Abstract: A specimen support tool for supporting a slice prepared by using a microtome includes a specimen support member on which a groove for guiding the slice is formed.

Abstract: A system and method control an automobile by decelerating the automobile at a first deceleration using a braking mechanism in response to detecting that a parking brake switch is turned on, a second deceleration which is smaller than the first deceleration, in response to not detecting that the parking brake switch is turned on and determining that the driver is incapacitated, and a third deceleration which is smaller than the first deceleration, in response to determining that an SOS switch is turned on, detecting that the parking brake switch is changed from on to off, and not determining that the driver is incapacitated.

Abstract: A railroad crossing obstacle detection system including: a laser radar device that includes an irradiator and a light receiver, the irradiator applying laser light at irradiation angles set every prescribed angle, and the light receiver receiving the laser light reflected; and a controller, wherein the laser radar device is configured to be supported by an object such that the laser radar device is located above a detection area of an obstacle in railroad crossing, and to apply the laser light from above to the detection area, and the controller is configured to detect an obstacle on the basis of measurement result representing a distance to an object having reflected the laser light, and an irradiation angle for the object; and monitor a change of at least one of a position or a direction of the laser radar device on the basis of the measurement result by the laser radar device.

Abstract: The present invention provides a method for producing a steam turbine member that is highly superior in smoothness. The present invention provides a method for producing a steam turbine member including a cladding layer forming step of forming a cladding layer from a powdered material containing a metal in a region of a base material in which corrosion easily occurs, and a surface heating step of heat-melting a surface of the cladding layer.

Abstract: A high reliable water injection device is provided that injects water into a reactor containment vessel and can reliably shut off cooling water at normal times and quickly and reliably inject water into the reactor containment vessel without the need for external power, in a case of emergency. The water injection device injects water into a reactor containment vessel includes a flow path through which cooling water is supplied; a disk that closes the flow path; a swing arm that is connected to the disk and performs closing and opening of the flow path by the disk; and a weight that is connected to the swing arm via a swing lever, in which the weight is supported by a support member made of a low melting point alloy.

Abstract: A high reliable water injection device is provided that injects water into a reactor containment vessel and can reliably shut off cooling water at normal times and quickly and reliably inject water into the reactor containment vessel without the need for external power, in a case of emergency. The water injection device injects water into a reactor containment vessel includes a flow path through which cooling water is supplied; a disk that closes the flow path; a swing arm that is connected to the disk and performs closing and opening of the flow path by the disk; and a weight that is connected to the swing arm via a swing lever, in which the weight is supported by a support member made of a low melting point alloy.

Abstract: An apparatus for controlling tomosynthesis imaging according to the present invention enables outputting only an oblique image as a diagnosis target, and alleviating the load on communication as well as the capacity load on a PACS server. When a reconstructed. tomosynthesis image is transmitted to an external apparatus such as the PACS server, transmitting only the required tomographic image(s) instead of transmitting the entire frame data enables efficient use of the storage capacity. Further, transmitting an oblique image with appended parameters enables efficient performance of diagnosis on an image from an external apparatus of a transmission destination, without performing reconstruction, thus facilitating re-imaging under an identical condition for the purpose of progress observation.

Abstract: A substituted amide compound is useful as an active ingredient of a pharmaceutical composition, in particular a pharmaceutical composition for treating diseases caused by lysophosphatidic acid (LPA). The compound is of a formula: In this formula, A is an optionally substituted aryl, etc.; B is an optionally substituted 5-membered aromatic hetero ring group; X is a single bond or —(CRX1RX2)n—; n is 1, 2, 3, or 4; RX1 and RX2 are hydrogen, etc.; Y1 to Y5 are each CRY or N; each RY is hydrogen, etc.; R1 and R2 are hydrogen, etc.; m is 1, 2, or 3; R3 is hydrogen, etc.; and R4 is an optically substituted lower alkyl, etc.

