Patents by Inventor Zhenhua Miao

Zhenhua Miao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions useful as ligands for the formyl peptide receptor like 1 receptor and methods of use thereof
    Patent number: 8637043
    Abstract: The inventors have discovered that a CK?8-1 truncation variant, CK?8-1 (25-116), is a bifunctional ligand for two distinct GPCRs, chemokine receptor CCR1 and formyl peptide receptor like 1 (FPRL1). Hence, the inventors have discovered that, in addition to its functional activity on CCR1, CK?8-1(25-116) is also a functional ligand for the GPCR receptor FPRL1 that is involved in inflammatory reactions and innate immunity by recruiting monocytes and neutrophils. In addition, the inventors have discovered an alternatively spliced exon of CK?8-1, named SHAAGtide. SHAAGtide, along with its parent chemokine CK?8-1 (25-116), is fully functional on both monocytes and neutrophils that are known to express FPRL1. This application relates generally to enhancing immune responses. Such immune responses may be elicited by vaccine administration. Compositions and methods for inducing or enhancing an immune response to an antigen are provided.
    Type: Grant
    Filed: July 5, 2005
    Date of Patent: January 28, 2014
    Assignee: Chemocentryx, Inc.
    Inventors: Thomas J. Schall, Zhenhua Miao, Robert Berahovich, Zheng Wei, Maureen Howard, Brett Premack
  • Antibodies that bind CXCR7 epitopes
    Patent number: 8088895
    Abstract: Antibodies that bind CXCR7 epitopes, as well as methods of identifying CXCR7 modulators are described.
    Type: Grant
    Filed: October 10, 2007
    Date of Patent: January 3, 2012
    Assignee: ChemoCentryx, Inc.
    Inventors: Brett Premack, Zhenhua Miao, Mark Penfold
  • COMPOSITIONS AND METHODS FOR DETECTING AND TREATING DISEASES AND CONDITIONS RELATED TO CHEMOKINE RECEPTORS
    Publication number: 20110165164
    Abstract: Ligands of CCX-CKR2 and the biological role of CCX-CKR2 in cancer is described.
    Type: Application
    Filed: December 9, 2010
    Publication date: July 7, 2011
    Applicant: ChemoCentryx, Inc.
    Inventors: Jennifer M. Burns, Bretton Summers, Maureen C. Howard, Thomas J. Schall, Zhenhua Miao
  • Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors
    Patent number: 7871619
    Abstract: Ligands of CCX-CKR2 and the biological role of CCX-CKR2 in cancer is described.
    Type: Grant
    Filed: August 4, 2004
    Date of Patent: January 18, 2011
    Assignee: ChemoCentryx, Inc.
    Inventors: Jennifer M. Burns, Bretton Summers, Maureen C. Howard, Thomas J. Schall, Zhenhua Miao
  • Methods and Compositions For Modulating Angiogenesis
    Publication number: 20100247540
    Abstract: The present invention provides method and compositions for modulating angiogenesis.
    Type: Application
    Filed: July 20, 2009
    Publication date: September 30, 2010
    Applicant: ChemoCentryx, Inc.
    Inventors: Jennifer Burns, Bretton Summers, Yu Wang, Maureen Howard, Thomas Schall, Zhenhua Miao
  • Enzymatic activities in chemokine-mediated inflammation
    Patent number: 7572600
    Abstract: Truncated chemokines lacking an N-terminal region that activate CCR1 and/or FPRL1 and compositions containing the truncated chemokines are provided. Methods of identifying agents that modulate CCR1 and/or FPRL1 activity either by modulating the production of the truncated chemokines or the ability of the truncated chemokines to activate CCR1 and/or FPRL1 are also disclosed. Methods using the truncated chemokines to inhibit or activate CCR1 and/or FPRL1 mediated biological activities are also disclosed.
    Type: Grant
    Filed: August 4, 2005
    Date of Patent: August 11, 2009
    Assignee: Chemocentryx, Inc.
    Inventors: Robert D. Berahovich, Zhenhua Miao, Brett Premack, Thomas J. Schall
  • ANTIBODIES THAT BIND CXCR7 EPITOPES
    Publication number: 20090022717
    Abstract: Antibodies that bind CXCR7 epitopes, as well as methods of identifying CXCR7 modulators are described.
