Patents by Inventor Zhi Hong

Zhi Hong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8722929
    Abstract: This invention provides compounds of formula A and formula B which are modulators of potassium ion channels and are useful for the treatment of seizure disorders.
    Type: Grant
    Filed: October 10, 2007
    Date of Patent: May 13, 2014
    Assignee: Valeant Pharmaceuticals International
    Inventors: Jean-Michel Vernier, Jianlan Song, Huanming Chen, Zhi Hong
  • Patent number: 8716318
    Abstract: This invention concerns N-(ortho phenylamino dihydropyridyl)sulfonamides and N-(ortho phenylamino dihydropyridyl), N?-alkyl sulfamides which are inhibitors of MEK and are useful in the treatment of cancer and other hyperproliferative diseases.
    Type: Grant
    Filed: January 19, 2011
    Date of Patent: May 6, 2014
    Assignee: Ardea Biosciences
    Inventors: Shunqi Yan, Jean-Michel Vernier, Zhi Hong, Suetying Chow, Yung-hyo Koh
  • Publication number: 20140066508
    Abstract: A method for ameliorating metabolic syndrome may include administering, to a patient in need thereof, an effective amount of a monounsaturated fatty acid having 22 carbons or a salt or an ester thereof and/or an effective amount of a monounsaturated fatty acid having 20 carbons or a salt or an ester thereof.
    Type: Application
    Filed: February 29, 2012
    Publication date: March 6, 2014
    Applicant: NIPPON SUISAN KAISHA, LTD.
    Inventors: Zhi-hong Yang, Hiroko Miyahara, Shuhei Takemura, Akimasa Hatanaka
  • Publication number: 20130313614
    Abstract: The present invention discloses a metal silicide self-aligned SiGe heterojunction bipolar transistor, which is designed to overcome the shortcomings such as the large base resistance RB of the prior art products. The metal silicide self-aligned SiGe heterojunction bipolar transistor of the present invention mainly comprises an Si collector region, a local dielectric region, a base region, a base-region low-resistance metal silicide layer, a polysilicon emitter region, an emitter-base spacer dielectric region composed of a liner silicon oxide layer and a silicon nitride inner sidewall, a monocrystalline emitter region, a contact hole dielectric layer, an emitter metal electrode and a base metal electrode. The base-region low-resistance metal silicide layer extends all the way to the outside of the emitter-base spacer dielectric region. The present invention discloses a method of forming a metal silicide self-aligned SiGe heterojunction bipolar transistor, which is used to form the aforesaid bipolar transistor.
    Type: Application
    Filed: September 24, 2012
    Publication date: November 28, 2013
    Applicant: TSINGHUA UNIVERSITY
    Inventors: Jun Fu, Yu-dong Wang, Wei Zhang, Gao-qing Li, Zheng-li Wu, Jie Cui, Yue Zhao, Zhi-hong Liu
  • Publication number: 20130307122
    Abstract: The present invention discloses a bipolar transistor with an embedded epitaxial external base region, which is designed to solve the problem of the TED effect with the prior art structures. The bipolar transistor with an embedded epitaxial external base region of the present invention comprises at least a collector region, a base region and an external base region on the collector region, an emitter on the base region, and sidewalls at both sides of the emitter. The external base region is grown through an in-situ doping selective epitaxy process and is embedded in the collector region. A portion of the external base region is located beneath the sidewalls. The present invention discloses a method of forming a bipolar transistor with an embedded epitaxial external base region.
    Type: Application
    Filed: September 24, 2012
    Publication date: November 21, 2013
    Applicant: TSINGHUA UNIVERSITY
    Inventors: Yu-dong Wang, Jun Fu, Jie Cui, Yue Zhao, Zhi-hong Liu, Wei Zhang, Gao-qing Li, Zheng-li Wu, Ping Xu
  • Patent number: 8552043
    Abstract: A series of S-triazolyl ?-mercaptoacetanilides having N-(?-mercaptoacetyl) p amino benzoic acid derivatives. are provided, where Q is CO2H, or a salt or ester thereof, or a C(O) N-linked amino acid. The compounds inhibit several variants of the reverse transcriptase of HIV, and are useful in the treatment of HIV infections.
    Type: Grant
    Filed: December 6, 2011
    Date of Patent: October 8, 2013
    Assignee: Ardea Biosciences, Inc.
