Patents by Inventor Zoltan Tuba

Zoltan Tuba has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8450476
    Abstract: The invention relates to a process for the preparation of 17-hydroxy-6?,7?;15?,16?-bismethylene-17?-pregn-4-ene-3-one-21-carboxylic acid ?-lactone of formula (I) as well as to key-intermediates for this process.
    Type: Grant
    Filed: October 11, 2005
    Date of Patent: May 28, 2013
    Assignee: Richter Gedeon Nyrt.
    Inventors: György Gálik, Judit Horváth, Béla Sörös, Sándor Mahö, Zoltán Tuba, Gábor Balogh
  • Patent number: 8309712
    Abstract: The invention relates to an industrial process for the preparation of 17-hydroxy-6?,7?;15?,16?-bismethylene-3-oxo-17?-pregn-4-ene-21-carboxylic acid ?-lactone of formula (I), and to the key-intermediates for this process.
    Type: Grant
    Filed: October 11, 2005
    Date of Patent: November 13, 2012
    Assignee: Richter Gedeon Nyrt.
    Inventors: Béla Sörös, Judit Horváth, György Gálik, József Bódi, Zoltán Tuba, Sándor Mahó, Gábor Balogh, Antal Aranyi
  • Patent number: 8183402
    Abstract: The present invention relates to a process for the synthesis of the 17-acetoxy-11?-[4-(dimethylamino)-phenyl]-21-methoxy-19-norpregna-4,9-dien-3,20-dione of formula (I): from 3,3-[1,2-etandiyl-bis(oxy)]-oestr-5(10),9(11)-dien-17-one of formula (II):
    Type: Grant
    Filed: June 19, 2008
    Date of Patent: May 22, 2012
    Assignee: Richter Gedeon Nyrt.
    Inventors: József Bódi, György Visky, János Széles, Sándor Mahó, Csaba Sánta, János Csörgei, Zoltán Tuba, László Terdy, Csaba Molnár, Antal Aranyi, Zoltán Horváth, Gábor Balogh
  • Patent number: 8110691
    Abstract: A new industrial process for the synthesis of solvate-free 17?-acetoxy-11?-[4-(N,N-dimethyl-amino)-phenyl]-19-norpregna-4,9-diene-3,20-dione [CDB-2914] of formula (I) which is a strong antiprogestogene and antiglucocorticoid agent. The invention also relates to compounds of formula (VII) and (VIII) used as intermediates in the process.
    Type: Grant
    Filed: May 18, 2007
    Date of Patent: February 7, 2012
    Assignee: Richter Gedeon Nyrt.
    Inventors: Lajosné Dancsi, György Visky, Zoltán Tuba, János Csörgei, Csaba Molnár, Endréné Magyari
  • Patent number: 7816546
    Abstract: The invention relates to a process for the synthesis of d-(17?)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-oxime (also known as norelgestromin) via acetylation of d-norgestrel at position 17; oximation of the oxo group at position 3 of the obtained d-(17?)-13-ethyl-17-(acetyloxy)-18,19-dinorpregn-4-ene-20-yn-3-one; and then hydrolyzing the acetyloxy group at position 17 of the obtained d-(17?)-13-ethyl-17-(acetyloxy)-18,19-dinorpregn-4-ene-20-yn-3-oxime derivative, thereby obtaining norelgestromin.
    Type: Grant
    Filed: June 30, 2004
    Date of Patent: October 19, 2010
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Zoltán Tuba, Sándor Mahó, János Kiss, Endréné Magyari, László Terdy
  • Publication number: 20100137622
    Abstract: The present invention relates to a process for the synthesis of the known 17-acetoxy-11-?-[4-(dimethyl amino)-phenyl]-21-methoxy-19-norpregna-4,9-dien-3,20-dione (further on CDB-4124) of formula (I) from 3,3-[1,2-ethandiyl-bis(oxy)]-oestr-5(10),9(11)-dien-17-one of formula (II). Compound CDB-4124 belongs to the group of anti-hormones.
