the probe against the tip that passes through the hole to be held by the buffer, in which the imaging unit is disposed to image the tip from an upper side to a lower side in a gravity direction.Type: ApplicationFiled: May 29, 2019Publication date: October 14, 2021Applicant: HITACHI HIGH-TECH CORPORATIONInventors: Takahiro Kumagai, Kazuhiro Noda, Yukinori Sakashita
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Patent number: 11106680Abstract: Example implementations described herein are directed to systems and methods for managing a relationship between real-time analysis processes and applications, where each of the applications are configured to utilize output from one or more of the corresponding real-time analysis processes. In an example implementation, resource adjustment is applied to the real-time analysis process based on a determined priority.Type: GrantFiled: November 8, 2016Date of Patent: August 31, 2021Assignee: HITACHI, LTD.Inventors: Hiroaki Shikano, Yukinori Sakashita
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Patent number: 10753953Abstract: Provided are an automated analyzer for analyzing a substance contained in an unknown sample and a liquid reservoir, the analyzer and the reservoir being capable of saving users' operation without remarkably increasing the number of components. A flow path outlet of an overflow portion of the liquid reservoirs projects closer to the inner circumferential side of a drain flow path than to an inner circumferential surface side of an outer wall of the drain flow path serving as a destination to which liquid overflows. In addition, the flow path outlet projects so as to come into contact with an outer wall of the inner pipe. The flow path outlet of the overflow portion projects into the drain flow path so as to be located below an upper end of the outer wall of the drain flow path.Type: GrantFiled: January 7, 2016Date of Patent: August 25, 2020Assignee: HITACHI HIGH-TECH CORPORATIONInventors: Reika Kuroda, Kenta Imai, Yukinori Sakashita, Yoshihiro Yamashita
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Patent number: 10670618Abstract: Provided is an automated analysis device equipped with a lid opening/closing mechanism with which it is possible to selectively open or close lids of a plurality of reagent containers, as well as to close all of the lids of the plurality of reagent containers, regardless of their current open/closed state. Each of a plurality of hooks 102 rotatably linked to a hook base part 104 has: a claw portion 203 which, when oriented to engage with a lid 101, causes force to act on the lid 101 in the opening direction; a basal part 202 which, when oriented to engage with the lid 101, causes force to act on the lid in the closing direction; and a closing protrusion 201 which, when oriented not to engage with the lid 101, causes force to act on the lid in the closing direction.Type: GrantFiled: January 7, 2016Date of Patent: June 2, 2020Assignee: HITACHI HIGH-TECH CORPORATIONInventors: Takushi Miyakawa, Kazuhiro Noda, Yukinori Sakashita
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Patent number: 10605818Abstract: The purpose of the present invention is to stably hold the lid of a reagent container in an open state without being influenced by reagent container lid opening and closing operations. An automated analyzer is provided with reagent containers 116-118, a cassette 100, a reagent container lid opening and closing mechanism, and a lid holding mechanism 131. The reagent containers 116-118 accommodate the reagent and have lids 101a-101c that pivot about a pivot point. The reagent containers 116-118 are mounted on the cassette 100. The reagent container lid opening and closing mechanism opens and closes the lids 101a-101c. The lid holding mechanism 131 holds the lids 101a opened by the reagent container lid opening and closing mechanism.Type: GrantFiled: July 8, 2016Date of Patent: March 31, 2020Assignee: Hitachi High-Technologies CorporationInventors: Kazuhiro Noda, Yukinori Sakashita, Takushi Miyakawa, Katsuhiro Kambara
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Publication number: 20200003768Abstract: An electrochemiluminescence method of detecting an analyte in a liquid sample and a corresponding analysis system. An analyte in a liquid sample is detected by first providing a receptacle containing a fluid comprising protein coated magnetic microparticles to a stirring unit. Stirring of the fluid is necessary since the density of the microparticles is usually higher than the density of the buffer fluid. Thus the microparticles tend to deposit on the bottom of the receptacle leading to an aggregation of the microparticles because of weak interactions. To obtain representative measurements a homogeneous distribution of the microparticles in the buffer fluid is necessary to ensure a constant concentration of microparticles for each analysis cycle. It is further necessary to provide disaggregation of the microparticles, which is also realized by stirring the fluid. Stirring is conducted with a rotational frequency that is adapted to the amount of fluid to be stirred.Type: ApplicationFiled: September 5, 2019Publication date: January 2, 2020Applicants: Roche Diagnostics Operations, Inc., Hitachi High-Technologies CorporationInventors: Ralf Kraus, Oliver Larbolette, Friedrich Staebler, Yoshihiro y Yamashita, Yukinori Sakashita, Shinya Matsuoka, Michihiro Saito, Taku Sakazume, Katsuaki Takahashi
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Patent number: 10422797Abstract: An electrochemiluminescence method of detecting an analyte in a liquid sample and a corresponding analysis system. An analyte in a liquid sample is detected by first providing a receptacle containing a fluid comprising protein coated magnetic microparticles to a stirring unit. Stirring of the fluid is necessary since the density of the microparticles is usually higher than the density of the buffer fluid. Thus the microparticles tend to deposit on the bottom of the receptacle leading to an aggregation of the microparticles because of weak interactions. To obtain representative measurements a homogeneous distribution of the microparticles in the buffer fluid is necessary to ensure a constant concentration of microparticles for each analysis cycle. It is further necessary to provide disaggregation of the microparticles, which is also realized by stirring the fluid. Stirring is conducted with a rotational frequency that is adapted to the amount of fluid to be stirred.Type: GrantFiled: December 14, 2015Date of Patent: September 24, 2019Assignees: ROCHE DIAGNOSTICS OPERATIONS, INC., HITACHI HIGH-TECHNOLOGIES CORPORATIONInventors: Ralf Kraus, Oliver Larbolette, Friedrich Staebler, Yoshihiro Yamashita, Yukinori Sakashita, Shinya Matsuoka, Michihiro Saito, Taku Sakazume, Katsuaki Takahashi
