Patents by Inventor Zhibin Guan

Zhibin Guan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GENERAL STRATEGY FOR POLYMER COMPATIBILIZATION
    Publication number: 20230039491
    Abstract: A polymer composition that operates as a polymer compatibilizer is provided. The polymer composition includes a plurality of polymer backbones cross-linked by cross-links that are Diels-Alder reaction products of at least one dienophile-containing moiety and at least one diene-containing moiety.
    Type: Application
    Filed: July 5, 2022
    Publication date: February 9, 2023
    Applicant: The Regents of the University of California
    Inventors: Chase Tretbar, Zhibin Guan
  • SILOXANE EXCHANGE CHEMISTRY FOR VITRIMERS
    Publication number: 20230043444
    Abstract: A vitrimer composition includes a first plurality of polymer backbones cross-linked with cross-linkers that include at least one siloxane moiety having formula 1: wherein R1, R2, R3, and R4 are each independently H or C1-6 alkyl. A catalyst that accelerates siloxane exchange is dispersed within the first plurality of polymer backbones.
    Type: Application
    Filed: July 5, 2022
    Publication date: February 9, 2023
    Applicant: The Regents of the University of California
    Inventors: Chase Tretbar, Zhibin Guan, Jordan A. Castro
  • Boroxine based dynamic thermosetting polymers
    Patent number: 11370889
    Abstract: The disclosure provides for dynamic thermosetting polymers comprising boroxine crosslinks that exhibit unusual mechanical behavior by being strong, highly malleable, recyclable and fully reprocessable. The disclosure further provides methods of making the thermosetting polymers and applications thereof.
    Type: Grant
    Filed: May 17, 2019
    Date of Patent: June 28, 2022
    Assignee: The Regents of the University of California
    Inventors: Zhibin Guan, William Ogden
  • PEPTIDE-FUNCTIONALIZED BIODEGRADABLE POLYMERS FOR EFFICIENT DELIVERY OF VARIOUS RNAS
    Publication number: 20220183990
    Abstract: The disclosure provides for peptide-functionalized biodegradable polymers, and methods of using the polymers for efficiently delivering RNAs of various sizes, and secondary structures inside cells.
    Type: Application
    Filed: February 21, 2020
    Publication date: June 16, 2022
    Inventors: Zhibin Guan, Dongchu Yang, Alexander Eldredge
  • PRACTICAL SYNTHESIS OF MULTIPHASE SELF-HEALING POLYMERS FROM COMMODITY MONOMERS
    Publication number: 20220041782
    Abstract: A self-healing polymer material that includes a multiphase copolymer, and a method of making the copolymer, are provided. The multiphase copolymer includes one or more hydrogen bond-forming copolymer segments, each segment including a polymerized acrylamide monomer and a polymerized acrylic monomer. The polymerized acrylamide monomer includes functional groups that form hydrogen bonds in the multiphase copolymer, and is present in the one or more copolymer segments in an amount sufficient for self-healing of the multiphase copolymer.
    Type: Application
    Filed: August 11, 2021
    Publication date: February 10, 2022
    Applicant: The Regents of the University of California
    Inventors: Zhibin GUAN, Aaron M. KUSHNER
  • Dynamic polymers based on silyl ether exchange
    Patent number: 11208534
    Abstract: The disclosure provides for dynamic polymers based on silyl ether exchange that are malleable and recyclable which have favorable mechanical properties and chemical resistance, methods of making thereof, and uses and applications thereof.
    Type: Grant
    Filed: June 26, 2018
    Date of Patent: December 28, 2021
    Assignee: The Regents of the University of California
    Inventor: Zhibin Guan
  • Synthesis of multiphase self-healing polymers from commodity monomers
    Patent number: 11111330
    Abstract: A self-healing polymer material that includes a multiphase copolymer, and a method of making the copolymer, are provided. The multiphase copolymer includes one or more hydrogen bond-forming copolymer segments, each segment including a polymerized acrylamide monomer and a polymerized acrylic monomer. The polymerized acrylamide monomer includes functional groups that form hydrogen bonds in the multiphase copolymer, and is present in the one or more copolymer segments in an amount sufficient for self-healing of the multiphase copolymer.
    Type: Grant
    Filed: June 20, 2016
    Date of Patent: September 7, 2021
    Assignee: The Regents of the University of California
    Inventors: Zhibin Guan, Aaron M. Kushner
  • Biodegradable vectors for efficient RNA delivery
    Patent number: 11097012
    Abstract: The disclosure provides for vectors, and methods of using the vectors to efficiently deliver mRNA and/or ssRNA into cells.
    Type: Grant
    Filed: March 10, 2017
    Date of Patent: August 24, 2021
    Assignee: The Regents of the University of California
    Inventors: Zhibin Guan, Nathan Oldenhuis
  • BOROXINE BASED DYNAMIC THERMOSETTING POLYMERS
    Publication number: 20190352469
    Abstract: The disclosure provides for dynamic thermosetting polymers comprising boroxine crosslinks that exhibit unusual mechanical behavior by being strong, highly malleable, recyclable and fully reprocessable. The disclosure further provides methods of making the thermosetting polymers and applications thereof.
    Type: Application
    Filed: May 17, 2019
    Publication date: November 21, 2019
    Inventors: Zhibin Guan, William Ogden
  • BIODEGRADABLE VECTORS FOR EFFICIENT RNA DELIVERY
    Publication number: 20190070304
    Abstract: The disclosure provides for vectors, and methods of using the vectors to efficiently deliver mRNA and/or ssRNA into cells.
