Patents by Inventor Zhaoli Sun

Zhaoli Sun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210251954
    Abstract: The present invention relates to the field of wound healing. More specifically, the present invention provides methods and compositions useful for improved wound healing via autologous stem cell mobilization. In one embodiment, a method for improving wound healing in a patient comprises administering to the patient a therapeutically effective amount of a stem cell mobilizer and a low dose of an immunosuppressive agent.
    Type: Application
    Filed: February 3, 2021
    Publication date: August 19, 2021
    Inventors: Zhaoli Sun, George Melville Williams, Qing Lin
  • Patent number: 10945993
    Abstract: The present invention relates to the field of wound healing. More specifically, the present invention provides methods and compositions useful for improved wound healing via autologous stem cell mobilization. In one embodiment, a method for improving wound healing in a patient comprises administering to the patient a therapeutically effective amount of a stem cell mobilizer and a low dose of an immunosuppressive agent.
    Type: Grant
    Filed: April 29, 2014
    Date of Patent: March 16, 2021
    Assignee: MedRegen, LLC
    Inventors: Zhaoli Sun, George Melville Williams, Qing Lin
  • Publication number: 20210008042
    Abstract: The present invention related to the field of organ transplantation. In one aspect, the present invention provides methods of treating an organ transplant recipient comprising administering to the recipient a therapeutically effective amount of a stem cell mobilizer and an immunosuppressive agent. In particular embodiments, the present invention provides a method of treating an organ transplant recipient comprising administering to the recipient a therapeutically effective amount of an agent that mobilizes CD34+ and/or CD133+ stem cells and a low dose of immunosuppressive agent.
    Type: Application
    Filed: September 22, 2020
    Publication date: January 14, 2021
    Inventors: Zhaoli Sun, George Melville Williams
  • Publication number: 20200392182
    Abstract: A compound of Formula I, and its analogs are provided. Compositions that include Formula I can be used to inhibit human equilibrative nucleoside transporter 1, increase adenosine signaling and produce effects that include increasing antiviral activity, increasing antiparasitic activity, increasing alcohol tolerance, decreasing pain protecting from ischemia as well as many other conditions.
    Type: Application
    Filed: August 26, 2020
    Publication date: December 17, 2020
    Inventors: Jun Liu, Jingxin Wang, Zhaoli Sun, Sam Hong
  • Patent number: 10813917
    Abstract: The present invention relates to the field of organ transplantation. In one aspect, the present invention provides methods of treating an organ transplant recipient comprising administering to the recipient a therapeutically effective amount of a stem cell mobilizer and an immunosuppressive agent. In particular embodiments, the present invention provides a method of treating an organ transplant recipient comprising administering to the recipient a therapeutically effective amount of an agent that mobilizes CD34+ and/or CD133+ stem cells and a low dose of an immunosuppressive agent.
    Type: Grant
    Filed: December 10, 2010
    Date of Patent: October 27, 2020
    Assignee: MedRegen, LLC
    Inventors: Zhaoli Sun, George Melville Williams
  • Patent number: 10774110
    Abstract: A compound of Formula (I), and its analogs are provided. Compositions that include Formula I can be used to inhibit human equilibrative nucleoside transporter 1, increase adenosine signaling and produce effects that include increasing antiviral activity, increasing antiparasitic activity, increasing alcohol tolerance, decreasing pain protecting from ischemia as well as many other conditions.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: September 15, 2020
    Assignee: The Johns Hopkins University
    Inventors: Jun Liu, Jingxin Wang, Zhaoli Sun, Sam Hong
  • Publication number: 20200038381
    Abstract: The present invention relates to the field of inflammatory bowel disease. In one aspect, the present invention provides methods for treating inflammatory bowel disease in a patient comprising administering to the patient a therapeutically effective amount of a stem cell mobilizer and an immunosuppressive agent. In particular embodiments, the present invention provides a method for treating inflammatory bowel disease in a patient comprising administering to the patient a therapeutically effective amount of an agent that mobilizes CD34+ and/or CD133+ stem cells and a low dose of an immunosuppressive agent.
    Type: Application
    Filed: August 14, 2019
    Publication date: February 6, 2020
    Inventors: Zhaoli Sun, Xuhang Li
  • Publication number: 20190314344
    Abstract: The present invention relates to the field of inflammatory bowel disease. In one aspect, the present invention provides methods for treating inflammatory bowel disease in a patient comprising administering to the patient a therapeutically effective amount of a stem cell mobilizer and an immunosuppressive agent. In particular embodiments, the present invention provides a method for treating inflammatory bowel disease in a patient comprising administering to the patient a therapeutically effective amount of an agent that mobilizes CD34+ and/or CD133+ stem cells and a low dose of an immunosuppressive agent.
