Patents by Inventor Yuyin Chen

Yuyin Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200157108
    Abstract: The present invention relates to PDE9 inhibitors, their synthesis, and their use for treatment of benign prostate hyperplasia, beta thalassemia, and sickle cell disease.
    Type: Application
    Filed: May 25, 2018
    Publication date: May 21, 2020
    Inventors: Niels SVENSTRUP, Jun ZHANG, Jikui SUN, Yuyin CHEN, Jianshe KONG, Rujian MA, Junhua ZHANG, Liang QIN, Huanming XIAO, Jinxu SUN, Xiao MENG, Fenglai SUN, Jingyang ZHU
  • Patent number: 10385102
    Abstract: Aspects of the invention relate to the engineering of biological nanostructures and materials.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: August 20, 2019
    Assignee: Massachusetts Institute of Technology
    Inventors: Timothy Kuan-Ta Lu, Allen Yuyin Chen
  • Patent number: 10369328
    Abstract: The present invention relates to a catheter that has adjustable stiffness that enables a user to select the stiffness of at least one region of the catheter during insertion and navigation through a body lumen. A preferred embodiment of the invention works in combination with a guidewire to enable placement of the catheter at a position within the vascular system, for example, to enable treatment of a variety of medical conditions. The catheter can include segments that undergo relative movement in response to actuation by the user to adjust the flexibility of the at least one region, preferably located at or near the distal end of the catheter.
    Type: Grant
    Filed: February 19, 2014
    Date of Patent: August 6, 2019
    Assignee: Beth Israel Deaconess Medical Center, Inc.
    Inventors: Leo Lee Tsai, Yuyin Chen, Vyas Ramanan
  • Patent number: 10265502
    Abstract: The present invention relates to a catheter that has adjustable stiffness that enables a user to select the stiffness of at least one region of the catheter during insertion and navigation through a body lumen. A preferred embodiment of the invention works in combination with a guidewire to enable placement of the catheter at a position within the vascular system, for example, to enable treatment of a variety of medical conditions. The catheter can include segments that undergo relative movement in response to actuation by the user to adjust the flexibility of the at least one region, preferably located at or near the distal end of the catheter.
    Type: Grant
    Filed: August 18, 2015
    Date of Patent: April 23, 2019
    Assignee: Beth Israel Deaconess Medical Center, Inc.
    Inventors: Leo Lee Tsai, Yuyin Chen, Vyas Ramanan
  • Publication number: 20180111968
    Abstract: Aspects of the invention relate to the engineering of biological nanostructures and materials.
    Type: Application
    Filed: February 17, 2017
    Publication date: April 26, 2018
    Applicant: Massachusetts Institute of Technology
    Inventors: Timothy Kuan-Ta Lu, Allen Yuyin Chen
  • Patent number: 9822116
    Abstract: This application discloses a novel process to synthesize 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds, which may be used, for example, as NK-1 inhibitor compounds in pharmaceutical preparations, intermediates useful in said process, and processes for preparing said intermediates; also disclosed is a process for removal of metals from N-heterocyclic carbine metal complexes.
    Type: Grant
    Filed: February 1, 2016
    Date of Patent: November 21, 2017
    Assignee: OPKO Health, Inc.
    Inventors: George G. Wu, Gerald Werne, Xiaoyong Fu, Robert K. Orr, Frank Xing Chen, Jian Cui, Victoria M. Sprague, Fucheng Zhang, Ji Xie, Liansheng Zeng, Louis Peter Castellanos, Yuyin Chen, Marc Poirier, Ingrid Mergelsberg
  • Patent number: 9580480
    Abstract: Aspects of the invention relate to the engineering of biological nanostructures and materials.
    Type: Grant
    Filed: May 31, 2012
    Date of Patent: February 28, 2017
    Assignee: Massachusetts Institute of Technology
    Inventors: Timothy Kuan-Ta Lu, Allen Yuyin Chen
  • Publication number: 20160145256
    Abstract: This application discloses a novel process to synthesize 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds, which may be used, for example, as NK-1 inhibitor compounds in pharmaceutical preparations, intermediates useful in said process, and processes for preparing said intermediates; also disclosed is a process for removal of metals from N-heterocyclic carbine metal complexes.