    Type: Application
    Filed: June 19, 2008
    Publication date: June 3, 2010
    Inventors: József Bódi, György Visky, János Széles, Sándor Mahó, Csaba Sánta, János Csörgei, Zoltán Tuba, László Terdy, Csaba Molnár, Antal Aranyi, Zoltán Horváth, Gábor Balogh
  • Publication number: 20090312299
    Abstract: The invention is directed to a process of preparing substantially pure d-(17?)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-3E- and -3Z-oxime isomers, as well as a process for the synthesis of the mixture of isomers and the pure isomers. The invention also relates to substantially pure d-(17?)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene20-yn-3-one-3E-oxime and substantially pure d-(17?)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-3Z-oxime isomer. Further aspects of the invention include a composition comprising substantially pure d-(17?)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene20-yn-3-one-3E-oxime or substantially pure d-(17?)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-3Z-oxime isomer, and methods of treatment using said compositions.
    Type: Application
    Filed: July 9, 2009
    Publication date: December 17, 2009
    Inventors: Zoltán TUBA, Sándor MAHÓ, György KESERÜ, József KOZMA, János HORVÁTH, Gábor BALOGH
  • Patent number: 7576226
    Abstract: The invention is directed to a process of preparing substantially pure d-(17?)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-3E- and -3Z-oxime isomers, as well as a process for the synthesis of the mixture of isomers and the pure isomers. The invention also relates to substantially pure d-(17?)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene20-yn-3-one-3E-oxime and substantially pure d-(17?)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-3Z-oxime isomer. Further aspects of the invention include a composition comprising substantially pure d-(17?)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene20-yn-3-one-3E-oxime or substantially pure d-(17?)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-3Z-oxime isomer, and methods of treatment using said compositions.
    Type: Grant
    Filed: June 30, 2004
    Date of Patent: August 18, 2009
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Zoltán Tuba, Sándor Mahó, György Keserü, József Kozma, János Horváth, Gábor Balogh
  • Publication number: 20090187032
    Abstract: The present invention relates to a new industrial process for the synthesis of solvate-free 17?-acetoxy-11?-[4-(N,N-dimethyl-amino)-phenyl]-19-norpregna-4,9-diene-3,20-dione [CDB-2914] of formula (I) which is a strong antiprogestogene and antiglucocorticoid agent. The invention also relates to compounds of formula (VII) and (VIII) used as intermediates in the process.
    Type: Application
    Filed: May 18, 2007
    Publication date: July 23, 2009
    Applicant: RICHTER GEDEON NYRT.
    Inventors: Lajosne Dancsi, Gyorgy Visky, Zoltan Tuba, Janos Csorgei, Csaba Molnar, Endrene Magyari
  • Publication number: 20080200668
    Abstract: The invention relates to an industrial process for the preparation of 17-hydroxy-6?,7?;15?,16?-bismethylene-3-oxo-17?-pregn-4-ene-21-carboxylic acid ?-lactone of formula (I), and to the key-intermediates for this process.
    Type: Application
    Filed: October 11, 2005
    Publication date: August 21, 2008
    Inventors: Bela Soros, Judit Horvath, Gyorgy Galik, Jozsef Bodi, Zoltan Tuba, Sandor Maho, Gabor Balogh, Antal Aranyi
  • Publication number: 20080194812
    Abstract: The invention relates to a process for the preparation of 17-hydroxy-6?,7?;15?,16?-bismethylene-17?-pregn-4-ene-3-one-21-carboxylic acid ?-lactone of formula (I) as well as to key-intermediates for this process.
    Type: Application
    Filed: October 11, 2005
    Publication date: August 14, 2008
    Inventors: Gyorgy Galik, Judit Horvath, Bela Soros, Sandor Maho, Zoltan Tuba, Gabor Balogh
  • Patent number: 7199257
    Abstract: A new process is disclosed for the synthesis of racemic or optically pure N-[4-cyano-3-trifluoro-methyl-phenyl]-3[4-fluorophenyl-sulfonyl]-2-hydroxy-2-methylpropionamide. The process includes the formation of several novel intermediates in the synthesis.
