Patents by Inventor Yuntao Wu

Yuntao Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR USING ACTIN-BASED PEPTIDES TO MODULATE CELLULAR BIOACTIVITY AND CELLULAR SUSCEPTIBILITY TO INTRACELLULAR PATHOGENS
    Publication number: 20180002390
    Abstract: Compositions and methods for using actin-based peptides to modulate cellular bioactivity, including modulation of cellular susceptibility to intracellular pathogens, such as bacteria and viruses.
    Type: Application
    Filed: March 1, 2017
    Publication date: January 4, 2018
    Inventor: Yuntao Wu
  • METHODS AND COMPOSITIONS FOR ASSESSING VIRAL NUCLEAR LOCALIZATION
    Publication number: 20170191068
    Abstract: In one aspect, the invention relates to methods and compositions for determining migration of a virus particle to the nucleus of a cell. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: December 23, 2016
    Publication date: July 6, 2017
    Inventors: Mark Spear, Yuntao Wu
  • Antiretroviral Cyclonucleoside Compositions and Methods and Articles of Title of Invention Manufacture Therewith
    Publication number: 20130303479
    Abstract: ASPECTS OF EMBODIMENTS RELATE TO methods of treating human immunodeficiency virus (HIV) infection. Further aspects of embodiments also relate to constellations of compositions for treating HIV infection. Still additional aspects of embodiments relate to a many methods of making compositions useful in the treatment of HIV infection.
    Type: Application
    Filed: January 19, 2012
    Publication date: November 14, 2013
    Inventors: Todd William Hawley, Yuntao Wu, Jia Guo
  • HIV-Dependent expression constructs and uses therefore
    Publication number: 20110207800
    Abstract: The invention provides a nucleic acid construct for targeting and killing cells infected with the human immunodeficiency virus (HIV). The construct includes an HIV Tat-dependent promoter operably linked to the coding region for a cell-killing protein, such as anthrolysin-O (anlO), which is partially or fully within an intron defined by a splice donor site and a splice acceptor site. The construct further includes a Rev Responsive Element (RRE). Therapeutic methods of treating HIV infection are also provided.
    Type: Application
    Filed: January 21, 2009
    Publication date: August 25, 2011
    Inventor: Yuntao Wu
  • NON-INTEGRATING REV-DEPENDENT LENTIVIRAL VECTOR AND METHODS OF USING THE SAME
    Publication number: 20110104789
    Abstract: Non-integrating, Rev-dependent (NIRD) lentiviral vectors and NIRD lentiviral particles carrying a therapeutic gene, such as DT-A or TRAF6 and methods of making the same are disclosed. The intracellular expression of DT-A or TRAF6 results in the selective killing of HIV-positive cells and, thus, these NIRD lentiviral vectors and lentiviral particles can be used in methods to kill HIV-infected cells or treat to HIV-infected subjects. Also disclosed is a human cell line comprising a mutation in the EF2 gene that confers resistance to DT-A.
    Type: Application
    Filed: November 1, 2010
    Publication date: May 5, 2011
    Inventors: Yuntao Wu, Zhirui Wang
  • COMPOSITIONS AND METHODS FOR DETECTING AND TREATING HIV INFECTIONS
    Publication number: 20100292181
    Abstract: HIV infection can be detected by measuring phosphorylation levels of the actin-depolymerizing factor (AFD)/cofilin family, and infection can be treated and/or prevented by modulating the HIV co-receptor signaling pathway.
    Type: Application
    Filed: December 16, 2009
    Publication date: November 18, 2010
    Inventors: Yuntao WU, Rebecca Alyson Crook Yoder, Jeremy Kelly, Dongyang Yu
  • Compositions and methods for detecting and treating HIV infections
    Patent number: 7662547
    Abstract: HIV infection can be detected by measuring phosphorylation levels of the actin-depolymerizing factor (AFD)/cofilin family, and infection can be treated and/or prevented by modulating the HIV co-receptor signaling pathway.
    Type: Grant
    Filed: May 4, 2007
    Date of Patent: February 16, 2010
    Assignee: George Mason Intellectual Properties, Inc.
    Inventors: Yuntao Wu, Rebecca Alyson Crook Yoder, Jeremy Kelly, Dongyang Yu
  • COMPOSITIONS AND METHODS FOR DETECTING AND TREATING HIV INFECTIONS
    Publication number: 20080064026
    Abstract: HIV infection can be detected by measuring phosphorylation levels of the actin-depolymerizing factor (AFD)/cofilin family, and infection can be treated and/or prevented by modulating the HIV co-receptor signaling pathway.
    Type: Application
    Filed: May 4, 2007
    Publication date: March 13, 2008
    Inventors: Yuntao WU, Rebecca Yoder, Jeremy Kelly, Dongyang Yu
  • Hiv-dependent expression constructs and uses therefor
    Publication number: 20070134767
    Abstract: The present invention provides nucleic acid molecules comprising expressible sequences, including reporter genes and therapeutic genes, whose expression is dependent on the presence of both HIV Tat and Rev proteins. Further provided are methods for detecting HIV, method for identifying compounds that can inhibit HIV infection and/or gene expression, methods for killing HIV-infected cells, and methods of treating HIV-infected subjects.
    Type: Application
    Filed: September 28, 2004
    Publication date: June 14, 2007
    Applicant: Government of the US, as represented by the Secretary, Department of Health and Human Services
    Inventors: Yuntao Wu, Jon Marsh