    Type: Application
    Filed: July 31, 2015
    Publication date: October 17, 2019
    Inventors: Zhaoli Sun, Xuhang Li
  • Patent number: 10420751
    Abstract: The present invention relates to the field of inflammatory bowel disease. In one aspect, the present invention provides methods for treating inflammatory bowel disease in a patient comprising administering to the patient a therapeutically effective amount of a stem cell mobilizer and an immunosuppressive agent. In particular embodiments, the present invention provides a method for treating inflammatory bowel disease in a patient comprising administering to the patient a therapeutically effective amount of an agent that mobilizes CD34+ and/or CD133+ stem cells and a low dose of an immunosuppressive agent.
    Type: Grant
    Filed: July 31, 2015
    Date of Patent: September 24, 2019
    Assignee: MedRegen, LLC
    Inventors: Zhaoli Sun, Xuhang Li
  • Publication number: 20190031716
    Abstract: A compound of Formula (I), and its analogs are provided. Compositions that include Formula I can be used to inhibit human equilibrative nucleoside transporter 1, increase adenosine signaling and produce effects that include increasing antiviral activity, increasing antiparasitic activity, increasing alcohol tolerance, decreasing pain protecting from ischemia as well as many other conditions.
    Type: Application
    Filed: February 3, 2017
    Publication date: January 31, 2019
    Inventors: Jun Liu, Jingxin Wang, Zhaoli Sun, Sam Hong
  • Publication number: 20180200232
    Abstract: The present invention relates to the field of tissue injury. More specifically, the present invention provides pharmaceutical compositions useful for the treatment of tissue injury. In certain embodiments, a pharmaceutical composition comprises (a) a stem cell mobilizer and (b) an immunosuppressive agent or non-immunosuppressive FK binding protein ligand. The pharmaceutical compositions of the invention can be administered by a variety of routes and dosing regimens.
    Type: Application
    Filed: July 15, 2016
    Publication date: July 19, 2018
    Inventor: Zhaoli Sun
  • Publication number: 20180161315
    Abstract: The present invention relates to the field of organ transplantation. In one aspect, the present invention provides methods of treating an organ transplant recipient comprising administering to the recipient a therapeutically effective amount of a stem cell mobilizer and an immunosuppressive agent. In particular embodiments, the present invention provides a method of treating an organ transplant recipient comprising administering to the recipient a therapeutically effective amount of an agent that mobilizes CD34+ and/or CD133+ stem cells and a low dose of an immunosuppressive agent.
    Type: Application
    Filed: December 10, 2010
    Publication date: June 14, 2018
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Zhaoli Sun, George Melville Williams
  • Publication number: 20160106710
    Abstract: The present invention relates to the field of wound healing. More specifically, the present invention provides methods and compositions useful for improved wound healing via autologous stem cell mobilization. In one embodiment, a method for improving wound healing in a patient comprises administering to the patient a therapeutically effective amount of a stem cell mobilizer and a low dose of an immunosuppressive agent.
    Type: Application
    Filed: April 29, 2014
    Publication date: April 21, 2016
    Applicant: The Johns Hopkins University
    Inventors: Zhaoli Sun, George Melville Williams, Qing Lin
  • Publication number: 20160008331
    Abstract: The present invention relates to the field of inflammatory bowel disease. In one aspect, the present invention provides methods for treating inflammatory bowel disease in a patient comprising administering to the patient a therapeutically effective amount of a stem cell mobilizer and an immunosuppressive agent. In particular embodiments, the present invention provides a method for treating inflammatory bowel disease in a patient comprising administering to the patient a therapeutically effective amount of an agent that mobilizes CD34+ and/or CD133+ stem cells and a low dose of an immunosuppressive agent.
    Type: Application
    Filed: July 31, 2015
    Publication date: January 14, 2016
    Inventors: Zhaoli Sun, Xuhang Li
  • Publication number: 20130338183
    Abstract: The present invention relates to the field of hematopoietic stem cells. More specifically, the present invention provides methods and composition useful for peripheral blood stem cell mobilization. In one embodiment, a method of treating an organ transplant recipient comprises administering to the recipient a low dose of Tacrolimus in an amount sufficient to mobilize stem cells to the peripheral blood of the recipient. In a specific embodiment, the low dose of Tacrolimus is in the range of about 0.05 mg/kg to about 0.5 mg/kg.
    Type: Application
    Filed: December 7, 2011
    Publication date: December 19, 2013
    Applicant: The Johns Hopkins University
    Inventors: Zhaoli Sun, Takehiro Okabayashi
  • Patent number: 8575716
    Abstract: A method of forming memory array and peripheral circuitry isolation includes chemical vapor depositing a silicon dioxide-comprising liner over sidewalls of memory array circuitry isolation trenches and peripheral circuitry isolation trenches formed in semiconductor material. Dielectric material is flowed over the silicon dioxide-comprising liner to fill remaining volume of the array isolation trenches and to form a dielectric liner over the silicon dioxide-comprising liner in at least some of the peripheral isolation trenches. The dielectric material is furnace annealed at a temperature no greater than about 500° C. The annealed dielectric material is rapid thermal processed to a temperature no less than about 800° C. A silicon dioxide-comprising material is chemical vapor deposited over the rapid thermal processed dielectric material to fill remaining volume of said at least some peripheral isolation trenches.
