Patents by Inventor Zhiwen Xu

Zhiwen Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250074990
    Abstract: Provided are antibodies and antigen-binding fragments thereof that specifically bind to human neuropilin-2 (NRP2) polypeptides, including those that modulate binding interactions between human NRP2 and at least one NRP2 ligand, for example, human histidyl-tRNA synthetase (HRS), and which thereby modulate subsequent NRP2-mediated downstream signaling events, including related therapeutic compositions and methods for modulating NRP2 activity and treating diseases such as NRP2-associated diseases.
    Type: Application
    Filed: July 8, 2024
    Publication date: March 6, 2025
    Inventors: Luke BURMAN, Yee Ting (Esther) CHONG, Yanyan GENG, Leslie Nangle GREENE, Kristina HAMEL, David KING, Ann MENEFEE, Kaitlyn RAUCH, Zhiwen XU, Liting ZHAI
  • Publication number: 20250066820
    Abstract: Provided in the present disclosure are a yeast protein having an antibacterial function and a preparation method therefor. The method includes: S1, performing liquid fermentation on a Saccharomyces cerevisiae strain, and then performing separation to obtain a yeast milk; S2, acidifying the yeast milk to obtain an acidified yeast milk; and optionally performing autolysis, or exogenous enzyme catalytic hydrolysis, or mechanical crushing on the yeast milk to obtain a cell wall emulsion; S3, mixing the acidified yeast milk and the optional cell wall emulsion and performing autolysis to obtain an autolysis mixed solution; S4, performing first enzymolysis with compound protease; S5, performing second enzymolysis with seminase; and performing third enzymolysis with ?-glucanase and cellulase to obtain a yeast protein emulsion; and S6, evaporating and concentrating the yeast protein emulsion to obtain the yeast protein.
    Type: Application
    Filed: December 27, 2022
    Publication date: February 27, 2025
    Inventors: Xianwu QIN, Zhipeng XU, Junpeng HU, Jinjun DAI, Zhiwen XIE, Xin HUANG
  • Patent number: 12065495
    Abstract: Provided are antibodies and antigen-binding fragments thereof that specifically bind to human neuropilin-2 (NRP2) polypeptides, including those that modulate binding interactions between human NRP2 and at least one NRP2 ligand, for example, human histidyl-tRNA synthetase (HRS), and which thereby modulate subsequent NRP2-mediated downstream signaling events, including related therapeutic compositions and methods for modulating NRP2 activity and treating diseases such as NRP2-associated diseases.
    Type: Grant
    Filed: October 20, 2022
    Date of Patent: August 20, 2024
    Assignee: aTyr Pharma, Inc.
    Inventors: Luke G. Burman, Yee Ting (Esther) Chong, Yanyan Geng, Leslie Nangle Greene, Kristina Hamel, David King, Ann Menefee, Kaitlyn Rauch, Zhiwen Xu, Liting Zhai
  • Publication number: 20240092917
    Abstract: Provided are affinity matured and humanized antibodies and antigen-binding fragments thereof that specifically bind to human neuropilin-2 (NRP2) polypeptides, including those that modulate binding interactions between human NRP2 and at least one NRP2 ligand, and which thereby modulate subsequent NRP2-mediated downstream signaling events, including related therapeutic compositions and methods for modulating NRP2 activity and treating diseases such as NRP2-associated diseases.
    Type: Application
    Filed: September 28, 2023
    Publication date: March 21, 2024
    Inventors: Luke BURMAN, Yeeting CHONG, Leslie Ann GREENE, David KING, Zhiwen XU, Ryan Andrew ADAMS
  • Patent number: 11807687
    Abstract: Provided are affinity matured and humanized antibodies and antigen-binding fragments thereof that specifically bind to human neuropilin-2 (NRP2) polypeptides, including those that modulate binding interactions between human NRP2 and at least one NRP2 ligand, and which thereby modulate subsequent NRP2-mediated downstream signaling events, including related therapeutic compositions and methods for modulating NRP2 activity and treating diseases such as NRP2-associated diseases.
    Type: Grant
    Filed: October 2, 2020
    Date of Patent: November 7, 2023
    Assignee: aTyr Pharma, Inc.
    Inventors: Luke Burman, Yeeting Chong, Leslie Ann Greene, David King, Zhiwen Xu, Ryan Andrew Adams
  • Publication number: 20230312730
    Abstract: Provided are antibodies and antigen-binding fragments thereof that specifically bind to human neuropilin-2 (NRP2) polypeptides, including those that modulate binding interactions between human NRP2 and at least one NRP2 ligand, for example, human histidyl-tRNA synthetase (HRS), and which thereby modulate subsequent NRP2-mediated downstream signaling events, including related therapeutic compositions and methods for modulating NRP2 activity and treating diseases such as NRP2-associated diseases.