    Type: Application
    Filed: October 10, 2007
    Publication date: January 22, 2009
    Applicant: ChemoCentryx, Inc.
    Inventors: Brett Premack, Zhenhua Miao, Mark Penfold
  • Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors
    Patent number: 7442512
    Abstract: The present invention provides methods for identifying an agent that specifically binds and/or modulates one topology of chemokine receptor but not a second topology of the receptor. Such agents are useful as therapeutics for diseases or conditions associated with a particular chemokine receptor topology. Moreover, the agents are useful for detecting a particular topology of a chemokine receptor, thereby diagnosing disease or predisposition for a disease. In addition, the agents are useful for identifying and isolating cells that express a particular topology of a chemokine receptor.
    Type: Grant
    Filed: September 16, 2002
    Date of Patent: October 28, 2008
    Assignee: ChemoCentryx, Inc.
    Inventors: Jennifer M. Burns, Zhenhua Miao, Zheng Wei, Maureen C. Howard, Brett A. Premack, Thomas J. Schall
  • Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors
    Patent number: 7413866
    Abstract: The present invention provides methods for identifying an agent that specifically binds and/or modulates one topology of a chemokine receptor but not a second topology of the receptor. Such agents are useful as therapeutics for diseases or conditions associated with a particular chemokine receptor topology. Moreover, the agents are useful for detecting a particular topology of a chemokine receptor, thereby diagnosing disease or predisposition for a disease. In addition, the agents are useful for identifying and isolating cells that express a particular topology of a chemokine receptor.
    Type: Grant
    Filed: May 30, 2003
    Date of Patent: August 19, 2008
    Assignee: ChemoCentryx, Inc.
    Inventors: Jennifer M. Burns, Zhenhua Miao, Zheng Wei, Maureen C. Howard, Brett A. Premack, Thomas J. Schall
  • Cell migration assay
    Patent number: 7396653
    Abstract: The present invention is directed to a modified cell migration assay allowing for improved identification and discrimination of chemokine receptor antagonists from non-specific blockers.
    Type: Grant
    Filed: April 17, 2007
    Date of Patent: July 8, 2008
    Assignee: ChemoCentryx, Inc.
    Inventors: Zheng Wei, Zhenhua Miao
  • Cell migration assay
    Patent number: 7282338
    Abstract: The present invention is directed to a modified cell migration assay allowing for improved identification and discrimination of chemokine receptor antagonists from non-specific blockers.
    Type: Grant
    Filed: May 22, 2002
    Date of Patent: October 16, 2007
    Assignee: ChemoCentryx, Inc.
    Inventors: Zheng Wei, Zhenhua Miao
  • Cell migration assay
    Publication number: 20070196855
    Abstract: The present invention is directed to a modified cell migration assay allowing for improved identification and discrimination of chemokine receptor antagonists from non-specific blockers.
    Type: Application
    Filed: April 17, 2007
    Publication date: August 23, 2007
    Inventors: Zheng Wei, Zhenhua Miao
  • Chemokine receptor
    Patent number: 7108990
    Abstract: The invention provides polypeptides and polynucleotides encoding a novel chemokine receptor, CCX CKR. The invention further provides reagents and methods for identifying agents that modulate the activity or expression of the receptors, as well as methods for detecting receptor expression.
    Type: Grant
    Filed: February 24, 2004
    Date of Patent: September 19, 2006
    Assignee: ChemoCentryx, Inc.
    Inventors: Jennifa Gosling, Daniel J. Dairaghi, Michael Hanley, Zhenhua Miao, Thomas J. Schall
  • Enzymatic activities in chemokine-mediated inflammation
    Publication number: 20060063223
    Abstract: Truncated chemokines lacking an N-terminal region that activate CCR1 and/or FPRL1 and compositions containing the truncated chemokines are provided. Methods of identifying agents that modulate CCR1 and/or FPRL1 activity either by modulating the production of the truncated chemokines or the ability of the truncated chemokines to activate CCR1 and/or FPRL1 are also disclosed. Methods using the truncated chemokines to inhibit or activate CCR1 and/or FPRL1 mediated biological activities are also disclosed.
