Patents by Inventor Zhiguo J. Song

Zhiguo J. Song has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tartaric Acid Salts of a Dipeptidyl Peptidase-IV Inhibitor
    Publication number: 20090124601
    Abstract: Tartaric acid salts of (3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl) butanoyl]hexahydro-3-(2,2,2-trifluoroethyl)-2H-1,4-diazepin-2-one are potent inhibitors of dipeptidyl peptidase-IV and are useful for the prevention and/or treatment of non-insulin dependent diabetes mellitus, also referred to as Type 2 diabetes. The invention also relates to crystalline anhydrate forms of the tartaric acid salts as well as a process for their preparation, pharmaceutical compositions containing these novel forms and methods of use for the treatment of Type 2 diabetes.
    Type: Application
    Filed: March 24, 2006
    Publication date: May 14, 2009
    Inventors: Zhiguo J. Song, Fei Zhang, Rebecca Leigh Shultz
  • Process to ribofuranose sugar derivatives as intermediates to branched-chain nucleosides
    Patent number: 7034167
    Abstract: A novel process is provided for the preparation of ribofuranose sugar derivatives which are useful in the synthesis of branched-chain ribonucleoside inhibitors of HCV polymerase for the treatment of HCV infection. Also provided are useful intermediates obtained from the instant process.
    Type: Grant
    Filed: December 5, 2003
    Date of Patent: April 25, 2006
    Assignee: Merck & Co., Inc.
    Inventors: Kimberly A. Savary, Zhiguo J. Song, J. Michael Williams, Feng Xu
  • Process to ribofuranose sugar derivatives as intermediates to branched-chain nucleosides
    Publication number: 20040175808
    Abstract: A novel process is provided for the preparation of ribofuranose sugar derivatives which are useful in the synthesis of branched-chain ribonucleoside inhibitors of HCV polymerase for the treatment of HCV infection. Also provided are useful intermediates obtained from the instant process.
    Type: Application
    Filed: December 5, 2003
    Publication date: September 9, 2004
    Inventors: Kimberly A. Savary, Zhiguo J. Song, J. Michael Williams, Feng Xu
  • Process for the synthesis of an endothelin receptor antagonist
    Publication number: 20020107391
    Abstract: The present invention relates to a practical and efficient way to synthesize the compound for the endothelin receptor antagonist involving a Grignard addition and a cyclization reaction to give a desired compound of the general formula shown below: 1
    Type: Application
    Filed: October 18, 2001
    Publication date: August 8, 2002
    Inventors: Lisa F. Frey, Cheng Y. Chen, Jing Li, Zhiguo J. Song, Lushi Tan, Richard D. Tillyer, David M. Tschaen, Matthew M. Zhao