Patents by Inventor Zaneta Nikolovska-Coleska

Zaneta Nikolovska-Coleska has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SMALL MOLECULES AND THEIR USE AS MALT1 INHIBITORS
    Publication number: 20240124410
    Abstract: Small molecule inhibitors that block the interaction between B-cell lymphoma 10 protein (BCL10) and mucosa- associated lymphoid tissue lymphoma translocation protein 1 (MALT1), thereby inhibiting both the protease and scaffolding activities of MALT1, and MALT1- dependent downstream signaling, including IL-6 and IL-10 secretion by B-cell lymphoma cells and IL-2 transcription and secretion by Jurkat T cells.
    Type: Application
    Filed: March 24, 2022
    Publication date: April 18, 2024
    Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, Regents of the University of Michigan
    Inventors: Peter C. Lucas, Linda M. McAllister, Heejae Kang, Beibei Chen, Lisa Maurer, Dong Hu, Jing Cheng, Linda Klei, Zaneta Nikolovska-Coleska
  • Small molecule inhibitors of Mcl-1 and uses thereof
    Patent number: 9914723
    Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a [(1-Piperazinyl)-4-pyridinylmethyl]-Naphtho[1,2-b]furan structure which function as inhibitors of Mcl-1 protein, and their use as therapeutics for the treatment of cancer and other diseases.
    Type: Grant
    Filed: March 29, 2013
    Date of Patent: March 13, 2018
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Zaneta Nikolovska-Coleska, Naval Bajwa, Chenzhong Liao, Lei Miao
  • Small molecule inhibitors of Mcl-1 and uses thereof
    Patent number: 9884841
    Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having benzoic acid structure which function as inhibitors of Mcl-1 protein, and their use as therapeutics for the treatment of cancer and other diseases.
    Type: Grant
    Filed: April 20, 2016
    Date of Patent: February 6, 2018
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Zaneta Nikolovska-Coleska, Jeanne A. Stuckey, Ahmed Mady, Lei Miao
  • Compositions and methods relating to hindering DOT1L recruitment by MLL-fusion proteins
    Patent number: 9862746
    Abstract: The present invention relates to MLL fusion proteins (e.g., AF9 and ENL), which activate target genes in part via recruitment of histone methyltransferase DOT1L. In particular, the present invention provides the AF9/ENL binding site in DOT1L and agents that block the protein-protein interactions between AF9/ENL and DOT1L, therefore inhibiting the activity of DOT1L, and inhibiting MLL-fusion protein associated leukemia.
    Type: Grant
    Filed: February 14, 2014
    Date of Patent: January 9, 2018
    Assignee: The Regents of the University of Michigan
    Inventors: Zaneta Nikolovska-Coleska, Chenxi Shen, Jay Hess
  • Small molecule inhibitors of Mcl-1 and the uses of thereof
    Patent number: 9486422
    Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having sulfonamido-1-hydroxynaphthalene structure which function as inhibitors of Mcl-1 protein, and their use as therapeutics for the treatment of cancer and other diseases.
    Type: Grant
    Filed: October 8, 2012
    Date of Patent: November 8, 2016
    Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, WAYNE STATE UNIVERSITY
    Inventors: Zaneta Nikolovska-Coleska, Hollis D. Showalter, Chenzhong Liao, Ramzi Mohammad, Fardokht Abulwerdi
  • SMALL MOLECULE INHIBITORS OF MCL-1 AND USES THEREOF
    Publication number: 20160304485
    Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having benzoic acid structure which function as inhibitors of Mcl-1 protein, and their use as therapeutics for the treatment of cancer and other diseases.
    Type: Application
    Filed: April 20, 2016
    Publication date: October 20, 2016
    Inventors: Zaneta Nikolovska-Coleska, Jeanne A. Stuckey, Ahmed Mady, Lei Miao
  • Small molecule inhibitors of MCL-1 and uses thereof
    Patent number: 9394303
    Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having pyrazolopyridine structure which function as inhibitors of Mcl-1 protein, and their use as therapeutics for the treatment of cancer and other diseases.
    Type: Grant
    Filed: April 3, 2015
    Date of Patent: July 19, 2016
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Zaneta Nikolovska-Coleska, Fardokht Abulwerdi, Hollis Showalter, Lei Miao, Jeanne Stuckey, Ahmed Mady
  • COMPOSITIONS AND METHODS RELATING TO HINDERING DOT1L RECRUITMENT BY MLL-FUSION PROTEINS
    Publication number: 20150368300
    Abstract: The present invention relates to MLL fusion proteins (e.g., AF9 and ENL), which activate target genes in part via recruitment of histone methyltransferase DOT1L. In particular, the present invention provides the AF9/ENL binding site in DOT1L and agents that block the protein-protein interactions between AF9/ENL and DOT1L, therefore inhibiting the activity of DOT1L, and inhibiting MLL-fusion protein associated leukemia.
    Type: Application
    Filed: February 14, 2014
    Publication date: December 24, 2015
    Inventors: Zaneta Nikolovska-Coleska, Chenxi Shen, Jay Hess
  • SMALL MOLECULE INHIBITORS OF MCL-1 AND USES THEREOF
    Publication number: 20150284387
    Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having pyrazolopyridine structure which function as inhibitors of Mcl-1 protein, and their use as therapeutics for the treatment of cancer and other diseases.