    Type: Application
    Filed: October 20, 2022
    Publication date: October 5, 2023
    Inventors: Luke G. BURMAN, Yee Ting (Esther) CHONG, Yanyan GENG, Leslie Nangle GREENE, Kristina HAMEL, David KING, Ann MENEFEE, Kaitlyn RAUCH, Zhiwen XU, Liting ZHAI
  • Patent number: 11714328
    Abstract: Disclosed is a terminal, including: a display screen including a sensor area, the sensor area being a transparent display area on the display screen; a sensor disposed below the display screen, the sensor having a photosensitive portion; and a color-changing layer above the display screen, where the photosensitive portion of the sensor is within a first orthographic projection range of the sensor area, and the sensor area is within a second orthographic projection range of the color-changing layer; the transparent display area is transparent when the sensor is in operation; and the color-changing layer is configured to switch between a colorless state and a colored state.
    Type: Grant
    Filed: November 22, 2019
    Date of Patent: August 1, 2023
    Assignee: Beijing Xiaomi Mobile Software Co., Ltd.
    Inventors: Lintao Zhang, Wei Chen, Jiwei Chen, Jing Gao, Zhiwen Xu
  • Patent number: 11505610
    Abstract: Provided are antibodies and antigen-binding fragments thereof that specifically bind to human neuropilin-2 (NRP2) polypeptides, including those that modulate binding interactions between human NRP2 and at least one NRP2 ligand, for example, human histidyl-tRNA synthetase (HRS), and which thereby modulate subsequent NRP2-mediated downstream signaling events, including related therapeutic compositions and methods for modulating NRP2 activity and treating diseases such as NRP2-associated diseases.
    Type: Grant
    Filed: April 5, 2019
    Date of Patent: November 22, 2022
    Assignee: aTyr Pharma, Inc.
    Inventors: Luke Burman, Yee Ting (Esther) Chong, Yanyan Geng, Leslie Nangle Greene, Kristina Hamel, David King, Ann Menefee, Kaitlyn Rauch, Zhiwen Xu, Liting Zhai
  • Publication number: 20220098327
    Abstract: Isolated histidyl-tRNA synthetase splice variant polynucleotides and polypeptides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
    Type: Application
    Filed: June 23, 2021
    Publication date: March 31, 2022
    Inventors: Jie ZHOU, Ching-Fun LAU, Zhiwen XU, Wing-Sze LO, Kristi Helen PIEHL, Leslie Ann GREENE
  • Patent number: 11280946
    Abstract: A polarizing sheet includes a base layer, and a polarizing layer attached to the base layer. The polarizing layer includes, in a same plane, a combination of any two or more of a first region, a second region, or a third region. The first region, the second region and the third region have different light transmission properties.
    Type: Grant
    Filed: August 29, 2019
    Date of Patent: March 22, 2022
    Assignee: BEIJING XIAOMI MOBILE SOFTWARE CO., LTD.
    Inventors: Wei Chen, Zhiwen Xu, Jiwei Chen
  • Patent number: 11100829
    Abstract: A display apparatus includes a fixing component and a display screen having a first pixel region and a second pixel region. An aligning mark line is provided at a joint of the first and second pixel regions. A method for calibrating a display region of the display apparatus includes: capturing a connecting part of the display screen and the fixing component to obtain a first image; determining whether the aligning mark line is shifted with respect to the fixing component; and generating a correction instruction when the aligning mark line is shifted with respect to the fixing component, wherein the correction instruction includes activating a pixel row of the second pixel region where the aligning mark line is shifted with respect to the fixing component to substitute for a pixel row of the first pixel region shifted to a connecting region of the fixing component.
    Type: Grant
    Filed: June 8, 2020
    Date of Patent: August 24, 2021
    Assignee: BEIJING XIAOMI MOBILE SOFTWARE CO., LTD.
    Inventors: Lei Tang, Jian Li, Zhiwen Xu
  • Patent number: 11078299
    Abstract: Isolated histidyl-tRNA synthetase splice variant polynucleotides and polypeptides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
    Type: Grant
    Filed: April 7, 2020
    Date of Patent: August 3, 2021
    Assignees: aTyr Pharma, Inc., Pangu BioPharma Limited
    Inventors: Jie Zhou, Ching-Fun Lau, Zhiwen Xu, Wing-Sze Lo, Kristi Helen Piehl, Leslie Ann Greene
  • Publication number: 20210217337
    Abstract: A display apparatus includes a fixing component and a display screen having a first pixel region and a second pixel region. An aligning mark line is provided at a joint of the first and second pixel regions. A method for calibrating a display region of the display apparatus includes: capturing a connecting part of the display screen and the fixing component to obtain a first image; determining whether the aligning mark line is shifted with respect to the fixing component; and generating a correction instruction when the aligning mark line is shifted with respect to the fixing component, wherein the correction instruction includes activating a pixel row of the second pixel region where the aligning mark line is shifted with respect to the fixing component to substitute for a pixel row of the first pixel region shifted to a connecting region of the fixing component.