    Type: Application
    Filed: February 1, 2016
    Publication date: May 26, 2016
    Inventors: George G. Wu, Gerald Werne, Xiaoyong Fu, Robert K. Orr, Frank Xing Chen, Jian Cui, Victoria M. Sprague, Fucheng Zhang, Ji Xie, Liansheng Zeng, Louis Peter Castellanos, Yuyin Chen, Marc Poirier, Ingrid Mergelsberg
  • Publication number: 20160136393
    Abstract: The present invention relates to a catheter that has adjustable stiffness that enables a user to select the stiffness of at least one region of the catheter during insertion and navigation through a body lumen. A preferred embodiment of the invention works in combination with a guidewire to enable placement of the catheter at a position within the vascular system, for example, to enable treatment of a variety of medical conditions. The catheter can include segments that undergo relative movement in response to actuation by the user to adjust the flexibility of the at least one region, preferably located at or near the distal end of the catheter.
    Type: Application
    Filed: August 18, 2015
    Publication date: May 19, 2016
    Applicant: Beth Israel Deacones Medical Center, Inc.
    Inventors: Leo Lee Tsai, Yuyin Chen, Vyas Ramanan
  • Patent number: 9249144
    Abstract: This application discloses a novel process to synthesize 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds, which may be used, for example, as NK-1 inhibitor compounds in pharmaceutical preparations, intermediates useful in said process, and processes for preparing said intermediates; also disclosed is a process for removal of metals from N-heterocyclic carbine metal complexes.
    Type: Grant
    Filed: October 1, 2013
    Date of Patent: February 2, 2016
    Assignee: OPKO Health, Inc.
    Inventors: George G. Wu, Gerald Werne, Xiaoyong Fu, Robert K. Orr, Frank Xing Chen, Jian Cui, Victoria M. Sprague, Fucheng Zhang, Ji Xie, Liansheng Zeng, Louis Peter Castellanos, Yuyin Chen, Marc Poirier, Ingrid Mergelsberg
  • Publication number: 20150118712
    Abstract: Aspects of the invention relate to the engineering of biological nanostructures and materials.
    Type: Application
    Filed: May 31, 2012
    Publication date: April 30, 2015
    Applicant: Massachusetts Institute of Technology
    Inventors: Timothy Kuan-Ta Lu, Allen Yuyin Chen
  • Publication number: 20140236120
    Abstract: The present invention relates to a catheter that has adjustable stiffness that enables a user to select the stiffness of at least one region of the catheter during insertion and navigation through a body lumen. A preferred embodiment of the invention works in combination with a guidewire to enable placement of the catheter at a position within the vascular system, for example, to enable treatment of a variety of medical conditions. The catheter can include segments that undergo relative movement in response to actuation by the user to adjust the flexibility of the at least one region, preferably located at or near the distal end of the catheter.
    Type: Application
    Filed: February 19, 2014
    Publication date: August 21, 2014
    Inventors: Leo Lee Tsai, Yuyin Chen, Vyas Ramanan
  • Publication number: 20140031549
    Abstract: This application discloses a novel process to synthesize 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds, which may be used, for example, as NK-1 inhibitor compounds in pharmaceutical preparations, intermediates useful in said process, and processes for preparing said intermediates; also disclosed is a process for removal of metals from N-heterocyclic carbine metal complexes.
    Type: Application
    Filed: October 1, 2013
    Publication date: January 30, 2014
    Applicant: OPKO Health, Inc.
    Inventors: George G. Wu, Gerald Werne, Xiaoyong Fu, Robert K. Orr, Frank Xing Chen, Jian Cui, Victoria M. Sprague, Fucheng Zhang, Ji Xie, Liansheng Zeng, Louis Peter Castellanos, Yuyin Chen, Marc Poirier, Ingrid Mergelsberg