Abstract: An object of the present invention is to provide a surface treatment agent that is excellent in antithrombogenicity and biocompatibility and has higher hydrophilicity compared to conventional medical materials. The present invention is an antithrombogenic material containing a (meth)acrylate copolymer consisting of a hydrophobic (meth)acrylate and a hydrophilic (meth)acrylate, in which the hydrophobic (meth)acrylate is a silicone (meth)acrylate and/or an alkyl (meth)acrylate, the (meth)acrylate copolymer having a residual monomer content of 4,000 ppm or less, a reduced viscosity (?sp/c) of 0.18 dl/g or more and 3.00 dl/g or less, and being water-insoluble, and being a viscous liquid at room temperature.

Abstract: A method for manufacturing a nerve regeneration-inducing tube with excellent pressure resistance, shape recovery property, anti-kink property, film exfoliation resistance, resistance to invasion of outer tissues, and leakage resistance. The tubular body is formed by weaving together fibers made up of biodegradable polymer. The outer surface of the tubular body is coated multiple times with a collagen solution. The lumen of the tubular body is filled with collagen. Viscosity of the collagen solution that is first applied to the outer surface of the tubular body is between 2 to 800 cps. Viscosity of the collagen solution that is subsequently applied is higher than viscosity of the first applied collagen solution.

Abstract: The present invention provides a medical tube mainly comprising a thermoplastic resin wherein the surface contacting the blood has been subjected to a heparinizing treatment and wherein quality defect due to whitening and oil defect is reduced. According to the present invention, there is provided a medical tube wherein an antithrombotic material is coated on the inner surface of a tube prepared by a melt extrusion molding of a composition comprising a thermoplastic resin and a plasticizer, characterized in that the difference (?L) between the brightness of the medical tube before coating and the brightness of the medical tube after coating measured in accordance with JIS Z 8722 is 1 or less.

Abstract: A problem that the present invention is to solve is to provide a pellet-shaped composition for medical use mainly comprising a polyvinyl chloride resin and exhibiting antithrombotic property when merely being molded. The present invention is a pellet-shaped composition for medical use which comprises 1 to 120 part(s) by weight of a plasticizer and 0.01 to 5 part(s) by weight of a (meth)acrylate copolymer containing a hydrophobic (meth)acrylate unit and a hydrophilic (meth)acrylate unit to 100 parts by weight of a polyvinyl chloride resin, wherein number-average molecular weight of the (meth)acrylate copolymer is 7,000 to 50,000.

Abstract: A nerve regeneration-inducing tube is provided which is excellent in cell growth property, resistance to pressure, shape recovery property, and anti-kink property in a nerve regeneration-inducing tube where a collagen solution is applied on the outer surface of a tubular body woven with ultrafine fiber comprising biodegradable and bioabsorbable polymer while collagen is filled in the inner area of the tubular body. The nerve regeneration-inducing tube has a degradation speed which is adjusted so as to make it suitable for the connection of nerve gaps of more than 40 mm. The nerve regeneration-inducing tube includes collagen coated on the outer surface of a tubular body woven with fiber bundles where plural ultrafine fibers comprising a biodegradable and bioabsorbable polymer are bundled. The tubular body mostly comprises a first polymer which is biodegradable and bioabsorbable and a second polymer which has higher biodegradability and bioabsorbability than those of the first polymer.

Abstract: The present invention provides a medical tube mainly comprising a thermoplastic resin wherein the surface contacting the blood has been subjected to a heparinizing treatment and wherein quality defect due to whitening and oil defect is reduced. According to the present invention, there is provided a medical tube wherein an antithrombotic material is coated on the inner surface of a tube prepared by a melt extrusion molding of a composition comprising a thermoplastic resin and a plasticizer, characterized in that the difference (?L) between the brightness of the medical tube before coating and the brightness of the medical tube after coating measured in accordance with JIS Z 8722 is 1 or less.

Abstract: A method for manufacturing a nerve regeneration-inducing tube with excellent pressure resistance, shape recovery property, anti-kink property, film exfoliation resistance, resistance to invasion of outer tissues, and leakage resistance. The tubular body is formed by weaving together fibers made up of biodegradable polymer. The outer surface of the tubular body is coated multiple times with a collagen solution. The lumen of the tubular body is filled with collagen. Viscosity of the collagen solution that is first applied to the outer surface of the tubular body is between 2 to 800 cps. Viscosity of the collagen solution that is subsequently applied is higher than viscosity of the first applied collagen solution.