    Type: Application
    Filed: April 3, 2015
    Publication date: October 8, 2015
    Inventors: Zaneta Nikolovska-Coleska, Fardokht Abulwerdi, Hollis Showalter, Lei Miao, Jeanne Stuckey, Ahmed Mady
  • SMALL MOLECULE INHIBITORS OF MCL-1 AND USES THEREOF
    Publication number: 20150045357
    Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a [(1-Piperazinyl)-4-pyridinylmethyl]-Naphtho[1,2-b]furan structure which function as inhibitors of Mcl-1 protein, and their use as therapeutics for the treatment of cancer and other diseases.
    Type: Application
    Filed: March 29, 2013
    Publication date: February 12, 2015
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Zaneta Nikolovska-Coleska, Naval Bajwa, Chenzhong Liao, Lei Miao
  • Small molecule inhibitors of MDM2 and the uses thereof
    Patent number: 8901117
    Abstract: The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).
    Type: Grant
    Filed: December 23, 2011
    Date of Patent: December 2, 2014
    Assignee: The Regents of The University of Michigan
    Inventors: Shaomeng Wang, Ke Ding, Yipin Lu, Zaneta Nikolovska-Coleska, Su Qiu, Guoping Wang, Dongguang Qin, Sanjeev Kumar
  • SMALL MOLECULE INHIBITORS OF MCL-1 AND THE USES OF THEREOF
    Publication number: 20140235702
    Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having sulfonamido-1-hydroxynaphthalene structure which function as inhibitors of Mcl-1 protein, and their use as therapeutics for the treatment of cancer and other diseases.
    Type: Application
    Filed: October 8, 2012
    Publication date: August 21, 2014
    Inventors: Zaneta Nikolovska-Coleska, Hollis D. Showalter, Chenzhong Liao, Ramzi Mohammad, Fardokht Abulwerdi
  • Diazo bicyclic Smac mimetics and the uses thereof
    Patent number: 8664212
    Abstract: The invention relates to diazo bicyclic mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
    Type: Grant
    Filed: July 25, 2012
    Date of Patent: March 4, 2014
    Assignee: The Regents of the University of Michigan
    Inventors: Shaomeng Wang, Yuefeng Peng, Haiying Sun, Qian Cai, Zaneta Nikolovska-Coleska, Jianfeng Lu, Su Qiu
  • Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof
    Patent number: 8557812
    Abstract: The invention relates to small molecules which function as inhibitors of anti-apoptotic Bcl-2 family member proteins (e.g., Bcl-2 and Bcl-xL). The invention also relates to the use of these compounds for inducing apoptotic cell death and sensitizing cells to the induction of apoptotic cell death.
    Type: Grant
    Filed: August 22, 2005
    Date of Patent: October 15, 2013
    Assignee: The Regents of the University of Michigan
    Inventors: Shaomeng Wang, Guoping Wang, Guozhi Tang, Renxiao Wang, Zaneta Nikolovska-Coleska, Dajun Yang, Liang Xu
  • Heteroaryl-substituted bicyclic Smac mimetics and the uses thereof
    Patent number: 8445473
    Abstract: The invention relates to heteroaryl-substituted bicyclic mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
    Type: Grant
    Filed: April 13, 2009
    Date of Patent: May 21, 2013
    Assignee: The Regents of the University of Michigan
    Inventors: Shaomeng Wang, Haiying Sun, Zaneta Nikolovska-Coleska
  • DIAZO BICYCLIC SMAC MIMETICS AND THE USES THEREOF
    Publication number: 20120309961
    Abstract: The invention relates to diazo bicyclic mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
    Type: Application
    Filed: July 25, 2012
    Publication date: December 6, 2012
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Shaomeng Wang, Yuefeng Peng, Haiying Sun, Qian Cai, Zaneta Nikolovska-Coleska, Jianfeng Lu, Su Qiu
  • Diazo bicyclic Smac mimetics and the uses thereof
    Patent number: 8278293
    Abstract: The invention relates to diazo bicyclic mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
    Type: Grant
    Filed: April 14, 2008
    Date of Patent: October 2, 2012
    Assignee: The Regents of the University of Michigan
    Inventors: Shaomeng Wang, Yuefeng Peng, Haiying Sun, Qian Cai, Zaneta Nikolovska-Coleska, Jianfeng Lu, Su Qiu
  • Bivalent SMAC mimetics and the uses thereof
    Patent number: 8202902
    Abstract: The invention relates to bivalent mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
    Type: Grant
    Filed: November 13, 2008
    Date of Patent: June 19, 2012
    Assignee: The Regents of the University of Michigan
    Inventors: Shaomeng Wang, Haiying Sun, Dongguang Qin, Zaneta Nikolovska-Coleska, Jianfeng Lu, Su Qiu, Yuefeng Peng, Qian Cai
  • SMALL MOLECULE INHIBITORS OF MDM2 AND THE USES THEREOF
    Publication number: 20120101092
    Abstract: The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).
    Type: Application
    Filed: December 23, 2011
    Publication date: April 26, 2012
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Shaomeng Wang, Ke Ding, Yipin Lu, Zaneta Nikolovska-Coleska, Su Qiu, Guoping Wang, Dongguang Qin, Sanjeev Kumar
  • Small molecule inhibitors of MDM2 and the uses thereof
    Patent number: 8088931
    Abstract: The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).
    Type: Grant
    Filed: June 24, 2010
    Date of Patent: January 3, 2012
    Assignee: The Regents of the University of Michigan
    Inventors: Shaomeng Wang, Ke Ding, Yipin Lu, Zaneta Nikolovska-Coleska, Su Qiu, Guoping Wang, Dongguang Qin, Sanjeev Kumar