Patents by Inventor Zhidong Xu

Zhidong Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20070149592
    Abstract: This invention provides compositions, methods and kits for the diagnosis and treatment of cancers expressing a GLI polypeptide, and in particular a GLI1, GLI2 or GLI3 polypeptide. The invention provides small molecule compounds mimicking the transcriptional activation domain of a GLI polypeptide. The small molecule inhibitors of the invention specifically block the activator function of a GLI polypeptide, but not the repressor function of GLI3.
    Type: Application
    Filed: December 7, 2006
    Publication date: June 28, 2007
    Applicant: REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Biao He, Naoaki Fujii, Liang You, Zhidong Xu, David Jablons
  • Publication number: 20070037157
    Abstract: This invention provides compositions and methods for the diagnosis and treatment of cancers that exhibit decreased SOCS-3 expression.
    Type: Application
    Filed: September 3, 2004
    Publication date: February 15, 2007
    Applicant: The Regents of the University of California
    Inventors: Biao He, Liang You, Zhidong Xu, David Jablons
  • Patent number: 7141600
    Abstract: Novel compounds that have been found effective in inhibiting PDZ domain interactions, and particularly interactions of PDZ domains in MAGIs with the oncogenic (tumor suppressor) protein PTEN and interactions between the PDZ domain in the Dishevelled (Dvl) protein and other proteins such as the Frizzled (Fz) protein, have the general formula The invention also includes combinatorial libraries, arrays and methods for screening and studying proteins using such compounds. Compounds of the invention have produced apoptosis in certain cell lines that overexpress the Dishevelled protein (Dvl); inhibiting Wnt signaling.
    Type: Grant
    Filed: April 15, 2004
    Date of Patent: November 28, 2006
    Assignee: The Regents of the University of California
    Inventors: R. Kiplin Guy, Irwin D. Kuntz, Jose Haresco, Naoaki Fujii, Kathleen P. Novak, David Stokoe, Biao He, Liang You, Zhidong Xu, David M. Jablons
  • Publication number: 20060040883
    Abstract: This invention relates to methods of inhibiting the growth of cells, in particular cancer cells, that overexpress Wnt2. The methods comprise contacting the cell with an agent that binds to Wnt2 mRNA or Wnt2 protein, interferes with Wnt2 signaling or inhibits binding of the Wnt2 protein to another protein, such as a Frizzled receptor.
    Type: Application
    Filed: May 16, 2005
    Publication date: February 23, 2006
    Applicant: The Regents of the University of California
    Inventors: Liang You, Biao He, Zhidong Xu, David Jablons
  • Publication number: 20050288226
    Abstract: This invention provides compositions, methods and kits for the diagnosis and treatment of cancers wherein Wnt Inhibitory Factor-1 (WIF-1) is underexpressed.
    Type: Application
    Filed: May 23, 2005
    Publication date: December 29, 2005
    Applicant: REGENTS OF THE UNIVERSITY OF California; Office of Technology Transfer
    Inventors: Liang You, Biao He, Zhidong Xu, David Jablons
  • Publication number: 20050043385
    Abstract: Novel compounds that have been found effective in inhibiting PDZ domain interactions, and particularly interactions of PDZ domains in MAGIs with the oncogenic (tumor suppressor) protein PTEN and interactions between the PDZ domain in the Dishevelled (Dvl) protein and other proteins such as the Frizzled (Fz) protein, have the general formula The invention also includes combinatorial libraries, arrays and methods for screening and studying proteins using such compounds. Compounds of the invention have produced apoptosis in certain cell lines that overexpress the Dishevelled protein (Dvl); inhibiting Wnt signaling.
    Type: Application
    Filed: April 15, 2004
    Publication date: February 24, 2005
    Applicant: The Regents of the University of California
    Inventors: R. Guy, Irwin Kuntz, Jose Haresco, Naoaki Fujii, Kathleen Novak, David Stokoe, Biao He, Liang You, Zhidong Xu, David Jablons
  • Publication number: 20040247593
    Abstract: This invention relates to methods of inhibiting the growth of cancer cells that overexpress a Wnt protein. The methods comprise contacting the cell with an agent that inhibits binding of the Wnt protein to a Frizzled receptor.
    Type: Application
    Filed: October 3, 2003
    Publication date: December 9, 2004
    Applicant: REGENTS OF THE UNIVERSITY OF CALIFORNIA,
    Inventors: Biao He, Liang You, Zhidong Xu, David M. Jablons
  • Publication number: 20030104432
    Abstract: The present invention provides efficient and novel methods for synthesizing and amplifying sense-strand RNA. The methods of the invention include methods of synthesizing probes useful for probing oligo and cDNA microarrays and for the development of subtractive and normalized expression libraries.
    Type: Application
    Filed: July 26, 2002
    Publication date: June 5, 2003
    Applicant: The Regents of the University of California
    Inventors: Zhidong Xu, David Jablons, Liang You, Biao He
  • Patent number: 6265165
    Abstract: A method for cloning of single EST-specific full length cDNA, and/or multiplex-EST-specific full-length cDNA cloning. The method involves cDNA synthesis from highly enriched, homogeneously purified mRNAs and includes hybrid selection for purification of specific mRNAs from total RNA by employing antisense oligonucleotide primers based on expressed sequence tag (EST) sequences.
    Type: Grant
    Filed: January 29, 1999
    Date of Patent: July 24, 2001
    Assignee: The Regents of the University of California
    Inventors: Zhidong Xu, Dieter C. Gruenert