Abstract: A method for manufacturing a nerve regeneration-inducing tube with excellent pressure resistance, shape recovery property, anti-kink property, film exfoliation resistance, resistance to invasion of outer tissues, and leakage resistance. The tubular body is formed by weaving together fibers made up of biodegradable polymer. The outer surface of the tubular body is coated multiple times with a collagen solution. The lumen of the tubular body is filled with collagen. Viscosity of the collagen solution that is first applied to the outer surface of the tubular body is between 2 to 800 cps. Viscosity of the collagen solution that is subsequently applied is higher than viscosity of the first applied collagen solution.

Abstract: A method for manufacturing a nerve regeneration-inducing tube with excellent pressure resistance, shape recovery property, anti-kink property, film exfoliation resistance, resistance to invasion of outer tissues, and leakage resistance. The tubular body is formed by weaving together fibers made up of biodegradable polymer. The outer surface of the tubular body is coated multiple times with a collagen solution. The lumen of the tubular body is filled with collagen. Viscosity of the collagen solution that is first applied to the outer surface of the tubular body is between 2 to 800 cps. Viscosity of the collagen solution that is subsequently applied is higher than viscosity of the first applied collagen solution.

Abstract: [Object] An object of the present invention is to provide a surface-treating agent excellent in antithrombogenicity, and accordingly, excellent in biocompatibility, and having high hydrophilicity as compared with conventional medical materials. Further, an object of the present invention is to provide a production method excellent in performance of removing unreacted monomers and further improving a yield as compared with conventional production methods. [Constitution] The present invention relates to a water-insoluble copolymer comprising alkyl(meth)acrylate and methoxypolyethylene glycol(meth)acrylate. The present invention also relates to a method for producing a water-insoluble (meth)acrylate copolymer by copolymerizing alkyl(meth)acrylate and methoxypolyethylene glycol(meth)acrylate in a common polymerization solvent.

Abstract: The invention provides an oxygenator of a hollow fiber membrane type where a plurality of hollow fiber membranes are received in a housing, wherein at least a part of the regions of the hollow fiber membranes to contact blood during use is coated with a water-insoluble (meth)acrylate copolymer in which a hydrophobic (meth)acrylate is copolymerized with a hydrophilic (meth)acrylate at a molar ratio of (50 to 90):(50 to 10).

Abstract: To provide a nerve regeneration-inducing tube being excellent in cell growth property, resistance to pressure, shape recovery property, and anti-kink property in a nerve regeneration-inducing tube where a collagen solution is applied on the outer surface of a tubular body knitted with ultrafine fiber comprising biodegradable and bioabsorbable polymer while collagen is filled in the inner area of the tubular body. Specifically, to provide a nerve regeneration-inducing tube where a degradation speed is adjusted so as to make it suitable for the connection of nerve gaps of more than 40 mm.

Abstract: To provide a method for the manufacture of a nerve regeneration-inducing tube being excellent in pressure resistance, shape recovery property, anti-kink property, film exfoliation resistance, property of prevention of invasion of outer tissues and leakage resistance. The present invention is a method for the manufacture of a nerve regeneration-inducting tube in which the outer surface of the tubular body knitted with a plurality of ultrafine fibers comprising biodegradable polymer is coated by application of a collagen solution for plural times to coat and then collagen is filled in the inner area of the above tubular body, characterized in that, viscosity of the collagen solution which is firstly applied on the outer surface of the tubular body is made 2 cps to 800 cps or, preferably, 5 cps to 200 cps. Preferably, viscosity of a collagen solution to be applied later is made high as compared with that of the firstly-applied one.

Abstract: The invention provides an oxygenator of a hollow fiber membrane type where a plurality of hollow fiber membranes are received in a housing, wherein at least a part of the regions of the hollow fiber membranes to contact blood during use is coated with a water-insoluble (meth)acrylate copolymer in which a hydrophobic (meth)acrylate is copolymerized with a hydrophilic (meth)acrylate at a molar ratio of (50 to 90):(50 to 10).

Abstract: [Object] An object of the present invention is to provide a surface-treating agent excellent in antithrombogenicity, and accordingly, excellent in biocompatibility, and having high hydrophilicity as compared with conventional medical materials. Further, an object of the present invention is to provide a production method excellent in performance of removing unreacted monomers and further improving a yield as compared with conventional production methods. [Constitution] The present invention relates to a water-insoluble copolymer comprising alkyl(meth)acrylate and methoxypolyethylene glycol(meth)acrylate. The present invention also relates to a method for producing a water-insoluble (meth)acrylate copolymer by copolymerizing alkyl(meth)acrylate and methoxypolyethylene glycol(meth)acrylate in a common polymerization solvent.