    Type: Application
    Filed: June 8, 2020
    Publication date: July 15, 2021
    Applicant: BEIJING XIAOMI MOBILE SOFTWARE CO., LTD.
    Inventors: Lei TANG, Jian LI, Zhiwen XU
  • Publication number: 20210163606
    Abstract: Provided are affinity matured and humanized antibodies and antigen-binding fragments thereof that specifically bind to human neuropilin-2 (NRP2) polypeptides, including those that modulate binding interactions between human NRP2 and at least one NRP2 ligand, and which thereby modulate subsequent NRP2-mediated downstream signaling events, including related therapeutic compositions and methods for modulating NRP2 activity and treating diseases such as NRP2-associated diseases.
    Type: Application
    Filed: October 2, 2020
    Publication date: June 3, 2021
    Inventors: Luke BURMAN, Yeeting CHONG, Leslie Ann GREENE, David KING, Zhiwen XU, Ryan Andrew ADAMS
  • Patent number: 10941214
    Abstract: Isolated histidyl-tRNA synthetase splice variant polynucleotides and polypeptides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
    Type: Grant
    Filed: November 19, 2019
    Date of Patent: March 9, 2021
    Assignees: aTyr Pharma, Inc., Paneu BioPharma Limited
    Inventors: Jie Zhou, Ching-Fun Lau, Zhiwen Xu, Wing-Sze Lo, Kristi Helen Piehl, Leslie Ann Greene
  • Publication number: 20200310210
    Abstract: Disclosed is a terminal, including: a display screen including a sensor area, the sensor area being a transparent display area on the display screen; a sensor disposed below the display screen, the sensor having a photosensitive portion; and a color-changing layer above the display screen, where the photosensitive portion of the sensor is within a first orthographic projection range of the sensor area, and the sensor area is within a second orthographic projection range of the color-changing layer; the transparent display area is transparent when the sensor is in operation; and the color-changing layer is configured to switch between a colorless state and a colored state.
    Type: Application
    Filed: November 22, 2019
    Publication date: October 1, 2020
    Applicant: BEIJING XIAOMI MOBILE SOFTWARE CO., LTD.
    Inventors: Lintao ZHANG, Wei CHEN, Jiwei CHEN, Jing GAO, Zhiwen XU
  • Publication number: 20200231704
    Abstract: Isolated histidyl-tRNA synthetase splice variant polynucleotides and polypeptides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
    Type: Application
    Filed: April 7, 2020
    Publication date: July 23, 2020
    Inventors: Jie ZHOU, Ching-Fun LAU, Zhiwen XU, Wing-Sze LO, Kristi Helen PIEHL, Leslie Ann GREENE
  • Publication number: 20200225396
    Abstract: A polarizing sheet includes a base layer, and a polarizing layer attached to the base layer. The polarizing layer includes, in a same plane, a combination of any two or more of a first region, a second region, or a third region. The first region, the second region and the third region have different light transmission properties.
    Type: Application
    Filed: August 29, 2019
    Publication date: July 16, 2020
    Applicant: BEIJING XIAOMI MOBILE SOFTWARE CO., LTD.
    Inventors: Wei CHEN, Zhiwen XU, Jiwei CHEN
  • Publication number: 20200216564
    Abstract: Isolated histidyl-tRNA synthetase splice variant polynucleotides and polypeptides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
    Type: Application
    Filed: November 19, 2019
    Publication date: July 9, 2020
    Inventors: Jie ZHOU, Ching-Fun LAU, Zhiwen XU, Wing-Sze LO, Kristi Helen PIEHL, Leslie Ann GREENE
  • Patent number: 10526419
    Abstract: Isolated histidyl-tRNA synthetase splice variant polynucleotides and polypeptides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
    Type: Grant
    Filed: June 11, 2018
    Date of Patent: January 7, 2020
    Assignees: aTyr Pharma, Inc., Pangu BioPharma Limited
    Inventors: Jie Zhou, Ching-Fun Lau, Zhiwen Xu, Wing-Sze Lo, Kristi Helen Piehl, Leslie Ann Greene