    Inventors: Jean-Luc Girardet, Yung-Hyo Koh, Martha De La Rosa, Zhi Hong, Stanley Lang
  • Patent number: 8494269
    Abstract: A method for screening of a to-be-analyzed candidate as a skin-whitening agent, includes the steps of: (a) setting a first feature parameter corresponding to a first group of zebrafish that are bred under a predetermined set of breeding conditions; (b) administering the to-be-analyzed candidate to a second group of zebrafish that are bred under the predetermined set of breeding conditions; (c) capturing images of the zebrafish in the second group; (d) determining, from the images captured in step (c), a second feature parameter corresponding to the second group of zebrafish; and (e) concluding that the to-be-analyzed candidate is suitable as a skin-whitening agent if a difference between the first and second feature parameters has statistical significance. A system for implementing the method is also disclosed.
    Type: Grant
    Filed: November 5, 2010
    Date of Patent: July 23, 2013
    Assignee: National Sun Yat-Sen University
    Inventors: Zhi-Hong Wen, Po-Shien Wu, Wen-Sheng Liu, Fu-Hsin Chang, Tsung-Wei Chen
  • Patent number: 8481581
    Abstract: A series of S-triazolyl ?-mercaptoacetanilides having general structure (1) are provided, where Q is CO2H, CONR2, SO3H, or SO2NR2. The compounds inhibit several variants of the reverse transcriptase of HIV, and are useful in the treatment of HIV infections.
    Type: Grant
    Filed: July 18, 2012
    Date of Patent: July 9, 2013
    Assignee: Ardea Biosciences, Inc.
    Inventors: Jean-Luc Girardet, Yung-Hyo Koh, Martha De La Rosa, Esmir Gunic, Zhi Hong, Stanley Lang, Hong-Woo Kim
  • Patent number: 8472212
    Abstract: A method for controlling operation of a resonant converter is to be implemented by a control module that generates a drive signal for controlling a power switch of the resonant converter to thereby control an output voltage and an output current provided by the resonant converter to a load. The method includes: (A) configuring the control module to determine if the load is operating in a first mode or a second mode; (B) configuring the control module to generate the drive signal according to the output voltage when the control module determines that the load is operating in the first mode; and (C) configuring the control module to generate the drive signal according to the output current when the control module determines that the load is operating in the second mode.
    Type: Grant
    Filed: September 27, 2010
    Date of Patent: June 25, 2013
    Assignees: Silitek Electronic (Guangzhou) Co., Ltd., Lite-On Technology Corp.
    Inventors: Ming-Zhu Li, Jing-Yan Li, Qing-Lin Zhao, Zhi-Hong Ye, Chun-Lin Zhang
  • Patent number: 8455023
    Abstract: The present invention provides a Cinnamomum subavenium extract for inhibiting melanogenesis. The present invention also provides a composition for inhibiting melanogenesis including compounds inhibit tyrosinase activity.
    Type: Grant
    Filed: August 2, 2010
    Date of Patent: June 4, 2013
    Assignee: Kaohsiung Medical University
    Inventors: Hui-Min Wang, Chung-Yi Chen, Zhi-Hong Wen
  • Publication number: 20130078216
    Abstract: The present invention relates to molecules that can be targeted to the liver. These liver targeting molecules (e.g.fusions and conjugates) comprise proteins, antibodies or antibody fragments such as immunoglobulin (antibody) single variable domains (dAbs) and also one or more additional molecules which it is desired to deliver to the liver such as interferons. The invention further relates to uses, formulations, compositions and devices comprising such liver targeting molecules. The invention also relates to immunoglobulin (antibody) single variable domains which bind to hepatocytes.
    Type: Application
    Filed: January 13, 2011
    Publication date: March 28, 2013
    Inventors: Grainne Dunlevy, Steven Holmes, Zhi Hong, Armin Sepp, Adam Walker
  • Patent number: 8399661
    Abstract: The invention relates to a sulfur-containing compound and the preparation thereof. The invention also relates to the uses of the sulfur-containing compound in inhibiting inducible nitric oxide synthase and/or cyclooxygenase-2 and in treating the diseases associated with inducible nitric oxide synthase and/or cyclooxygenase-2. This invention also describes a series of chemical analogues of the said sulfur-containing compound and the preparation of these compounds.
    Type: Grant
    Filed: July 14, 2008
    Date of Patent: March 19, 2013
    Assignee: National Sun Yat-Sen University
    Inventors: Jyh-Horng Sheu, Chih-Hua Chao, Zhi-Hong Wen
  • Patent number: 8399403
    Abstract: The present disclosure provides drug-ligand conjugates that are potent cytotoxins, wherein the drug is linked to the ligand through either a peptidyl, hydrazine, or disulfide linker. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.
    Type: Grant
    Filed: November 2, 2009
    Date of Patent: March 19, 2013
    Assignee: Medarex, Inc.
