Patents by Inventor Yvonne Alice Nagel

Yvonne Alice Nagel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • STABILIZED POLYPEPTIDES AND USES THEREOF
    Publication number: 20160244494
    Abstract: The present invention provides inventive stabilized STAT polypeptides, pharmaceutical compositions thereof and methods of making and using inventive stabilized STAT polypeptides.
    Type: Application
    Filed: October 1, 2014
    Publication date: August 25, 2016
    Applicant: President and Fellows of Harvard College
    Inventors: Gregory L. Verdine, Yvonne Alice Nagel
  • STABILIZED POLYPEPTIDE INSULIN RECEPTOR MODULATORS
    Publication number: 20160215036
    Abstract: Provided herein are stabilized ?-CT polypeptides comprising an alpha-helical segment, and wherein the polypeptide is of Formula (I-1) or Formula (I-2): Rf—[XAA]s—XA1—XA2—XA3—XA4—XA5—XA6—XA7—XA8—XA9—XA10—XA11—XA12—XA13—XA14—[XAA]t—Re (I-1) Rf—[XAA]s—XC1—XC2—XC3—XC4—XC5—XC6—XC7—XC8—XC9—XC10—XC11—XC12—XC13—XC14—XC15—XC16—XC17—XC18—XC19—XC20—[XAA]t—Re (I-2) wherein the ?-CT polypeptide binds to the insulin receptor, and wherein the ?-CT polypeptide includes at least one staple (i.e. two cross-linked amino acids) and/or at least one stitch (i.e. three cross-linked amino acids). Further provided are insulin analogues including the stapled or stitched ?-CT polypeptides, pharmaceutical compositions thereof, methods of use, e.g., methods of treating a diabetic condition or complications thereof.
    Type: Application
    Filed: June 13, 2014
    Publication date: July 28, 2016
    Applicant: President and Fellows of Harvard College
    Inventors: Gregory L. Verdine, Gerard Hilinski, Rebecca Yue Liang, Yvonne Alice Nagel, Minyun Zhou