    Type: Application
    Filed: August 4, 2005
    Publication date: March 23, 2006
    Inventors: Robert Berahovich, Zhenhua Miao, Brett Premack, Thomas Schall
  • Compositions useful as ligands for the formyl peptide receptor like 1 receptor and methods of use thereof
    Publication number: 20060034863
    Abstract: The inventors have discovered that a CK?8-1 truncation variant, CK?8-1 (25-116), is a bifunctional ligand for two distinct GPCRs, chemokine receptor CCR1 and formyl peptide receptor like 1 (FPRL1). Hence, the inventors have discovered that, in addition to its functional activity on CCR1, CK?8-1(25-116) is also a functional ligand for the GPCR receptor FPRL1 that is involved in inflammatory reactions and innate immunity by recruiting monocytes and neutrophils. In addition, the inventors have discovered an alternatively spliced exon of CK?8-1, named SHAAGtide. SHAAGtide, along with its parent chemokine CK?8-1 (25-116), is fully functional on both monocytes and neutrophils that are known to express FPRL1. This application relates generally to enhancing immune responses. Such immune responses may be elicited by vaccine administration. Compositions and methods for inducing or enhancing an immune response to an antigen are provided.
    Type: Application
    Filed: July 5, 2005
    Publication date: February 16, 2006
    Inventors: Thomas Schall, Zhenhua Miao, Robert Berahovich, Zheng Wei, Maureen Howard, Brett Premack
  • Method for identifying a modulator of the binding of CCX CKR polypeptide to a chemokine
    Patent number: 6998239
    Abstract: The invention provides polypeptides and polynucleotides encoding a novel chemokine receptor, CCX CKR. The invention further provides reagents and methods for identifying agents that modulate the activity or expression of the receptors, as well as methods for detecting receptor expression.
    Type: Grant
    Filed: November 21, 2000
    Date of Patent: February 14, 2006
    Assignee: ChemoCentryx, Inc.
    Inventors: Jennifa Gosling, Daniel J. Dairaghi, Michael Hanley, Zhenhua Miao, Dale Talbot, Thomas J. Schall
  • Method for identifying a modulator of the binding of CCX CKR polypeptide to a chemokine
    Publication number: 20050239130
    Abstract: The invention provides polypeptides and polynucleotides encoding a novel chemokine receptor, CCX CKR. The invention further provides reagents and methods for identifying agents that modulate the activity or expression of the receptors, as well as methods for detecting receptor expression.
    Type: Application
    Filed: June 28, 2005
    Publication date: October 27, 2005
    Applicant: ChemoCentryx, Inc.
    Inventors: Jennifa Gosling, Daniel Dairaghi, Zhenhua Miao, Thomas Schall
  • Methods and compositions for modulating angiogenesis
    Publication number: 20050214287
    Abstract: The present invention provides method and compositions for modulating angiogenesis.
    Type: Application
    Filed: February 2, 2005
    Publication date: September 29, 2005
    Applicant: ChemoCentryx, Inc.
    Inventors: Jennifer Burns, Bretton Summers, Yu Wang, Maureen Howard, Thomas Schall, Zhenhua Miao
  • Cell migration assay
    Publication number: 20050186556
    Abstract: The present invention is directed to a modified cell migration assay allowing for improved identification and discrimination of chemokine receptor antagonists from non-specific blockers.
    Type: Application
    Filed: January 24, 2005
    Publication date: August 25, 2005
    Inventors: Zheng Wei, Zhenhua Miao
  • Methods for identifying modulators of CCX CKR activity
    Patent number: RE39849
    Abstract: The invention provides polypeptides and polynucleotides encoding a novel chemokine receptor, CCX CKR. The invention further provides reagents and methods for identifying agents that modulate the activity or expression of the receptors, as well as methods for detecting receptor expression.
    Type: Grant
    Filed: December 29, 2005
    Date of Patent: September 18, 2007
    Assignee: ChemoCentryx, Inc.
    Inventors: Jennifa Gosling, Daniel J. Dairaghi, Michael Hanley, Zhenhua Miao, Thomas J. Schall