Abstract: A substituted amide compound is useful as an active ingredient of a pharmaceutical composition, in particular a pharmaceutical composition for treating diseases caused by lysophosphatidic acid (LPA). The compound is of a formula: In this formula, A is an optionally substituted aryl, etc.; B is an optionally substituted 5-membered aromatic hetero ring group; X is a single bond or —(CRX1RX2)n—; n is 1, 2, 3, or 4; RX1 and RX2 are hydrogen, etc.; Y1 to Y5 are each CRY or N; each RY is hydrogen, etc.; R1 and R2 are hydrogen, etc.; m is 1, 2, or 3; R3 is hydrogen, etc.; and R4 is an optionally substituted lower alkyl, etc.

Abstract: A substituted amide compound is useful as an active ingredient of a pharmaceutical composition, in particular a pharmaceutical composition for treating diseases caused by lysophosphatidic acid (LPA). The compound is of a formula: In this formula, A is an optionally substituted aryl, etc.; B is an optionally substituted 5-membered aromatic hetero ring group; X is a single bond or —(CRX1RX2)n—; n is 1, 2, 3, or 4; RX1 and RX2 are hydrogen, etc.; Y1 to Y5 are each CRY or N; each RY is hydrogen, etc.; R1 and R2 are hydrogen, etc.; m is 1, 2, or 3; R3 is hydrogen, etc.; and R4 is an optically substituted lower alkyl, etc.

Abstract: [Object] A compound which is useful as an EP1 receptor antagonist is provided. [Means for Solution] The present inventors investigated EP1 receptor antagonists, and confirmed that a compound having a sulfonamide structure, in which the nitrogen atom of the sulfonamide structure is substituted with 2-fluoropropyl group, 3-fluoro-2-methylpropyl group or the like, has a potent EP1 receptor antagonistic action, thereby completing the present invention. The sulfonamide compound of the present invention has a potent EP1 receptor antagonistic action and can be used as an agent for preventing and/or treating a lower urinary tract symptom or the like.

Abstract: A substituted amide compound is useful as an active ingredient of a pharmaceutical composition, in particular a pharmaceutical composition for treating diseases caused by lysophosphatidic acid (LPA). The compound is of a formula: In this formula, A is an optionally substituted aryl, etc.; B is an optionally substituted 5-membered aromatic hetero ring group; X is a single bond or —(CRX1RX2)n—; n is 1, 2, 3, or 4; RX1 and RX2 are hydrogen, etc.; Y1 to Y5 are each CRY or N; each RY is hydrogen, etc.; R1 and R2 are hydrogen, etc.; m is 1, 2, or 3; R3 is hydrogen, etc.; and R4 is an optionally substituted lower alkyl, etc.

Abstract: [Object] A compound which is useful as an EP1 receptor antagonist is provided. [Means for Solution] The present inventors investigated EP1 receptor antagonists, and confirmed that a compound having a sulfonamide structure, in which the nitrogen atom of the sulfonamide structure is substituted with 2-fluoropropyl group, 3-fluoro-2-methylpropyl group or the like, has a potent EP1 receptor antagonistic action, thereby completing the present invention. The sulfonamide compound of the present invention has a potent EP1 receptor antagonistic action and can be used as an agent for preventing and/or treating a lower urinary tract symptom or the like.

Abstract: A compound that can be used as an agent for treating a disease associated with an EP1 receptor, in particular a lower urinary tract symptom. It was confirmed that a sulfonamide compound having an amide structure and characterized by a chemical structure in which a carbon atom in the amide bonds to the N atom in sulfonamide through lower alkylene, or a salt thereof, has a potent EP1 receptor antagonistic activity, accomplishing the present invention. Since the sulfonamide compound of the present invention or a pharmaceutically acceptable salt thereof has a potent EP1 receptor antagonistic activity, it is useful as an agent for treating a disease associated with an EP1 receptor, in particular, a lower urinary tract symptom.

Abstract: [Object] A compound that can be used as an agent for treating a disease associated with an EP1 receptor, in particular, a lower urinary tract symptom. [Means for Solution] It was confirmed that a sulfonamide compound having an amide structure and characterized by a chemical structure in which a carbon atom in the amide bonds to the N atom in sulfonamide through lower alkylene, or a salt thereof, has a potent EP1 receptor antagonistic activity, accomplishing the present invention. Since the sulfonamide compound of the present invention or a pharmaceutically acceptable salt thereof has a potent EP1 receptor antagonistic activity, it is useful as an agent for treating a disease associated with an EP1 receptor, in particular, a lower urinary tract symptom.