Patents by Inventor Yuri Kagawa

Yuri Kagawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for producing optically active carboxylic acid amide
    Patent number: 5476791
    Abstract: N-(3-acetylthio-2-D-methylpropionyl)-L-proline useful as a precursor of captopril, one of antihypertensive agents, is prepared by allowing thioacetic acid to react with methyl methacrylate to prepare racetalc methyl 3-acetylthio-2-DL-methylpropionate, contacting the propionate with cells of, for example, Pseudomonas in order to effect biological and asymmetric hydrolysis, extracting 3-acetylthio-D-2-methylpropionic acid and allowing the acid to react with L-proline.
    Type: Grant
    Filed: May 16, 1994
    Date of Patent: December 19, 1995
    Assignee: Mitsubishi Rayon Company, Limited
    Inventors: Akihiro Sakimae, Yuri Kagawa, Ryozo Numazawa, Hisao Onishi
  • Process for preparing optically active carboxylic acids and antipode esters thereof
    Patent number: 4629701
    Abstract: Organic carboxylic acid ester represented by the formula (II): ##STR1## wherein R.sub.1 is an alkyl, an aralkyl or an aryl group; R.sub.2 is an alkyl group; R.sub.3 is an alkyl group; n is 1 or 2, are synthesized in racemic form, and then the acid ester (II) is treated with a source containing enzyme capable of rearranging with or without asymmetrically hydrolyzing ester bond until either a d-form or 1-form optically active carboxylic acid ester represented by the formula (II) with or without the antipode acid thereof is produced.
    Type: Grant
    Filed: July 2, 1984
    Date of Patent: December 16, 1986
    Assignee: Mitsubishi Rayon Company, Limited
    Inventors: Akihiro Sakimae, Yuri Kagawa, Ryozo Numazawa, Hisao Onishi