Patents by Inventor Yuri L. Khmelnitsky

Yuri L. Khmelnitsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CYTOPROTECTIVE DERIVATIVES OF AVICIN D AND METHODS OF MAKING AND USING THEREOF
    Publication number: 20140179624
    Abstract: Disclosed herein are novel cytoprotective derivatives of avicin D, including those of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising these derivative compounds. Methods and intermediates useful for making the derivatives, and methods of using the derivatives and compositions thereof, including for the treatment of cancer, are also provided.
    Type: Application
    Filed: December 20, 2013
    Publication date: June 26, 2014
    Applicant: Research Development Foundation
    Inventors: Jordan GUTTERMAN, Valsala HARIDAS, Peter C. MICHELS, Yuri L. KHMELNITSKY, Vadim M. MOZHAEV
  • Taxol derivatives
    Patent number: 6465625
    Abstract: Highly specific biocatalytic reactions have been used to create a population of taxol derivatives.
    Type: Grant
    Filed: June 19, 2000
    Date of Patent: October 15, 2002
    Assignee: Albany Molecular Research, Inc.
    Inventors: Jonathan S. Dordick, Douglas S. Clark, Peter C. Michels, Yuri L. Khmelnitsky
  • Two step enzymatic acylation
    Patent number: 6261813
    Abstract: A method for derivatizing a compound having a hydroxyl group by back to back acylation is provided. The compound is acylated with a bifunctional acyl donor in the presence of a hydrolase to form an activated acyl ester or carbonate. Preferably the bifunctional acylating donor is a di(vinyl) ester or carbonate. The activated acyl ester or carbonate is then used to acylate a nucleophile in the presence of a lipase. The method of the invention provides regioselective enzymatic acylation of the base compound.
    Type: Grant
    Filed: November 23, 1998
    Date of Patent: July 17, 2001
    Assignee: Albany Molecular Research, Inc.
    Inventors: Yuri L. Khmelnitsky, Cheryl L. Budde, John M. Arnold, Joseph O. Rich, Sharon S. Chen, Alexander Ya. Usyatinsky, Douglas S. Clark, Jonathan S. Dordick
  • Biocatalytic methods for synthesizing and identifying biologically active compounds
    Patent number: 6136961
    Abstract: Highly specific biocatalytic reactions have been used to create a population of derivatives from a single starting compound. Examples demonstrate synthesis of derivatives of taxol, taxol-2'-adipate, taxol-2'-vinyl adipate, 2,3-(methylenedioxy) benzaldehyde, (.+-.)-(2-endo, 3-exo)-bicyclo (2.2.2)octo-5-ene-2,3-dimethanol, adenosine and erythromycin.
    Type: Grant
    Filed: June 29, 1998
    Date of Patent: October 24, 2000
    Assignee: EnzyMed, Inc.
    Inventors: Jonathan S. Dordick, Douglas S. Clark, Peter C. Michels, Yuri L. Khmelnitsky