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Publication number: 20190257719Abstract: There is provided an abnormal-state detection system including: a processing execution unit that executes an application which performs information processing based on the received data after receiving the data sent from factory equipment; a data relation generation unit that generates a data association result which is information indicating the presence of relation between the data; an abnormal-state determination unit that determines whether or not the factory equipment is in an abnormal state which is a state other than a normal state which is a state where manufacturing of a product is actually performed, based on the data association result; a control unit that performs a control for preventing an influence of the application on the information processing based on a result of the determination; and a tag unit for tagging the data if the factory equipment is determined to be in the abnormal state.Type: ApplicationFiled: September 12, 2018Publication date: August 22, 2019Applicant: HITACHI, LTD.Inventors: Yoji Ozawa, Yukinori Sakashita
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Patent number: 10307782Abstract: The nozzle cleaning method includes the following steps: a first cleaning step in which a pre-pressurization liquid is discharged from a dispensing nozzle in a first cleaning position so as to clean the inside wall thereof and a first cleaning liquid is applied to the outside wall of the dispensing nozzle so as to clean said outside wall; a second cleaning step in which a second cleaning liquid is suctioned into the dispensing nozzle in a second cleaning position so as to clean the inside wall thereof; and a third cleaning step in which the second cleaning liquid is discharged from the dispensing nozzle in a third cleaning position so as to clean the inside wall thereof and a third cleaning liquid is applied to the outside wall of the dispensing nozzle so as to clean said outside wall.Type: GrantFiled: July 24, 2014Date of Patent: June 4, 2019Assignee: Hitachi High-Technologies CorporationInventors: Takushi Miyakawa, Yukinori Sakashita, Yoshihiro Yamashita, Katsuhiro Kambara
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Publication number: 20190145997Abstract: The purpose of the present invention is to constantly keep a state in a flow cell steady by filling a detection flow channel with a liquid. The configuration of the present invention for solving the aforementioned problem is as follows. Specifically, the present invention is an automatic analysis apparatus provided with a detection unit including a flow cell that accommodates a liquid serving as an analysis subject; a suction nozzle that is positioned upstream of the flow cell and that sucks the liquid to be introduced into the flow cell; a pump that is positioned downstream of the flow cell and that supplies the liquid to the flow cell; flow channels that connect the flow cell, the suction nozzle, and the pump; a power source; and a power-cutting instructing unit that gives an instruction to cut the power supply at least to the pump.Type: ApplicationFiled: January 19, 2017Publication date: May 16, 2019Applicant: Hitachi High-Technologies CorporationInventors: Yoshihiro KABE, Yukinori SAKASHITA, Katsuhiro KAMBARA, Taku SAKAZUME, Tatsuya FUKUGAKI
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Publication number: 20190065555Abstract: Example implementations described herein are directed to systems and methods for managing a relationship between real-time analysis processes and applications, where each of the applications are configured to utilize output from one or more of the corresponding real-time analysis processes. In an example implementation, resource adjustment is applied to the real-time analysis process based on a determined priority.Type: ApplicationFiled: November 8, 2016Publication date: February 28, 2019Inventors: Hiroaki SHIKANO, Yukinori SAKASHITA
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Publication number: 20180267713Abstract: Example implementations are directed to systems and methods for how an application defines storage infrastructure. Such example implementations described herein may be used by application programmers to develop applications quickly and flexibly, without having to communicate with storage administrators to make storage infrastructure changes. In an example implementation, there is an application configured to perform storage management operations that change the storage resources allocated to the application.Type: ApplicationFiled: March 31, 2016Publication date: September 20, 2018Inventors: Hideo SAITO, Keisuke HATASAKI, Yasutaka KONO, Yukinori SAKASHITA
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Publication number: 20180188275Abstract: The purpose of the present invention is to stably hold the lid of a reagent container in an open state without being influenced by reagent container lid opening and closing operations. An automated analyzer is provided with reagent containers 116-118, a cassette 100, a reagent container lid opening and closing mechanism, and a lid holding mechanism 131. The reagent containers 116-118 accommodate the reagent and have lids 101a-101c that pivot about a pivot point. The reagent containers 116-118 are mounted on the cassette 100. The reagent container lid opening and closing mechanism opens and closes the lids 101a-101c. The lid holding mechanism 131 holds the lids 101a opened by the reagent container lid opening and closing mechanism.Type: ApplicationFiled: July 8, 2016Publication date: July 5, 2018Inventors: Kazuhiro NODA, Yukinori SAKASHITA, Takushi MIYAKAWA, Katsuhiro KAMBARA