Abstract: The present disclosure provides a method for predicting a three-dimensional frost heaving deformation of a formation during freezing construction of a metro tunnel and relates to the field of metro tunnel construction. The method includes: firstly determining a freezing construction position, obtaining soil horizon parameters of undisturbed soil within a range of a freezing wall, determining thermophysical and mechanical parameters of soil, layering a soil horizon above the freezing wall according to soil horizon properties thereof and existing buildings (structures), and determining a horizon where a frost heaving influence range exists; subsequently calculating an unsteady temperature field of a single freezing pipe and a radius of a freezing front; then calculating an inner radius and an outer radius of the freezing front after closure of the freezing wall according to a tunnel excavation type, and calculating a frost heaving region; and finally calculating a frost heaving displacement.

Abstract: A selenium-chelating pea oligopeptide, a preparation method thereof and use thereof. After the selenium-chelating pea oligopeptide is subjected to digestion treatment in at least one of following three ways, a change rate of selenium content not more than 3% with respect to the selenium content before the digestion treatment: hydrolyzing for 4 hours by a pepsin at a pH value of 2 and a temperature of 37° C.; hydrolyzing for 6 hours by a trypsin at a pH value of 7.5 and a temperature of 37° C.; maintaining the temperature constant at 37° C., firstly hydrolyzing for 4 hours by the pepsin at a pH value of 2, and then continuing to hydrolyze for 6 hours by a trypsin at a pH value of 6.8. The preparation method thereof includes mixing and reacting an aqueous solution of pea oligopeptide and sodium selenite, and then being subjected to alcohol precipitation and drying.

Abstract: The present invention relates to a structurally novel TLR8 (Toll-like receptor 8) agonist and, in particular, to a compound thereof of formula (I), a pharmaceutically acceptable salt and an isomer thereof.

Abstract: A TLR8 (Toll-like receptor 8) agonist, a compound of the structure shown in formula (I), an isomer thereof, or a pharmaceutically acceptable salt thereof.

Abstract: A detachable atomizing device and a container thereof are provided. The container is detachably assembled to an atomizing assembly. The container includes a cup and a flexible film. The cup has an opening arranged at an end thereof, the flexible film covers the opening of the cup, and the flexible film has a tension region and an outer ring-shaped region that surrounds the tension region. The tension region has a plurality of atomizing holes having an average diameter within a range of 1 ?m to 20 ?m, and the outer ring-shaped region is attached to the cup. When the cup is assembled to the atomizing assembly, a tension value of the tension region of the flexible film is increased from an initial tension value to an atomizing tension value by being pressed from the atomizing assembly, and the atomizing holes of the tension region are configured to allow liquid to pass there-through and to be formed as aerosol mist having an average atomized particle diameter less than a predetermined value.

Abstract: Disclosed is a crystal form of a hepatitis B surface antigen inhibitor and a preparation method, and an application of the crystal form in the preparation of the hepatitis B surface antigen inhibitor.

Abstract: Provided is an isochroman compound represented by formula (I), or a pharmaceutically acceptable salt thereof, which is used as an aldo-keto reductase (AKR1C3) inhibitor for the treatment of liver cancer.

Abstract: Disclosed are a crystalline form of a Toll-like receptor 8 (TLR8) agonist as represented by formula (I) and a preparation method therefor. Further provided is an application of the crystalline form in the preparation of a drug for treating a disease responsive to the TLR8 agonist.

Abstract: The present invention relates to a combination of a compound represented by formula (I) and other drugs for treating hepatitis B that is used for treating hepatitis B, and use of the combination in the preparation of drugs for treating hepatitis B.

Abstract: Disclosed is a crystal form of a hepatitis B surface antigen inhibitor and a preparation method, and an application of the crystal form in the preparation of the hepatitis B surface antigen inhibitor.

Abstract: Macrocyclic derivatives, preparation methods therefor and pharmaceutical compositions comprising said derivatives, and uses thereof as therapeutic agents, especially as factor XIa inhibitors and in drugs for treating and preventing thromboembolisms and other diseases. Specifically disclosed is a compound represented by formula (I), and an isomer and pharmaceutically acceptable salt thereof.

Abstract: A TLR8 (Toll-like receptor 8) agonist, a compound of the structure shown in formula (I), an isomer thereof, or a pharmaceutically acceptable salt thereof.

Abstract: The present invention relates to a structurally novel TLR8 (Toll-like receptor 8) agonist and, in particular, to a compound thereof of formula (I), a pharmaceutically acceptable salt and an isomer thereof.

Abstract: A detachable atomizing device and a container thereof are provided. The container is detachably assembled to an atomizing assembly. The container includes a cup and a flexible film. The cup has an opening arranged at an end thereof, the flexible film covers the opening of the cup, and the flexible film has a tension region and an outer ring-shaped region that surrounds the tension region. The tension region has a plurality of atomizing holes having an average diameter within a range of 1 ?m to 20 ?m, and the outer ring-shaped region is attached to the cup. When the cup is assembled to the atomizing assembly, a tension value of the tension region of the flexible film is increased from an initial tension value to an atomizing tension value by being pressed from the atomizing assembly, and the atomizing holes of the tension region are configured to allow liquid to pass there-through and to be formed as aerosol mist having an average atomized particle diameter less than a predetermined value.

Abstract: The present invention discloses a benzimidazole-linked indole compound acting as novel divalent IAP antagonist, specifically disclosing the compound shown in formulas (I) or a pharmaceutically acceptable salt thereof.

Abstract: The present invention discloses a benzimidazole-linked indole compound acting as novel divalent IAP antagonist, specifically disclosing the compound shown in formulas (I) or a pharmaceutically acceptable salt thereof.

Abstract: Disclosed are a method for preparing a series of novel pyridine derivatives and a use thereof. Such derivatives can be used in the treatment of related diseases caused by mycobacteria, in particular diseases caused by pathogenic mycobacteria, such as Mycobacterium tuberculosis, Mycobacterium bovis, Mycobacterium avium and Mycobacterium marinum.

Abstract: Disclosed are a method for preparing a series of novel pyridine derivatives and a use thereof. Such derivatives can be used in the treatment of related diseases caused by mycobacteria, in particular diseases caused by pathogenic mycobacteria, such as Mycobacterium tuberculosis, Mycobacterium bovis, Mycobacterium avium and Mycobacterium marinum.

Abstract: The present invention relates to a finger-worn input device, which comprises a movement detecting unit, a main controller and a connection structure. After being assembled, users can insert their finger in between the movement detecting unit and the main controller in order to move the movement detecting unit and to press a key. The main controller receives a movement signal and a key signal, converts these signals into a computer control signal, which is then transmitted to a computer for further process through a wired or wireless transmission method. By using the finger-worn input device with the structure mentioned above, the user usage is more convenient and the input device can be minimized. In addition, the present invention also discloses an input method applying the finger-worn input device.