    Inventors: Sharon E. Boyd, Liang Chen, Sanjeev Gangwar, Vincent Guerlavais, Kilian Horgan, Zhi-Hong Li, Bilal Sufi
  • Patent number: 8354532
    Abstract: This application concerns certain 2-phenylamino-6-aryl amino-, 6-aryloxy-, and 6-arylthio-purines, -azapurines and -deazapurines. These compounds are non-nucleoside reverse transcriptase inhibitors and have potential as anti-HIV treatment.
    Type: Grant
    Filed: May 11, 2012
    Date of Patent: January 15, 2013
    Assignee: Ardea Biosciences, Inc.
    Inventors: Jean-Luc Girardet, Yung-hyo Koh, Stephanie Shaw, Hong Woo Kim, Zhi Hong
  • Patent number: 8324223
    Abstract: This application concerns certain 4-cyanophenylamino-substituted bicyclic heterocycles of formula I where the dashed line represents a double bond that may be located either between A and C(V) or between C(V) and D, where A is S or C(Z); D is S or C(W); provided that one and only one of A and D is S; where T is NH, O, or S; and where other substituents are defined herein. These compounds are non-nucleoside reverse transcriptase inhibitors and have potential as anti-HIV treatment.
    Type: Grant
    Filed: May 11, 2012
    Date of Patent: December 4, 2012
    Assignee: Ardea Biosciences, Inc.
    Inventors: Jean-Luc Girardet, Zhi Hong, Stephanie Shaw, Yung-hyo Koh
  • Publication number: 20120283301
    Abstract: A series of S-triazolyl ?-mercaptoacetanilides having general structure (1) are provided, where Q is CO2H, CONR2, SO3H, or SO2NR2. The compounds inhibit several variants of the reverse transcriptase of HIV, and are useful in the treatment of HIV infections.
    Type: Application
    Filed: July 18, 2012
    Publication date: November 8, 2012
    Applicant: Ardea Biosciences Inc.
    Inventors: Jean-Luc Girardet, Yung-Hyo Koh, Martha De La Rosa, Esmir Gunic, Zhi Hong, Stanley Lang, Woo-Hong Kim
  • Publication number: 20120225894
    Abstract: This application concerns certain 4-cyanophenylamino-substituted bicyclic heterocycles of formula I where the dashed line represents a double bond that may be located either between A and C(V) or between C(V) and D, where A is S or C(Z); D is S or C(W); provided that one and only one of A and D is S; where T is NH, O, or S; and where other substituents are defined herein. These compounds are non-nucleoside reverse transcriptase inhibitors and have potential as anti-HIV treatment.
    Type: Application
    Filed: May 11, 2012
    Publication date: September 6, 2012
    Applicant: Ardea Biosciences, Inc.
    Inventors: Jean-Luc GIRARDET, Zhi HONG, Stephanie SHAW, Yung-hyo KOH
  • Publication number: 20120226037
    Abstract: This application concerns certain 2-phenylamino-6-aryl amino-, 6-aryloxy-, and 6-arylthio-purines, -azapurines and -deazapurines. These compounds are non-nucleoside reverse transcriptase inhibitors and have potential as anti-HIV treatment.
    Type: Application
    Filed: May 11, 2012
    Publication date: September 6, 2012
    Applicant: Ardea Biosciences, Inc.
    Inventors: Jean-Luc Girardet, Yung-Hyo Koh, Stephanie Shaw, Hong Woo Kim, Zhi Hong
  • Publication number: 20120221731
    Abstract: A method for scheduling service applications is applied in a computing device. The method creates a software interface and sets a scheduled time and operation parameters of a service application. The software interface is called and bound to the service application. The service application is added to a scheduling queue. At the scheduled time, the service application is selected from the scheduling queue and executed according to the operation parameters of the service application.
    Type: Application
    Filed: December 28, 2011
    Publication date: August 30, 2012
    Applicants: HON HAI PRECISION INDUSTRY CO., LTD., HONG FU JIN PRECISION INDUSTRY (ShenZhen) CO., LTD.
    Inventors: ZHI-HONG LI, CHIEN-FA YEH, CHUNG-I LEE
  • Patent number: 8252828
    Abstract: A series of S-triazolyl ?-mercaptoacetanilides having general structure (1) are provided, where Q is CO2H, CONR2, SO3H, or SO2NR2. The compounds inhibit several variants of the reverse transcriptase of HIV, and are useful in the treatment of HIV infections.
    Type: Grant
    Filed: June 30, 2011
    Date of Patent: August 28, 2012
    Assignee: Ardea Biosciences, Inc.
    Inventors: Jean-Luc Girardet, Yung Hyo Koh, Martha De La Rosa, Esmir Gunic, Zhi Hong, Stanley Lang, Hong Woo Kim