    Type: Grant
    Filed: May 14, 2013
    Date of Patent: November 5, 2013
    Assignee: Micron Technology, Inc.
    Inventors: James Mathew, Brett D. Lowe, Yunjun Ho, H. Jim Fulford, Jie Sun, Zhaoli Sun
  • Publication number: 20130249050
    Abstract: A method of forming memory array and peripheral circuitry isolation includes chemical vapor depositing a silicon dioxide-comprising liner over sidewalls of memory array circuitry isolation trenches and peripheral circuitry isolation trenches formed in semiconductor material. Dielectric material is flowed over the silicon dioxide-comprising liner to fill remaining volume of the array isolation trenches and to form a dielectric liner over the silicon dioxide-comprising liner in at least some of the peripheral isolation trenches. The dielectric material is furnace annealed at a temperature no greater than about 500° C. The annealed dielectric material is rapid thermal processed to a temperature no less than about 800° C. A silicon dioxide-comprising material is chemical vapor deposited over the rapid thermal processed dielectric material to fill remaining volume of said at least some peripheral isolation trenches.
    Type: Application
    Filed: May 14, 2013
    Publication date: September 26, 2013
    Applicant: Micron Technology, Inc.
    Inventors: James Mathew, Brett D. Lowe, Yunjun Ho, H. Jim Fulford, Jie Sun, Zhaoli Sun
  • Patent number: 8461016
    Abstract: A method of forming memory array and peripheral circuitry isolation includes chemical vapor depositing a silicon dioxide-comprising liner over sidewalls of memory array circuitry isolation trenches and peripheral circuitry isolation trenches formed in semiconductor material. Dielectric material is flowed over the silicon dioxide-comprising liner to fill remaining volume of the array isolation trenches and to form a dielectric liner over the silicon dioxide-comprising liner in at least some of the peripheral isolation trenches. The dielectric material is furnace annealed at a temperature no greater than about 500° C. The annealed dielectric material is rapid thermal processed to a temperature no less than about 800° C. A silicon dioxide-comprising material is chemical vapor deposited over the rapid thermal processed dielectric material to fill remaining volume of said at least some peripheral isolation trenches.
    Type: Grant
    Filed: October 7, 2011
    Date of Patent: June 11, 2013
    Assignee: Micron Technology, Inc.
    Inventors: James Mathew, Brett D. Lowe, Yunjun Ho, H. Jim Fulford, Jie Sun, Zhaoli Sun
  • Patent number: 8431483
    Abstract: A method of forming an electrically conductive plug includes providing an opening within electrically insulative material over a node location on a substrate. An electrically conductive material is formed within the opening and elevationally over the insulative material. Some of the conductive material is removed effective to recess an outermost surface of the conductive material to from about 100 Angstroms to about 200 Angstroms from an outermost surface of the insulative material after said removing of some of the conductive material. After removing some of the conductive material, remaining volume of the opening over the conductive material is overfilled with an electrically conductive metal material different from that of the conductive material. The metal material is polished effective to form an electrically conductive plug within the opening comprising the conductive material and the metal material. Other aspects and implementations are contemplated.
    Type: Grant
    Filed: March 26, 2007
    Date of Patent: April 30, 2013
    Assignee: Micron Technology, Inc.
    Inventors: Zhaoli Sun, Jun Liu, Dapeng Wang
  • Publication number: 20130087883
    Abstract: A method of forming memory array and peripheral circuitry isolation includes chemical vapor depositing a silicon dioxide-comprising liner over sidewalls of memory array circuitry isolation trenches and peripheral circuitry isolation trenches formed in semiconductor material. Dielectric material is flowed over the silicon dioxide-comprising liner to fill remaining volume of the array isolation trenches and to form a dielectric liner over the silicon dioxide-comprising liner in at least some of the peripheral isolation trenches. The dielectric material is furnace annealed at a temperature no greater than about 500° C. The annealed dielectric material is rapid thermal processed to a temperature no less than about 800° C. A silicon dioxide-comprising material is chemical vapor deposited over the rapid thermal processed dielectric material to fill remaining volume of said at least some peripheral isolation trenches.
    Type: Application
    Filed: October 7, 2011
    Publication date: April 11, 2013
    Inventors: James Mathew, Brett D. Lowe, Yunjun Ho, H. Jim Fulford, Jie Sun, Zhaoli Sun