    Type: Grant
    Filed: May 26, 2000
    Date of Patent: April 3, 2007
    Assignee: Richter Gedeon Vegyeszeti Gyar RT.
    Inventors: Bela Sörös, Zoltan Tuba, György Galik, Adam Bor, Adam Demeter, Ferenc Trischler, Janos Horvath, Janos Brlik
  • Publication number: 20050032764
    Abstract: The invention is directed to a process of preparing substantially pure d-(17?)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-3E- and -3Z-oxime isomers, as well as a process for the synthesis of the mixture of isomers and the pure isomers. The invention also relates to substantially pure d-(17?)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene20-yn-3-one-3E-oxime and substantially pure d-(17?)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-3Z-oxime isomer. Further aspects of the invention include a composition comprising substantially pure d-(17?)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene20-yn-3-one-3E-oxime or substantially pure d-(17?)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-3Z-oxime isomer, and methods of treatment using said compositions.
    Type: Application
    Filed: June 30, 2004
    Publication date: February 10, 2005
    Inventors: Zoltan Tuba, Sandor Maho, Gyorgy Keseru, Jozsef Kozma, Janos Horvath, Gabor Balogh
  • Publication number: 20050032763
    Abstract: The invention relates to a process for the synthesis of d-(17?)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-oxime (also known as norelgestromin) via acetylation of d-norgestrel at position 17; oximation of the oxo group at position 3 of the obtained d-(17?)-13-ethyl-17-(acetyloxy)-18,19-dinorpregn-4-ene-20-yn-3-one; and then hydrolyzing the acetyloxy group at position 17 of the obtained d-(17?)-13-ethyl-17-(acetyloxy)-18,19-dinorpregn-4-ene-20-yn-3-oxime derivative, thereby obtaining norelgestromin.
    Type: Application
    Filed: June 30, 2004
    Publication date: February 10, 2005
    Inventors: Zoltan Tuba, Sandor Maho, Janos Kiss, Endrene Magyari, Laszlo Terdy
  • Patent number: 6583298
    Abstract: The invention relates to a new process for the synthesis of 17&bgr;-hydroxy-17&agr;-methyl-2-oxa-5&agr;-androstane-3-one of formula (I).
    Type: Grant
    Filed: November 30, 2001
    Date of Patent: June 24, 2003
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Csaba Santa, Zoltan Tuba, Sandor Maho, Janos Szeles, Katalin Ferenczi, Peter Horvath, Krisztina Lancos, Tamas Mester, Arpad Trompler
  • Patent number: 6448413
    Abstract: The invention relates to a new process for the synthesis of 17&bgr;-hydroxy-17&agr;-methyl-1,3-seco-2-nor-5&agr;-androstane-3-acid derivatives of formula (I) wherein the meaning of Z is carboxyl or formyl group and to the new secoindoxylidene carboxylic acid derivatives of formula (II) wherein R1 and R2 independently are C1-C4 alkyl or alkoxy group, hydrogen or halogen atom—which are intermediates for preparing the compounds of formula (I). The 17&bgr;-hydroxy-17&agr;-methyl-1,3-seco-2-nor-5&agr;-androstane-3-acid derivatives of formula (I) are intermediates in the synthesis of oxandrolon (17&bgr;-hydroxy-17&agr;-methyl-2-oxa-5&agr;-androstane-3-one), which is used as anabolic in therapy.
    Type: Grant
    Filed: November 30, 2001
    Date of Patent: September 10, 2002
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Csaba Santa, Zoltan Tuba, Sandor Maho, Janos Szeles, Gabor Balogh, Janos Brlik, Ferenc Trischler, Gabriella Szilagyi, Erika Bakcsi
  • Patent number: 5591735
    Abstract: There is disclosed novel, therapeutically active androstane derivatives having neuromuscular blocking effect, which are substituted by a quaternary ammonium group in 16-position; pharmaceutically composition containing them; process for producing them; and novel intermediates for the production.