    Type: Application
    Filed: March 10, 2017
    Publication date: March 7, 2019
    Inventors: Zhibin Guan, Nathan Oldenhuis
  • Dendronized polymers for nucleic acid delivery
    Patent number: 10179837
    Abstract: The disclosure provides for dendronized polymers, and the use of the polymers as carriers for the intracellular delivery of nucleic acids.
    Type: Grant
    Filed: August 28, 2017
    Date of Patent: January 15, 2019
    Assignee: The Regents of the University of California
    Inventors: Zhibin Guan, Hanxiang Zeng
  • DYNAMIC POLYMERS BASED ON SILYL ETHER EXCHANGE
    Publication number: 20180371183
    Abstract: The disclosure provides for dynamic polymers based on silyl ether exchange that are malleable and recyclable which have favorable mechanical properties and chemical resistance, methods of making thereof, and uses and applications thereof.
    Type: Application
    Filed: June 26, 2018
    Publication date: December 27, 2018
    Inventor: Zhibin Guan
  • SYNTHESIS OF MULTIPHASE SELF-HEALING POLYMERS FROM COMMODITY MONOMERS
    Publication number: 20180171055
    Abstract: A self-healing polymer material that includes a multiphase copolymer, and a method of making the copolymer, are provided. The multiphase copolymer includes one or more hydrogen bond-forming copolymer segments, each segment including a polymerized acrylamide monomer and a polymerized acrylic monomer. The polymerized acrylamide monomer includes functional groups that form hydrogen bonds in the multiphase copolymer, and is present in the one or more copolymer segments in an amount sufficient for self-healing of the multiphase copolymer.
    Type: Application
    Filed: June 20, 2016
    Publication date: June 21, 2018
    Applicant: The Regents of the University of California
    Inventors: Aaron M. Kushner, Zhibin Guan
  • Bio-inspired method to obtain multifunctional dynamic nanocomposites
    Patent number: 9938368
    Abstract: A method for a polymeric or nanocomposite material. The method includes assembling a multiphase hard-soft structure, where the structure includes a hard micro- or nano-phase, and a soft micro- or nano-phase that includes a polymeric scaffold. In the method, the polymeric scaffold includes dynamically interacting motifs and has a glass transition temperature (Tg) lower than the intended operating temperature of the material.
    Type: Grant
    Filed: March 7, 2013
    Date of Patent: April 10, 2018
    Assignee: The Regents of the University of California
    Inventors: Aaron M. Kushner, Zhibin Guan, Gregory Williams, Yulin Chen
  • DENDRONIZED POLYMERS FOR NUCLEIC ACID DELIVERY
    Publication number: 20180072849
    Abstract: The disclosure provides for dendronized polymers, and the use of the polymers as carriers for the intracellular delivery of nucleic acids.
    Type: Application
    Filed: August 28, 2017
    Publication date: March 15, 2018
    Inventors: Zhibin Guan, Hanxiang Zeng
  • Vectors for delivery of agents across biological membranes
    Patent number: 9867845
    Abstract: The disclosure provides for peptide-based bolaamphiphile vectors that are capable of encapsulating a variety of agents, including peptides, proteins, nucleic acids, and drugs. The disclosure further provides for delivering these agents across biological membranes using the peptide-based bolaamphiphile vectors.
    Type: Grant
    Filed: July 30, 2015
    Date of Patent: January 16, 2018
    Assignee: The Regents of the University of California
    Inventors: Zhibin Guan, Hanxiang Zeng, Mark Edward Johnson
  • Dendronized polymers for nucleic acid delivery
    Patent number: 9745421
    Abstract: The disclosure provides for dendronized polymers, and the use of the polymers as carriers for the intracellular delivery of nucleic acids.
    Type: Grant
    Filed: March 20, 2014
    Date of Patent: August 29, 2017
    Assignee: The Regents of the University of California
    Inventors: Zhibin Guan, Hanxiang Zeng
  • Saccharide-peptide hydrogels
    Patent number: 9289500
    Abstract: The disclosure provides for saccharide-peptide based hydrogels, the functionalization of the saccharide-peptide based hydrogels with one or more biological agents, and the encapsulation of one or more biological materials and/or pharmaceutical agents in the hydrogels. The disclosure further provides for the use of the saccharide-peptide based hydrogels in treating a disease or disorder in a subject.
    Type: Grant
    Filed: February 21, 2014
    Date of Patent: March 22, 2016
    Assignees: The Regents of the University of California, City of Hope
    Inventors: Zhibin Guan, Yoko Mullen, Sophia W. Liao
  • VECTORS FOR DELIVERY OF AGENTS ACROSS BIOLOGICAL MEMBRANES
    Publication number: 20160030590
    Abstract: The disclosure provides for peptide-based bolaamphiphile vectors that are capable of encapsulating a variety of agents, including peptides, proteins, nucleic acids, and drugs. The disclosure further provides for delivering these agents across biological membranes using the peptide-based bolaamphiphile vectors.
    Type: Application
    Filed: July 30, 2015
    Publication date: February 4, 2016
    Inventors: Zhibin Guan, Hanxiang Zeng, Mark Edward Johnson
  • Polymeric materials and methods
    Patent number: 9238697
    Abstract: Chimeric polymer compositions and methods are provided in which a plurality of carbohydrate moieties and amino acids form the backbone of a polymer. Most preferably, the polymer includes alternating saccharide and peptide portions to form the chimeric polymer.
    Type: Grant
    Filed: February 24, 2006
    Date of Patent: January 19, 2016
    Assignee: The Regents of the University of California
    Inventor: Zhibin Guan