Patents by Inventor Zhijian Zhao

Zhijian Zhao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of treating cancer
    Publication number: 20060142178
    Abstract: The present invention is directed to a method of treating cancer which comprises administration of a compound which selectively inhibits the activity of one or two of the isoforms of Akt, a serine/threonine protein kinase. The invention is particularly directed to the method wherein the compound is dependent on the presence of the pleckstrin homology domain of Akt for its inhibitory activity.
    Type: Application
    Filed: April 4, 2003
    Publication date: June 29, 2006
    Inventors: Stanley Barnett, Deborah DeFeo-Jones, George Hartman, Kathleen Haskell, Hans Huber, Craig Lindsley, Zhijian Zhao
  • Inhibitors of akt activity
    Publication number: 20050288294
    Abstract: The present invention is directed to compounds which contain a five-membered heterocyclic ring fused to a substituted pyrazine moiety which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.
    Type: Application
    Filed: October 24, 2003
    Publication date: December 29, 2005
    Inventors: Mark Duggan, Craig Lindsley, Zhijian Zhao
  • Inhibitors of akt activity
    Publication number: 20050222155
    Abstract: The present invention is directed to compounds comprising a 2,3-diphenylquinoxaline moiety which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.
    Type: Application
    Filed: April 4, 2003
    Publication date: October 6, 2005
    Inventors: Mark Bilodeau, Mark Duggan, John Hartnett, Craig Lindsley, Peter Manley, Zhicai Wu, Zhijian Zhao
  • Inhibitors of akt activity
    Publication number: 20050182256
    Abstract: The present invention is directed to compounds comprising a 2,3-diphenylpyrazine moiety which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.
    Type: Application
    Filed: April 4, 2003
    Publication date: August 18, 2005
    Inventors: Mark Duggan, Craig Lindsley, Zhijian Zhao
  • Inhibitors of akt activity
    Publication number: 20050159422
    Abstract: The present invention is directed to compounds comprising a ring-fused quinoxalinyl moiety which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.
    Type: Application
    Filed: April 4, 2003
    Publication date: July 21, 2005
    Inventors: Craig Lindsley, Zhijian Zhao
  • Inhibitors of akt activity
    Publication number: 20050130977
    Abstract: The present invention is directed to compounds comprising a 2,3-diphenylquinoxaline moiety which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.
    Type: Application
    Filed: April 4, 2003
    Publication date: June 16, 2005
    Inventors: Craig Lindsley, Zhijian Zhao