    Type: Grant
    Filed: October 27, 1993
    Date of Patent: January 7, 1997
    Assignee: Marvishi Pharmaceutical Co., Ltd.
    Inventors: Zoltan Tuba, E. Szilveszter Vizi, Francis F. Foldes, Sandor Maho
  • Patent number: 5547949
    Abstract: Novel, therapeutically active 21-aminosteroids of formula (I) ##STR1## with pregnane skeleton, are disclosed wherein two of X, Y and Z are a nitrogen atom each and the third one is a methine group; R.sup.1 and R.sup.2 are independently from each other, a primary amino group bearing as substituent a branched-chain C.sub.4-8 alkyl -alkenyl or -alkynyl group, or a C.sub.4-10 cycloalkyl group comprising 1 to 3 ring(s) and being optionally substituted by at least one C.sub.1-3 alkyl group; or R.sup.1 and R.sup.2 are each a spiro-heterocyclic secondary amino group containing at most 10 carbon atoms and optionally at least one oxygen atom as additional heteroatom; or one of R.sup.1 and R.sup.2 is an unsubstituted heterocyclic secondary amino group containing 4 to 7 carbon atoms and the other one is an above-identified primary amino group, an above-identified spiro-heterocyclic secondary amino group, or a heterocyclic secondary amino group containing 4 to 7 carbon atoms and substituted by at least one C.sub.
    Type: Grant
    Filed: December 8, 1994
    Date of Patent: August 20, 1996
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Sandor Maho, Zoltan Tuba, Aniko Gere, Pal Vittay, Bela Kiss, Eva Palosi, Laszlo Szporny, Erzsebet C. Francsicsne, Anna M. Boorne, Gabor Balogh, Sandor Gorog
  • Patent number: 5510345
    Abstract: The invention relates to novel eburnamenine derivatives of formula (I): ##STR1## wherein R.sup.1 and R.sup.2 as well as R.sup.3 and R.sup.4, independently from each other, stand for hydrogen, C.sub.2-6 alkyl group, C.sub.2-6 alkenyl group; or a C.sub.3-10 alicyclic group involving 1 to 3 rings, and this latter group may be substituted by a C.sub.1-6 alkyl or C.sub.2-6 alkenyl group; or R.sup.1 and R.sup.2 and/or R.sup.3 and R.sup.4, together with the adjacent nitrogen atom and optionally with an additional oxygen or nitrogen atom, form a 4- to 6-membered, saturated or unsaturated cyclic group which may be substituted by a C.sub.1-6 alkyl or C.sub.2-6 alkenyl group; two of X, Y and Z are nitrogen whereas the third of them means a methine group; n is 1 or 2; W means oxygen or two hydrogen atoms; and the wavy line means .alpha.-/.alpha.-, .alpha.-/.beta.- or .beta.-/.alpha.- steric position, as well as their acid addition salts and solvates.
    Type: Grant
    Filed: December 8, 1994
    Date of Patent: April 23, 1996
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Zoltan Tuba, Sandor Maho, Aniko Gere, Pal Vittay, Bela Kiss, Eva Palosi, Laszlo Szporny, Csaba Szantay, Ferenc Soti, Zsuzsa Baloghne Kardos, Maria Incze, Gabor Balogh, Maria Gazdag
  • Patent number: 5410040
    Abstract: New monoquaternary and diquaternary 5-alpha-hydroxy-3,16-diaminoandrostane salts are disclosed with curare-like muscle relaxant activity. The new salts are characterized by a surprisingly rapid onset time.
    Type: Grant
    Filed: June 27, 1986
    Date of Patent: April 25, 1995
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Zoltan Tuba, Judit Horvath, Maria Lovas nee Marsai, Miklos Riesz, deceased, Katalin Biro, Laszle Szporny, Egon Karpati